{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:48:12Z","timestamp":1782859692298,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":1034,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\"><jats:list-item><jats:p>The roles of voltage\u2010gated (<jats:italic>K<\/jats:italic><jats:sub>V<\/jats:sub>) and large conductance Ca<jats:sup>2+<\/jats:sup>\u2010activated K<jats:sup>+<\/jats:sup>(BK<jats:sub>Ca<\/jats:sub>) channels in regulating basal contractility in myometrial smooth muscle are unresolved. The aim of this study was to determine the effects of inhibition of these channels on spontaneous rhythmic contraction in myometrial strips from four groups of rats: nonpregnant and during early (day 7), mid\u2010 (day 14), and late (day 21) pregnancy.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>BK<jats:sub>Ca<\/jats:sub>channels were inhibited using iberiotoxin (1\u2013100\u2003n<jats:sc>M<\/jats:sc>), paxilline (1\u201310\u2003<jats:italic>\u03bc<\/jats:italic><jats:sc>M<\/jats:sc>) or penitrem A (1\u2013500, or 3000\u2003n<jats:sc>M<\/jats:sc>);<jats:italic>K<\/jats:italic><jats:sub>V<\/jats:sub>channels were inhibited using tetraethylammonium (TEA; 1\u201310\u2003m<jats:sc>M<\/jats:sc>) and\/or 4\u2010aminopyridine (4\u2010AP; 1\u20135\u2003m<jats:sc>M<\/jats:sc>). Contractility was assessed as mean integral tension (MIT). Time\/vehicle controls were also performed.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>None of the selective BK<jats:sub>Ca<\/jats:sub>channel inhibitors significantly affected contractility in myometrial strips from either nonpregnant or pregnant animals.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>4\u2010AP caused concentration\u2010dependent increases in MIT in myometrium in all four groups. TEA (5 and 10\u2003m<jats:sc>M<\/jats:sc>) significantly increased MIT in myometrium from nonpregnant, and mid\u2010 and late pregnant rats, but not in myometrium from early pregnant rats. TEA and 4\u2010AP still caused an increase in MIT following treatment with 3000\u2003n<jats:sc>M<\/jats:sc>penitrem A or a combination of propranolol, phentolamine, atropine (all 1\u2003<jats:italic>\u03bc<\/jats:italic><jats:sc>M<\/jats:sc>) and capsaicin (10\u2003<jats:italic>\u03bc<\/jats:italic><jats:sc>M<\/jats:sc>) in myometrial strips from nonpregnant rats.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>These results indicate that whereas BK<jats:sub>Ca<\/jats:sub>channels play little or no part in controlling basal rhythmicity in rat myometrium,<jats:italic>K<\/jats:italic><jats:sub>V<\/jats:sub>channels appear to play a crucial role in this regard, especially during mid\u2010 and late pregnancy.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2006)<jats:bold>147<\/jats:bold>, 815\u2013824. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706644\">10.1038\/sj.bjp.0706644<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706644","type":"journal-article","created":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T13:58:04Z","timestamp":1137419884000},"page":"815-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["A role for voltage\u2010gated, but not Ca<sup>2+<\/sup>\u2010activated, K<sup>+<\/sup>channels in regulating spontaneous contractile activity in myometrium from virgin and pregnant rats"],"prefix":"10.1111","volume":"147","author":[{"given":"Philip Irving","family":"Aaronson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma","family":"Sarwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Gin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uli","family":"Rockenbauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Tillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Marie","family":"Tribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00489-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.4.C976"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.263.5.C1049"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00442"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.6.C1668"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.102"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00236.2004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/8.10.941"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030221"},{"key":"e_1_2_7_11_1","first-page":"1227","article-title":"Pharmacological characterization of five cloned voltage\u2010gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mamMalian cell lines","volume":"45","author":"GRISSMER S.","year":"1994","journal-title":"Mol. 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