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MDEA produced a transient but nonsignificant fall in diastolic pressure. The pressor response produced by MDA was accompanied by bradycardia.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>All three amphetamine derivatives caused an initial hypothermic response; however, MDA also produced a subsequent hyperthermia, and the speed of recovery from hypothermia was MDA&gt;MDMA&gt;MDEA. The<jats:italic>\u03b1<\/jats:italic><jats:sub>2A<\/jats:sub>\u2010adrenoceptor antagonist 2\u2010((4,5\u2010dihydro\u20101<jats:italic>H<\/jats:italic>\u2010imidazol\u20102\u2010yl)methyl)\u20102,3\u2010dihydro\u20101\u2010methyl\u20101<jats:italic>H<\/jats:italic>\u2010isoindole (BRL 44408) (1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) prolonged the hypothermic response to MDMA.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Only MDA induced locomotor activity when given alone, but in the presence of BRL 44408, MDMA produced increased locomotor activity.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>The order of potency for producing isometric contractions of rat aorta (<jats:italic>\u03b1<\/jats:italic><jats:sub>1D<\/jats:sub>) and vas deferens (<jats:italic>\u03b1<\/jats:italic><jats:sub>1A<\/jats:sub>) was MDA&gt;MDMA&gt;MDEA, with MDEA acting as an<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>\u2010adrenoceptor antagonist with a p<jats:italic>K<\/jats:italic><jats:sub>B<\/jats:sub>of 4.79\u00b10.12 (<jats:italic>n<\/jats:italic>=4) in aorta.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>The order of potency for prejunctional inhibition of stimulation\u2010evoked contractions in rat vas deferens (<jats:italic>\u03b1<\/jats:italic><jats:sub>2A<\/jats:sub>\u2010adrenoceptor mediated) was MDA&gt;MDMA&gt;MDEA.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Blood pressure actions of the three amphetamine derivatives may be at least partly due to<jats:italic>\u03b1<\/jats:italic><jats:sub>1<\/jats:sub>\u2010adrenoceptor agonism or antagonism. The reversal of the hypothermic actions are at least partly due to<jats:italic>\u03b1<\/jats:italic><jats:sub>2A<\/jats:sub>\u2010adrenoceptor agonism since the hypothermic response was more prolonged with MDEA which exhibits low<jats:italic>\u03b1<\/jats:italic><jats:sub>2A<\/jats:sub>\u2010adrenoceptor potency, and effects of MDMA after<jats:italic>\u03b1<\/jats:italic><jats:sub>2A<\/jats:sub>\u2010adrenoceptor antagonism were similar to those of MDEA.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2006)<jats:bold>147<\/jats:bold>, 926\u2013934. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706688\">10.1038\/sj.bjp.0706688<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706688","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T17:14:51Z","timestamp":1140455691000},"page":"926-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Effects of MDMA, MDA and MDEA on blood pressure, heart rate, locomotor activity and body temperature in the rat involve<i>\u03b1<\/i>\u2010adrenoceptors"],"prefix":"10.1111","volume":"147","author":[{"given":"Sotiria","family":"Bexis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R","family":"Docherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01070-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2004.00114.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.302.3.898"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0022-3565(24)29607-5","article-title":"3,4\u2010Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin\u2013dopamine interactions","volume":"297","author":"BANKSON M.G.","year":"2001","journal-title":"J. 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