{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:06:57Z","timestamp":1760954817959},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":1004,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>There is direct chemical evidence that <jats:sc>L<\/jats:sc>\u2010<jats:italic>\u03b2<\/jats:italic>,<jats:italic>\u03b2<\/jats:italic>\u2010dimethylcysteine (<jats:sc>L<\/jats:sc>\u2010penicillamine (<jats:sc>L<\/jats:sc>\u2010PEN)) is a scavenger of peroxynitrite. The aim of this study was to determine whether <jats:sc>L<\/jats:sc>\u2010PEN attenuates the haemodynamic responses elicited by peroxynitrite in pentobarbital\u2010anaesthetized rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Peroxynitrite (1\u201320\u2003<jats:italic>\u03bc<\/jats:italic>mol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) elicited dose\u2010dependent reductions in mean arterial blood pressure (MAP) and mesenteric and hindquarter vascular resistances.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:sc>L<\/jats:sc>\u2010PEN (2\u2003mmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) elicited relatively minor but significant increases in MAP and vascular resistances. The initial reductions in MAP and vascular resistances elicited by peroxynitrite were not diminished after administration of <jats:sc>L<\/jats:sc>\u2010PEN whereas they were much shorter in duration. As such, the total reductions in MAP and vascular resistances were markedly reduced by <jats:sc>L<\/jats:sc>\u2010PEN.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The finding that <jats:sc>L<\/jats:sc>\u2010PEN (2\u2003mmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) did not affect the hypotensive or vasodilator responses elicited of the ATP\u2010dependent potassium\u2010channel agonist, cromakalim (3\u201318\u2003<jats:italic>\u03bc<\/jats:italic>g\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.), suggests that this dose of <jats:sc>L<\/jats:sc>\u2010PEN is not a nonselective inhibitor of vasodilation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These findings suggest that <jats:sc>L<\/jats:sc>\u2010PEN may effectively scavenge peroxynitrite <jats:italic>in vivo<\/jats:italic> and\/or interfere with the mechanisms by which peroxynitrite elicits its vasodilator responses.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2006) <jats:bold>148<\/jats:bold>, 7\u201315. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706692\">10.1038\/sj.bjp.0706692<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706692","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T17:14:51Z","timestamp":1140455691000},"page":"7-15","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>L<\/scp>\u2010<i>\u03b2<\/i>,<i>\u03b2<\/i>\u2010Dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats"],"prefix":"10.1111","volume":"148","author":[{"given":"Jonathan E","family":"Graves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil W","family":"Kooy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"243","article-title":"Structure activity relationships of peroxynitrite scavengers an approach to nitric oxide neurotoxicity","volume":"83","author":"ALTHAUS J.S.","year":"1994","journal-title":"Res. 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