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The centrally acting antiobesity drug, sibutramine, was used as the reference comparator.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          Sustained body weight loss and decreased cumulative food intake of DIO\u2010rats was observed with E\u20106837 (30\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          , p.o., twice a day) during the 4\u2010week treatment period. The onset of the E\u20106837 effect on body weight was slower than that of sibutramine (5\u2003mg\u2003kg\n                          <jats:sup>\u22121<\/jats:sup>\n                          , p.o.), while its maximal effect was greater, that is \u221215.7 versus \u221211.0%.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>E\u20106837\u2010induced weight loss was exclusively mediated by a decrease (31.7%) in fat mass, with a concomitant reduction (49.6%) in plasma leptin. Reduced obesity was also reflected in improved glycemic control.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Although weight regain occurred after withdrawal from either compound, the body weights after E\u20106837 (\u22126.6%) remained lower than after sibutramine (\u22123.8%) indicating that the greater efficacy of the former did not result in profound rebound hyperphagia\/weight gain.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          These results show that the 5\u2010HT\n                          <jats:sub>6<\/jats:sub>\n                          receptor partial agonist, E\u20106837, is a promising new approach to the management of obesity with the potential to produce greater sustained weight loss than sibutramine.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>British Journal of Pharmacology<\/jats:italic>\n                    (2006)\n                    <jats:bold>148<\/jats:bold>\n                    , 973\u2013983. doi:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706807\">10.1038\/sj.bjp.0706807<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1038\/sj.bjp.0706807","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T07:18:12Z","timestamp":1150701492000},"page":"973-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Chronic 5\u2010HT\n                    <sub>6<\/sub>\n                    receptor modulation by E\u20106837 induces hypophagia and sustained weight loss in diet\u2010induced obese rats"],"prefix":"10.1111","volume":"148","author":[{"given":"Angels","family":"Fisas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Codony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Dordal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Giraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Merc\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Holenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Heal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Buschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrus Johan","family":"Pauwels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(02)00311-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.151"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.4.11.1901"},{"key":"e_1_2_6_5_1","first-page":"A64","article-title":"5\u2010HT6 antisense oligonucleotide i.c.v. affects rat performance in the water maze and feeding","volume":"11","author":"BENTLEY J.C.","year":"1997","journal-title":"J Psychopharmacol."},{"key":"e_1_2_6_6_1","first-page":"66P","article-title":"Effect of the 5\u2010HT6 antagonist, Ro 04\u20106790 on food consumption in rats trained to a fixed feeding","volume":"126","author":"BENTLEY J.C.","year":"1999","journal-title":"Br. 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