{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:50:15Z","timestamp":1791186615796,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":790,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:sec><jats:title>Background and purpose:<\/jats:title><jats:p>The acetylcholinesterase inhibitor, donepezil, is also a high affinity \u03c3<jats:sub>1<\/jats:sub>receptor agonist. We examined the involvement of \u03c3<jats:sub>1<\/jats:sub>receptors in its anti\u2010amnesic and neuroprotective properties against amyloid \u03b2<jats:sub>25\u201035<\/jats:sub>peptide\u2010induced toxicity in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>Mice were given an intracerebroventricular (i.c.v.) injection of A\u03b2<jats:sub>25\u201035<\/jats:sub>peptide (9 nmol) 7\u20109 days before being tested for spontaneous alternation and passive avoidance. Hippocampal lipid peroxidation was measured 7 days after A\u03b2<jats:sub>25\u201035<\/jats:sub>injection to evaluate oxidative stress. Donepezil, the \u03c3<jats:sub>1<\/jats:sub>agonist PRE\u2010084 or the cholinesterase (ChE) inhibitors tacrine, rivastigmine and galantamine were administered either 20 min before behavioural sessions to check their anti\u2010amnesic effects, or 20 min before A\u03b2<jats:sub>25\u201035<\/jats:sub>injection, or 24 h after A\u03b2<jats:sub>25\u201035<\/jats:sub>injection and then once daily before behavioural sessions, to check their pre\u2010 and post\u2010i.c.v. neuroprotective activity, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>All the drugs tested were anti\u2010amnesic, but only the effects of PRE\u2010084 and donepezil were prevented by the \u03c3<jats:sub>1<\/jats:sub>antagonist BD1047. Only PRE\u2010084 and donepezil showed neuroprotection when administered pre i.c.v.; they blocked lipid peroxidation and learning deficits, effects inhibited by BD1047. Post i.c.v., PRE\u2010084 and donepezil showed complete neuroprotection whereas the other ChE inhibitors showed partial effects. BD1047 blocked these effects of PRE\u2010084, attenuated those of donepezil, but did not affect the partial effects of the other ChE inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications.<\/jats:title><jats:p>The potent anti\u2010amnesic and neuroprotective effects of donepezil against A\u03b2<jats:sub>25\u201035<\/jats:sub>\u2010induced toxicity involve both its cholinergic and \u03c3<jats:sub>1<\/jats:sub>agonistic properties. This dual action may explain its sustained activity compared to other ChE inhibitors.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2006)<jats:bold>149<\/jats:bold>, 998\u20131012. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706927\">10.1038\/sj.bjp.0706927<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1038\/sj.bjp.0706927","type":"journal-article","created":{"date-parts":[[2006,10,23]],"date-time":"2006-10-23T14:03:20Z","timestamp":1161612200000},"page":"998-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":265,"title":["The anti\u2010amnesic and neuroprotective effects of donepezil against amyloid \u03b2<sub>25\u201035<\/sub>peptide\u2010induced toxicity in mice involve an interaction with 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