{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:53:22Z","timestamp":1783151602765,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T00:00:00Z","timestamp":1234828800000},"content-version":"vor","delay-in-days":566,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:sec><jats:title>Background and purpose:<\/jats:title><jats:p>Studies were designed to examine the effects of dietary fats on metabolic effects of 3,4\u2010methylenedioxymethamphetamine (MDMA, Ecstasy). These effects included hyperthermia, expression of uncoupling protein (UCP1 and 3) in brown adipose tissue or skeletal muscle and plasma free fatty acid (FFA) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>Male Sprague\u2010Dawley rats were fed either a high\u2010fat diet (HFD, 60%\u2003kcal) or a lower fat isocaloric controlled diet (LFD, 10%\u2003kcal) for 28 days before MDMA challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>No significant differences were observed between LFD and HFD groups in terms of body weight, plasma thyroxine (T4) levels and expression of brown fat UCP1 or skeletal muscle UCP3 protein. HFD significantly raised levels of circulating FFA and potentiated the thermogenesis induced by MDMA (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.), compared to the effects of the LFD. Moreover, 30 and 60\u2003min after MDMA administration, plasma FFA levels decreased in HFD animals, but were markedly elevated in the LFD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications:<\/jats:title><jats:p>These results indicate that high\u2010fat feeding regulates MDMA\u2010induced thermogenesis by augmenting the activation of UCP rather than its expression.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2007) <jats:bold>151<\/jats:bold>, 1103\u20131108; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" 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