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The aim of this study was to evaluate the<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>pharmacological behaviour of the derivative avarol\u20103\u2032\u2010thiosalicylate (TA) on some inflammatory parameters related to the pathogenesis of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>Human neutrophils and monocytes as well as the human keratinocyte cell line HaCaT were used to study the effect of TA on oxidative stress, the arachidonic acid pathway, tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>(TNF\u2010<jats:italic>\u03b1<\/jats:italic>) release and nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) activation. All these parameters were also determined<jats:italic>in vivo<\/jats:italic>using the zymosan induced mouse air pouch model and the 12\u2010<jats:italic>O<\/jats:italic>\u2010tetradecanoylphorbol\u201013\u2010acetate (TPA) induced mouse epidermal hyperplasia model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>TA showed antioxidant properties in human neutrophils and in the hypoxanthine\/xanthine oxidase assay. This compound reduced, in a concentration\u2010dependent manner, leukotriene B<jats:sub>4<\/jats:sub>, prostaglandin E<jats:sub>2<\/jats:sub>and TNF\u2010<jats:italic>\u03b1<\/jats:italic>production in activated leukocytes. Oral and intrapouch administration of TA in the mouse air pouch model produced a dose\u2010dependent reduction of all these inflammatory mediators. TA also inhibited secretory phospholipase A<jats:sub>2<\/jats:sub>activity and NF\u2010<jats:italic>\u03ba<\/jats:italic>B DNA\u2010binding in HaCaT keratinocytes. In TPA\u2010induced mouse epidermal hyperplasia, topical administration of TA reduced oedema, leukocyte infiltration, eicosanoid levels and TNF\u2010<jats:italic>\u03b1<\/jats:italic>in skin. In addition, interleukin (IL)\u20101<jats:italic>\u03b2<\/jats:italic>and IL\u20102 production were also inhibited. Finally, TA was also capable of suppressing NF\u2010<jats:italic>\u03ba<\/jats:italic>B nuclear translocation<jats:italic>in vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications:<\/jats:title><jats:p>TA inhibited several key biomarkers up\u2010regulated in the inflammatory response of psoriatic skin and this compound could be a promising antipsoriatic agent.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2007)<jats:bold>152<\/jats:bold>, 353\u2013365; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0707394\">10.1038\/sj.bjp.0707394<\/jats:ext-link>; published online 16 July 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