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Accordingly, in this study we examined the effect of pentobarbital, propofol or \u03b1\u2010chloralose anaesthesia on the pro\u2010arrhythmic activity of the class III anti\u2010arrhythmic dofetilide in \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor\u2010stimulated rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>Rabbits anaesthetized intravenously with pentobarbital, propofol or \u03b1\u2010chloralose were infused simultaneously with the \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor agonist phenylephrine (15\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003min<jats:sup>\u22121<\/jats:sup>, i.v.) and dofetilide (0.04\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003min<jats:sup>\u22121<\/jats:sup>, i.v.). The electrocardiographic QT interval, the <jats:italic>T<\/jats:italic>\n<jats:sub>peak<\/jats:sub>\u2013<jats:italic>T<\/jats:italic>\n<jats:sub>end<\/jats:sub> interval and certain QT variability parameters were measured. The heart rate variability and the baroreflex sensitivity were utilized to assess the vagal nerve activity. The spectral power of the systolic arterial pressure was calculated in the frequency range 0.15\u20130.5\u2003Hz to assess the sympathetic activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>Pentobarbital considerably reduced, whereas propofol did not significantly affect the incidence of dofetilide\u2010induced torsades de pointes (TdP) as compared with the results with \u03b1\u2010chloralose (40% (<jats:italic>P<\/jats:italic>=0.011) and 70% (<jats:italic>P<\/jats:italic>=0.211) vs 100%, respectively). In additional experiments, neither doubling of the rate of the dofetilide infusion nor tripling of the rate of phenylephrine infusion elevated the incidence of TdP to the level seen with \u03b1\u2010chloralose. None of the repolarization\u2010related parameters predicted TdP. The indices of the parasympathetic and sympathetic activity were significantly depressed in the \u03b1\u2010chloralose and propofol anaesthesia groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications:<\/jats:title><jats:p>In rabbits, anaesthetics may affect drug\u2010induced TdP genesis differently, which must be considered when results of different studies are compared.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2008) <jats:bold>153<\/jats:bold>, 75\u201389; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0707536\">10.1038\/sj.bjp.0707536<\/jats:ext-link>; published online 29 October 2007<\/jats:p><\/jats:sec>","DOI":"10.1038\/sj.bjp.0707536","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T09:37:07Z","timestamp":1193650627000},"page":"75-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Relevance of anaesthesia for dofetilide\u2010induced torsades de pointes in \u03b1<sub>1<\/sub>\u2010adrenoceptor\u2010stimulated rabbits"],"prefix":"10.1111","volume":"153","author":[{"given":"D","family":"Vincze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A S","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Rudas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Makra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Cs\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Lepr\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Forster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Csan\u00e1dy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Varr\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"324","article-title":"Propofol in rabbits. 1. 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