{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:29:13Z","timestamp":1769200153920,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":334,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:sec><jats:title>Background and purpose:<\/jats:title><jats:p>Studies have shown that the angiotensin II AT<jats:sub>1<\/jats:sub>receptor antagonist, losartan, accentuates the hypotensive response in the orthostatic stress test (tilt) performed in anaesthetized rats. The same effect was not reported with other AT<jats:sub>1<\/jats:sub>antagonists. The aim of this study was to re\u2010evaluate the effects of AT<jats:sub>1<\/jats:sub>receptor blockade on the cardiovascular response to tilt in a model developed for conscious rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>Rats (<jats:italic>n<\/jats:italic>=5\u20137 per group) were instrumented for infusion of drugs and recording of cardiovascular parameters and, after recovery, placed in a plastic tube positioned over the tilt board. The tilt test was conducted by raising the head side of the tilt board from horizontal position to 75\u00b0 head up position for 15\u2003min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>Compared with control group (NaCl 0.9%, 1\u2003ml\u2003kg<jats:sup>\u22121<\/jats:sup>), oral treatment with 1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>per day of losartan or telmisartan did not alter the blood pressure response during tilt. With the 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>dose, both antagonists altered the blood pressure response during tilt (mean maximum changes \u221211\u00b13\u2003mm\u2003Hg;<jats:italic>P<\/jats:italic>&lt;0.01). A post\u2010tilt hypotension was observed with both doses in losartan and telmisartan groups (\u221213\u00b11 and \u22129\u00b12\u2003mm\u2003Hg, respectively;<jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications:<\/jats:title><jats:p>The present results indicate that the effect of losartan on the cardiovascular reactivity to tilt shares a similar profile to that of other AT<jats:sub>1<\/jats:sub>antagonists. Evidence discussed addresses the importance of using a conscious model for testing the influence of antihypertensive drugs on the cardiovascular reactivity to orthostatic challenges.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2008)<jats:bold>153<\/jats:bold>, 966\u2013971; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0707652\">10.1038\/sj.bjp.0707652<\/jats:ext-link>; published online 14 January 2008<\/jats:p><\/jats:sec>","DOI":"10.1038\/sj.bjp.0707652","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T11:13:02Z","timestamp":1200309182000},"page":"966-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiovascular reactivity after blockade of angiotensin AT<sub>1<\/sub>receptors in the experimental model of tilting test in conscious 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