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Acetylsalicylic acid (aspirin) reduces this flush only by about 30%, presumably through decreasing prostaglandin D<jats:sub>2<\/jats:sub>(PGD<jats:sub>2<\/jats:sub>). We investigated whether niacin\u2010induced flush in a rat model involves PGD<jats:sub>2<\/jats:sub>and 5\u2010HT, and the effect of certain flavonoids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>Three skin temperature measurements from each ear were recorded with an infrared pyrometer for each time point immediately before i.p. injection with either niacin or a flavonoid. The temperature was then measured every 10\u2003min for 60\u2003min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>Niacin (7.5\u2003mg per rat, equivalent to a human dose of 1750\u2003mg per 80\u2003kg) maximally increased ear temperature to 1.9\u00b10.2<jats:sup>o<\/jats:sup>C at 45\u2003min. Quercetin and luteolin (4.3\u2003mg per rat; 1000 mg per human), administered i.p. 45\u2003min prior to niacin, inhibited the niacin effect by 96 and 88%, respectively. Aspirin (1.22\u2003mg per rat; 325\u2003mg per human) inhibited the niacin effect by only 30%. Niacin almost doubled plasma PGD<jats:sub>2<\/jats:sub>and 5\u2010HT, but aspirin reduced only PGD<jats:sub>2<\/jats:sub>by 86%. In contrast, luteolin inhibited both plasma PGD<jats:sub>2<\/jats:sub>and 5\u2010HT levels by 100 and 67%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications.<\/jats:title><jats:p>Niacin\u2010induced skin temperature increase is associated with PGD<jats:sub>2<\/jats:sub>and 5\u2010HT elevations in rats; luteolin may be a better inhibitor of niacin\u2010induced flush because it blocks the rise in both mediators.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2008)<jats:bold>153<\/jats:bold>, 1382\u20131387; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0707668\">10.1038\/sj.bjp.0707668<\/jats:ext-link>; published online 28 January 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