{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:45:37Z","timestamp":1761540337388},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2000,7,1]]},"DOI":"10.1038\/sj.bmt.1702465","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T15:44:10Z","timestamp":1031154250000},"page":"141-145","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Phase 1 study of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in breast cancer patients after autologous peripheral blood progenitor cell (PBPC) transplantation"],"prefix":"10.1038","volume":"26","author":[{"given":"B","family":"Bolwell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Vredenburgh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Overmoyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Chap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DM","family":"Menchaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Cruickshank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Glaspy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,7,17]]},"reference":[{"key":"BF1702465_CR1","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1182\/blood.V81.7.1709.1709","volume":"81","author":"WP Peters","year":"1993","unstructured":"Peters WP, Rosner G, Ross M et al. Comparative effects of granulocyte\u2013macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy Blood 1993 81: 1709\u20131719","journal-title":"Blood"},{"key":"BF1702465_CR2","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1200\/JCO.1995.13.6.1328","volume":"13","author":"J Beyer","year":"1995","unstructured":"Beyer J, Schwella N, Zingsem J et al. Hematopoietic rescue after high-dose chemotherapy using autologous peripheral-blood progenitor cells or bone marrow: a randomized comparison J Clin Oncol 1995 13: 1328\u20131335","journal-title":"J Clin Oncol"},{"key":"BF1702465_CR3","first-page":"913","volume":"14","author":"BJ Bolwell","year":"1994","unstructured":"Bolwell BJ, Goormastic M, Yanssens T et al. Comparison of G-CSF with GM-CSF for mobilizing peripheral blood progenitor cells and for enhancing marrow recovery after autologous bone marrow transplant Bone Marrow Transplant 1994 14: 913\u2013918","journal-title":"Bone Marrow Transplant"},{"key":"BF1702465_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1200\/JCO.1997.15.1.5","volume":"15","author":"TJ Smith","year":"1997","unstructured":"Smith TJ, Hillner BE, Schmitz N et al. Economic analysis of a randomized clinical trial to compare filgrastim-mobilized peripheral-blood progenitor-cell transplantation and autologous bone marrow transplantation in patients with Hodgkin's and non-Hodgkin's lymphoma J Clin Oncol 1997 15: 5\u201310","journal-title":"J Clin Oncol"},{"key":"BF1702465_CR5","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0140-6736(96)90536-X","volume":"347","author":"N Schmitz","year":"1996","unstructured":"Schmitz N, Linch DC, Dreger P et al. Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients Lancet 1996 347: 353\u2013357","journal-title":"Lancet"},{"key":"BF1702465_CR6","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1182\/blood.V85.12.3754.bloodjournal85123754","volume":"85","author":"R Haas","year":"1995","unstructured":"Haas R, Witt B, Mohle R et al. Sustained long-term hematopoiesis after myeloablative therapy with peripheral blood progenitor cell support Blood 1995 85: 3754\u20133761","journal-title":"Blood"},{"key":"BF1702465_CR7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1089\/scd.1.1994.3.185","volume":"3","author":"J Reiffers","year":"1994","unstructured":"Reiffers J, Faberes C, Boiron JM et al. Peripheral blood progenitor cell transplantation in 118 patients with hematological malignancies: analysis of factors affecting the rate of engraftment J Hematother 1994 3: 183\u2013191","journal-title":"J Hematother"},{"key":"BF1702465_CR8","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1089\/scd.1.1996.5.407","volume":"5","author":"HT Hassan","year":"1996","unstructured":"Hassan HT, Zander AR . Thrombocytopenia after high-dose chemotherapy and autologous stem cell transplantation: an unresolved problem and possible approaches to resolve it J Hematother 1996 5: 407\u2013414","journal-title":"J Hematother"},{"key":"BF1702465_CR9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/sj.bmt.1700717","volume":"19","author":"SA Bentley","year":"1997","unstructured":"Bentley SA, Brecher ME, Powell E et al. Long-term engraftment failure after marrow ablation and autologous hematopoietic reconstitution: differences between peripheral blood stem cell and bone marrow recipients Bone Marrow Transplant 1997 19: 557\u2013563","journal-title":"Bone Marrow Transplant"},{"key":"BF1702465_CR10","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/369568a0","volume":"369","author":"K Kaushansky","year":"1994","unstructured":"Kaushansky K, Lok S, Holly RD et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin Nature 1994 369: 568\u2013571","journal-title":"Nature"},{"key":"BF1702465_CR11","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/369571a0","volume":"369","author":"F Wendling","year":"1994","unstructured":"Wendling F, Maraskovsky E, Debili N et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis Nature 1994 369: 571\u2013574","journal-title":"Nature"},{"key":"BF1702465_CR12","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/0092-8674(94)90450-2","volume":"77","author":"TD Bartley","year":"1994","unstructured":"Bartley TD, Bogenberger J, Hunt P et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl Cell 1994 77: 1117\u20131124","journal-title":"Cell"},{"key":"BF1702465_CR13","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/369533a0","volume":"369","author":"FJ de Sauvage","year":"1994","unstructured":"de Sauvage FJ, Hass PE, Spencer SD et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand Nature 1994 369: 533\u2013538","journal-title":"Nature"},{"key":"BF1702465_CR14","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1073\/pnas.91.23.11104","volume":"91","author":"DJ Kuter","year":"1994","unstructured":"Kuter DJ, Beeler DL, Rosenberg RD . The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production Proc Natl Acad Sci USA 1994 91: 104\u2013111","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1702465_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/oxfordjournals.jbchem.a124883","volume":"118","author":"T Kato","year":"1995","unstructured":"Kato T, Ogami K, Shimada Y et al. Purification and characterization of thrombopoietin J Biochem 1995 118: 229\u2013236","journal-title":"J Biochem"},{"key":"BF1702465_CR16","first-page":"1224","volume":"23","author":"H Miyazaki","year":"1995","unstructured":"Miyazaki H, Horie K, Shimada Y et al. A simple and quantitative liquid culture system to measure megakaryocyte growth using highly purified CFU-MK Exp Hematol 1995 23: 1224\u20131228","journal-title":"Exp Hematol"},{"key":"BF1702465_CR17","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1182\/blood.V86.2.540.bloodjournal862540","volume":"86","author":"P Hunt","year":"1995","unstructured":"Hunt P, Li Y-S, Nichol JL et al. Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor Blood 1995 86: 540\u2013547","journal-title":"Blood"},{"key":"BF1702465_CR18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood.V88.2.511.bloodjournal882511","volume":"88","author":"LA Harker","year":"1996","unstructured":"Harker LA, Marzec UM, Hunt P et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates Blood 1996 88: 511\u2013521","journal-title":"Blood"},{"key":"BF1702465_CR19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1182\/blood.V86.3.971.971","volume":"86","author":"TR Ulich","year":"1995","unstructured":"Ulich TR, del Castillo J, Yin S et al. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice Blood 1995 86: 971\u2013976","journal-title":"Blood"},{"key":"BF1702465_CR20","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1056\/NEJM199702063360603","volume":"336","author":"M Fanucchi","year":"1997","unstructured":"Fanucchi M, Glaspy J, Crawford J et al. Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer New Engl J Med 1997 336: 404\u2013409","journal-title":"New Engl J Med"},{"key":"BF1702465_CR21","first-page":"3118","volume":"89","author":"RL Basser","year":"1997","unstructured":"Basser RL, Rasko JE, Clarke K et al. Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer Blood 1997 89: 3118\u20133128","journal-title":"Blood"},{"key":"BF1702465_CR22","doi-asserted-by":"publisher","first-page":"673","DOI":"10.7326\/0003-4819-126-9-199705010-00001","volume":"126","author":"S Vadhan-Raj","year":"1997","unstructured":"Vadhan-Raj S, Murray LJ, Bueso-Ramos C et al. Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer Ann Intern Med 1997 126: 673\u2013681","journal-title":"Ann Intern Med"},{"key":"BF1702465_CR23","first-page":"355b (Abstr. 43","volume":"90","author":"B Bolwell","year":"1997","unstructured":"Bolwell B, Overmoyer B, Goormastic M et al. Breast cancer patients have a higher platelet count six weeks after autologous PBPC transplant than patients with hematologic malignancies Blood 1997 90: 355b (Abstr. 4348)","journal-title":"Blood"},{"key":"BF1702465_CR24","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/S0140-6736(96)04471-6","volume":"348","author":"RL Basser","year":"1996","unstructured":"Basser RL, Rasko JE, Clarke K et al. Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer Lancet 1996 348: 1279\u20131281","journal-title":"Lancet"},{"key":"BF1702465_CR25","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1002\/1097-0142(19941201)74:11<2964::AID-CNCR2820741112>3.0.CO;2-X","volume":"74","author":"LB Marks","year":"1994","unstructured":"Marks LB, Rosner GL, Prosnitz LR et al. The impact of conventional plus high dose chemotherapy with autologous bone marrow transplantation on hematologic toxicity during subsequent local-regional radiotherapy for breast cancer Cancer 1994 74: 2964\u20132971","journal-title":"Cancer"},{"key":"BF1702465_CR26","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/0360-3016(92)90908-Z","volume":"23","author":"LB Marks","year":"1992","unstructured":"Marks LB, Halperin EC, Prosnitz LR et al. Post-mastectomy radiotherapy following adjuvant chemotherapy and autologous bone marrow transplantation for breast cancer patients with \u2a7e10 positive axillary lymph nodes Int J Radiat Oncol Biol Phys 1992 23: 1021\u20131026","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1702465","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702465.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702465.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T21:38:11Z","timestamp":1648071491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1702465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,7,1]]}},"alternative-id":["BF1702465"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1702465","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7,1]]},"assertion":[{"value":"17 July 2000","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}