{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:05:00Z","timestamp":1753355100750},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2000,7,1]]},"DOI":"10.1038\/sj.bmt.1702468","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T15:42:19Z","timestamp":1031154139000},"page":"61-67","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["High-dose melphalan-based chemotherapy and autologous stem cell transplantation after second look laparotomy in patients with chemosensitive advanced ovarian carcinoma: long-term results"],"prefix":"10.1038","volume":"26","author":[{"given":"F","family":"Bertucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Viens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JR","family":"Delpero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VJ","family":"Bardou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Faucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Houvenaeghel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Maraninchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,7,7]]},"reference":[{"key":"BF1702468_CR1","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1056\/NEJM199311183292108","volume":"329","author":"S Cannistra","year":"1993","unstructured":"Cannistra S . A. Cancer of the ovary New Engl J Med 1993 329: 1550\u20131559","journal-title":"New Engl J Med"},{"key":"BF1702468_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1056\/NEJM199601043340101","volume":"334","author":"WP McGuire","year":"1996","unstructured":"McGuire WP, Hoskins WJ, Brady MF et al. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage 3 and 4 ovarian cancer New Engl J Med 1996 334: 1\u20136","journal-title":"New Engl J Med"},{"key":"BF1702468_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0002-9343(80)90472-6","volume":"69","author":"III Frei E","year":"1980","unstructured":"Frei E III, Canellos GP . Dose: a critical factor in cancer chemotherapy Am J Med 1980 69: 585\u2013594","journal-title":"Am J Med"},{"key":"BF1702468_CR4","first-page":"471","volume":"68","author":"D Maraninchi","year":"1984","unstructured":"Maraninchi D, Abecassis M, Gastaut JA et al. High-dose melphalan with autologous bone marrow rescue for the treatment of advanced adult solid tumors Cancer Treat Rep 1984 68: 471\u2013474","journal-title":"Cancer Treat Rep"},{"key":"BF1702468_CR5","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1200\/JCO.1989.7.4.515","volume":"7","author":"E Frei","year":"1989","unstructured":"Frei E, Antman B, Teicher B et al. Bone marrow autotransplantation for solid tumors. Prospects J Clin Oncol 1989 7: 515\u2013526","journal-title":"J Clin Oncol"},{"key":"BF1702468_CR6","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1200\/JCO.1987.5.5.756","volume":"5","author":"L Levin","year":"1987","unstructured":"Levin L, Hryniuk W . Dose intensity analysis of chemotherapy regimens in ovarian carcinoma J Clin Oncol 1987 5: 756\u2013767","journal-title":"J Clin Oncol"},{"key":"BF1702468_CR7","first-page":"439","volume":"6","author":"ED Ellis","year":"1990","unstructured":"Ellis ED, Williams SF, Moormeier JA . A phase I\u2013II study of high-dose cyclophosphamide, thiotepa and escalating doses of mitoxantrone with autologous stem cell rescue in patients with refractory malignancies Bone Marrow Transplant 1990 6: 439\u2013442","journal-title":"Bone Marrow Transplant"},{"key":"BF1702468_CR8","first-page":"227","volume":"5","author":"P Viens","year":"1990","unstructured":"Viens P, Maraninchi D, Legros M et al. High-dose melphalan and autologous marrow rescue in advanced epithelial ovarian carcinoma: a retrospective analysis of 35 patients treated in France Bone Marrow Transplant 1990 5: 227\u2013233","journal-title":"Bone Marrow Transplant"},{"key":"BF1702468_CR9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1182\/blood.V36.4.507.507","volume":"36","author":"ED Thomas","year":"1970","unstructured":"Thomas ED, Storb R . Technique of human marrow grafting Blood 1970 36: 507\u2013515","journal-title":"Blood"},{"key":"BF1702468_CR10","first-page":"175","volume-title":"Cancer of the Ovary","author":"SC Rubin","year":"1993","unstructured":"Rubin SC . Second look laparotomy in ovarian cancer. In: Markman M, Hoskins WJ (eds) Cancer of the Ovary Raven Press: New York 1993 175\u2013185"},{"key":"BF1702468_CR11","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1200\/JCO.1997.15.5.1870","volume":"15","author":"KH Antman","year":"1997","unstructured":"Antman KH, Rowlings PA, Vaughan WP et al. High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America J Clin Oncol 1997 15: 1870\u20131879","journal-title":"J Clin Oncol"},{"key":"BF1702468_CR12","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1002\/1097-0142(19841201)54:2+<2706::AID-CNCR2820541417>3.0.CO;2-L","volume":"54","author":"MS Piver","year":"1984","unstructured":"Piver MS . Ovarian carcinoma. A decade of progress Cancer 1984 54: (Suppl. 11) 2706\u20132715","journal-title":"Cancer"},{"key":"BF1702468_CR13","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1200\/JCO.1986.4.12.1827","volume":"4","author":"DD Von Hoff","year":"1986","unstructured":"Von Hoff DD, Clark GM, Weiss GR et al. Use of in vitro dose response effects to select antineoplastics for high-dose or regional administration regimens J Clin Oncol 1986 4: 1827\u20131834","journal-title":"J Clin Oncol"},{"key":"BF1702468_CR14","first-page":"6417","volume":"48","author":"III Frei E","year":"1988","unstructured":"Frei E III, Teicher BA, Holden SA et al. Effect of alkylating agent dose: preclinical studies and possible clinical correlation Cancer Res 1988 48: 6417\u20136423","journal-title":"Cancer Res"},{"key":"BF1702468_CR15","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1200\/JCO.1983.1.6.359","volume":"1","author":"HM Lazarus","year":"1983","unstructured":"Lazarus HM, Herzig RH, Graham-Pole J et al. Intensive melphalan chemotherapy and cryopreserved autologous bone marrow transplantation for the treatment of refractory cancer J Clin Oncol 1983 1: 359\u2013367","journal-title":"J Clin Oncol"},{"key":"BF1702468_CR16","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1200\/JCO.1997.15.4.1302","volume":"15","author":"M Legros","year":"1997","unstructured":"Legros M, Dauplat J, Fleury J et al. High-dose chemotherapy with hematopoietic rescue in patients with stage III to IV ovarian cancer: long-term results J Clin Oncol 1997 15: 1302\u20131308","journal-title":"J Clin Oncol"},{"key":"BF1702468_CR17","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000401484","volume":"23","author":"Jr Schabel FM","year":"1978","unstructured":"Schabel FM Jr, Trader MW, Laster WR Jr et al. Patterns of resistance and therapeutic synergism among alkylating agents Antibiot Chemother 1978 23: 200\u2013215","journal-title":"Antibiot Chemother"},{"key":"BF1702468_CR18","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/ijc.2910490513","volume":"49","author":"YJ Lidor","year":"1991","unstructured":"Lidor YJ, Shpall EJ, Peters WP . Synergistic cytotoxicity of different alkylating agents for epithelial ovarian cancer Int J Cancer 1991 49: 704\u2013710","journal-title":"Int J Cancer"},{"key":"BF1702468_CR19","doi-asserted-by":"publisher","first-page":"454","DOI":"10.2165\/00019053-199711050-00007","volume":"11","author":"AG Le Corroller","year":"1997","unstructured":"Le Corroller AG, Faucher C, Auperin A et al. Autologous peripheral blood progenitor-cell transplantation versus autologous bone marrow transplantation for adults and children with non-leukaemic malignant disease. A randomised economic study Pharmacoeconomics 1997 11: 454\u2013463","journal-title":"Pharmacoeconomics"},{"key":"BF1702468_CR20","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/S0140-6736(84)91434-X","volume":"1","author":"B Mascret","year":"1984","unstructured":"Mascret B, Maraninchi D, Gastaut JA et al. Risk factors for streptococcal septicaemia after marrow transplantation Lancet 1984 1: 1185\u20131186","journal-title":"Lancet"},{"key":"BF1702468_CR21","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/sj.bmt.1700713","volume":"19","author":"CH Weaver","year":"1997","unstructured":"Weaver CH, Schwartzberg LS, Hainsworth J et al. Treatment-related mortality in 1000 consecutive patients receiving high-dose chemotherapy and peripheral blood progenitor cell transplantation in community cancer centers Bone Marrow Transplant 1997 19: 671\u2013678","journal-title":"Bone Marrow Transplant"},{"key":"BF1702468_CR22","doi-asserted-by":"publisher","first-page":"S122","DOI":"10.1006\/gyno.1994.1350","volume":"55","author":"WT Creasman","year":"1994","unstructured":"Creasman WT . Second-look laparotomy in ovarian cancer Gynecol Oncol 1994 55: S122\u2013S127","journal-title":"Gynecol Oncol"},{"key":"BF1702468_CR23","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/S0936-6555(05)80210-9","volume":"2","author":"F Lawton","year":"1990","unstructured":"Lawton F, Luesley D, Blackledge G et al. A randomized trial comparing whole abdominal radiotherapy with chemotherapy following cisplatinum cytoreduction in epithelial ovarian cancer. West Midlands Ovarian Cancer Group Trial II Clin Oncol (R Coll Radiol) 1990 2: 4\u20139","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"BF1702468_CR24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1200\/JCO.1996.14.2.343","volume":"14","author":"E Pujade-Lauraine","year":"1996","unstructured":"Pujade-Lauraine E, Guastalla JP et al. Intraperitoneal recombinant interferon gamma in ovarian cancer patients with residual disease at second-look laparotomy J Clin Oncol 1996 14: 343\u2013350","journal-title":"J Clin Oncol"},{"key":"BF1702468_CR25","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1006\/gyno.1997.4689","volume":"65","author":"M Bruzzone","year":"1997","unstructured":"Bruzzone M, Rubagotti A, Gadducci A et al. Intraperitoneal carboplatin with or without interferon-alpha in advanced ovarian cancer patients with minimal residual disease at second look: a prospective randomized trial of 111 patients. GONO Gruppo Oncologic Nord Ovest Gynecol Oncol 1997 65: 499\u2013505","journal-title":"Gynecol Oncol"},{"key":"BF1702468_CR26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/1097-0142(19880701)62:1<40::AID-CNCR2820620110>3.0.CO;2-O","volume":"62","author":"A Goldhirsch","year":"1988","unstructured":"Goldhirsch A, Greiner R, Dreher E et al. Treatment of advanced ovarian cancer with surgery, chemotherapy, and consolidation of response by whole-abdominal radiotherapy Cancer 1988 62: 40\u201347","journal-title":"Cancer"},{"key":"BF1702468_CR27","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1200\/JCO.1988.6.9.1433","volume":"6","author":"MF Schray","year":"1988","unstructured":"Schray MF, Martinez A, Howes AE et al. Advanced epithelial ovarian cancer: salvage whole abdominal irradiation for patients with recurrent or persistent disease after combination chemotherapy J Clin Oncol 1988 6: 1433\u20131439","journal-title":"J Clin Oncol"},{"key":"BF1702468_CR28","unstructured":"Shpall EJ, Cagnoni PJ, Bearman SI et al. High dose chemotherapy with autologous hematopoietic cell support (AHCS) for the treatment of epithelial ovarian cancer. 31st Annual Meeting of the American Society of Clinical Oncology, Los Angeles, CA, USA, 20\u201323 May 1995 360\u2013364"},{"key":"BF1702468_CR29","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1002\/(SICI)1097-0142(19960615)77:12<2550::AID-CNCR19>3.0.CO;2-R","volume":"77","author":"JP Lotz","year":"1996","unstructured":"Lotz JP, Bouleuc C, Andre T et al. Tandem high-dose chemotherapy with ifosfamide, carboplatin, and teniposide with autologous bone marrow transplantation for the treatment of poor prognosis common epithelial ovarian carcinoma Cancer 1996 77: 2550\u20132559","journal-title":"Cancer"},{"key":"BF1702468_CR30","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1006\/gyno.1997.4890","volume":"68","author":"A Gadducci","year":"1998","unstructured":"Gadducci A, Sartori E, Maggino T et al. Analysis of failures after negative second-look in patients with advanced ovarian cancer: an Italian multicenter study Gynecol Oncol 1998 68: 150\u2013155","journal-title":"Gynecol Oncol"},{"key":"BF1702468_CR31","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/(SICI)1097-0142(19960101)77:1<128::AID-CNCR21>3.0.CO;2-6","volume":"77","author":"G Bolis","year":"1996","unstructured":"Bolis G, Villa A, Guarnerio P et al. Survival of women with advanced ovarian cancer and complete pathologic response at second-look laparotomy Cancer 1996 77: 128\u2013131","journal-title":"Cancer"},{"key":"BF1702468_CR32","first-page":"287","volume":"15","author":"B Sorbe","year":"1996","unstructured":"Sorbe B, Trope C, Nordal R et al. Chemotherapy versus radiotherapy as consolidation treatment of ovarian carcinoma stage III at surgical complete remission from induction chemotherapy Proc Am Soc Clin Oncol 1996 15: 287","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF1702468_CR33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/(SICI)1520-6823(1998)6:2<97::AID-ROI5>3.0.CO;2-C","volume":"6","author":"KS Condra","year":"1998","unstructured":"Condra KS, Mendenhall WM, Morgan LS, Marcus RB Jr . Consolidative 32P after second-look laparotomy for ovarian carcinoma Radiat Oncol Invest 1998 6: 97\u2013102","journal-title":"Radiat Oncol Invest"},{"key":"BF1702468_CR34","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/0090-8258(91)90309-S","volume":"41","author":"G Franchin","year":"1991","unstructured":"Franchin G, Tumolo S, Scarabelli C et al. Whole abdomen radiation therapy after a short chemotherapy course and second-look laparotomy in advanced ovarian cancer Gynecol Oncol 1991 41: 206\u2013211","journal-title":"Gynecol Oncol"},{"key":"BF1702468_CR35","first-page":"S26","volume":"24","author":"DW Fennelly","year":"1997","unstructured":"Fennelly DW, Aghajanian C, Shapiro F et al. Dose escalation of paclitaxel with high-dose carboplatin using peripheral blood progenitor cell support in patients with advanced ovarian cancer Semin Oncol 1997 24: (Suppl. 2) S26\u2013S30","journal-title":"Semin Oncol"},{"key":"BF1702468_CR36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3109\/07853899509031949","volume":"27","author":"P Benedetti-Panici","year":"1995","unstructured":"Benedetti-Panici P, Greggi S, Scambia G et al. High-dose chemotherapy with autologous peripheral stem cell support in advanced ovarian cancer Ann Med 1995 27: 133\u2013138","journal-title":"Ann Med"},{"key":"BF1702468_CR37","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1093\/jnci\/84.24.1935","volume":"84","author":"J Crown","year":"1992","unstructured":"Crown J, Wassherheit C, Hakes T et al. Rapid delivery of multiple high-dose chemotherapy courses with granulocyte colony-stimulating factor and peripheral blood-derived hematopoietic progenitor cells J Natl Cancer Inst 1992 84: 1935\u20131936","journal-title":"J Natl Cancer Inst"},{"key":"BF1702468_CR38","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/sj.bmt.1700870","volume":"20","author":"P Viens","year":"1997","unstructured":"Viens P, Gravis G, Genre D et al. High-dose sequential chemotherapy with stem cell support for non-metastatic breast cancer Bone Marrow Transplant 1997 20: 199\u2013203","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1702468","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702468.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702468.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T21:31:46Z","timestamp":1648071106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1702468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,7,1]]}},"alternative-id":["BF1702468"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1702468","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7,1]]},"assertion":[{"value":"1 February 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}