{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:55:21Z","timestamp":1770472521004,"version":"3.49.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2000,7,28]],"date-time":"2000-07-28T00:00:00Z","timestamp":964742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,7,28]],"date-time":"2000-07-28T00:00:00Z","timestamp":964742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2000,8,1]]},"DOI":"10.1038\/sj.bmt.1702481","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T15:45:47Z","timestamp":1031154347000},"page":"257-268","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High-dose chemotherapy (CTM) for breast cancer"],"prefix":"10.1038","volume":"26","author":[{"given":"LE","family":"Damon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JL","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HS","family":"Rugo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AR","family":"Zander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Cecchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CA","family":"Ries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CA","family":"Linker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,7,28]]},"reference":[{"key":"BF1702481_CR1","first-page":"pp 189","volume-title":"Autologous Bone marrow transplantation. Proceedings of the First International Symposium","author":"WP Peters","year":"1985","unstructured":"Peters WP . The rationale for high-dose chemotherapy with autologous bone marrow support in treating breast cancer. In: Dicke K, Spitzer G, Zander A (eds) Autologous Bone marrow transplantation. Proceedings of the First International Symposium MD Anderson Cancer Center Press: Houston, TX 1985 pp 189\u2013196"},{"key":"BF1702481_CR2","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1200\/JCO.1989.7.4.515","volume":"7","author":"III Frei E","year":"1989","unstructured":"Frei E III, Antman K, Teicher B et al. Bone marrow autotransplantation for solid tumors \u2013 Prospects J Clin Oncol 1989 7: 515\u2013526","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR3","first-page":"pp 423","volume-title":"New Strategies in Bone Marrow Transplantation","author":"K Antman","year":"1991","unstructured":"Antman K, Bearman SI, Davidson N et al. Dose intensive strategy in breast cancer: current status. In: Champlin RE, Gale RP (eds) New Strategies in Bone Marrow Transplantation Allen R. Liss: New York 1991 pp 423\u2013436"},{"key":"BF1702481_CR4","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1200\/JCO.1986.4.8.1162","volume":"4","author":"W Hryniuk","year":"1986","unstructured":"Hryniuk W, Levine MN . Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer J Clin Oncol 1986 4: 1162\u20131170","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR5","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1200\/JCO.1984.2.11.1281","volume":"2","author":"WM Hryniuk","year":"1986","unstructured":"Hryniuk WM, Bush H . The importance of dose intensity in chemotherapy of metastatic breast cancer J Clin Oncol 1986 2: 1281\u20131288","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR6","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1200\/JCO.1993.11.6.1132","volume":"11","author":"WP Peters","year":"1993","unstructured":"Peters WP, Ross M, Vredenburgh JJ et al. High-dose chemotherapy and autologous bone marrow support as consolidation after standard-dose adjuvant therapy for high-risk primarybreast cancer J Clin Oncol 1993 11: 1132\u20131143","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR7","first-page":"317 (Abstr. 933","volume":"14","author":"WP Peters","year":"1995","unstructured":"Peters WP, Berry D, Vredenburgh JJ et al. Five year followup of high-dose combination alkylating agents with ABMT as consolidation after standard-dose CAF for primary breast cancer involving \u2a7e10 axillary lymph nodes (Duke\/CALGB 8782) Proc Am Soc Clin Oncol 1995 14: 317 (Abstr. 933)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF1702481_CR8","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1200\/JCO.1997.15.6.2312","volume":"15","author":"AM Gianni","year":"1997","unstructured":"Gianni AM, Siena S, Bregni M et al. Efficacy, toxicity, and applicability of high-dose sequential chemotherapy as adjuvant treatment in operable breast cancer with 10 or more involved axillary lymph nodes: five-year results J Clin Oncol 1997 15: 2312\u20132321","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1200\/JCO.1992.10.4.657","volume":"10","author":"D Eddy","year":"1992","unstructured":"Eddy D . High-dose chemotherapy with autologous bonemarrow transplantation for the treatment of metastatic breastcancer J Clin Oncol 1992 10: 657\u2013670","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR10","first-page":"789","volume-title":"Bone Marrow Transplantation","author":"WP Peters","year":"1994","unstructured":"Peters WP . Autologous bone marrow transplantation for breast cancer. In: Forman SJ, Blume KG, Thomas ED (eds) Bone Marrow Transplantation Blackwell Scientific Publications: Boston 1994 789\u2013801"},{"key":"BF1702481_CR11","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1200\/JCO.1997.15.10.3171","volume":"15","author":"ZU Rahman","year":"1997","unstructured":"Rahman ZU, Frye DK, Buzdar AU et al. Impact of selection process on response rate and long-term survival of potential high-dose chemotherapy candidates treated with standard-dose doxorubicin containing chemotherapy in patients with metastatic breast cancer J Clin Oncol 1997 15: 3171\u20133177","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR12","doi-asserted-by":"publisher","first-page":"599","DOI":"10.7326\/0003-4819-125-7-199610010-00010","volume":"125","author":"WJ Gradishar","year":"1996","unstructured":"Gradishar WJ, Tallman MS, Abrams JS . High-dose chemotherapy for breast cancer Ann Intern Med 1996 125: 599\u2013604","journal-title":"Ann Intern Med"},{"key":"BF1702481_CR13","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1200\/JCO.1995.13.10.2483","volume":"13","author":"WR Bezwoda","year":"1995","unstructured":"Bezwoda WR, Seymor L, Dansey RD . High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: a randomized trial J Clin Oncol 1995 13: 2483\u20132489","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR14","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1200\/JCO.1988.6.9.1368","volume":"6","author":"WP Peters","year":"1988","unstructured":"Peters WP, Schpall EJ, Jones RB et al. High-dose combination alkylating agents with bone marrow support as initial treatment for metastatic breast cancer J Clin Oncol 1988 6: 1368\u20131376","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR15","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1164\/ajrccm\/147.5.1264","volume":"147","author":"NW Todd","year":"1993","unstructured":"Todd NW, Peters, Ost AH et al. Pulmonary drug toxicity in patients with primary breast cancer treated with high-dose combination chemotherapy and autologous bone marrow transplantation Am Rev Respir Dis 1993 147: 1264\u20131270","journal-title":"Am Rev Respir Dis"},{"key":"BF1702481_CR16","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1093\/jnci\/85.8.640","volume":"85","author":"RB Jones","year":"1993","unstructured":"Jones RB, Matthes S, Shpall EJ et al. Acute lung injury following treatment with high-dose cyclophosphamide, cisplatin, and carmustine: pharmacodynamic evaluation of carmustine J Natl Cancer Inst 1993 85: 640\u2013647","journal-title":"J Natl Cancer Inst"},{"key":"BF1702481_CR17","unstructured":"Beahrs OH, Henson DE, Hutter RVP, Myers MH (eds) . In: Manual for Staging of Cancer JB Lippincott Company: Philadelphia 1988 pp 145\u2013150"},{"key":"BF1702481_CR18","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","volume":"5","author":"MM Oken","year":"1982","unstructured":"Oken MM, Creech RH, Tormey DC et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group Am J Clin Oncol 1982 5: 649\u2013655","journal-title":"Am J Clin Oncol"},{"key":"BF1702481_CR19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1182\/blood.V81.2.311.311","volume":"81","author":"CA Linker","year":"1993","unstructured":"Linker CA, Ries CA, Damon LE et al. Autologous bone marrow transplantation for acute myeloid leukemia using busulfan plus etoposide as a preparative regimen Blood 1993 81: 311\u2013318","journal-title":"Blood"},{"key":"BF1702481_CR20","first-page":"408a (Abstr. 16","volume":"86","author":"H Rugo","year":"1995","unstructured":"Rugo H, Damon L, Ries C, Linker C . Single day large volume leukopheresis following standard dose chemotherapy forbreast cancer is adequate for transplantation Blood 1995 86: (Suppl. 1) 408a (Abstr. 1618)","journal-title":"Blood"},{"key":"BF1702481_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1200\/JCO.1992.10.1.102","volume":"10","author":"K Antman","year":"1992","unstructured":"Antman K, Ayash L, Elias A et al. A phase II study of high-dose cyclophosphamide, thiotepa and, carboplatin with autologous marrow support in women with measurable advanced breast cancer responding to standard-dose therapy J Clin Oncol 1992 10: 102\u2013110","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR22","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1056\/NEJM197902083000603","volume":"300","author":"J Alexander","year":"1979","unstructured":"Alexander J, Dainiak N, Berger HJ et al. Serial assessment of doxorubicin cardiac toxicity with quantitative radionuclide angiocardiography New Engl J Med 1979 300: 278\u2013283","journal-title":"New Engl J Med"},{"key":"BF1702481_CR23","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1200\/JCO.1989.7.5.560","volume":"7","author":"IC Henderson","year":"1989","unstructured":"Henderson IC, Allegra JC, Woodcock T et al. Randomized clinical trial comparing mitoxantrone with doxorubicin in previously treated patients with metastatic breast cancer J Clin Oncol 1989 7: 560\u2013571","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR24","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0002-9343(89)80606-0","volume":"87","author":"RA Robbins","year":"1989","unstructured":"Robbins RA, Linder J, Stahl MG et al. Diffuse alveolar hemorrhage in autologous bone marrow transplant recipients Am J Med 1989 87: 511\u2013518","journal-title":"Am J Med"},{"key":"BF1702481_CR25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.7326\/0003-4819-114-2-145","volume":"114","author":"NJ Chao","year":"1991","unstructured":"Chao NJ, Duncan SR, Long GD et al. Corticosteroid therapy for diffuse alveolar hemorrhage in autologous bone marrow transplant recipients Ann Int Med 1991 114: 145\u2013146","journal-title":"Ann Int Med"},{"key":"BF1702481_CR26","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/00000421-198710000-00005","volume":"10","author":"SE Jones","year":"1987","unstructured":"Jones SE, Moon TE, Bonadonna G et al. Comparison of different trials of adjuvant chemotherapy in stage II breast cancer using a natural history data base Am J Clin Oncol 1987 10: 387\u2013395","journal-title":"Am J Clin Oncol"},{"key":"BF1702481_CR27","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/00000421-198710000-00006","volume":"10","author":"TE Moon","year":"1987","unstructured":"Moon TE, Jones SE, Bonadonna G et al. Development and use of a natural history data base of breast cancer studies Am J Clin Oncol 1987 10: 396\u2013403","journal-title":"Am J Clin Oncol"},{"key":"BF1702481_CR28","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/jnci\/82.7.570","volume":"82","author":"MD Abeloff","year":"1990","unstructured":"Abeloff MD, Beveridge RA, Donehower RC et al. Sixteen-week dose-intense chemotherapy in the adjuvant treatment of breast cancer J Natl Cancer Inst 1990 82: 570\u2013574","journal-title":"J Natl Cancer Inst"},{"key":"BF1702481_CR29","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1093\/jnci\/84.5.301","volume":"84","author":"NE Davidson","year":"1992","unstructured":"Davidson NE, Abeloff MD . Adjuvant systemic therapy in women with early-stage breast cancer at high risk for relapse J Natl Cancer Inst 1992 84: 301\u2013305","journal-title":"J Natl Cancer Inst"},{"key":"BF1702481_CR30","first-page":"337","volume-title":"Adjuvant Therapy of Cancer V","author":"M Kaufman","year":"1987","unstructured":"Kaufman M, Jonat W, Caffier H et al. Adjuvant systemic risk adapted cytotoxic \u00b1 tamoxifen therapy in women with node positive breast cancer. In: Salmon S (ed) Adjuvant Therapy of Cancer V Grune & Stratton: Orlando 1987 337\u2013346"},{"key":"BF1702481_CR31","first-page":"49","volume":"3","author":"GM Clark","year":"1989","unstructured":"Clark GM, McGuire WL . New biologic prognostic factors in breast cancer Oncol 1989 3: 49\u201354","journal-title":"Oncol"},{"key":"BF1702481_CR32","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1200\/JCO.1991.9.12.2134","volume":"9","author":"R Buzzoni","year":"1991","unstructured":"Buzzoni R, Bonadonna G, Valagussa P et al. Adjuvantchemotherapy with doxorubicin plus cyclophosphamide, methotrexate, and fluorouracil in the treatment of resectable breastcancer with more than three positive axillary nodes J Clin Oncol 1991 9: 2134\u20132140","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR33","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1001\/jama.1995.03520310040027","volume":"273","author":"G Bonadonna","year":"1995","unstructured":"Bonadonna G, Zambetti M, Valagussa P . Sequential or alternating doxorubicin and CMF regimens in breast cancer with more than three positive nodes. Ten year results JAMA 1995 273: 542\u2013547","journal-title":"JAMA"},{"key":"BF1702481_CR34","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/1097-0142(19920115)69:2<448::AID-CNCR2820690229>3.0.CO;2-K","volume":"69","author":"AV Buzdar","year":"1992","unstructured":"Buzdar AV, Kau S-W, Hortobagyi GN et al. Clinical course of patients with breast cancer with ten or more positive nodes who were treated with doxorubicin-containing adjuvant therapy Cancer 1992 69: 448\u2013452","journal-title":"Cancer"},{"key":"BF1702481_CR35","first-page":"1919","volume":"10","author":"KW Gilchrist","year":"1993","unstructured":"Gilchrist KW, Gray R, Fowble B et al. Tumor necrosis factor is a prognostic predictor for early recurrance and death in lymph-node positive breast cancer: a 10-year follow-up study of 728 Eastern Cooperative Oncology Group patients J Clin Oncol 1993 10: 1919\u20131935","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR36","first-page":"106 (Abstr. 226","volume":"13","author":"D Spaeth","year":"1994","unstructured":"Spaeth D, Luprosi E, Weber B et al. High-risk primary breast cancer (PBC) with 10 or more positive axillary lymph nodes (PALN). A 163 patients (pts) series Proc Am Soc Clin Oncol 1994 13: 106 (Abstr. 226)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF1702481_CR37","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1200\/JCO.1995.13.2.435","volume":"13","author":"O Ung","year":"1995","unstructured":"Ung O, Langlands AO, Barraclough B et al. Combined chemotherapy and radiotherapy for patients with breast cancer and extensive nodal involvement J Clin Oncol 1995 13: 435\u2013443","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR38","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1200\/JCO.1997.15.10.3178","volume":"15","author":"R Garcia-Carbenero","year":"1997","unstructured":"Garcia-Carbenero R, Hidalgo M, Paz-Ares L et al. Patient selection in high-dose chemotherapy trials: relevance in high-risk breast cancer J Clin Oncol 1997 15: 3178\u20133184","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR39","first-page":"44","volume":"15","author":"T Tajita","year":"1989","unstructured":"Tajita T, Tokuda J, Ohta M et al. Role of autologous bone marrow transplantation in cancer chemotherapy Low Temp Med 1989 15: 44\u201350","journal-title":"Low Temp Med"},{"key":"BF1702481_CR40","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1200\/JCO.1997.15.8.2882","volume":"15","author":"G Somlo","year":"1997","unstructured":"Somlo G, Doroshow JH, Forman S et al. High-dose chemotherapy and stem-cell rescue in the treatment of high-riskbreast cancer: prognostic indicators of progression-free andoverall survival J Clin Oncol 1997 15: 2882\u20132893","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR41","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1200\/JCO.1996.14.1.66","volume":"14","author":"M Crump","year":"1996","unstructured":"Crump M, Goss PE, Prince M, Girouard C . Outcome of extensive evaluation before adjuvant therapy in women with breast cancer and 10 or more positive axillary lymph nodes J Clin Oncol 1996 14: 66\u201369","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR42","first-page":"130a (Abstr. 45","volume":"16","author":"SG Diab","year":"1997","unstructured":"Diab SG, deMoor CA, Clark GM et al. Radiation therapy improves survival by decreasing local failure in breast cancer patients with 10 or more positive axillary lymph nodes (ALN) treated with mastectomy Proc Am Soc Clin Oncol 1997 16: 130a (Abstr. 458)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF1702481_CR43","first-page":"1a (Abstr. 2)","volume":"18","author":"W Peters","year":"1999","unstructured":"Peters W, Rosner G, Vredenburgh J et al. A prospective, randomized comparison of two of combination alkylating agents (AA) as consolidation after CAF in high-risk primary breast cancer involving ten or more axillary lymph nodes (LN): preliminary results of CALGB 9082\/SWOG 9114\/NCICMA-13 Proc Am Soc Clin Oncol 1999 18: 1a (Abstr. 2)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF1702481_CR44","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1200\/JCO.1997.15.5.1870","volume":"15","author":"K Antman","year":"1997","unstructured":"Antman K, Rowlings PA, Vaughan WP et al. High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America J Clin Oncol 1997 15: 1870\u20131879","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR45","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1056\/NEJM199710023371401","volume":"337","author":"M Overgaard","year":"1997","unstructured":"Overgaard M, Hansen PS, Overgaard J et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy New Engl J Med 1997 337: 949\u2013955","journal-title":"New Engl J Med"},{"key":"BF1702481_CR46","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1056\/NEJM199710023371402","volume":"337","author":"J Ragaz","year":"1997","unstructured":"Ragaz J, Jackson SM, Le N et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer New Engl J Med 1997 337: 956\u2013962","journal-title":"New Engl J Med"},{"key":"BF1702481_CR47","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S0140-6736(98)01350-6","volume":"352","author":"S Rodenhuis","year":"1998","unstructured":"Rodenhuis S, Richel DJ, van der Wall E et al. Randomised trial of high-dose chemotherapy and haemopoietic progenitor-cell support in operable breast cancer with extensive axillary lymph-node involvement Lancet 1998 352: 515\u2013521","journal-title":"Lancet"},{"key":"BF1702481_CR48","first-page":"123a (Abstr. 47","volume":"17","author":"GN Hortobagyi","year":"1998","unstructured":"Hortobagyi GN, Buzdar AU, Champlin R et al. Lack of efficacy of adjuvant high-dose (HD) tandem combination chemotherapy (CT) for high-risk primary breast cancer (HRPBC) \u2013 a randomized trial Proc Am Soc Clin Oncol; 1998 17: 123a (Abstr. 471)","journal-title":"Proc Am Soc Clin Oncol;"},{"key":"BF1702481_CR49","first-page":"2a (Abstr. 4)","volume":"18","author":"WR Bezwoda","year":"1999","unstructured":"Bezwoda WR . Randomised, controlled trial of high dose chemotherapy for high risk, surgically treated, primary breast cancer Proc Am Soc Clin Oncol 1999 18: 2a (Abstr. 4)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF1702481_CR50","first-page":"802","volume-title":"High-Dose Cancer Therapy: Pharmacology, Hematopoietins, Stem Cells, 2nd edition","author":"L Vahdat","year":"1995","unstructured":"Vahdat L, Antman K . Dose-intensive chemotherapy in breast cancer. In: Armitage J, Antman K (eds) High-Dose Cancer Therapy: Pharmacology, Hematopoietins, Stem Cells, 2nd edition Williams and Wilkins: Philadelphia 1995 802\u2013823"},{"key":"BF1702481_CR51","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1200\/JCO.1992.10.6.1014","volume":"10","author":"JA Jaiyesimi","year":"1992","unstructured":"Jaiyesimi JA, Buzdar AV, Hortobagyi G . Inflammatory breast cancer: a review J Clin Oncol 1992 10: 1014\u20131024","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR52","first-page":"9","volume":"16","author":"ER Broun","year":"1993","unstructured":"Broun ER, Sledge GW, Einhorn LH et al. High-dose carboplatin and mitoxantrone with autologous bone marrow support in the treatment of advanced breast cancer Am J Clin Oncol 1993 16: 9\u201313","journal-title":"Am J Clin Oncol"},{"key":"BF1702481_CR53","first-page":"59","volume":"20","author":"KK Fields","year":"1993","unstructured":"Fields KK, Elfenbein GJ, Perkins JD et al. Two novel high-dose treatment regimens for metastatic breast cancer \u2013ifosfamide, carboplatin, plus etoposide and mitoxantrone plusthiotepa: outcomes and toxicities Semin Oncol 1993 20: (Suppl. 6) 59\u201366","journal-title":"Semin Oncol"},{"key":"BF1702481_CR54","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1200\/JCO.1989.7.12.1824","volume":"7","author":"SF Williams","year":"1989","unstructured":"Williams SF, Mick R, Desser R et al. High-dose consolidation therapy with autologous stem cell rescue in stage IV breast cancer J Clin Oncol 1989 7: 1824\u20131830","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR55","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1093\/jnci\/83.13.920","volume":"83","author":"MJ Kennedy","year":"1991","unstructured":"Kennedy MJ, Beveridge RA, Rowley SD et al. High-dose chemotherapy with reinfusion of purged autologous bone marrow following dose-intense induction as initial therapy for metastatic breast cancer J Natl Cancer Inst 1991 83: 920\u2013926","journal-title":"J Natl Cancer Inst"},{"key":"BF1702481_CR56","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1200\/JCO.1994.12.1.37","volume":"12","author":"LJ Ayash","year":"1994","unstructured":"Ayash LJ, Elias A, Wheeler C et al. Double dose-intensive chemotherapy with autologous marrow and peripheral blood progenitor-cell support for metastatic breast cancer: a feasibility study J Clin Oncol 1994 12: 37\u201344","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR57","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1200\/JCO.1994.12.2.342","volume":"12","author":"R Ghalie","year":"1994","unstructured":"Ghalie R, Richman CM, Adler SS et al. Treatment of metastatic breast cancer with a split course high-dosechemotherapy regimen and autologous bone marrow transplantation J Clin Oncol 1994 12: 342\u2013346","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR58","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1200\/JCO.1993.11.6.1144","volume":"11","author":"J Crown","year":"1993","unstructured":"Crown J, Kritz A, Vahdat L et al. Rapid administration of multiple cycles of high-dose myelosuppressive chemotherapy in patients with metastatic breast cancer J Clin Oncol 1993 11: 1144\u20131149","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR59","first-page":"337","volume":"11","author":"TR Klumpp","year":"1993","unstructured":"Klumpp TR, Mangan KF, Glenn LD et al. Phase II pilot study of high-dose busulfan and cyclophosphamide followed by autologous bone marrow or peripheral stem cell transplantation in patients with advanced chemosensitive breast cancer Bone Marrow Transplant 1993 11: 337\u2013339","journal-title":"Bone Marrow Transplant"},{"key":"BF1702481_CR60","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1200\/JCO.1995.13.8.2043","volume":"13","author":"LJ Ayash","year":"1995","unstructured":"Ayash LJ, Wheeler C, Fairclough D et al. Prognostic factors for prolonged progression-free survival with high-dose chemotherapy with autologous stem cell support for advanced breast cancer J Clin Oncol 1995 13: 2043\u20132049","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR61","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1002\/1097-0142(19940415)73:8<2157::AID-CNCR2820730821>3.0.CO;2-1","volume":"73","author":"FR Dunphy","year":"1994","unstructured":"Dunphy FR, Spitzer G, Rossiter-Fornoff JE et al. Factors predicting long-term survival for metastatic breast cancer patients treated with high-dose chemotherapy and bone marrow support Cancer 1994 73: 2157\u20132167","journal-title":"Cancer"},{"key":"BF1702481_CR62","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1200\/JCO.1991.9.12.2153","volume":"9","author":"G Falkson","year":"1991","unstructured":"Falkson G, Gelman R, Falkson CI et al. Factors predicting for response, time to treatment failure, and survival in women with metastatic breast cancer treated with DAVTH: a prospective Eastern Cooperative Oncology Group study J Clin Oncol 1991 9: 2153\u20132161","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR63","first-page":"121 (Abstr. 149","volume":"15","author":"WP Peters","year":"1996","unstructured":"Peters WP, Jones RB, Vredenburgh J et al. A large, prospective, randomized trial of high-dose combination alkylating agents (CPB) with autologous cellular support (ABMS) as consolidation for patients with metastatic breast cancer achieving complete remission after intensive doxorubicin-based induction chemotherapy (AFM) Proc Am Soc Clin Oncol 1996 15: 121 (Abstr. 149)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF1702481_CR64","first-page":"319 (Abstr. 942","volume":"14","author":"J Doroshow","year":"1995","unstructured":"Doroshow J, Somlo G, Ahn C et al. Prognostic factors predicting progression-free (PFS) and overall survival (OS) in patients (PTS) with responsive metastatic breast cancer (MBC) treated with high-dose chemotherapy (HDCT) and bone marrow stem cell reinfusion Proc Am Soc Clin Oncol 1995 14: 319 (Abstr. 942)","journal-title":"Proc Am Soc Clin Oncol"},{"key":"BF1702481_CR65","first-page":"1","volume":"12","author":"R Stuart-Harris","year":"1982","unstructured":"Stuart-Harris R, Bozek T, Pavlidis AN et al. An active new agent in the treatment of advanced breast cancer Cancer Chemother Pharmacol 1982 12: 1\u20134","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF1702481_CR66","doi-asserted-by":"publisher","first-page":"694","DOI":"10.7326\/0003-4819-95-6-694","volume":"95","author":"HY Yap","year":"1981","unstructured":"Yap HY, Blumenschein G, Schell F et al. Dihydroxyanthracenedione: a promising new drug in the treatment of metastatic breast cancer Ann Intern Med 1981 95: 694\u2013697","journal-title":"Ann Intern Med"},{"key":"BF1702481_CR67","first-page":"1511","volume":"68","author":"M Levin","year":"1984","unstructured":"Levin M, Pandya KJ, Khandekar JD et al. Phase II study of mitoxantrone in advanced breast cancer: An Eastern Cooperative Oncology Group pilot study Cancer Treat Rep 1984 68: 1511\u20131512","journal-title":"Cancer Treat Rep"},{"key":"BF1702481_CR68","first-page":"1039","volume":"67","author":"R Smalley","year":"1983","unstructured":"Smalley R, Gams R . Phase II study of mitoxantrone in patients with metastatic breast carcinoma: a Southeastern Cancer Study Group project Cancer Treat Rep 1983 67: 1039\u20131040","journal-title":"Cancer Treat Rep"},{"key":"BF1702481_CR69","doi-asserted-by":"publisher","first-page":"67","DOI":"10.7326\/0003-4819-105-1-67","volume":"105","author":"TD Shenkenberg","year":"1986","unstructured":"Shenkenberg TD, Van Hoff DD . Mitoxantrone a new anticancer drug with significant clinical activity Ann Int Med 1986 105: 67\u201381","journal-title":"Ann Int Med"},{"key":"BF1702481_CR70","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1200\/JCO.1986.4.5.672","volume":"4","author":"JA Neidhart","year":"1986","unstructured":"Neidhart JA, Gochonur D, Roch R et al. A comparison of mitoxantrone and doxorubicin in breast cancer J Clin Oncol 1986 4: 672\u2013677","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR71","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/0277-5379(84)90215-3","volume":"20","author":"RE Coleman","year":"1984","unstructured":"Coleman RE, Maisey MN, Knight RK et al. Mitoxantrone in advanced breast cancer \u2013 a phase II study with special attention to cardiac toxicity Eur J Cancer Clin Oncol 1984 20: 771\u2013776","journal-title":"Eur J Cancer Clin Oncol"},{"key":"BF1702481_CR72","volume-title":"Proceedings of the workshop on mitoxantrone cardiac toxicity and the workshop on clinical evaluation of anthracycline cardiac toxicity. Cancer Treat Symposia, vol. 3","author":"JG Baum","year":"1984","unstructured":"Baum JG, McCarthy A, LeRoy DK et al. Proceedings of the workshop on mitoxantrone cardiac toxicity and the workshop on clinical evaluation of anthracycline cardiac toxicity. Cancer Treat Symposia, vol. 3 National Institutes of Health: Bethesda, Maryland 1984"},{"key":"BF1702481_CR73","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1200\/JCO.1990.8.11.1782","volume":"8","author":"Jr Wallerstein R","year":"1990","unstructured":"Wallerstein R Jr, Spitzer G, Dunphy F et al. A phase II study of mitoxantrone, etoposide, and thiotepa with autologous bone marrow support for patients with relapsed breast cancer J Clin Oncol 1990 8: 1782\u20131788","journal-title":"J Clin Oncol"},{"key":"BF1702481_CR74","first-page":"525","volume":"12","author":"C Bowers","year":"1993","unstructured":"Bowers C, Adkins D, Dunphy F et al. Dose escalation of mitoxantrone given with thiotepa and autologous bone marrow transplantation for metastatic breast cancer Bone Marrow Transplant 1993 12: 525\u2013530","journal-title":"Bone Marrow Transplant"},{"key":"BF1702481_CR75","first-page":"857","volume":"18","author":"C Gisselbrecht","year":"1996","unstructured":"Gisselbrecht C, Extra JM, Lotz JP et al. Cyclophos-phamide\/mitoxantrone\/melphalan (CMA) regimen prior to autologous bone marrow transplantation (ABMT) in metastatic breast cancer Bone Marrow Transplant 1996 18: 857\u2013863","journal-title":"Bone Marrow Transplant"},{"key":"BF1702481_CR76","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/0959-8049(94)90076-0","volume":"30A","author":"H de Graaf","year":"1994","unstructured":"de Graaf H, Willemse PHB, de Vries EGE et al. Intensive chemotherapy with autologous bone marrow transfusion as primary treatment in women with breast cancer and more than five involved axillary lymph nodes Eur J Cancer 1994 30A: 150\u2013153","journal-title":"Eur J Cancer"},{"key":"BF1702481_CR77","first-page":"17","volume-title":"High-dose Thiotepa and Autologous Marrow Transplantation","author":"RH Herzig","year":"1987","unstructured":"Herzig RH, Fay JW, Herzig GP et al. Phase I\u2013II studies with high-dose thiotepa and autologous bone marrow transplantation in patients with refractory malignancies. In: Herzig GP (ed) High-dose Thiotepa and Autologous Marrow Transplantation John Wiley & Sons Medical Group: Dallas 1987 17\u201323"},{"key":"BF1702481_CR78","first-page":"25","volume-title":"High-dose Thiotepa and Autologous Marrow Transplantation","author":"SN Wolff","year":"1987","unstructured":"Wolff SN, Herzig RH, Herzig GP et al. High-dose thiotepa with autologous bone marrow transplantation for metastatic malignant melanoma. In: Herzig GP (ed) High-dose Thiotepa and Autologous Marrow Transplantation John Wiley & Sons Medical Group: Dallas 1987 25\u201330"},{"key":"BF1702481_CR79","first-page":"3584","volume":"41","author":"HL Gurtoo","year":"1981","unstructured":"Gurtoo HL, Hipkens JH, Sharma SD . Role of glutathione in the metabolism-dependent toxicity in chemotherapy of cyclophosphamide Cancer Res 1981 41: 3584\u20133591","journal-title":"Cancer Res"},{"key":"BF1702481_CR80","first-page":"359","volume":"4","author":"LS Kaminer","year":"1989","unstructured":"Kaminer LS, Williams SF, Beschorner J et al. High-dose chemotherapy with autologous hematopoietic stem cell support in the refractory stage IV breast carcinoma Bone Marrow Transplant 1989 4: 359\u2013362","journal-title":"Bone Marrow Transplant"},{"key":"BF1702481_CR81","first-page":"A604 (Abstr.)","volume":"141","author":"K Jules-Elyse","year":"1990","unstructured":"Jules-Elyse K, Gulati S, Stover DE et al. Pulmonary complications in autologous bone marrow transplantation Am Rev Respir Dis 1990 141: A604 (Abstr.)","journal-title":"Am Rev Respir Dis"},{"key":"BF1702481_CR82","first-page":"S24","volume":"18","author":"AR Zander","year":"1996","unstructured":"Zander AR, Kruger W, Kroger N et al. High dose mitoxantrone with thiotepa, cyclophosphamide and autologous stem cell rescue for high risk stage II and stage III breast cancer Bone Marrow Transplant 1996 18: (Suppl. 1) S24\u2013S25","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1702481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702481","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T21:45:40Z","timestamp":1648071940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1702481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,28]]},"references-count":82,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,8,1]]}},"alternative-id":["BF1702481"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1702481","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7,28]]},"assertion":[{"value":"27 August 1999","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}