{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:52:21Z","timestamp":1791298341195,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2000,8,1]]},"DOI":"10.1038\/sj.bmt.1702519","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T15:46:11Z","timestamp":1031154371000},"page":"397-404","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":177,"title":["Unrelated donor marrow transplantation for acute myeloid leukemia: an update of the Seattle experience"],"prefix":"10.1038","volume":"26","author":[{"given":"J","family":"Sierra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Storer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JA","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PJ","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EW","family":"Petersdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Woolfrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JE","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Storb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FR","family":"Appelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Anasetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2000,8,30]]},"reference":[{"key":"BF1702519_CR1","first-page":"5","volume":"13","author":"A Gratwohl","year":"1994","unstructured":"Gratwohl A, Hermans J . Bone marrow transplantation activity in Europe 1992: report from the European Group for Bone Marrow Transplantation Bone Marrow Transplant 1994 13: 5\u201310","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1399-0012.1995.tb00349.x","volume":"9","author":"A Gratwohl","year":"1995","unstructured":"Gratwohl A, Hermans J . Indications and donor source of hematopoietic stem cell transplants in Europe 1993: report from the European Group for Blood and Marrow Transplantation Clin Transplant 1995 9: 355\u2013363","journal-title":"Clin Transplant"},{"key":"BF1702519_CR3","first-page":"137","volume":"17","author":"A Gratwohl","year":"1996","unstructured":"Gratwohl A, Hermans J, Baldomero H . Hematopoietic precursor cell transplants in Europe: activity in 1994. Report from the European Group for Blood and Marrow Transplantation Bone Marrow Transplant 1996 17: 137\u2013148","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR4","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/sj.bmt.1700694","volume":"19","author":"A Gratwohl","year":"1997","unstructured":"Gratwohl A, Hermans J, Baldomero H . Blood and marrow transplantation activity in Europe 1995 Bone Marrow Transplant 1997 19: 407\u2013419","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/sj.bmt.1701329","volume":"22","author":"A Gratwohl","year":"1998","unstructured":"Gratwohl A . Blood and marrow transplantation activity in Europe 1996. Special report Bone Marrow Transplant 1998 22: 227\u2013240","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/sj.bmt.1701866","volume":"24","author":"A Gratwohl","year":"1999","unstructured":"Gratwohl A, Passweg J, Baldomero H, Hermans J . Blood and marrow transplantation activity in Europe 1997 Bone Marrow Transplant 1999 24: 231\u2013245","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/00001622-200003000-00004","volume":"12","author":"C Anasetti","year":"2000","unstructured":"Anasetti C, Petersdorf EW, Martin PJ et al. Improving availability and safety of unrelated donor transplants Curr Opin Oncol 2000 12: 121\u2013126","journal-title":"Curr Opin Oncol"},{"key":"BF1702519_CR8","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1182\/blood.V92.10.3515","volume":"92","author":"EW Petersdorf","year":"1998","unstructured":"Petersdorf EW, Gooley T, Anasetti C et al. Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient Blood 1998 92: 3515\u20133520","journal-title":"Blood"},{"key":"BF1702519_CR9","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1056\/NEJM199810223391701","volume":"339","author":"T Sasazuki","year":"1998","unstructured":"Sasazuki T, Juji T, Morishima Y et al. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor New Engl J Med 1998 339: 1177\u20131185","journal-title":"New Engl J Med"},{"key":"BF1702519_CR10","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/sj.bmt.1701031","volume":"20","author":"T Lamparelli","year":"1997","unstructured":"Lamparelli T, Van Lint MT, Gualandi F et al. Bone marrow transplantation for chronic myeloid leukemia from unrelated and sibling donors: single center experience Bone Marrow Transplant 1997 20: 1057\u20131062","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR11","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1182\/blood.V86.10.3987.bloodjournal86103987","volume":"86","author":"MJ Hessner","year":"1995","unstructured":"Hessner MJ, Endean DJ, Casper JT et al. Use of unrelated marrow grafts compensates for reduced graft-versus-leukemia reactivity after T-cell-depleted allogeneic marrow transplantation for chronic myelogenous leukemia Blood 1995 86: 3987\u20133996","journal-title":"Blood"},{"key":"BF1702519_CR12","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1182\/blood.V89.11.4226","volume":"89","author":"J Sierra","year":"1997","unstructured":"Sierra J, Storer B, Hansen JA et al. Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose Blood 1997 89: 4226\u20134235","journal-title":"Blood"},{"key":"BF1702519_CR13","first-page":"850","volume-title":"Manual of Clinical Laboratory Immunology, 4th edn","author":"JA Hansen","year":"1992","unstructured":"Hansen JA, Mickelson EM, Choo SY et al. Clinical bone marrow transplantation: donor selection and recipient monitoring. In: Rose NR, De Macario EC, Fahey JL et al (eds) Manual of Clinical Laboratory Immunology, 4th edn American Society for Microbiology: Washington, DC 1992 850\u2013867"},{"key":"BF1702519_CR14","first-page":"22","volume-title":"Bone Marrow Transplantation","author":"B Dupont","year":"1994","unstructured":"Dupont B, Yang SY . Histocompatibility. In: Forman SJ, Blume KJ, Thomas ED (eds) Bone Marrow Transplantation Blackwell: Boston, MA 1994 22\u201340"},{"key":"BF1702519_CR15","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/BF00230505","volume":"33","author":"EW Petersdorf","year":"1991","unstructured":"Petersdorf EW, Smith AG, Mickelson EM et al. Ten HLA-DR4 alleles defined by sequence polymorphism within the DRB1 first domain Immunogenetics 1991 33: 267\u2013275","journal-title":"Immunogenetics"},{"key":"BF1702519_CR16","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1182\/blood.V73.6.1729.1729","volume":"73","author":"R Storb","year":"1989","unstructured":"Storb R, Deeg J, Pepe M et al. Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial Blood 1989 73: 1729\u20131734","journal-title":"Blood"},{"key":"BF1702519_CR17","first-page":"825","volume":"15","author":"D Przepiorka","year":"1995","unstructured":"Przepiorka D, Weisdorf D, Martin P et al. 1994 consensus conference on acute GVHD grading Bone Marrow Transplant 1995 15: 825\u2013828","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR18","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EL Kaplan","year":"1958","unstructured":"Kaplan EL, Meier P . Nonparametric estimation for incomplete observations J Am Stat Assoc 1958 53: 457\u2013481","journal-title":"J Am Stat Assoc"},{"key":"BF1702519_CR19","volume-title":"The Statistical Analysis of Failure Time Data","author":"JD Kalbfleish","year":"1980","unstructured":"Kalbfleish JD, Prentice RL . The Statistical Analysis of Failure Time Data Wiley: New York 1980"},{"key":"BF1702519_CR20","first-page":"242","volume-title":"Bone Marrow Transplantation","author":"JC Niland","year":"1994","unstructured":"Niland JC, Fisher LD . Biostatistical methods in marrow transplantation. In: Forman SJ, Blume KJ, Thomas ED (eds) Bone Marrow Transplantation Blackwell: Boston, MA 1994 242\u2013258"},{"key":"BF1702519_CR21","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/j.1365-2141.1993.tb04697.x","volume":"83","author":"MS Pepe","year":"1993","unstructured":"Pepe MS, Longton G, Pettinger M et al. Summarizing data on survival, relapse, and chronic graft-versus-host disease after bone marrow transplantation: motivation for and description of new methods Br J Haematol 1993 83: 602\u2013607","journal-title":"Br J Haematol"},{"key":"BF1702519_CR22","first-page":"445","volume":"4","author":"R Clift","year":"1989","unstructured":"Clift R, Goldman J, Gratwohl A, Horowitz M . Proposals for standardized reporting of results of bone marrow transplantation for leukaemia Bone Marrow Transplant 1989 4: 445\u2013448","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR23","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1182\/blood.V83.10.3077.3077","volume":"83","author":"A Busca","year":"1994","unstructured":"Busca A, Anasetti C, Anderson G et al. Unrelated donor or autologous marrow transplantation for treatment of acute leukemia Blood 1994 83: 3077\u20133084","journal-title":"Blood"},{"key":"BF1702519_CR24","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1182\/blood.V86.8.3247.3247","volume":"86","author":"A Balduzzi","year":"1995","unstructured":"Balduzzi A, Gooley T, Anasetti C et al. Unrelated donor marrow transplantation in children Blood 1995 86: 3247\u20133256","journal-title":"Blood"},{"key":"BF1702519_CR25","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/sj.bmt.1700787","volume":"19","author":"O Ringd\u00e9n","year":"1997","unstructured":"Ringd\u00e9n O, Labopin M, Gluckman E et al. Donor search or autografting in patients with acute leukaemia who lack an HLA-identical sibling? A matched-pair analysis Bone Marrow Transplant 1997 19: 963\u2013968","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR26","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/sj.bmt.1700775","volume":"19","author":"panel Consensus","year":"1997","unstructured":"Consensus panel . A consensus statement on unrelated donor bone marrow transplantation from the consensus panel chaired by EC Gordon-Smith Bone Marrow Transplant 1997 19: 959\u2013962","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0950-3536(96)80038-2","volume":"9","author":"JM Rowe","year":"1996","unstructured":"Rowe JM, Liesveld JL . Treatment and prognostic factors in acute myeloid leukaemia Bailli\u00e8res Clin Haematol 1996 9: 87\u2013105","journal-title":"Bailli\u00e8res Clin Haematol"},{"key":"BF1702519_CR28","first-page":"4173","volume":"58","author":"CD Bloomfield","year":"1998","unstructured":"Bloomfield CD, Lawrence D, Byrd JC et al. Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype Cancer Res 1998 58: 4173\u20134179","journal-title":"Cancer Res"},{"key":"BF1702519_CR29","first-page":"203","volume":"16","author":"RP Gale","year":"1995","unstructured":"Gale RP, Horowitz MM, Weiner RS et al. Impact of cytogenetic abnormalities on outcome of bone marrow transplants in acute myeloid leukemia in first remission Bone Marrow Transplant 1995 16: 203\u2013208","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR30","first-page":"2931","volume":"90","author":"A Ferrant","year":"1997","unstructured":"Ferrant A, Labopin M, Frassoni F et al. Karyotype in acute myeloblastic leukemia: prognostic significance for bone marrow transplantation in first remission. A European Group for Blood and Marrow Transplantation study Blood 1997 90: 2931\u20132938","journal-title":"Blood"},{"key":"BF1702519_CR31","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood.V92.7.2322","volume":"92","author":"D Grimwade","year":"1998","unstructured":"Grimwade D, Walker H, Oliver F et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 Trial Blood 1998 92: 2322\u20132333","journal-title":"Blood"},{"key":"BF1702519_CR32","first-page":"95","volume":"6","author":"M Labopin","year":"1993","unstructured":"Labopin M, Gorin NC . Autologous bone marrow transplantation in 2502 patients with acute leukemia in Europe: a retrospective study Leukemia 1993 6: (Suppl. 4) 95\u201399","journal-title":"Leukemia"},{"key":"BF1702519_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.bmt.1701089","volume":"21","author":"JM Goldman","year":"1998","unstructured":"Goldman JM, Schmitz N, Niethammer D, Gratwohl A . Allogeneic and autologous transplantation for haematological diseases, solid tumors and immune disorders: current practice in Europe in 1998 Bone Marrow Transplant 1998 21: 1\u20137","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR34","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1056\/NEJM199804023381405","volume":"338","author":"JA Hansen","year":"1998","unstructured":"Hansen JA, Gooley T, Martin PJ et al. Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia New Engl J Med 1998 338: 962\u2013968","journal-title":"New Engl J Med"},{"key":"BF1702519_CR35","first-page":"907","volume":"15","author":"T Demirer","year":"1995","unstructured":"Demirer T, Gooley T, Buckner CD et al. Influence of total nucleated cell dose from marrow harvests on outcome in patients with acute myelogenous leukemia undergoing autologous transplantation Bone Marrow Transplant 1995 15: 907\u2013913","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR36","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1365-2141.1988.tb07597.x","volume":"69","author":"D Neiderwieser","year":"1988","unstructured":"Neiderwieser D, Pepe M, Storb R et al. Improvement in rejection, engraftment rate and survival without increase in graft-versus-host disease by high marrow cell dose in patients transplanted for aplastic anaemia Br J Haematol 1988 69: 23\u201328","journal-title":"Br J Haematol"},{"key":"BF1702519_CR37","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1001\/jama.1983.03330330044034","volume":"249","author":"M Bortin","year":"1983","unstructured":"Bortin M, Gale RP, Kay HEM, Rimm AA . Bone marrow transplantation for acute myelogenous leukemia. Factors associated with early mortality JAMA 1983 249: 1166\u20131172","journal-title":"JAMA"},{"key":"BF1702519_CR38","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1182\/blood.V88.8.3223.bloodjournal8883223","volume":"88","author":"D Mavroudis","year":"1996","unstructured":"Mavroudis D, Read E, Cottler-Fox M et al. CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies Blood 1996 88: 3223\u20133229","journal-title":"Blood"},{"key":"BF1702519_CR39","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1046\/j.1365-2141.1998.00790.x","volume":"102","author":"G Dini","year":"1998","unstructured":"Dini G, Lamparelli T, Rondelli D et al. Unrelated donor marrow transplantation for chronic myelogenous leukaemia Br J Haematol 1998 102: 544\u2013552","journal-title":"Br J Haematol"},{"key":"BF1702519_CR40","first-page":"903","volume":"90","author":"P Anderlini","year":"1997","unstructured":"Anderlini P, Korbling M, Sale D et al. Allogeneic blood stem cell transplantation: considerations for donors Blood 1997 90: 903\u2013908","journal-title":"Blood"},{"key":"BF1702519_CR41","first-page":"35","volume":"18","author":"A Urbano-Ispizua","year":"1996","unstructured":"Urbano-Ispizua A, Solano C, Brunet S et al. Allogeneic peripheral blood progenitor cell transplantation: analysis of short-term engraftment and acute GVHD incidence in 33 cases Bone Marrow Transplant 1996 18: 35\u201340","journal-title":"Bone Marrow Transplant"},{"key":"BF1702519_CR42","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1182\/blood.V88.7.2775.bloodjournal8872775","volume":"88","author":"HD Ottinger","year":"1996","unstructured":"Ottinger HD, Beelen DW, Scheulen B et al. Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow Blood 1996 88: 2775\u20132779","journal-title":"Blood"},{"key":"BF1702519_CR43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1182\/blood.V94.2.455","volume":"94","author":"O Ringden","year":"1999","unstructured":"Ringden O, Remberger M, Runde V et al. Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation Blood 1999 94: 455\u2013464","journal-title":"Blood"},{"key":"BF1702519_CR44","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1182\/blood.V90.12.4705","volume":"90","author":"J Storek","year":"1997","unstructured":"Storek J, Gooley T, Siadak M et al. Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease Blood 1997 90: 4705\u20134709","journal-title":"Blood"},{"key":"BF1702519_CR45","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1038\/sj.bmt.1701500","volume":"22","author":"C Solano","year":"1998","unstructured":"Solano C, Mart\u00ednez C, Brunet S et al. Chronic graft-versus-host disease after allogeneic peripheral blood progenitor cell or bone marrow transplantation from matched related donors. A case\u2013control study Bone Marrow Transplant 1998 22: 1129\u20131135","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1702519.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702519","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702519.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T11:08:04Z","timestamp":1733569684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1702519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8,1]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,8,1]]}},"alternative-id":["BF1702519"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1702519","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,1]]},"assertion":[{"value":"21 February 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}