{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:43:39Z","timestamp":1790700219429,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2000,8,31]],"date-time":"2000-08-31T00:00:00Z","timestamp":967680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,8,31]],"date-time":"2000-08-31T00:00:00Z","timestamp":967680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2000,9,1]]},"DOI":"10.1038\/sj.bmt.1702545","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T15:46:56Z","timestamp":1031154416000},"page":"545-551","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effect of gastrointestinal inflammation and age on the pharmacokinetics of oral microemulsion cyclosporin A in the first month after bone marrow transplantation"],"prefix":"10.1038","volume":"26","author":[{"given":"KR","family":"Schultz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TJ","family":"Nevill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RF","family":"Balshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CL","family":"Toze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Corr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CJ","family":"Currie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DK","family":"Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PA","family":"Keown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2000,8,31]]},"reference":[{"key":"BF1702545_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2165\/00003088-198611020-00002","volume":"11","author":"RJ Ptachcinski","year":"1986","unstructured":"Ptachcinski RJ, Venkataramanan R, Burkart GJ . Clinical pharmacokinetics of cyclosporin Clin Pharmacokinet 1986 11: 107\u2013132","journal-title":"Clin Pharmacokinet"},{"key":"BF1702545_CR2","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1097\/00007890-198511000-00001","volume":"40","author":"BD Kahan","year":"1985","unstructured":"Kahan BD . Individualization of cyclosporine therapy using pharmacokinetic and pharmacodynamic parameters Transplantation 1985 40: 457\u2013476","journal-title":"Transplantation"},{"key":"BF1702545_CR3","first-page":"130S-134S","volume":"11","author":"GC Yee","year":"1991","unstructured":"Yee GC . Recent advances in cyclosporine pharmacokinetics Pharmacotherapy 1991 11: 130S-134S","journal-title":"Pharmacotherapy"},{"key":"BF1702545_CR4","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/clinchem\/33.7.1269","volume":"33","author":"LM Shaw","year":"1987","unstructured":"Shaw LM, Bowers L, Demers L et al. Critical issues in cyclosporine monitoring: report of the task force on cyclosporine monitoring Clin Chem 1987 33: 1269\u20131288","journal-title":"Clin Chem"},{"key":"BF1702545_CR5","doi-asserted-by":"publisher","first-page":"472","DOI":"10.2165\/00003088-199324060-00004","volume":"24","author":"A Fahr","year":"1993","unstructured":"Fahr A . Cyclosporin clinical pharmacokinetics Clin Pharmacokinet 1993 24: 472\u2013495","journal-title":"Clin Pharmacokinet"},{"key":"BF1702545_CR6","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/00007691-199111000-00001","volume":"13","author":"A Lindholm","year":"1991","unstructured":"Lindholm A . Factors influencing the pharmacokinetics of cyclosporine in man Ther Drug Monit 1991 13: 465\u2013477","journal-title":"Ther Drug Monit"},{"key":"BF1702545_CR7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/BF01046702","volume":"34","author":"A Lindholm","year":"1988","unstructured":"Lindholm A, Henricsson S, Lind M et al. Intraindividual variability in the relative systemic availability of cyclosporine after oral dosing Eur J Clin Pharmacol 1988 34: 46\u201344","journal-title":"Eur J Clin Pharmacol"},{"key":"BF1702545_CR8","unstructured":"Sandimmune Neoral product monograph Sandoz Canada Inc: Quebec, 11 January 1995"},{"key":"BF1702545_CR9","first-page":"2979","volume":"26","author":"RA Superina","year":"1994","unstructured":"Superina RA, Strong DK, Acal LA, DeLuca E . Relative bioavailability of Sandimmune and Sandimmune Neoral in pediatric liver recipients Transplant Proc 1994 26: 2979\u20132980","journal-title":"Transplant Proc"},{"key":"BF1702545_CR10","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/0016-5085(86)91137-6","volume":"90","author":"GB McDonald","year":"1986","unstructured":"McDonald GB, Shulman HM, Sullivan KM, Spencer GD . Intestinal and hepatic complications of human bone marrow transplantation. Part II Gastroenterology 1986 90: 770\u2013784","journal-title":"Gastroenterology"},{"key":"BF1702545_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1365-2141.1984.tb03950.x","volume":"56","author":"K Atkinson","year":"1984","unstructured":"Atkinson K, Biggs JC, Britton R et al. Oral administration of cyclosporin A for recipients of allogeneic marrow transplants: implications of clinical gut dysfunction Br J Haematol 1984 56: 223\u2013231","journal-title":"Br J Haematol"},{"key":"BF1702545_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6","volume":"47","author":"AB Miller","year":"1981","unstructured":"Miller AB, Hoogstraten B, Staquet M, Winkler A . Reporting results of cancer treatment Cancer 1981 47: 207\u2013214","journal-title":"Cancer"},{"key":"BF1702545_CR13","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2165\/00003088-199732060-00004","volume":"32","author":"GF Cooney","year":"1997","unstructured":"Cooney GF, Habucky K, Hoppu K . Cyclosporin pharmacokinetics in paediatric transplant recipients Clin Pharmacokinet 1997 32: 481\u2013495","journal-title":"Clin Pharmacokinet"},{"key":"BF1702545_CR14","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s004670050284","volume":"11","author":"SC Kabasakul","year":"1997","unstructured":"Kabasakul SC, Clarke M, Kane H et al. Comparison of Neoral and Sandimmun cyclosporin A pharmacokinetic profiles in young renal transplant recipients Pediatr Nephrol 1997 11: 318\u2013321","journal-title":"Pediatr Nephrol"},{"key":"BF1702545_CR15","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1432-2277.1997.tb00718.x","volume":"10","author":"M Melter","year":"1997","unstructured":"Melter M, Rodeck B, Kardorff R et al. Pharmacokinetics of cyclosporine in pediatric long-term liver transplant recipients converted from Sandimmun to Neoral Transpl Int 1997 10: 419\u2013425","journal-title":"Transpl Int"},{"key":"BF1702545_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1046\/j.1365-2125.1997.t01-1-00599.x","volume":"44","author":"YJ Lee","year":"1997","unstructured":"Lee YJ, Chung SJ, Shim CK . Decreased oral availability of cyclosporin A at second administration in humans Br J Clin Pharmacol 1997 44: 343\u2013345","journal-title":"Br J Clin Pharmacol"},{"key":"BF1702545_CR17","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1111\/j.1432-2277.1996.tb00991.x","volume":"9","author":"RT Krmar","year":"1996","unstructured":"Krmar RT, Wuhl E, Ding R et al. Pharmacokinetics of a new microemulsion formulation of cyclosporin A (Neoral) in young patients after renal transplantation Transpl Int 1996 9: 476\u2013480","journal-title":"Transpl Int"},{"key":"BF1702545_CR18","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1111\/j.1476-5381.1996.tb15612.x","volume":"118","author":"G Fricker","year":"1996","unstructured":"Fricker G, Drewe J, Huwyler J et al. Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation Br J Pharmacol 1996 118: 1841\u20131847","journal-title":"Br J Pharmacol"},{"key":"BF1702545_CR19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S0009-9236(97)90027-8","volume":"62","author":"KS Lown","year":"1997","unstructured":"Lown KS, Mayo RR, Leichtman AB et al. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine Clin Pharmacol Ther 1997 62: 248\u2013260","journal-title":"Clin Pharmacol Ther"},{"key":"BF1702545_CR20","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1365-2125.1991.tb03906.x","volume":"32","author":"TL Schwinghammer","year":"1991","unstructured":"Schwinghammer TL, Przepiorka D, Venkataramanan R et al. The kinetics of cyclosporine and its metabolites in bone marrow transplant patients Br J Clin Pharmacol 1991 32: 323\u2013328","journal-title":"Br J Clin Pharmacol"},{"key":"BF1702545_CR21","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1006\/bbrc.1993.2487","volume":"197","author":"PF Augustijns","year":"1993","unstructured":"Augustijns PF, Bradshaw TP, Gan LS et al. Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport Biochem Biophys Res Comm 1993 197: 360\u2013365","journal-title":"Biochem Biophys Res Comm"},{"key":"BF1702545_CR22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0169-409X(97)00497-3","volume":"25","author":"J Hunter","year":"1997","unstructured":"Hunter J, Hirst BH . Intestinal secretion of drugs \u2013 the role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption Adv Drug Del Rev 1997 25: 129\u2013157","journal-title":"Adv Drug Del Rev"},{"key":"BF1702545_CR23","first-page":"344","volume":"24","author":"LSL Gan","year":"1996","unstructured":"Gan LSL, Moseley MA, Khosla B et al. Cyp3a-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells \u2013 interaction between the two biochemical barriers to intestinal transport Drug Metab Dispos 1996 24: 344\u2013349","journal-title":"Drug Metab Dispos"},{"key":"BF1702545_CR24","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/j.1365-2125.1995.tb05796.x","volume":"40","author":"KT Kivisto","year":"1995","unstructured":"Kivisto KT, Kroemer HK, Eichelbaum M . The role of human cytochrome P450 enzymes in the metabolism of anticancer agents \u2013 implications for drug interactions Br J Clin Pharmacol 1995 40: 523\u2013530","journal-title":"Br J Clin Pharmacol"},{"key":"BF1702545_CR25","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2165\/00002018-199818040-00002","volume":"18","author":"U Fuhr","year":"1998","unstructured":"Fuhr U . Drug interactions with grapefruit juice \u2013 extent, probable mechanism and clinical relevance Drug Safety 1998 18: 251\u2013272","journal-title":"Drug Safety"},{"key":"BF1702545_CR26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000205827","volume":"78","author":"G Bandini","year":"1987","unstructured":"Bandini G, Strocchi E, Ricci P et al. Cyclosporin A: correlation of blood levels with acute graft-versus-host disease after bone marrow transplantation Acta Haematol 1987 78: 6\u201312","journal-title":"Acta Haematol"},{"key":"BF1702545_CR27","doi-asserted-by":"publisher","first-page":"668","DOI":"10.2165\/00003495-199345050-00004","volume":"45","author":"GB Vogelsang","year":"1993","unstructured":"Vogelsang GB, Morris LE . Prevention and management of graft-versus-host disease. Practical recommendations Drugs 1993 45: 668\u2013676","journal-title":"Drugs"},{"key":"BF1702545_CR28","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/clpt.1986.204","volume":"40","author":"GC Yee","year":"1986","unstructured":"Yee GC, Lennon TP, Gmur DJ et al. Age-dependent cyclosporine: pharmacokinetics in marrow transplant recipients Clin Pharmacol Ther 1986 40: 438\u2013443","journal-title":"Clin Pharmacol Ther"},{"key":"BF1702545_CR29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2165\/00003088-199630020-00004","volume":"30","author":"C Campana","year":"1996","unstructured":"Campana C, Regazzi MB, Buggia I, Molinaro M . Clinically significant drug interactions with cyclosporin \u2013 an update Clin Pharmacokinet 1996 30: 141\u2013179","journal-title":"Clin Pharmacokinet"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1702545.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702545","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1702545.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T21:40:26Z","timestamp":1648071626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1702545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8,31]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,9,1]]}},"alternative-id":["BF1702545"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1702545","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,31]]},"assertion":[{"value":"1 December 1999","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}