{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:35:33Z","timestamp":1761100533198},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2001,4,1]]},"DOI":"10.1038\/sj.bmt.1703010","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T15:51:24Z","timestamp":1031154684000},"page":"855-861","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oral busulfan pharmacokinetics and engraftment in children with Hurler syndrome and other inherited metabolic storage diseases undergoing hematopoietic cell transplantation"],"prefix":"10.1038","volume":"27","author":[{"given":"P","family":"Jacobson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JJ","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TE","family":"DeFor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Thrall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Abel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Krivit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,7,26]]},"reference":[{"key":"BF1703010_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(81)91046-1","volume":"2","author":"JR Hobbs","year":"1981","unstructured":"Hobbs JR, Hugh-Jones K, Barrett AJ et al. Reversal of clinical features of Hurler's disease and biochemical improvement after treatment by bone-marrow transplantation Lancet 1981 2: 709\u2013712","journal-title":"Lancet"},{"key":"BF1703010_CR2","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1056\/NEJM198412203112504","volume":"311","author":"W Krivit","year":"1984","unstructured":"Krivit W, Pierpont ME, Ayaz K et al. Bone-marrow transplantation in the Maroteaux\u2013Lamy syndrome (mucopoly-saccharidosis type VI). Biochemical and clinical status 24 months after transplantation New Engl J Med 1984 311: 1606\u20131611","journal-title":"New Engl J Med"},{"key":"BF1703010_CR3","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/S0022-3476(98)70237-9","volume":"133","author":"DA Wall","year":"1998","unstructured":"Wall DA, Grange DK, Goulding P et al. Bone marrow transplantation for the treatment of alpha-mannosidosis J Pediatr 1998 133: 282\u2013285","journal-title":"J Pediatr"},{"key":"BF1703010_CR4","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1056\/NEJM199006283222607","volume":"322","author":"P Aubourg","year":"1990","unstructured":"Aubourg P, Blanche S, Jambaque I et al. Reversal of early neurologic and neuroradiologic manifestations of X-linked adrenoleukodystrophy by bone marrow transplantation New Engl J Med 1990 322: 1860\u20131866","journal-title":"New Engl J Med"},{"key":"BF1703010_CR5","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1056\/NEJM199001043220106","volume":"322","author":"W Krivit","year":"1990","unstructured":"Krivit W, Shapiro E, Kennedy W et al. Treatment of late infantile metachromatic leukodystrophy by bone marrow transplantation (see comments) New Engl J Med 1990 322: 28\u201332","journal-title":"New Engl J Med"},{"key":"BF1703010_CR6","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJM199804163381605","volume":"338","author":"W Krivit","year":"1998","unstructured":"Krivit W, Shapiro EG, Peters C et al. Hematopoietic stem-cell transplantation in globoid-cell leukodystrophy New Engl J Med 1998 338: 1119\u20131126","journal-title":"New Engl J Med"},{"key":"BF1703010_CR7","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1182\/blood.V87.11.4894.bloodjournal87114894","volume":"87","author":"C Peters","year":"1996","unstructured":"Peters C, Balthazor M, Shapiro EG et al. Outcome of unrelated donor bone marrow transplantation in 40 children with Hurler syndrome Blood 1996 87: 4894\u20134902","journal-title":"Blood"},{"key":"BF1703010_CR8","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1182\/blood.V91.7.2601","volume":"91","author":"C Peters","year":"1998","unstructured":"Peters C, Shapiro EG, Anderson J et al. Hurler syndrome: II. Outcome of HLA-genotypically identical sibling and HLA-haploidentical related donor bone marrow transplantation in fifty-four children. The Storage Disease Collaborative Study Group Blood 1998 91: 2601\u20132608","journal-title":"Blood"},{"key":"BF1703010_CR9","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1182\/blood.V79.9.2475.2475","volume":"79","author":"G Vassal","year":"1992","unstructured":"Vassal G, Deroussent A, Challine D et al. Is 600 mg\/m2 the appropriate dosage of busulfan in children undergoing bone marrow transplantation? Blood 1992 79: 2475\u20132479","journal-title":"Blood"},{"key":"BF1703010_CR10","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1182\/blood.V80.9.2425.2425","volume":"80","author":"AM Yeager","year":"1992","unstructured":"Yeager AM, Wagner JE Jr, Graham ML et al. Optimization of busulfan dosage in children undergoing bone marrow transplantation: a pharmacokinetic study of dose escalation Blood 1992 80: 2425\u20132428","journal-title":"Blood"},{"key":"BF1703010_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/clpt.1993.108","volume":"54","author":"MB Regazzi","year":"1993","unstructured":"Regazzi MB, Locatelli F, Buggia I et al. Disposition of high-dose busulfan in pediatric patients undergoing bone marrow transplantation Clin Pharmacol Ther 1993 54: 45\u201352","journal-title":"Clin Pharmacol Ther"},{"key":"BF1703010_CR12","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/BF00689702","volume":"28","author":"M Hassan","year":"1991","unstructured":"Hassan M, Oberg G, Bekassy AN et al. Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology Cancer Chemother Pharmacol 1991 28: 130\u2013134","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF1703010_CR13","first-page":"1466","volume":"27","author":"JP Gibbs","year":"1999","unstructured":"Gibbs JP, Liacouras CA, Baldassano RN, Slattery JT . Up-regulation of glutathione S-transferase activity in enterocytes of young children Drug Metab Dispos 1999 27: 1466\u20131469","journal-title":"Drug Metab Dispos"},{"key":"BF1703010_CR14","first-page":"1015","volume":"24","author":"M Czerwinski","year":"1996","unstructured":"Czerwinski M, Gibbs JP, Slattery JT . Busulfan conjugation by glutathione S-transferases alpha, mu, and pi Drug Metab Dispos 1996 24: 1015\u20131019","journal-title":"Drug Metab Dispos"},{"key":"BF1703010_CR15","first-page":"31","volume":"16","author":"JT Slattery","year":"1995","unstructured":"Slattery JT, Sanders JE, Buckner CD et al. Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics (published erratum appears in Bone Marrow Transplant 1996 Oct;18(4):829) Bone Marrow Transplant 1995 16: 31\u201342","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR16","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/sj.bmt.1702165","volume":"25","author":"JL Byrne","year":"2000","unstructured":"Byrne JL, Stainer C, Cull G et al. The effect of the serotherapy regimen used and the marrow cell dose received on rejection, graft-versus-host disease and outcome following unrelated donor bone marrow transplantation for leukaemia Bone Marrow Transplant 2000 25: 411\u2013417","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1182\/blood.V94.2.455","volume":"94","author":"O Ringden","year":"1999","unstructured":"Ringden O, Remberger M, Runde V et al. Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation Blood 1999 94: 455\u2013464","journal-title":"Blood"},{"key":"BF1703010_CR18","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1016\/S0301-472X(99)00121-6","volume":"27","author":"NC Gorin","year":"1999","unstructured":"Gorin NC, Labopin M, Laporte JP et al. Importance of marrow dose on posttransplant outcome in acute leukemia: models derived from patients autografted with mafosfamide-purged marrow at a single institution Exp Hematol 1999 27: 1822\u20131830","journal-title":"Exp Hematol"},{"key":"BF1703010_CR19","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0167-5699(98)01428-5","volume":"20","author":"Y Reisner","year":"1999","unstructured":"Reisner Y, Martelli MF . Stem cell escalation enables HLA-disparate haematopoietic transplants in leukaemia patients Immunol Today 1999 20: 343\u2013347","journal-title":"Immunol Today"},{"key":"BF1703010_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/sj.bmt.1701048","volume":"21","author":"K Cornetta","year":"1998","unstructured":"Cornetta K, Gharpure V, Mills B et al. Rapid engraftment after allogeneic transplantation using CD34-enriched marrow cells Bone Marrow Transplant 1998 21: 65\u201371","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/sj.bmt.1701296","volume":"22","author":"E Clarke","year":"1998","unstructured":"Clarke E, Potter MN, Hale G et al. Double T cell depletion of bone marrow using sequential positive and negative cell immunoaffinity or CD34+ cell selection followed by Campath-1M; effect on CD34+ cells and progenitor cell recoveries Bone Marrow Transplant 1998 22: 117\u2013124","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR22","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/sj.bmt.1701476","volume":"22","author":"PV O'Donnell","year":"1998","unstructured":"O'Donnell PV, Jones RJ, Vogelsang GB et al. CD34+ stem cell augmentation of elutriated allogeneic bone marrow grafts: results of a phase II clinical trial of engraftment and graft-versus-host disease prophylaxis in high-risk hematologic malignancies Bone Marrow Transplant 1998 22: 947\u2013955","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR23","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1182\/blood.V75.6.1370.1370","volume":"75","author":"JE Wagner","year":"1990","unstructured":"Wagner JE, Santos GW, Noga SJ et al. Bone marrow graft engineering by counterflow centrifugal elutriation: results of a phase I\u2013II clinical trial Blood 1990 75: 1370\u20131377","journal-title":"Blood"},{"key":"BF1703010_CR24","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/00007691-199810000-00017","volume":"20","author":"JT Slattery","year":"1998","unstructured":"Slattery JT, Risler LJ . Therapeutic monitoring of busulfan in hematopoietic stem cell transplantation Ther Drug Monit 1998 20: 543\u2013549","journal-title":"Ther Drug Monit"},{"key":"BF1703010_CR25","volume-title":"Statistical Methods, 8th edn","author":"G Snedecor","year":"1989","unstructured":"Snedecor G, Cochran W . Statistical Methods, 8th edn Iowa State University Press: Ames, IA 1989"},{"key":"BF1703010_CR26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EM Kaplan","year":"1958","unstructured":"Kaplan EM, Meier P . Non parametric estimation from incomplete observations J Am Stat Assoc 1958 53: 457","journal-title":"J Am Stat Assoc"},{"key":"BF1703010_CR27","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1182\/blood.V82.3.1030.1030","volume":"82","author":"G Vassal","year":"1993","unstructured":"Vassal G, Fischer A, Challine D et al. Busulfan disposition below the age of three: alteration in children with lysosomal storage disease Blood 1993 82: 1030\u20131034","journal-title":"Blood"},{"key":"BF1703010_CR28","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1182\/blood.V75.8.1723.1723","volume":"75","author":"LB Grochow","year":"1990","unstructured":"Grochow LB, Krivit W, Whitley CB, Blazar B . Busulfan disposition in children Blood 1990 75: 1723\u20131727","journal-title":"Blood"},{"key":"BF1703010_CR29","first-page":"843","volume":"18","author":"M Hassan","year":"1996","unstructured":"Hassan M, Fasth A, Gerritsen B et al. Busulphan kinetics and limited sampling model in children with leukemia and inherited disorders Bone Marrow Transplant 1996 18: 843\u2013850","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR30","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/sj.bmt.1702371","volume":"25","author":"AM Bolinger","year":"2000","unstructured":"Bolinger AM, Zangwill AB, Slattery JT et al. An evaluation of engraftment, toxicity and busulfan concentration in children receiving bone marrow transplantation for leukemia or genetic disease Bone Marrow Transplant 2000 25: 925\u2013930","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR31","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/sj.bmt.1701001","volume":"20","author":"AB Pawlowska","year":"1997","unstructured":"Pawlowska AB, Blazar BR, Angelucci E et al. Relationship of plasma pharmacokinetics of high-dose oral busulfan to the outcome of allogeneic bone marrow transplantation in children with thalassemia Bone Marrow Transplant 1997 20: 915\u2013920.","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR32","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1182\/blood.V87.8.3229.bloodjournal8783229","volume":"87","author":"P Gupta","year":"1996","unstructured":"Gupta P, McCarthy JB, Verfaillie CM . Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells Blood 1996 87: 3229\u20133236","journal-title":"Blood"},{"key":"BF1703010_CR33","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1182\/blood.V92.12.4641","volume":"92","author":"P Gupta","year":"1998","unstructured":"Gupta P, Oegema TR Jr, Brazil JJ et al. Structurally specific heparan sulfates support primitive human hematopoiesis by formation of a multimolecular stem cell niche Blood 1998 92: 4641\u20134651","journal-title":"Blood"},{"key":"BF1703010_CR34","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1182\/blood.V93.7.2196","volume":"93","author":"O Ringden","year":"1999","unstructured":"Ringden O, Remberger M, Ruutu T et al. Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group (see comments) Blood 1999 93: 2196\u20132201.","journal-title":"Blood"},{"key":"BF1703010_CR35","first-page":"171","volume":"18","author":"MJ Styler","year":"1996","unstructured":"Styler MJ, Crilley P, Biggs J et al. Hepatic dysfunction following busulfan and cyclophosphamide myeloablation: a retrospective, multicenter analysis Bone Marrow Transplant 1996 18: 171\u2013176","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR36","first-page":"467","volume":"7","author":"MF Ozkaynak","year":"1991","unstructured":"Ozkaynak MF, Weinberg K, Kohn D et al. Hepatic veno-occlusive disease post-bone marrow transplantation in children conditioned with busulfan and cyclophosphamide: incidence, risk factors, and clinical outcome Bone Marrow Transplant 1991 7: 467\u2013474","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR37","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/00000421-199006000-00009","volume":"13","author":"R Brodsky","year":"1990","unstructured":"Brodsky R, Topolsky D, Crilley P et al. Frequency of veno-occlusive disease of the liver in bone marrow transplantation with a modified busulfan\/cyclophosphamide preparative regimen Am J Clin Oncol 1990 13: 221\u2013225","journal-title":"Am J Clin Oncol"},{"key":"BF1703010_CR38","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/sj.bmt.1701334","volume":"22","author":"AR Hartman","year":"1998","unstructured":"Hartman AR, Williams SF, Dillon JJ . Survival, disease-free survival and adverse effects of conditioning for allogeneic bone marrow transplantation with busulfan\/cyclophosphamide vs total body irradiation: a meta-analysis Bone Marrow Transplant 1998 22: 439\u2013443","journal-title":"Bone Marrow Transplant"},{"key":"BF1703010_CR39","first-page":"577","volume":"13","author":"G Bandini","year":"1994","unstructured":"Bandini G, Belardinelli A, Rosti G et al. Toxicity of high-dose busulphan and cyclophosphamide as conditioning therapy for allogeneic bone marrow transplantation in adults with haematological malignancies Bone Marrow Transplant 1994 13: 577\u2013581","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1703010","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T22:06:07Z","timestamp":1648073167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1703010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,1]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,4,1]]}},"alternative-id":["BF1703010"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1703010","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,1]]},"assertion":[{"value":"30 November 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}