{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:59:21Z","timestamp":1789387161578,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2001,8,1]]},"DOI":"10.1038\/sj.bmt.1703150","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T16:37:42Z","timestamp":1032280662000},"page":"341-347","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Reduced-intensity conditioning reduces the risk of severe infections after allogeneic peripheral blood stem cell transplantation"],"prefix":"10.1038","volume":"28","author":[{"given":"R","family":"Martino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MD","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Canals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"San Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rovira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bargay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"P\u00e9rez-Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sarr\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Brunet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"de la Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the alloPBSCT and Infectious\/Non-infectious Complications Subcommittees of the Grupo Espanol de Trasplante Hematopoyetico (GETH)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,9,18]]},"reference":[{"key":"BF1703150_CR1","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1182\/blood.V89.12.4531","volume":"89","author":"S Giralt","year":"1997","unstructured":"Giralt S, Estey E, Albitar M et al. Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy Blood 1997 89: 4531\u20134536","journal-title":"Blood"},{"key":"BF1703150_CR2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood.V91.3.756","volume":"91","author":"S Slavin","year":"1998","unstructured":"Slavin S, Nagler A, Naparstek E et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases Blood 1998 91: 756\u2013763","journal-title":"Blood"},{"key":"BF1703150_CR3","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1200\/JCO.1998.16.8.2817","volume":"16","author":"IF Khouri","year":"1998","unstructured":"Khouri IF, Keating M, K\u00f6rbling M et al. Transplant-lite. Induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies J Clin Oncol 1998 16: 2817\u20132824","journal-title":"J Clin Oncol"},{"key":"BF1703150_CR4","first-page":"904","volume":"83","author":"AM Carella","year":"1998","unstructured":"Carella AM, Lerma E, Dejana A et al. Engraftment of HLA-matched sibling hematopoietic stem cells after immunosuppressive conditioning regimen in patients with hematologic neoplasias Haematologica 1998 83: 904\u2013909","journal-title":"Haematologica"},{"key":"BF1703150_CR5","first-page":"393a","volume":"94","author":"P McSweeney","year":"1999","unstructured":"McSweeney P, Niederwieser D, Shizuru J et al. Outpatient allografting with minimally myelosuppressive, immunosuppressive conditioning of low-dose TBI and postgrafting cyclosporine and mycophenolate mofetil Blood 1999 94: (Suppl. 1) 393a","journal-title":"Blood"},{"key":"BF1703150_CR6","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood.V94.9.3234","volume":"94","author":"R Childs","year":"1999","unstructured":"Childs R, Clave E, Contentin N et al. Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses Blood 1999 94: 3234\u20133241","journal-title":"Blood"},{"key":"BF1703150_CR7","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/sj.bmt.1702204","volume":"25","author":"AM Carella","year":"2000","unstructured":"Carella AM, Champlin R, Slavin S et al. Mini-allografts: ongoing trials in humans Bone Marrow Transplant 2000 25: 345\u2013350","journal-title":"Bone Marrow Transplant"},{"key":"BF1703150_CR8","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1086\/515103","volume":"28","author":"EA Engels","year":"1999","unstructured":"Engels EA, Ellis CA, Supran SE et al. Early infections in bone marrow transplantation: Quantitative study of clinical factors that affect risk Clin Infect Dis 1999 28: 256\u2013266","journal-title":"Clin Infect Dis"},{"key":"BF1703150_CR9","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/sj.bmt.1702447","volume":"25","author":"NMA Blijlevens","year":"2000","unstructured":"Blijlevens NMA, Donnelly JP, De Pauw BE . Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview Bone Marrow Transplant 2000 25: 1269\u20131278","journal-title":"Bone Marrow Transplant"},{"key":"BF1703150_CR10","first-page":"pp 704","volume-title":"Hematopoietic Cell Transplantation","author":"R Parkman","year":"1999","unstructured":"Parkman R, Weinberg KI . Immunological reconstitution following hematopoietic stem cell transplantation In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Cell Transplantation 2nd edn Blackwell Scientific Publications: Boston, MA 1999 pp 704\u2013711"},{"key":"BF1703150_CR11","first-page":"825","volume":"15","author":"D Przepiorka","year":"1995","unstructured":"Przepiorka D, Weisdorf D, Martin P et al. 1994 Consensus conference on acute GVHD grading Bone Marrow Transplant 1995 15: 825\u2013828","journal-title":"Bone Marrow Transplant"},{"key":"BF1703150_CR12","unstructured":"Martino R, Caballero MD, Canals C et al. Allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning: results of a prospective multicenter study Br J Haematol (in press)"},{"key":"BF1703150_CR13","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1182\/blood.V76.9.1867.1867","volume":"76","author":"RA Clift","year":"1990","unstructured":"Clift RA, Buckner CD, Appelbaum FR et al. Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens Blood 1990 76: 1876\u20131871","journal-title":"Blood"},{"key":"BF1703150_CR14","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1182\/blood.V77.8.1660.1660","volume":"77","author":"RA Clift","year":"1991","unstructured":"Clift RA, Buckner CD, Appelbaum FR et al. Allogeneic marrow transplantation in patients with chronic myeloid leukemia in the chronic phase: a randomized trial of two irradiation regimens Blood 1991 77: 1660\u20131665","journal-title":"Blood"},{"key":"BF1703150_CR15","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/sj.bmt.1702509","volume":"26","author":"M Mohty","year":"2000","unstructured":"Mohty M, Faucher C, Vey N et al. High rate of secondary viral and bacterial infections in patients undergoing allogeneic bone marrow mini-transplantation Bone Marrow Transplant 2000 26: 251\u2013255","journal-title":"Bone Marrow Transplant"},{"key":"BF1703150_CR16","first-page":"337a","volume":"94","author":"N Hensel","year":"1999","unstructured":"Hensel N, Almeida K, Bahceci E et al. Factors affecting incidence and timing of cytomegalovirus reactivation after allogeneic peripheral blood stem cell transplants Blood 1999 94: (Suppl. 1) 337a","journal-title":"Blood"},{"key":"BF1703150_CR17","first-page":"586a","volume":"96","author":"S Chakrabarti","year":"2000","unstructured":"Chakrabarti S, Kottaridis P, Ogormon P et al. High incidence of early and late CMV infection and delayed immune reconstitution after allogeneic transplants with nonmyeloablative conditioning using CAMPATH (anti-CD52 antibody) Blood 2000 96: (Suppl. 1) 586a","journal-title":"Blood"},{"key":"BF1703150_CR18","doi-asserted-by":"crossref","first-page":"191a","DOI":"10.1182\/blood.V96.4.1617","volume":"96","author":"V Reddy","year":"2000","unstructured":"Reddy V, Pollock BH, Sharda S et al. GVHD and CMV antigenemia after allogeneic peripheral blood stem cell transplantation: comparison between myeloablative and non-myeloablative (mini) conditioning regimens Blood 2000 96: (Suppl. 1) 191a","journal-title":"Blood"},{"key":"BF1703150_CR19","first-page":"65","volume":"3","author":"TN Small","year":"1997","unstructured":"Small TN, Avigan D, Dupont B et al. Immune reconstitution following T-cell depleted bone marrow transplantation: effect of age and posttransplant graft rejection prophylaxis Biol Blood Marrow Transplant 1997 3: 65\u201375","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1703150_CR20","doi-asserted-by":"crossref","first-page":"188a","DOI":"10.1182\/blood.V96.1.188","volume":"96","author":"C Junghanss","year":"2000","unstructured":"Junghanss C, Boeckh M, Carter R et al. Incidence of herpesvirus infections following nonmyeloablative allogeneic stem cell transplantation Blood 2000 96: (Suppl. 1) 188a","journal-title":"Blood"},{"key":"BF1703150_CR21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/00007890-198507000-00009","volume":"40","author":"O Ringd\u00e9n","year":"1985","unstructured":"Ringd\u00e9n O, Nilsson B . Death by graft-versus-host disease associated with HLA mismatch, high recipient age, low marrow cell dose and splenectomy Transplantation 1985 40: 39\u201344","journal-title":"Transplantation"},{"key":"BF1703150_CR22","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1182\/blood.V88.8.3223.bloodjournal8883223","volume":"88","author":"D Mavroudis","year":"1996","unstructured":"Mavroudis D, Fox M, Read EJ et al. Effect of CD34+ cell dose on outcome following T-depleted marrow transplantation Blood 1996 88: 3223\u20133229","journal-title":"Blood"},{"key":"BF1703150_CR23","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1182\/blood.V89.11.4226","volume":"89","author":"J Sierra","year":"1997","unstructured":"Sierra J, Storer B, Hansen JA et al. Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemia burden, donor HLA-matching and marrow cell dose Blood 1997 89: 4226\u20134235","journal-title":"Blood"},{"key":"BF1703150_CR24","first-page":"3323","volume":"95","author":"AJ Barrett","year":"2000","unstructured":"Barrett AJ, Ringd\u00e9n O, Zhang M-J et al. Effect of nucleated marrow cell dose on relapse and survival in identical twin bone marrow transplants for leukemia Blood 2000 95: 3323\u20133327","journal-title":"Blood"},{"key":"BF1703150_CR25","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1046\/j.1365-2141.2000.01838.x","volume":"108","author":"E Bah\u00e7eci","year":"2000","unstructured":"Bah\u00e7eci E, Read E, Leitman S et al. CD34+ cell dose predicts relapse and survival after T-cell-depleted HLA-identical haematopoietic stem cell transplantation (HSCT) for haematological malignancies Br J Haematol 2000 108: 408\u2013414","journal-title":"Br J Haematol"},{"key":"BF1703150_CR26","unstructured":"Martino R, Rovira M, Carreras E et al. Severe infections after allogeneic peripheral blood stem cell transplantation: a comparison of unmanipulated and CD34+ cell-selected transplantation (submitted for publication)"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1703150","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T22:28:12Z","timestamp":1648074492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1703150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,1]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,8,1]]}},"alternative-id":["BF1703150"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1703150","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,1]]},"assertion":[{"value":"1 March 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}