{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:14:48Z","timestamp":1776899688978,"version":"3.51.2"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2002,1,1]]},"DOI":"10.1038\/sj.bmt.1703324","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:18:14Z","timestamp":1031249894000},"page":"81-85","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Engraftment syndrome: a common cause for rash and fever following autologous hematopoietic stem cell transplantation for multiple sclerosis"],"prefix":"10.1038","volume":"29","author":[{"given":"Y","family":"Oyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Traynor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Brush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RK","family":"Burt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,2,7]]},"reference":[{"key":"BF1703324_CR1","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1212\/WNL.43.4.662","volume":"43","author":"DW Paty","year":"1993","unstructured":"Paty DW, Li DK UBC MS\/MRI Study Group IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial Neurology 1993 43: 662 667","journal-title":"Neurology"},{"key":"BF1703324_CR2","doi-asserted-by":"crossref","unstructured":"The IFNB Multiple Sclerosis Study Group University of British Columbia MS\/MRI Analysis Group. Interferon (beta)-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial Neurology 1995 45: 1277 1285","DOI":"10.1212\/WNL.45.7.1277"},{"key":"BF1703324_CR3","doi-asserted-by":"crossref","unstructured":"PRISMS (Prevention of Relapses and Disability by Interferon (beta)-1a Subcutaneously in Multiple Sclerosis) Study Group. Randomised double-blind placebo-controlled study of interferon (beta)-1a in relapsing\/remitting multiple sclerosis. (Published erratum, Lancet 1999; 353: 678) Lancet 1998 352: 1498 1504","DOI":"10.1016\/S0140-6736(98)03334-0"},{"key":"BF1703324_CR4","doi-asserted-by":"crossref","unstructured":"European Study Group on Interferon (beta)-1b in Secondary Progressive MS. Placebo-controlled multicentre randomised trial of interferon (beta)-1b in treatment of secondary progressive multiple sclerosis Lancet 1998 352: 1491 1497","DOI":"10.1016\/S0140-6736(98)10039-9"},{"key":"BF1703324_CR5","doi-asserted-by":"crossref","unstructured":"The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial Neurology 1993 43: 655 661","DOI":"10.1212\/WNL.43.4.655"},{"key":"BF1703324_CR6","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1212\/WNL.45.7.1268","volume":"45","author":"KP Johnson","year":"1995","unstructured":"Johnson KP, Brooks BR, Cohen JA et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial Neurology 1995 45: 1268 1276","journal-title":"Neurology"},{"key":"BF1703324_CR7","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1212\/WNL.50.3.701","volume":"50","author":"KP Johnson","year":"1998","unstructured":"Johnson KP, Brooks BR, Cohen JA et al. Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability Neurology 1998 50: 701 708","journal-title":"Neurology"},{"key":"BF1703324_CR8","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s004150050066","volume":"244","author":"E Millefiorini","year":"1997","unstructured":"Millefiorini E, Gasperini C, Pozzilli C et al. Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome J Neurol 1997 244: 153 159","journal-title":"J Neurol"},{"key":"BF1703324_CR9","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1136\/jnnp.62.2.112","volume":"62","author":"G Edan","year":"1997","unstructured":"Edan G, Miller D, Clanet M et al. Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria J Neurol Neurosurg Psychiat 1997 62: 112 118","journal-title":"J Neurol Neurosurg Psychiat"},{"key":"BF1703324_CR10","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1212\/WNL.41.8.1193","volume":"41","author":"AD Sadovnick","year":"1991","unstructured":"Sadovnick AD, Eisen K, Ebers GC, Paty DW . Cause of death in patients attending multiple sclerosis clinics Neurology 1991 41: 1193 1196","journal-title":"Neurology"},{"key":"BF1703324_CR11","first-page":"1","volume":"16","author":"RK Burt","year":"1995","unstructured":"Burt RK, Burns W, Hess A . Bone marrow transplantation for multiple sclerosis Bone Marrow Transplant 1995 16: 1 6","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR12","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1182\/blood.V94.8.2915.420k42_2915_2922","volume":"94","author":"RK Burt","year":"1999","unstructured":"Burt RK, Padilla J, Dal Canto MC, Miller SD . Viral hyperinfection of the central nervous system and high mortality after hematopoietic stem cell transplantation for treatment of Theiler's murine encephalomyelitis virus-induced demyelinating disease Blood 1999 94: 2915 2922","journal-title":"Blood"},{"key":"BF1703324_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1023\/A:1006682225181","volume":"20","author":"DW van Bekkum","year":"2000","unstructured":"van Bekkum DW . Stem cell transplantation in experimental models of autoimmune disease J Clin Immunol 2000 20: 10 16","journal-title":"J Clin Immunol"},{"key":"BF1703324_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1177\/135245859900500104","volume":"5","author":"D Karussis","year":"1999","unstructured":"Karussis D, Vourka-Karussis U, Mizrachi-Koll R, Abramsky O . Acute\/relapsing experimental autoimmune encephalomyelitis: induction of long lasting, antigen-specific tolerance by syngeneic bone marrow transplantation Multiple Sclerosis 1999 5: 17 21","journal-title":"Multiple Sclerosis"},{"key":"BF1703324_CR15","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1182\/blood.V91.7.2609","volume":"91","author":"RK Burt","year":"1998","unstructured":"Burt RK, Padilla J, Begolka WS et al. Effect of disease stage on clinical outcome after syngeneic bone marrow transplantation for relapsing experimental autoimmune encephalomyelitis Blood 1998 91: 2609 2616","journal-title":"Blood"},{"key":"BF1703324_CR16","first-page":"1029","volume":"18","author":"M Van Gelder","year":"1996","unstructured":"Van Gelder M, van Bekkum DW . Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation Bone Marrow Transplant 1996 18: 1029 1034","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR17","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1172\/JCI116648","volume":"92","author":"DM Karussis","year":"1993","unstructured":"Karussis DM, Vourka-Karussis U, Lehmann D et al. Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation J Clin Invest 1993 92: 765 772","journal-title":"J Clin Invest"},{"key":"BF1703324_CR18","first-page":"233","volume":"11","author":"M van Gelder","year":"1993","unstructured":"van Gelder M, Kinwel-Bohre EP, van Bekkum DW . Treatment of experimental allergic encephalomyelitis in rats with total body irradiation and syngeneic BMT Bone Marrow Transplant 1993 11: 233 241","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR19","first-page":"343","volume":"16","author":"M van Gelder","year":"1995","unstructured":"van Gelder M, van Bekkum DW . Treatment of relapsing experimental autoimmune encephalomyelitis in rats with allogeneic bone marrow transplantation from a resistant strain Bone Marrow Transplant 1995 16: 343 351","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR20","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1002\/jnr.490410412","volume":"41","author":"RK Burt","year":"1995","unstructured":"Burt RK, Burns W, Ruvolo P et al. Syngeneic bone marrow transplantation eliminates V beta 8.2 T lymphocytes from the spinal cord of Lewis rats with experimental allergic encephalomyelitis J Neurosci Res 1995 41: 526 531","journal-title":"J Neurosci Res"},{"key":"BF1703324_CR21","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/sj.bmt.1700944","volume":"20","author":"A Fassas","year":"1997","unstructured":"Fassas A, Anagnostopoulos A, Kazis A et al. Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study Bone Marrow Transplant 1997 20: 631 638","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR22","first-page":"537","volume":"21","author":"RK Burt","year":"1998","unstructured":"Burt RK, Traynor AE, Cohen B et al. T cell-depleted autologous hematopoietic stem cell transplantation for multiple sclerosis: report on the first three patients Bone MarrowTransplant 1998 21: 537 541","journal-title":"Bone MarrowTransplant"},{"key":"BF1703324_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1023\/A:1006686426090","volume":"20","author":"A Fassas","year":"2000","unstructured":"Fassas A, Anagnostopoulos A, Kazis A et al. Autologous stem cell transplantation in progressive multiple sclerosis \u2013 an interim analysis of efficacy J Clin Immunol 2000 20: 24 30","journal-title":"J Clin Immunol"},{"key":"BF1703324_CR24","unstructured":"Nash RA, Kraft GH, Bowen JD et al. Treatment of severe multiple sclerosis (MS) with high-dose immunosuppressive therapy (HDIT) and autologous stem cell transplantation (SCT) Blood 2000 96: (Suppl. 1) 842 (Abstr. 3640)"},{"key":"BF1703324_CR25","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S1083-8791(00)70066-8","volume":"6","author":"H Openshaw","year":"2000","unstructured":"Openshaw H, Lund BT, Kashyap A et al. Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: report of toxicity and immunological monitoring Biol Blood Marrow Transplant 2000 6: 563 575","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1703324_CR26","first-page":"69","volume":"7","author":"E Carreras","year":"2001","unstructured":"Carreras E, Saiz A, Graus F et al. Autologous CD34+ selected hematopoietic stem cell transplantation (CD34+\/HSCT) for multiple sclerosis: update of a single center experience in 10 patients Biol Blood Marrow Transplant 2001 7: 69 (Abstr.)","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1703324_CR27","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s004150070112","volume":"247","author":"P Mandalfino","year":"2000","unstructured":"Mandalfino P, Rice G, Smith A et al. Bone marrow transplantation in multiple sclerosis J Neurol 2000 247: 691 695","journal-title":"J Neurol"},{"key":"BF1703324_CR28","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/sj.bmt.1702180","volume":"25","author":"T Kozak","year":"2000","unstructured":"Kozak T, Havrdova E, Pit'ha J et al. High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis Bone Marrow Transplant 2000 25: 525 531","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR29","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/ana.410130331","volume":"13","author":"SG Waxman","year":"1983","unstructured":"Waxman SG, Geschwind N . Major morbidity related to hyperthermia in multiple sclerosis Ann Neurol 1983 13: 348","journal-title":"Ann Neurol"},{"key":"BF1703324_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00313541","volume":"227","author":"A Kazis","year":"1982","unstructured":"Kazis A, Vlaikidis N, Xafenias D et al. Fever and evoked potentials in multiple sclerosis J Neurol 1982 227: 1 10","journal-title":"J Neurol"},{"key":"BF1703324_CR31","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/sj.bmt.1702155","volume":"25","author":"WJ Edenfield","year":"2000","unstructured":"Edenfield WJ, Moores LK, Goodwin G, Lee N . An engraftment syndrome in autologous stem cell transplantation related to mononuclear cell dose Bone Marrow Transplant 2000 25: 405 409","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR32","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/sj.bmt.1702110","volume":"25","author":"C Kawano","year":"2000","unstructured":"Kawano C, Muroi K, Kuribara R et al. Engraftment syndrome after autologous peripheral blood stem cell transplantation with high numbers of peripheral blood stem cells followed by granulocyte colony-stimulating factor administration Bone Marrow Transplant 2000 25: 228 229","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR33","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/sj.bmt.1701619","volume":"23","author":"F de Arriba","year":"1999","unstructured":"de Arriba F, Corral J, Ayala F et al. Autoaggression syndrome resembling acute graft-versus-host disease grade IV after autologous peripheral blood stem cell transplantation for breast cancer Bone Marrow Transplant 1999 23: 621 624","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR34","first-page":"943","volume":"18","author":"C Ravoet","year":"1996","unstructured":"Ravoet C, Feremans W, Husson B et al. Clinical evidence for an engraftment syndrome associated with early and steep neutrophil recovery after autologous blood stem cell transplantation Bone Marrow Transplant 1996 18: 943 947","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR35","first-page":"175","volume":"16","author":"CK Lee","year":"1995","unstructured":"Lee CK, Gingrich RD, Hohl RJ, Ajram KA . Engraftment syndrome in autologous bone marrow and peripheral stem cell transplantation Bone Marrow Transplant 1995 16: 175 182","journal-title":"Bone Marrow Transplant"},{"key":"BF1703324_CR36","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/sj.bmt.1703015","volume":"21","author":"TR Spitzer","year":"2001","unstructured":"Spitzer TR . Engraftment syndrome following hematopoietic stem cell transplantation Bone Marrow Transplant 2001 21: 893 898","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1703324","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703324.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703324.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T22:27:00Z","timestamp":1648074420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1703324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1,1]]}},"alternative-id":["BF1703324"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1703324","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,1]]},"assertion":[{"value":"17 August 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}