{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:56:22Z","timestamp":1788260182863,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2002,12,1]]},"DOI":"10.1038\/sj.bmt.1703737","type":"journal-article","created":{"date-parts":[[2002,12,13]],"date-time":"2002-12-13T11:57:22Z","timestamp":1039780642000},"page":"899-903","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Basiliximab is well tolerated and effective in the treatment of steroid-refractory acute graft-versus-host disease after allogeneic stem cell transplantation"],"prefix":"10.1038","volume":"30","author":[{"given":"G","family":"Massenkeil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Rackwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Genvresse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"D\u00f6rken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,12,12]]},"reference":[{"key":"BF1703737_CR1","first-page":"515","volume-title":"Hematopoietic Cell Transplantation, 2nd edn","author":"KM Sullivan","year":"1999","unstructured":"Sullivan KM . Graft-versus-host disease. In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Cell Transplantation, 2nd edn Blackwell Science: Malden, MA 1999 515 536"},{"key":"BF1703737_CR2","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1056\/NEJM199310213291703","volume":"329","author":"NJ Chao","year":"1993","unstructured":"Chao NJ, Schmidt GM, Niland JC et al. Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease New Engl J Med 1993 329: 1225 1230","journal-title":"New Engl J Med"},{"key":"BF1703737_CR3","first-page":"1241","volume":"25","author":"O Ringden","year":"1993","unstructured":"Ringden O . Decreased transplant-related complications and improved leukemia-free survival in adults receiving methotrexate combined with cyclosporin compared with either agent alone for prevention of graft-versus-host disease. Advisory Committee of the International Bone Marrow Transplant Registry Transplant Proc 1993 25: 1241 1242","journal-title":"Transplant Proc"},{"key":"BF1703737_CR4","first-page":"147","volume":"16","author":"TL Schwinghammer","year":"1995","unstructured":"Schwinghammer TL, Bloom EJ, Rosenfeld CS et al. High-dose cyclosporine and corticosteroids for prophylaxis of acute and chronic graft-versus-host disease Bone Marrow Transplant 1995 16: 147 154","journal-title":"Bone Marrow Transplant"},{"key":"BF1703737_CR5","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V76.8.1464.1464","volume":"76","author":"PJ Martin","year":"1990","unstructured":"Martin PJ, Schoch G, Fisher L et al. A retrospective analysis of therapy for acute graft-versus-host disease: initial treatment Blood 1990 76: 1464 1472","journal-title":"Blood"},{"key":"BF1703737_CR6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/300267a0","volume":"300","author":"WJ Leonard","year":"1982","unstructured":"Leonard WJ, Depper JM, Uchiyama T et al. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor Nature 1982 300: 267 269","journal-title":"Nature"},{"key":"BF1703737_CR7","first-page":"219","volume":"10","author":"GE Ringheim","year":"1991","unstructured":"Ringheim GE, Freimark BD, Robb RJ . Quantitative characterization of the intrinsic ligand-binding affinity of the interleukin 2 receptor beta chain and its modulation by the alpha chain and a second affinity-modulating element Lymphokine Cytokine Res 1991 10: 219 224","journal-title":"Lymphokine Cytokine Res"},{"key":"BF1703737_CR8","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1084\/jem.160.4.1126","volume":"160","author":"RJ Robb","year":"1984","unstructured":"Robb RJ, Greene WC, Rusk CM . Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen J Exp Med 1984 160: 1126 1146","journal-title":"J Exp Med"},{"key":"BF1703737_CR9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1089\/15258160050079407","volume":"9","author":"JL Ferrara","year":"2000","unstructured":"Ferrara JL . Pathogenesis of acute graft-versus-host disease: cytokines and cellular effectors J Hematother Stem Cell Res 2000 9: 299 306","journal-title":"J Hematother Stem Cell Res"},{"key":"BF1703737_CR10","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/S0140-6736(97)09278-7","volume":"350","author":"B Nashan","year":"1997","unstructured":"Nashan B, Moore R, Amlot P et al. Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients. CHIB 201 International Study Group Lancet 1997 350: 1193 1198","journal-title":"Lancet"},{"key":"BF1703737_CR11","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/00007890-199901270-00016","volume":"67","author":"BD Kahan","year":"1999","unstructured":"Kahan BD, Rajagopalan PR, Hall M . Reduction of the occurrence of acute cellular rejection among renal allograft recipients treated with basiliximab, a chimeric anti-interleukin-2-receptor monoclonal antibody. United States Basiliximab Renal Study Group Transplantation 1999 67: 276 284","journal-title":"Transplantation"},{"key":"BF1703737_CR12","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","volume":"18","author":"H Glucksberg","year":"1974","unstructured":"Glucksberg H, Storb R, Fefer A et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors Transplantation 1974 18: 295 304","journal-title":"Transplantation"},{"key":"BF1703737_CR13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0002-9343(80)90380-0","volume":"69","author":"HM Shulman","year":"1980","unstructured":"Shulman HM, Sullivan KM, Weiden PL et al. Chronic graft-versus-host syndrome in man: a clinicopathological study of 20 long-term Seattle patients Am J Med 1980 69: 204 217","journal-title":"Am J Med"},{"key":"BF1703737_CR14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1182\/blood.V95.1.83","volume":"95","author":"D Przepiorka","year":"2000","unstructured":"Przepiorka D, Kernan NA, Ippoliti C et al. Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease Blood 2000 95: 83 89","journal-title":"Blood"},{"key":"BF1703737_CR15","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/sj.bmt.1700745","volume":"19","author":"T Ruutu","year":"1997","unstructured":"Ruutu T, Niederwieser D, Gratwohl A, Apperley JF . A survey of the prophylaxis and treatment of acute GVHD in Europe: a report of the European Group for Blood and Marrow, Transplantation (EBMT). Chronic Leukaemia Working Party of the EBMT Bone Marrow Transplant 1997 19: 759 764","journal-title":"Bone Marrow Transplant"},{"key":"BF1703737_CR16","first-page":"177a","volume":"96","author":"R Pasquini","year":"2000","unstructured":"Pasquini R, Moreira VA, Medeiros de CR et al. Basiliximab \u2013 a selective interleukin-2 receptor antagonist \u2013 as therapy for refractory acute graft-versus-host disease following bone marrow transplantation Blood 2000 96: 177a (Abstr. 762)","journal-title":"Blood"},{"key":"BF1703737_CR17","first-page":"921","volume":"18","author":"O Ringden","year":"1996","unstructured":"Ringden O, Labopin M, Gluckman E et al. Graft-versus-leukemia effect in allogeneic marrow transplant recipients with acute leukemia is maintained using cyclosporin A combined with methotrexate as prophylaxis. Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation Bone Marrow Transplant 1996 18: 921 929","journal-title":"Bone Marrow Transplant"},{"key":"BF1703737_CR18","first-page":"560","volume-title":"Hematopoietic Cell Transplantation, 2nd edn","author":"JA Zaia","year":"1999","unstructured":"Zaia JA . Cytomegalovirus infections. In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Cell Transplantation, 2nd edn Blackwell Science: Malden, MA 1999 560 583"},{"key":"BF1703737_CR19","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1097\/00007890-199712270-00012","volume":"64","author":"J Kovarik","year":"1997","unstructured":"Kovarik J, Wolf P, Cisterne JM et al. Disposition of basiliximab, an interleukin-2 receptor monoclonal antibody, in recipients of mismatched cadaver renal allografts Transplantation 1997 64: 1701 1705","journal-title":"Transplantation"},{"key":"BF1703737_CR20","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1182\/blood.V84.4.1320.1320","volume":"84","author":"C Anasetti","year":"1994","unstructured":"Anasetti C, Hansen JA, Waldmann TA et al. Treatment of acute graft-versus-host disease with humanized anti-Tac: an antibody that binds to the interleukin-2 receptor Blood 1994 84: 1320 1327","journal-title":"Blood"},{"key":"BF1703737_CR21","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1046\/j.1365-2141.2001.02582.x","volume":"112","author":"W Willenbacher","year":"2001","unstructured":"Willenbacher W, Basara N, Blau IW et al. Treatment of steroid refractory acute and chronic graft-versus-host disease with daclizumab Br J Haematol 2001 112: 820 823","journal-title":"Br J Haematol"},{"key":"BF1703737_CR22","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/sj.bmt.1703032","volume":"27","author":"H Khoury","year":"2001","unstructured":"Khoury H, Kashyap A, Adkins DR et al. Treatment of steroid-resistant acute graft-versus-host disease with anti-thymocyte globulin Bone Marrow Transplant 2001 27: 1059 1064","journal-title":"Bone Marrow Transplant"},{"key":"BF1703737_CR23","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","volume":"66","author":"J Liu","year":"1991","unstructured":"Liu J, Farmer JD, Lane WS et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes Cell 1991 66: 807 815","journal-title":"Cell"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1703737","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703737.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703737.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:24:30Z","timestamp":1648077870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1703737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,1]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,12,1]]}},"alternative-id":["BF1703737"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1703737","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,1]]},"assertion":[{"value":"14 January 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}