{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:36:54Z","timestamp":1761100614361},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2003,4,1]]},"DOI":"10.1038\/sj.bmt.1703856","type":"journal-article","created":{"date-parts":[[2003,4,11]],"date-time":"2003-04-11T16:31:03Z","timestamp":1050078663000},"page":"655-661","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adjuvant treatment of high-risk stage II breast cancer with doxorubicin followed by high-dose chemotherapy and autologous stem-cell transplantation: a single-institution experience with 132 consecutive patients"],"prefix":"10.1038","volume":"31","author":[{"given":"S M","family":"Stemmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Hardan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Raz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Adamou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Inbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gottfried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Merrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sulkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Ben-Baruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R P","family":"Pfeffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rizel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,4,11]]},"reference":[{"key":"BF1703856_CR1","unstructured":"Peters WP, Roser G, Vredenbrugh J et al. Updated results of a prospective, randomized comparison of two doses of combination alkylating agents as consolidation after CAF in high-risk primary breast cancer involving ten or more axillary lymph nodes. Proceedings of the Annual Meeting of the American Society of Clinical Oncology, #81, San Francisco, CA, May 2001 CALGB 9082\/SWO 9114\/NCIC Ma-13."},{"key":"BF1703856_CR2","unstructured":"Gianni A, Bonadonna G . Five-year results of the randomized clinical trial comparing standard versus high-dose myeloablative chemotherapy in the adjuvant treatment of breast cancer with &gt;3 positive nodes. Proceedings of the Annual Meeting of the American Society of Clinical Oncology, #80, San Francisco, CA, May 2001."},{"key":"BF1703856_CR3","unstructured":"Rodenhuis S, Bontenbal M, Beex LVAM et al. Randomized phase III study of high-dose chemotherapy with cyclophos-phamide, thiotepa and carboplatin in operable breast cancer with 4 or more axillary lymph nodes. Proceedings of the Annual Meeting of the American Society of Clinical Oncology,#286, New Orleans, LA, May 2000."},{"key":"BF1703856_CR4","volume-title":"American Joint Committee on Cancer Staging Manual","author":"ID Fleming","year":"1997","unstructured":"Fleming ID, Cooper JS, Henson DE et al. (Eds.) American Joint Committee on Cancer Staging Manual, 5th edn. Lippincott Raven: Philadelphia, 1997."},{"key":"BF1703856_CR5","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1002\/1097-0142(20010601)91:11<1983::AID-CNCR1223>3.0.CO;2-6","volume":"91","author":"SM Stemmer","year":"2001","unstructured":"Stemmer SM, Pfeffer MR, Rizel S et al. Feasibility and low toxicity of early radiotherapy after high-dose chemotherapy and autologous stem cell transplantation for patients with high-risk stage II\u2013III and locally advanced breast carcinoma. Cancer 2001; 91: 1983\u20131991.","journal-title":"Cancer"},{"key":"BF1703856_CR6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1200\/JCO.1992.10.1.102","volume":"10","author":"K Antman","year":"1992","unstructured":"Antman K, Ayash L, Elias A et al. A phase II study of high-dose cyclophosphamide, thiotepa, and carboplatin with autologous marrow support in women with measurable advanced breast cancer responding to standard-dose therapy. J Clin Oncol 1992; 10: 102\u2013110.","journal-title":"J Clin Oncol"},{"key":"BF1703856_CR7","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1200\/JCO.1993.11.6.1132","volume":"11","author":"WP Peters","year":"1993","unstructured":"Peters WP, Ross M, Vredenburgh JJ et al. High dose chemotherapy and autologous bone marrow support as consolidation after standard dose adjuvant therapy for high-risk primary breast cancer. J Clin Oncol 1993; 11: 1132\u20131143.","journal-title":"J Clin Oncol"},{"key":"BF1703856_CR8","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1200\/JCO.1997.15.6.2312","volume":"15","author":"AM Gianni","year":"1997","unstructured":"Gianni AM, Siena S, Bregni M et al. Efficacy, toxicity, and applicability of high-dose sequential chemotherapy as adjuvant treatment in operable breast cancer with 10 or more involved axillary nodes: Five-year results. J Clin Oncol 1997; 15: 2312\u20132321.","journal-title":"J Clin Oncol"},{"key":"BF1703856_CR9","doi-asserted-by":"crossref","unstructured":"International Breast Cancer Study Group. Duration and reintroduction of adjuvant chemotherapy for node-positive premenopausal breast cancer patients. J Clin Oncol 1996; 14: 1885\u20131894.","DOI":"10.1200\/JCO.1996.14.6.1885"},{"key":"BF1703856_CR10","unstructured":"Roche HH, Pouillart P, Meyer N et al. Adjuvant high dose chemotherapy (HDC) improves early outcome for high risk (N&gt;7) breast cancer patients: the Pegase 01 trial. Proceedings of the Annual Meeting of the American Society of Clinical Oncology, #102, San Francisco, CA, May 2001."},{"key":"BF1703856_CR11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-3-642-46836-0_3","volume":"144","author":"C Gisselbrecht","year":"1998","unstructured":"Gisselbrecht C . Autologous stem cell transplantation in aggressive non-Hodgkin's lymphoma. Recent Results Cancer Res 1998; 144: 15\u201326.","journal-title":"Recent Results Cancer Res"},{"key":"BF1703856_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/sj.bmt.1701068","volume":"21","author":"DC Fisher","year":"1998","unstructured":"Fisher DC, Vredenburgh JJ, Petros WP et al. Reduced mortality following bone marrow transplantation for breast cancer with the addition of peripheral blood progenitor cells is due to a marked reduction in veno-occlusive diseases of the liver. Bone Marrow Transplant 1998; 21: 117\u2013122.","journal-title":"Bone Marrow Transplant"},{"key":"BF1703856_CR13","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/jnci\/92.3.225","volume":"92","author":"GN Hortobagyi","year":"2000","unstructured":"Hortobagyi GN, Buzdar AU, Theriault RL et al. Randomized trial of high-dose chemotherapy and blood cell autografts for high-risk primary breast carcinoma. J Natl Cancer Inst 2000; 92: 225\u2013233.","journal-title":"J Natl Cancer Inst"},{"key":"BF1703856_CR14","unstructured":"Bolwell BJ, Andresen SW, Pohlman BL et al. The prognostic importance of the axillary lymph node ratio in autologous transplantation for high-risk stage II\u2013III breast cancer. Proceedings of the Annual Meeting of the American Society of Clinical Oncology, #57, New Orleans, LA, May 2000."},{"key":"BF1703856_CR15","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/sj.bmt.1701000","volume":"20","author":"SI Bearman","year":"1997","unstructured":"Bearman SI, Overmoyer BA, Bolwel BJ et al. High-dose chemotherapy with autologous peripheral blood progenitor cell support for primary breast cancer in patients with 4\u20139 involved axillary lymph nodes. Bone Marrow Transplant 1997; 20: 931\u2013937.","journal-title":"Bone Marrow Transplant"},{"key":"BF1703856_CR16","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/0360-3016(92)90908-Z","volume":"23","author":"LB Marks","year":"1992","unstructured":"Marks LB, Halperin EC, Prosnitz LR et al. Post-mastectomy radiotherapy following adjuvant chemotherapy with autologous bone marrow transplant for breast cancer patients with &gt;10 positive axillary lymph nodes. Int J Radiat Oncol Biol Phys 1992; 23: 1021\u20131026.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl","key":"BF1703856_CR17","first-page":"45","volume":"195a","author":"LB Marks","year":"1999","unstructured":"Marks LB, Fitzgerald TJ, Laurie F et al. Preliminary analysis of radiotherapy data from CALGB 9082: variability of treatment fields for local\/regional breast cancer and the impact of high dose chemotherapy to deliver radiation therapy [Abstract]. Int J Radiat Oncol Biol Phys 1999; 195a (Suppl): 45.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BF1703856_CR18","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1200\/JCO.1997.15.8.2882","volume":"15","author":"G Somlo","year":"1997","unstructured":"Somlo G, Doroshow JH, Forman SJ et al. High-dose chemotherapy and stem cell rescue in the treatment of high-risk breast cancer: prognostic indicators of progression-free and overall survival. J Clin Oncol 1997; 15: 2882\u20132893.","journal-title":"J Clin Oncol"},{"key":"BF1703856_CR19","first-page":"6","volume":"141a","author":"K Cornetta","year":"2000","unstructured":"Cornetta K, Yanovich S, Rosenfeld C et al. High-dose chemotherapy and stem cell transplant in breast cancer patients: a randomized multicenter study of CD 34 selection [abstract]. Biol Blood Marrow Transplant 2000; 141a: 6.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1703856_CR20","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/jnci\/82.7.570","volume":"82","author":"MD Abeloff","year":"1990","unstructured":"Abeloff MD, Beveridge RA, Donehower RC et al. Sixteen week dose intense chemotherapy in the adjuvant treatment of breast cancer. J Natl Cancer Inst 1990; 82: 570\u2013574.","journal-title":"J Natl Cancer Inst"},{"key":"BF1703856_CR21","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/1097-0142(19920115)69:2<448::AID-CNCR2820690229>3.0.CO;2-K","volume":"69","author":"AV Buzdar","year":"1992","unstructured":"Buzdar AV, Kau SW, Hortobagyi GN et al. Clinical course of patients with breast cancer with ten or more positive nodes who were treated with doxorubicin containing adjuvant therapy. Cancer 1992; 69: 448\u2013452.","journal-title":"Cancer"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1703856","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703856.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1703856.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:38:17Z","timestamp":1648078697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1703856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,1]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,4,1]]}},"alternative-id":["BF1703856"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1703856","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,1]]},"assertion":[{"value":"18 March 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}