{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:37:08Z","timestamp":1761100628370},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2003,6,1]]},"DOI":"10.1038\/sj.bmt.1704066","type":"journal-article","created":{"date-parts":[[2003,6,10]],"date-time":"2003-06-10T10:43:24Z","timestamp":1055241804000},"page":"1081-1087","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Paediatric allogeneic bone marrow transplantation for homozygous \u03b2-thalassaemia, the Dutch experience"],"prefix":"10.1038","volume":"31","author":[{"given":"L M","family":"Ball","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Lankester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P C","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M H","family":"van Weel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C L","family":"Harteveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G M","family":"Bredius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F J","family":"Smiers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Egeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M J J","family":"Vossen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,6,10]]},"reference":[{"key":"BF1704066_CR1","first-page":"299","volume":"6","author":"JF Apperley","year":"1993","unstructured":"Apperley JF . Bone marrow transplant for the hemoglobinopathies: past, present and future. Clin Haematol 1993; 6: 299\u2013325.","journal-title":"Clin Haematol"},{"key":"BF1704066_CR2","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1056\/NEJM199309163291212","volume":"329","author":"D Weatherall","year":"1993","unstructured":"Weatherall D . The treatment of thalassaemia, slow progress and new dilemmas. N Engl J Med 1993; 329: 877\u2013879.","journal-title":"N Engl J Med"},{"key":"BF1704066_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/00062752-200001000-00003","volume":"7","author":"WC Mentzer","year":"2000","unstructured":"Mentzer WC . Bone marrow transplantation for hemoglobinopathies. Curr Opin Hematology 2000; 7: 9\u201317.","journal-title":"Curr Opin Hematology"},{"key":"BF1704066_CR4","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1749-6632.1998.tb10486.x","volume":"850","author":"A Piga","year":"1998","unstructured":"Piga A, Longo F, Voi V et al. Late effects of bone marrow transplantation for thalassemia. Ann NY Acad Sci 1998; 850: 294\u2013299.","journal-title":"Ann NY Acad Sci"},{"key":"BF1704066_CR5","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1056\/NEJM199002153220701","volume":"322","author":"G Lucarelli","year":"1990","unstructured":"Lucarelli G, Galimberti M, Polchi P et al. Bone marrow transplantation in patients with thalassemia. N Engl J Med 1990; 322: 417\u2013421.","journal-title":"N Engl J Med"},{"key":"BF1704066_CR6","first-page":"57","volume":"19S2","author":"RA Clift","year":"1997","unstructured":"Clift RA, Johnson FL . Marrow transplants for thalassemia: the USA experience. Bone Marrow Transplant 1997; 19S2: 57\u201359.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704066_CR7","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/j.1749-6632.1998.tb10483.x","volume":"850","author":"G Lucarelli","year":"1998","unstructured":"Lucarelli G, Galimberti M, Giardani C et al. Bone marrow transplantation in thalassemia: the experience of Pesaro. Ann NY Acad Sci 1998; 850: 270\u2013275.","journal-title":"Ann NY Acad Sci"},{"key":"BF1704066_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1749-6632.1998.tb10479.x","volume":"850","author":"C Borgna-Pignatti","year":"1998","unstructured":"Borgna-Pignatti C, Rugolotto S, De Stafano P et al. Survival and disease complications in thalassemia major. Ann NY Acad Sci 1998; 850: 227\u2013231.","journal-title":"Ann NY Acad Sci"},{"key":"BF1704066_CR9","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1182\/blood.V80.6.1603.1603","volume":"80","author":"G Lucarelli","year":"1992","unstructured":"Lucarelli G, Galimberti M, Polchi P et al. Bone marrow transplantation in adult thalassemia. Blood 1992; 80: 1603\u20131609.","journal-title":"Blood"},{"key":"BF1704066_CR10","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1182\/blood.V87.5.2082.2082","volume":"87","author":"G Lucarelli","year":"1996","unstructured":"Lucarelli G, Clift RA, Galimberti M et al. Marrow transplantation for patients with thalassemia: results in class 3 patients. Blood 1996; 87: 2082\u20132088.","journal-title":"Blood"},{"key":"BF1704066_CR11","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1182\/blood.V93.4.1164","volume":"93","author":"G Lucarelli","year":"1999","unstructured":"Lucarelli G, Clift RA, Galimberti M et al. Bone marrow transplantation in adult thalassemic patients. Blood 1999; 93: 1164\u20131167.","journal-title":"Blood"},{"key":"BF1704066_CR12","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1111\/j.1365-2141.1995.tb08412.x","volume":"89","author":"E Angelucci","year":"1995","unstructured":"Angelucci E, Baronciani D, Lucarelli G et al. Needle liver biopsy in thalassemia: analyses of diagnostic accuracy and safety in 1184 consecutive biopsies. Br J Haematol 1995; 89: 757\u2013761.","journal-title":"Br J Haematol"},{"key":"BF1704066_CR13","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1046\/j.1365-2125.2002.01555.x","volume":"53","author":"S Cremers","year":"2002","unstructured":"Cremers S, Schoemaker R, Bredius R et al. Pharmacokinetics of intravenous busulfan in children prior to stem cell transplantation. Br J Clin Pharmacol 2002; 53: 386\u2013389.","journal-title":"Br J Clin Pharmacol"},{"key":"BF1704066_CR14","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/BF01969527","volume":"9","author":"JM Vossen","year":"1990","unstructured":"Vossen JM, Heidt PJ, van den Berg H et al. Prevention of infection and graft-versus-host disease by suppression of intestinal microflora in children treated with allogeneic bone marrow transplantation. Eur J Clin Microbiol Infect Dis. 1990; 9: 14\u201323.","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"BF1704066_CR15","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V76.8.1464.1464","volume":"76","author":"PJ Martin","year":"1990","unstructured":"Martin PJ, Schoch G, Fischer L et al. A retrospective analysis of therapy for acute graft-versus-host disease: Initial treatment. Blood 1990; 76: 1464\u20131470.","journal-title":"Blood"},{"key":"BF1704066_CR16","first-page":"1464","volume":"76","author":"K Sullivan","year":"1992","unstructured":"Sullivan K . Prevention and treatment of chronic graft-versus-host disease. Marrow Transplant Rev 1992; 76: 1464\u20131468.","journal-title":"Marrow Transplant Rev"},{"key":"BF1704066_CR17","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/BF01458491","volume":"2","author":"LF Bernini","year":"1969","unstructured":"Bernini LF . Rapid estimation of hemoglobin A2 by DEAE chromatography. Biochem Genet 1969; 2: 305\u2013310.","journal-title":"Biochem Genet"},{"key":"BF1704066_CR18","first-page":"243","volume":"1","author":"PC Giordano","year":"1998","unstructured":"Giordano PC, Harteveld CL, Heister JGAM et al. The molecular spectrum of \u03b2-thalassemia and abnormal hemoglobins in the allochthonous and autochthonous Dutch population. Commun Genet 1998; 1: 243\u2013251.","journal-title":"Commun Genet"},{"key":"BF1704066_CR19","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1046\/j.1365-2257.1999.00197.x","volume":"21","author":"PC Giordano","year":"1999","unstructured":"Giordano PC, van Delft P, Batelaan D et al. Hemoglobinopathy analyses in the Netherlands: a report of an in vitro globin chain biosynthesis survey using a rapid, modified method. Clin Lab Haem 1999; 21: 247\u2013255.","journal-title":"Clin Lab Haem"},{"key":"BF1704066_CR20","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/sj.bmt.1701122","volume":"21","author":"MJD Van Tol","year":"1998","unstructured":"Van Tol MJD, Langlois van den Bergh R, Mesker W et al. Simultaneous detection of X and Y chromosomes by two colour fluorescence in situ hybridisation in combination with immunophenotyping of single cells to document chimerism after sex-mismatched bone marrow transplantation. Bone Marrow Transplant 1998; 21: 497\u2013503.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704066_CR21","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1365-2141.1991.tb04525.x","volume":"79","author":"JEM Van Leeuwen","year":"1991","unstructured":"Van Leeuwen JEM, van Tol MJD, Bodzinga BG et al. Detection of mixed chimerism in flow-sorted cell subpopulations by PCR-amplified VNTR markers after allogeneic bone marrow transplantation. Br J Haematol 1991; 79: 218\u2013225.","journal-title":"Br J Haematol"},{"key":"BF1704066_CR22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1081\/HEM-100103068","volume":"25","author":"M Yavarian","year":"2001","unstructured":"Yavarian M, Harteveld CL, Batelaan D et al. Molecular spectrum of \u03b2-thalassemia in the Iranian province of Hormozgan. Hemoglobin 2001; 25: 35\u201343.","journal-title":"Hemoglobin"},{"key":"BF1704066_CR23","first-page":"100","volume":"12","author":"MAJ van Rossum","year":"1995","unstructured":"van Rossum MAJ, Kahkonen M, van Weel MH et al. High rejection rates after bone marrow transplantation for pediatric thalassemia major patients. Bone Marrow Transplant 1995; 12: 100.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704066_CR24","first-page":"417","volume":"11","author":"KH Lin","year":"1989","unstructured":"Lin KH, Lin KS . Allogeneic bone marrow transplantation for thalassemia in Taiwain: factors associated with graft failure. Am J Pediatr Hematol Oncol 1989; 11: 417\u2013423.","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"BF1704066_CR25","first-page":"97","volume":"47","author":"D Frappaz","year":"1990","unstructured":"Frappaz D, Gluckman E, Souillet G et al. Allogeneic bone marrow graft for thalassemia major. The French experience. Arch Fr Pediatr 1990; 47: 97\u2013102.","journal-title":"Arch Fr Pediatr"},{"key":"BF1704066_CR26","first-page":"88","volume":"12","author":"EF Saunders","year":"1993","unstructured":"Saunders EF, Oliveri N, Freedman MH . Unexpected complications after bone marrow transplant in transfusion-dependent children. Bone Marrow Transplant 1993; 12: 88\u201390.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704066_CR27","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3109\/08880019709030887","volume":"14","author":"H Solh","year":"1997","unstructured":"Solh H, Rao K, Martins da Cunha A et al. Engraftment failure following bone marrow transplantation in children with thalassemia major using busulfan and cyclophosphamide conditioning. Pediatr Hematol Oncol 1997; 14: 73\u201377.","journal-title":"Pediatr Hematol Oncol"},{"key":"BF1704066_CR28","first-page":"S209","volume":"29","author":"LM Ball","year":"2002","unstructured":"Ball LM, Bredius RGM, Lankester AC et al. Oral complications associated with melphalan in pediatric stem cell transplantation (SCT). Bone Marrow Transplant 2002; 29: S209.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704066_CR29","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1749-6632.1998.tb10484.x","volume":"850","author":"R Storb","year":"1998","unstructured":"Storb R, Yu C, Deeg HJ et al. Current and future preparative regimens for bone marrow transplantation in thalassemia. Ann NY Acad Sci 1998; 850: 276\u2013287.","journal-title":"Ann NY Acad Sci"},{"key":"BF1704066_CR30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1182\/blood.V67.3.811.811","volume":"67","author":"RS Hill","year":"1986","unstructured":"Hill RS, Petersen FB, Storb R et al. Mixed hematological chimerism after allogeneic marrow transplantation for severe aplastic anemia is associated with a higher risk for graft rejection and a lessened incidence of acute graft versus host disease. Blood 1986; 67: 811\u2013816.","journal-title":"Blood"},{"key":"BF1704066_CR31","first-page":"143","volume":"10","author":"C Nesci","year":"1992","unstructured":"Nesci C, Manna M, Andreani M et al. Mixed chimerism in thalassemic patients after bone marrow transplantation. Bone Marrow Transplant 1992; 10: 143\u2013146.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704066_CR32","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1182\/blood.V86.8.3241.3241","volume":"86","author":"J Kapelushnik","year":"1995","unstructured":"Kapelushnik J, Or R, Filon D et al. Analysis of beta-globin mutations shows stable mixed chimerism in patients with thalassemia after bone marrow transplantation. Blood 1995; 86: 3241\u20133246.","journal-title":"Blood"},{"key":"BF1704066_CR33","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1182\/blood.V87.8.3494.bloodjournal8783494","volume":"87","author":"M Andreani","year":"1996","unstructured":"Andreani M, Manna M, Lucarelli G et al. Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia. Blood 1996; 87: 3494\u20133499.","journal-title":"Blood"},{"key":"BF1704066_CR34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/sj.bmt.1702151","volume":"25","author":"M Andreani","year":"2000","unstructured":"Andreani M, Nesci C, Lucarelli G et al. Long-term survival of ex-thalassemic patients with persistent mixed chimerism after bone marrow transplantation. Bone Marrow Transplant 2000; 25: 401\u2013404.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704066_CR35","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.1365-2141.2001.02931.x","volume":"114","author":"PJ Amrolia","year":"2001","unstructured":"Amrolia PJ, Vulliamy T, Vassiliou G et al. Analysis of chimerism in thalassaemic children undergoing stem cell transplantation. Br J Haematol 2001; 114: 219\u2013225.","journal-title":"Br J Haematol"},{"key":"BF1704066_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1046\/j.1365-2141.1997.3413154.x","volume":"99","author":"RS Weinberg","year":"1997","unstructured":"Weinberg RS, Vlachos A, Najfeld V et al. Disparate lympho-erythroid donor to recipient chimerism in a beta (0)-thalassaemia bone marrow transplant recipient with red cell indices indicative of apparent full engraftment. Br J Haematol 1997; 99: 61\u201363.","journal-title":"Br J Haematol"},{"key":"BF1704066_CR37","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/00007890-199108000-00025","volume":"52","author":"A Locasciulli","year":"1991","unstructured":"Locasciulli A, Bacigalupo A, van Lint MT et al. Hepatitis-C virus infection in patients undergoing allogeneic bone marrow transplantation. Transplantation 1991; 52: 315\u2013318.","journal-title":"Transplantation"},{"key":"BF1704066_CR38","first-page":"369","volume":"14","author":"B Erer","year":"1994","unstructured":"Erer B, Angelucci E, Lucarelli G et al. Hepatitis-C virus infections in thalassemia patients undergoing allogeneic bone marrow transplantation . Bone Marrow Transplant 1994; 14: 369\u2013372.","journal-title":". Bone Marrow Transplant"},{"key":"BF1704066_CR39","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1002\/hep.510290609","volume":"29","author":"SI Strasser","year":"1999","unstructured":"Strasser SI, Myerson D, Spurgeon CL et al. Hepatis-C virus infection and bone marrow transplantation: a cohort study with ten year follow-up. Hepatology 1999; 29: 1893\u20131899.","journal-title":"Hepatology"},{"key":"BF1704066_CR40","first-page":"657","volume":"145","author":"CA Finch","year":"1986","unstructured":"Finch CA, Bellotti B, Stray S et al. Plasma ferritin determination as a diagnostic tool. West J Med 1986; 145: 657\u2013664.","journal-title":"West J Med"},{"key":"BF1704066_CR41","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/ajh.2830420116","volume":"42","author":"GM Brittenham","year":"1993","unstructured":"Brittenham GM, Cohen AR, McLaren C et al. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol 1993; 42: 81\u201387.","journal-title":"Am J Hematol"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1704066.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704066","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704066.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:47:16Z","timestamp":1648079236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1704066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,1]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,6,1]]}},"alternative-id":["BF1704066"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1704066","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,1]]},"assertion":[{"value":"17 July 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2003","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2003","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}