{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:09:41Z","timestamp":1756897781583},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2003,8,1]]},"DOI":"10.1038\/sj.bmt.1704096","type":"journal-article","created":{"date-parts":[[2003,8,21]],"date-time":"2003-08-21T13:51:25Z","timestamp":1061473885000},"page":"S41-S44","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Immunological questions on hematopoietic stem cell transplantation for multiple sclerosis"],"prefix":"10.1038","volume":"32","author":[{"given":"P A","family":"Muraro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,8,21]]},"reference":[{"key":"BF1704096_CR1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1212\/WNL.58.1.136","volume":"58","author":"CW Noonan","year":"2002","unstructured":"Noonan CW, Kathman SJ, White MC . Prevalence estimates for MS in the United States and evidence of an increasing trend for women. Neurology 2002; 58: 136\u2013138.","journal-title":"Neurology"},{"key":"BF1704096_CR2","volume-title":"Multiple Sclerosis \u2013 Clinical and pathogenetic basis","author":"CS Raine","year":"1997","unstructured":"Raine CS, McFarland HF, Tourtellotte WW . Multiple Sclerosis \u2013 Clinical and pathogenetic basis. Chapman & Hall Medical: London, 1997."},{"key":"BF1704096_CR3","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1056\/NEJM199801293380502","volume":"338","author":"BD Trapp","year":"1998","unstructured":"Trapp BD, Peterson J, Ransohoff RM et al. Axonal transection in the lesions of multiple sclerosis. [See comments.]. N Engl J Med 1998; 338: 278\u2013285.","journal-title":"N Engl J Med"},{"key":"BF1704096_CR4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q","volume":"47","author":"C Lucchinetti","year":"2000","unstructured":"Lucchinetti C, Bruck W, Parisi J et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000; 47: 707\u2013717.","journal-title":"Ann Neurol"},{"key":"BF1704096_CR5","first-page":"221","volume-title":"Multiple Sclerosis: Clinical and pathogenetic basis","author":"R Martin","year":"1997","unstructured":"Martin R, McFarland HF . Immunology of multiple sclerosis and experimental allergic encephalomyelitis. In: Raine CS, McFarland HF, Tourtellotte WW (eds). Multiple Sclerosis: Clinical and pathogenetic basis. Chapman & Hall: London, 1997. pp 221\u2013242."},{"key":"BF1704096_CR6","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/brain\/123.3.508","volume":"123","author":"N Goebels","year":"2000","unstructured":"Goebels N, Hofstetter H, Schmidt S et al. Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects - Epitope spreading versus clonal persistence. Brain 2000; 123: 508\u2013518.","journal-title":"Brain"},{"key":"BF1704096_CR7","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/jnr.1243","volume":"66","author":"M Vergelli","year":"2001","unstructured":"Vergelli M, Mazzanti B, Traggiai E et al. Short-term evolution of autoreactive T cell repertoire in multiple sclerosis. J Neurosci Res 2001; 66: 517\u2013524.","journal-title":"J Neurosci Res"},{"key":"BF1704096_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0165-5728(02)00052-8","volume":"126","author":"N Hellings","year":"2002","unstructured":"Hellings N, Gelin G, Medaer R et al. Longitudinal study of antimyelin T-cell reactivity in relapsing-remitting multiple sclerosis: association with clinical and MRI activity. J Neuroimmunol 2002; 126: 143\u2013160.","journal-title":"J Neuroimmunol"},{"key":"BF1704096_CR9","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1038\/80516","volume":"6","author":"B Bielekova","year":"2000","unstructured":"Bielekova B, Goodwin B, Richert N et al. Encephalitogenic potential of myelin basic protein peptide (83\u201399) in multiple sclerosis \u2013 Results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000; 6: 1167\u20131175.","journal-title":"Nat Med"},{"key":"BF1704096_CR10","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1002\/ana.410320609","volume":"32","author":"HF McFarland","year":"1992","unstructured":"McFarland HF, Frank JA, Albert PS et al. Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. Ann Neurol 1992; 32: 758\u2013766.","journal-title":"Ann Neurol"},{"key":"BF1704096_CR11","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1084\/jem.186.12.2023","volume":"186","author":"H Neumann","year":"1997","unstructured":"Neumann H, Schmidt H, Wekerle H . Interferon gamma gene expression in sensory neurons: evidence for autocrine gene regulation. J Exp Med 1997; 186: 2023.","journal-title":"J Exp Med"},{"key":"BF1704096_CR12","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1172\/JCI119622","volume":"100","author":"KW Wucherpfennig","year":"1997","unstructured":"Wucherpfennig KW, Catz I, Hausmann S et al. Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes. J Clin Invest 1997; 100: 1114\u20131122.","journal-title":"J Clin Invest"},{"key":"BF1704096_CR13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1212\/WNL.58.2.169","volume":"58","author":"DS Goodin","year":"2002","unstructured":"Goodin DS, Frohman EM, Garmany Jr GP et al. Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology 2002; 58: 169\u2013178.","journal-title":"Neurology"},{"key":"BF1704096_CR14","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S1083-8791(00)70066-8","volume":"6","author":"H Openshaw","year":"2000","unstructured":"Openshaw H, Lund BT, Kashyap A et al. Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: report of toxicity and immunological monitoring. Biol Blood Marrow Transplant 2000; 6: 563\u2013575.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1704096_CR15","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1007\/s00415-002-0800-7","volume":"249","author":"A Fassas","year":"2002","unstructured":"Fassas A, Passweg JR, Anagnostopoulos A et al. Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study. J Neurol 2002; 249: 1088\u20131097.","journal-title":"J Neurol"},{"key":"BF1704096_CR16","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V92.10.3505","volume":"92","author":"RK Burt","year":"1998","unstructured":"Burt RK, Traynor AE, Pope R et al. Treatment of autoimmune disease by intense immunosuppressive conditioning and autologous hematopoietic stem cell transplantation. Blood 1998; 92: 3505\u20133514.","journal-title":"Blood"},{"key":"BF1704096_CR17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1023\/A:1006686426090","volume":"20","author":"A Fassas","year":"2000","unstructured":"Fassas A, Anagnostopoulos A, Kazis A et al. Autologous stem cell transplantation in progressive multiple sclerosis \u2013 an interim analysis of efficacy. J Clin Immunol 2000; 20: 24\u201330.","journal-title":"J Clin Immunol"},{"key":"BF1704096_CR18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/sj.bmt.1702180","volume":"25","author":"T Kozak","year":"2000","unstructured":"Kozak T, Havrdova E, Pit'ha J et al. High-dose immunosuppressive therapy with PBPC support in the treatment of poor risk multiple sclerosis. Bone Marrow Transplant 2000; 25: 525\u2013531.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704096_CR19","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1212\/WNL.57.1.62","volume":"57","author":"GL Mancardi","year":"2001","unstructured":"Mancardi GL, Saccardi R, Filippi M et al. Autologous hematopoietic stem cell transplantation suppresses Gdenhanced MRI activity in MS. Neurology 2001; 57: 62\u201368.","journal-title":"Neurology"},{"key":"BF1704096_CR20","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1212\/WNL.56.8.1084","volume":"56","author":"A Saiz","year":"2001","unstructured":"Saiz A, Carreras E, Berenguer J et al. MRI and CSF oligoclonal bands after autologous hematopoietic stem cell transplantation in MS. Neurology 2001; 56: 1084\u20131089.","journal-title":"Neurology"},{"key":"BF1704096_CR21","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/sj.bmt.1700944","volume":"20","author":"A Fassas","year":"1997","unstructured":"Fassas A, Anagnostopoulos A, Kazis A et al. Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study. Bone Marrow Transplant 1997; 20: 631\u2013638.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704096_CR22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature00900","volume":"418","author":"JH Kim","year":"2002","unstructured":"Kim JH, Auerbach JM, Rodriguez-Gomez JA et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002; 418: 50\u201356.","journal-title":"Nature"},{"key":"BF1704096_CR23","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1073\/pnas.0336479100","volume":"100","author":"E Mezey","year":"2003","unstructured":"Mezey E, Key S, Vogelsang G et al. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci USA 2003; 100: 1364\u20131369.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1704096_CR24","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1126\/science.290.5497.1779","volume":"290","author":"E Mezey","year":"2000","unstructured":"Mezey E, Chandross KJ, Harta G et al. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290: 1779\u20131782.","journal-title":"Science"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1704096","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:10:53Z","timestamp":1648077053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1704096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,1]]},"references-count":24,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2003,8,1]]}},"alternative-id":["BF1704096"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1704096","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,1]]},"assertion":[{"value":"21 August 2003","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}