{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:44:04Z","timestamp":1790700244469,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2004,11,1]]},"DOI":"10.1038\/sj.bmt.1704653","type":"journal-article","created":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T08:48:56Z","timestamp":1099298936000},"page":"855-875","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Haematopoietic stem cell transplantation (HSCT) in Europe 2002. Changes in indication and impact of team density. A report of the EBMT activity survey"],"prefix":"10.1038","volume":"34","author":[{"given":"A","family":"Gratwohl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Baldomero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Horisberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Urbano-Ispizua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,11,2]]},"reference":[{"issue":"Suppl. 7","key":"BF1704653_CR1","first-page":"95","volume":"36","author":"ED Thomas","year":"1999","unstructured":"Thomas ED . Bone marrow transplantation: a review. Semin Hematol 1999; 36 (Suppl. 7): 95\u2013103.","journal-title":"Semin Hematol"},{"key":"BF1704653_CR2","volume-title":"Hematopoietic Cell Transplantation","author":"SJ Forman","year":"2003","unstructured":"Forman SJ, Blume KG, Thomas ED (Eds). Hematopoietic Cell Transplantation, 3rd edn. Blackwell Scientific Publishers Inc.: London, New York, 2003."},{"key":"BF1704653_CR3","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1136\/bmj.321.7258.433","volume":"321","author":"AL Lennard","year":"2000","unstructured":"Lennard AL, Jackson GH . Stem cell transplantation. BMJ 2000; 321: 433\u2013437.","journal-title":"BMJ"},{"key":"BF1704653_CR4","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/sj.bmt.1703535","volume":"29","author":"A Urbano-Ispizua","year":"2002","unstructured":"Urbano-Ispizua A, Schmitz N, de Witte T et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: definitions and current practice in Europe. Bone Marrow Transplant 2002; 29: 639\u2013646.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704653_CR5","first-page":"197","volume":"8","author":"A Gratwohl","year":"1991","unstructured":"Gratwohl A . Bone marrow transplantation activity in Europe 1990. Report from the European Group for Bone Marrow Transplantation (EBMT). Bone Marrow Transplant 1991; 8: 197\u2013201.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704653_CR6","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/sj.leu.2402896","volume":"17","author":"A Gratwohl","year":"2003","unstructured":"Gratwohl A, Baldomero H, Passweg J et al. Hematopoietic stem cell transplantation for hematological malignancies in Europe. Leukemia 2003; 17: 941\u2013959.","journal-title":"Leukemia"},{"key":"BF1704653_CR7","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1093\/annonc\/mdh142","volume":"15","author":"A Gratwohl","year":"2004","unstructured":"Gratwohl A, Baldomero H, Demirer T et al. Hematopoietic stem cell transplantation for solid tumours in Europe. Ann Oncol 2004; 15: 653\u2013660.","journal-title":"Ann Oncol"},{"key":"BF1704653_CR8","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1182\/blood-2002-03-0675","volume":"100","author":"A Gratwohl","year":"2002","unstructured":"Gratwohl A, Baldomero H, Horisberger B, Schmid C . Current trends in hematopoietic stem cell transplantation in Europe. Blood 2002; 100: 2374\u20132386.","journal-title":"Blood"},{"key":"BF1704653_CR9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/S0140-6736(02)07831-5","volume":"359","author":"A Gratwohl","year":"2002","unstructured":"Gratwohl A, Baldomero H, Urbano-Ispizua A . Transplantation in chronic myeloid leukemia. Lancet 2002; 359: 712\u2013713.","journal-title":"Lancet"},{"key":"BF1704653_CR10","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1046\/j.1365-2141.2002.03440.x","volume":"117","author":"A Gratwohl","year":"2002","unstructured":"Gratwohl A, Passweg J, Baldomero H, et al. for the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT). Economics, health care systems and utilisation of haematopoietic stem cell transplants in Europe. Br J Haematol 2002; 117: 451\u2013468.","journal-title":"Br J Haematol"},{"issue":"12","key":"BF1704653_CR11","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/sj.bmt.1703819","volume":"30","author":"A Gratwohl","year":"2002","unstructured":"Gratwohl A, Baldomero H, Passweg J, Urbano-Ispizua for the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT). Increasing use of reduced intensity conditioning transplants: report of the 2001 EBMT activity survey. Bone Marrow Transplant 2002; 30: 813\u2013831.","journal-title":"Bone Marrow Transplantation"},{"key":"BF1704653_CR12","volume-title":"Diffusion of Innovations","author":"EM Rogers","year":"1983","unstructured":"Rogers EM . Diffusion of Innovations, 3rd edn. The Free Press: New York, 1983."},{"key":"BF1704653_CR13","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1056\/NEJMoa030513","volume":"349","author":"TP Hughes","year":"2003","unstructured":"Hughes TP, Kaeda J, Branford S et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003; 349: 1423\u20131432.","journal-title":"N Engl J Med"},{"key":"BF1704653_CR14","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S0140-6736(03)14182-7","volume":"362","author":"D Marin","year":"2003","unstructured":"Marin D, Marktel S, Szydlo R et al. Survival of patients with chronic-phase chronic myeloid leukaemia on imatinib after failure on interferon alfa. Lancet 2003; 362: 617\u2013619.","journal-title":"Lancet"},{"key":"BF1704653_CR15","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1056\/NEJMoa022457","volume":"348","author":"SG O'Brien","year":"2003","unstructured":"O'Brien SG, Guilhot F, Larson RA et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994\u20131004.","journal-title":"N Engl J Med"},{"key":"BF1704653_CR16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1056\/NEJMoa022794","volume":"349","author":"S Rodenhuis","year":"2003","unstructured":"Rodenhuis S, Bontenbal M, Beex LV et al. High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer. N Engl J Med 2003; 349: 7\u201316.","journal-title":"N Engl J Med"},{"key":"BF1704653_CR17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1056\/NEJMoa030684","volume":"349","author":"MS Tallman","year":"2003","unstructured":"Tallman MS, Gray R, Robert NJ et al. Conventional adjuvant chemotherapy with or without high-dose chemotherapy and autologous stem-cell transplantation in high-risk breast cancer. N Engl J Med 2003; 349: 17\u201326.","journal-title":"N Engl J Med"},{"key":"BF1704653_CR18","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1056\/NEJMe030087","volume":"349","author":"GJ Elfenbein","year":"2003","unstructured":"Elfenbein GJ . Stem-cell transplantation for high-risk breast cancer. N Engl J Med 2003; 349: 80\u201382.","journal-title":"N Engl J Med"},{"key":"BF1704653_CR19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S1470-2045(00)00153-4","volume":"1","author":"C Craddock","year":"2000","unstructured":"Craddock C . Haemopoietic stem-cell transplantation: recent progress and future promise. Lancet Oncol 2000; 1: 227\u2013234.","journal-title":"Lancet Oncol"},{"key":"BF1704653_CR20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1046\/j.1365-2141.2000.02405.x","volume":"111","author":"J Barrett","year":"2000","unstructured":"Barrett J, Childs R . Non-myeloablative stem cell transplants. Br J Haematol 2000; 111: 6\u201317.","journal-title":"Br J Haematol"},{"key":"BF1704653_CR21","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1200\/JCO.2002.06.060","volume":"20","author":"M Kletzel","year":"2002","unstructured":"Kletzel M, Katzenstein HM, Haut PR et al. Treatment of high-risk neuroblastoma with triple-tandem high-dose therapy and stem-cell rescue: results of the Chicago Pilot II Study. J Clin Oncol 2002; 20: 2284\u20132292.","journal-title":"J Clin Oncol"},{"key":"BF1704653_CR22","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/S0959-8049(01)00131-9","volume":"37","author":"CR Pinkerton","year":"2001","unstructured":"Pinkerton CR, Bataillard A, Guillo S . Treatment strategies for metastatic Ewing's sarcoma. Eur J Cancer 2001; 37: 1338\u20131344.","journal-title":"Eur J Cancer"},{"key":"BF1704653_CR23","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1200\/JCO.2001.19.10.2696","volume":"19","author":"D Strother","year":"2001","unstructured":"Strother D, Ashley D, Kellie SJ et al. Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study. J Clin Oncol 2001; 19: 2696\u20132704.","journal-title":"J Clin Oncol"},{"key":"BF1704653_CR24","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/sj.bmt.1703824","volume":"31","author":"A Tartarone","year":"2003","unstructured":"Tartarone A, Romano G, Galasso R et al. Should we continue to study high-dose chemotherapy in metastatic breast cancer patients? A critical review of the published data. Bone Marrow Transplant 2003; 31: 525\u2013530.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704653_CR25","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1093\/jnci\/92.24.1972","volume":"92","author":"A Twombly","year":"2000","unstructured":"Twombly A . News: stem cell transplant numbers decline; research continues. J Natl Cancer Inst 2000; 92: 1972\u20131973.","journal-title":"J Natl Cancer Inst"},{"key":"BF1704653_CR26","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1002\/(SICI)1097-0142(19971001)80:7<1221::AID-CNCR4>3.0.CO;2-N","volume":"80","author":"C Bokemeyer","year":"1997","unstructured":"Bokemeyer C, Franzke A, Hartmann JT et al. A phase I\/II study of sequential, dose-escalated, high dose ifosfamide plus doxorubicin with peripheral blood stem cell support for the treatment of patients with advanced soft tissue sarcomas. Cancer 1997; 80: 1221\u20131227.","journal-title":"Cancer"},{"key":"BF1704653_CR27","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1023\/A:1011136807190","volume":"12","author":"JA Ledermann","year":"2001","unstructured":"Ledermann JA, Herd R, Maraninchi D et al. High-dose chemotherapy for ovarian carcinoma: long-term results from the Solid Tumour Registry of the European Group for Blood and Marrow Transplantation (EBMT). Ann Oncol 2001; 12: 693\u2013699.","journal-title":"Ann Oncol"},{"key":"BF1704653_CR28","first-page":"1041","volume":"3","author":"A Tyndall","year":"2003","unstructured":"Tyndall A, Matucci-Cerinic M . HSCT for the treatment of systemic sclerosis and other autoimmune disorders. Cell Tissue based Ther 2003; 3: 1041\u20131049.","journal-title":"Cell Tissue based Ther"},{"key":"BF1704653_CR29","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1017\/S0266462300006450","volume":"5","author":"RN Battista","year":"1989","unstructured":"Battista RN . Innovation and diffusion of health related technologies. Int J Technol Assess Health Care 1989; 5: 227\u2013248.","journal-title":"Int J Technol Assess Health Care"},{"key":"BF1704653_CR30","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1056\/NEJM197911153012004","volume":"301","author":"HV Fineberg","year":"1979","unstructured":"Fineberg HV, Hiatt HH . Evaluation of medical practices \u2013 the case for technology assessment. N Engl J Med 1979; 301: 1086\u20131091.","journal-title":"N Engl J Med"},{"key":"BF1704653_CR31","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1001\/jama.289.15.1969","volume":"289","author":"M Berwick-Donald","year":"2003","unstructured":"Berwick-Donald M . Disseminating innovations in health care. JAMA 2003; 289: 1969\u20131975.","journal-title":"JAMA"},{"key":"BF1704653_CR32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0168-8510(96)90054-8","volume":"37","author":"CD Dirksen","year":"1996","unstructured":"Dirksen CD, Ament AJH, Go PMN . Diffusion of six surgical endoscopic procedures in the Netherlands. Stimulating and restraining factors. Health Policy 1996; 37: 91\u2013104.","journal-title":"Health Policy"},{"key":"BF1704653_CR33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1017\/S0266462301107105","volume":"17","author":"NF Wieringa","year":"2001","unstructured":"Wieringa NF, Denig P, de Graeff PA et al. Assessment of new cardiovascular drugs. Relationships between considerations, professional characteristics, and prescribing. Int J Technol Assess Health Care 2001; 17: 559\u2013570.","journal-title":"Int J Technol Assess Health Care"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1704653","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T19:51:28Z","timestamp":1648065088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1704653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,1]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,11,1]]}},"alternative-id":["BF1704653"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1704653","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,1]]},"assertion":[{"value":"3 December 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}