{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:11:11Z","timestamp":1767705071309},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T00:00:00Z","timestamp":1100476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T00:00:00Z","timestamp":1100476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2005,2,1]]},"DOI":"10.1038\/sj.bmt.1704760","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T10:20:07Z","timestamp":1100514007000},"page":"253-260","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Long-term follow-up of nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma: The University of Chicago Experience"],"prefix":"10.1038","volume":"35","author":[{"given":"A S","family":"Artz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Van Besien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T F","family":"Gajewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B I","family":"Rini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H S","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M","family":"Stadler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N J","family":"Vogelzang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,11,15]]},"reference":[{"key":"BF1704760_CR1","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1200\/JCO.1995.13.3.688","volume":"13","author":"G Fyfe","year":"1995","unstructured":"Fyfe G, Fisher RI, Rosenberg SA et al. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 1995; 13: 688\u2013696.","journal-title":"J Clin Oncol"},{"key":"BF1704760_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1200\/JCO.2002.20.1.289","volume":"20","author":"RJ Motzer","year":"2002","unstructured":"Motzer RJ, Bacik J, Murphy BA et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289\u2013296.","journal-title":"J Clin Oncol"},{"key":"BF1704760_CR3","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/S0022-5347(05)67889-5","volume":"163","author":"RJ Motzer","year":"2000","unstructured":"Motzer RJ, Russo P . Systemic therapy for renal cell carcinoma. J Urol 2000; 163: 408\u2013417.","journal-title":"J Urol"},{"key":"BF1704760_CR4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/(SICI)1097-0215(19960516)66:4<564::AID-IJC23>3.0.CO;2-6","volume":"66","author":"A Caignard","year":"1996","unstructured":"Caignard A, Guillard M, Gaudin C et al. In situ demonstration of renal-cell-carcinoma-specific T-cell clones. Int J Cancer 1996; 66: 564\u2013570.","journal-title":"Int J Cancer"},{"key":"BF1704760_CR5","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1056\/NEJM198106183042507","volume":"304","author":"PL Weiden","year":"1981","unstructured":"Weiden PL, Sullivan KM, Flournoy N et al. Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. N Engl J Med 1981; 304: 1529\u20131533.","journal-title":"N Engl J Med"},{"key":"BF1704760_CR6","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood.V54.5.1039.1039","volume":"54","author":"PL Weiden","year":"1979","unstructured":"Weiden PL, Storb R, Deeg HJ et al. Prolonged disease-free survival in dogs with lymphoma after total-body irradiation and autologous marrow transplantation consolidation of combination-chemotherapy-induced remissions. Blood 1979; 54: 1039\u20131049.","journal-title":"Blood"},{"key":"BF1704760_CR7","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1182\/blood.V86.5.2041.bloodjournal8652041","volume":"86","author":"HJ Kolb","year":"1995","unstructured":"Kolb HJ, Schattenberg A, Goldman JM et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood 1995; 86: 2041\u20132050.","journal-title":"Blood"},{"key":"BF1704760_CR8","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1056\/NEJM200009143431101","volume":"343","author":"R Childs","year":"2000","unstructured":"Childs R, Chernoff A, Contentin N et al. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med 2000; 343: 750\u2013758.","journal-title":"N Engl J Med"},{"key":"BF1704760_CR9","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1182\/blood-2003-04-1022","volume":"102","author":"NT Ueno","year":"2003","unstructured":"Ueno NT, Cheng YC, Rondon G et al. Rapid induction of complete donor chimerism by the use of a reduced-intensity conditioning regimen composed of fludarabine and melphalan in allogeneic stem-cell transplantation for metastatic solid tumors. Blood 2003; 102: 3829\u20133836.","journal-title":"Blood"},{"key":"BF1704760_CR10","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1200\/JCO.2002.08.068","volume":"20","author":"BI Rini","year":"2002","unstructured":"Rini BI, Zimmerman T, Stadler WM et al. Allogeneic stem-cell transplantation of renal cell cancer after nonmyeloablative chemotherapy: feasibility, engraftment, and clinical results. J Clin Oncol 2002; 20: 2017\u20132024.","journal-title":"J Clin Oncol"},{"key":"BF1704760_CR11","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1002\/cncr.10491","volume":"94","author":"P Pedrazzoli","year":"2002","unstructured":"Pedrazzoli P, Da Prada GA, Giorgiani G et al. Allogeneic blood stem cell transplantation after a reduced-intensity, preparative regimen: a pilot study in patients with refractory malignancies. Cancer 2002; 94: 2409\u20132415.","journal-title":"Cancer"},{"key":"BF1704760_CR12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/sj.bmt.1703811","volume":"31","author":"P Hentschke","year":"2003","unstructured":"Hentschke P, Barkholt L, Uzunel M et al. Low-intensity conditioning and hematopoietic stem cell transplantation in patients with renal and colon carcinoma. Bone Marrow Transplant 2003; 31: 253\u2013261.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704760_CR13","first-page":"479","volume":"88","author":"F Baron","year":"2003","unstructured":"Baron F, Frere P, Baudoux E et al. Non-myeloablative stem cell transplantation with low-dose total body irradiation and fludarabine for metastatic renal cell carcinoma. Haematologica 2003; 88: 479\u2013480.","journal-title":"Haematologica"},{"key":"BF1704760_CR14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1182\/blood-2003-07-2236","volume":"103","author":"D Blaise","year":"2004","unstructured":"Blaise D, Bay JO, Faucher C et al. Reduced-intensity preparative regimen and allogeneic stem cell transplantation for advanced solid tumors. Blood 2004; 103: 435\u2013441.","journal-title":"Blood"},{"key":"BF1704760_CR15","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1200\/JCO.1999.17.8.2530","volume":"17","author":"RJ Motzer","year":"1999","unstructured":"Motzer RJ, Mazumdar M, Bacik J et al. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999; 17: 2530\u20132540.","journal-title":"J Clin Oncol"},{"key":"BF1704760_CR16","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1200\/JCO.2004.06.132","volume":"22","author":"RJ Motzer","year":"2004","unstructured":"Motzer RJ, Bacik J, Schwartz LH et al. Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol 2004; 22: 454\u2013463.","journal-title":"J Clin Oncol"},{"key":"BF1704760_CR17","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1159\/000474469","volume":"31","author":"G Citterio","year":"1997","unstructured":"Citterio G, Bertuzzi A, Tresoldi M et al. Prognostic factors for survival in metastatic renal cell carcinoma: retrospective analysis from 109 consecutive patients. Eur Urol 1997; 31: 286\u2013291.","journal-title":"Eur Urol"},{"key":"BF1704760_CR18","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1097\/01.ju.0000081122.57148.ec","volume":"170","author":"A Mejean","year":"2003","unstructured":"Mejean A, Hopirtean V, Bazin JP et al. Prognostic factors for the survival of patients with papillary renal cell carcinoma: meaning of histological typing and multifocality. J Urol 2003; 170: 764\u2013767.","journal-title":"J Urol"},{"key":"BF1704760_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0090-4295(91)80200-Q","volume":"37","author":"S Naito","year":"1991","unstructured":"Naito S, Kimiya K, Sakamoto N et al. Prognostic factors and value of adjunctive nephrectomy in patients with stage IV renal cell carcinoma. Urology 1991; 37: 95\u201399.","journal-title":"Urology"},{"key":"BF1704760_CR20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1080\/003655900750041979","volume":"34","author":"B Ljungberg","year":"2000","unstructured":"Ljungberg B, Landberg G, Alamdari FI . Factors of importance for prediction of survival in patients with metastatic renal cell carcinoma, treated with or without nephrectomy. Scand J Urol Nephrol 2000; 34: 246\u2013251.","journal-title":"Scand J Urol Nephrol"},{"key":"BF1704760_CR21","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/sj.bmt.1704166","volume":"32","author":"K Van Besien","year":"2003","unstructured":"Van Besien K, Devine S, Wickrema A et al. Regimen-related toxicity after fludarabine\u2013melphalan conditioning: a prospective study of 31 patients with hematologic malignancies. Bone Marrow Transplant 2003; 32: 471\u2013476.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704760_CR22","unstructured":"Stata Statistical Software [computer program]. Version 8.0. Stata Corporation: College Station, TX, 2003."},{"key":"BF1704760_CR23","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1021\/jm00368a016","volume":"27","author":"MF Stevens","year":"1984","unstructured":"Stevens MF, Hickman JA, Stone R et al. Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one, a novel broad-spectrum antitumor agent. J Med Chem 1984; 27: 196\u2013201.","journal-title":"J Med Chem"},{"key":"BF1704760_CR24","first-page":"86","volume":"4","author":"DS Lee","year":"1998","unstructured":"Lee DS, White DE, Hurst R et al. Patterns of relapse and response to retreatment in patients with metastatic melanoma or renal cell carcinoma who responded to interleukin-2-based immunotherapy. Cancer J Sci Am 1998; 4: 86\u201393.","journal-title":"Cancer J Sci Am"},{"key":"BF1704760_CR25","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1200\/JCO.1999.17.7.2039","volume":"17","author":"B Escudier","year":"1999","unstructured":"Escudier B, Chevreau C, Lasset C et al. Cytokines in metastatic renal cell carcinoma: is it useful to switch to interleukin-2 or interferon after failure of a first treatment? Groupe Francais d\u2019Immunotherape. J Clin Oncol 1999; 17: 2039\u20132043.","journal-title":"J Clin Oncol"},{"key":"BF1704760_CR26","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood.V94.9.3234","volume":"94","author":"R Childs","year":"1999","unstructured":"Childs R, Clave E, Contentin N et al. Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses. Blood 1999; 94: 3234\u20133241.","journal-title":"Blood"},{"key":"BF1704760_CR27","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1182\/blood.V100.12.3877","volume":"100","author":"A Gratwohl","year":"2002","unstructured":"Gratwohl A, Brand R, Apperley J et al. Graft-versus-host disease and outcome in HLA-identical sibling transplantations for chronic myeloid leukemia. Blood 2002; 100: 3877\u20133886.","journal-title":"Blood"},{"key":"BF1704760_CR28","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1200\/JCO.2002.20.8.1965","volume":"20","author":"FR Appelbaum","year":"2002","unstructured":"Appelbaum FR, Sandmaier B . Sensitivity of renal cell cancer to nonmyeloablative allogeneic hematopoietic cell transplantations: unusual or unusually important? J Clin Oncol 2002; 20: 1965\u20131967.","journal-title":"J Clin Oncol"},{"key":"BF1704760_CR29","first-page":"431","volume":"22","author":"P Frost","year":"2003","unstructured":"Frost P, Caliliw R, Belldegrun A, Bonavida B . Immunosensitization of resistant human tumor cells to cytotoxicity by tumor infiltrating lymphocytes. Int J Oncol 2003; 22: 431\u2013437.","journal-title":"Int J Oncol"},{"key":"BF1704760_CR30","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.1182\/blood.V99.11.4234","volume":"99","author":"M Bregni","year":"2002","unstructured":"Bregni M, Dodero A, Peccatori J et al. Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer. Blood 2002; 99: 4234\u20134236.","journal-title":"Blood"},{"key":"BF1704760_CR31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/00130404-200201000-00002","volume":"8","author":"R Childs","year":"2002","unstructured":"Childs R, Srinivasan R . Advances in allogeneic stem cell transplantation: directing graft-versus-leukemia at solid tumors. Cancer J 2002; 8: 2\u201311.","journal-title":"Cancer J"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1704760","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704760.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704760.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:38:43Z","timestamp":1648078723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1704760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,15]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,2,1]]}},"alternative-id":["BF1704760"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1704760","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,15]]},"assertion":[{"value":"26 March 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}