{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:26:08Z","timestamp":1759580768391},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T00:00:00Z","timestamp":1107734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T00:00:00Z","timestamp":1107734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2005,4,1]]},"DOI":"10.1038\/sj.bmt.1704874","type":"journal-article","created":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T10:45:14Z","timestamp":1107773114000},"page":"691-697","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of T-1 cell numbers prior to allogeneic stem cell transplantation in patients with severe graft-versus-host disease"],"prefix":"10.1038","volume":"35","author":[{"given":"U","family":"Banning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Krahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Mauz-K\u00f6rholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Krutmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Niederwieser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"K\u00f6rholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,2,7]]},"reference":[{"key":"BF1704874_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/annonc\/mdf010","volume":"13","author":"H Bertz","year":"2002","unstructured":"Bertz H, Illerhaus G, Veelken H, Finke J . Allogeneic hematopoietic stem-cell transplantation for patients with relapsed or refractory lymphomas: comparison of high-dose conventional conditioning versus fludarabine-based reduced-intensity regimens. Ann Oncol 2002; 13: 135\u2013139.","journal-title":"Ann Oncol"},{"key":"BF1704874_CR2","doi-asserted-by":"publisher","first-page":"3835","DOI":"10.1182\/blood.V101.10.3835","volume":"101","author":"A Borgmann","year":"2003","unstructured":"Borgmann A, von Stackelberg A, Hartmann R et al. Unrelated donor stem cell transplantation compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission: a matched-pair analysis. Blood 2003; 101: 3835\u20133839.","journal-title":"Blood"},{"key":"BF1704874_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/BF02982720","volume":"76","author":"K Yumura-Yagi","year":"2002","unstructured":"Yumura-Yagi K, Hara J, Horibe K et al. Outcome after relapse in childhood acute lymphoblastic leukemia. Int J Hematol 2002; 76: 61\u201368.","journal-title":"Int J Hematol"},{"key":"BF1704874_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0037-1963(03)70043-2","volume":"40","author":"J Barrett","year":"2003","unstructured":"Barrett J . Allogeneic stem cell transplantation for chronic myeloid leukemia. Semin Hematol 2003; 40: 59\u201371.","journal-title":"Semin Hematol"},{"key":"BF1704874_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/1042819021000050061","volume":"44","author":"MH Gilleece","year":"2003","unstructured":"Gilleece MH, Dazzi F . Donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukaemia. Leuk Lymphoma 2003; 44: 23\u201328.","journal-title":"Leuk Lymphoma"},{"key":"BF1704874_CR6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/sj.bmt.1704048","volume":"32","author":"IA Hassan","year":"2003","unstructured":"Hassan IA, Chopra R, Swindell R, Mutton KJ . Respiratory viral infections after bone marrow\/peripheral stem-cell transplantation: the Christie hospital experience. Bone Marrow Transplant 2003; 32: 73\u201377.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704874_CR7","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S1083-8791(03)00100-9","volume":"9","author":"A Daly","year":"2003","unstructured":"Daly A, McAfee S, Dey B et al. Nonmyeloablative bone marrow transplantation: infectious complications in 65 recipients of HLA-identical and mismatched transplants. Biol Blood Marrow Transplant 2003; 9: 373\u2013382.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"Suppl. 2","key":"BF1704874_CR8","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1038\/sj.bmt.1702350","volume":"25","author":"H Bonig","year":"2000","unstructured":"Bonig H, Schneider DT, Sprock I et al. Sepsis' and multi-organ failure: predictors of poor outcome after hematopoietic stem cell transplantation in children. Bone Marrow Transplant 2000; 25 (Suppl. 2): S32\u2013S34.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704874_CR9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/sj.bmt.1703618","volume":"30","author":"SM Pastores","year":"2002","unstructured":"Pastores SM, Papadopoulos E, van den Brink M et al. Septic shock and multiple organ failure after hematopoietic stem cell transplantation: treatment with recombinant human activated protein C. Bone Marrow Transplant 2002; 30: 131\u2013134.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704874_CR10","first-page":"555","volume":"88","author":"R Martino","year":"2003","unstructured":"Martino R, Giralt S, Caballero MD et al. Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lympho-blastic leukemia: a feasibility study. Haematologica 2003; 88: 555\u2013560.","journal-title":"Haematologica"},{"issue":"Suppl. 1","key":"BF1704874_CR11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/BF03165242","volume":"76","author":"GE Georges","year":"2002","unstructured":"Georges GE, Maris M, Sandmaier BM et al. Related and unrelated nonmyeloablative hematopoietic stem cell transplantation for malignant diseases. Int J Hematol 2002; 76 (Suppl. 1): 184\u2013189.","journal-title":"Int J Hematol"},{"key":"BF1704874_CR12","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1182\/blood.V94.11.3941","volume":"94","author":"J Cavet","year":"1999","unstructured":"Cavet J, Middleton PG, Segall M et al. Recipient tumor necrosis factor-\u03b1 and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants. Blood 1999; 94: 3914\u20133946.","journal-title":"Blood"},{"key":"BF1704874_CR13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/sj.bmt.1702126","volume":"25","author":"E Holler","year":"2000","unstructured":"Holler E, Roncarolo MG, Hintermeier-Knabe R et al. Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation. Bone Marrow Transplant 2000; 25: 237\u2013241.","journal-title":"Bone Marrow Transplant"},{"key":"BF1704874_CR14","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/0952-7915(93)90136-G","volume":"5","author":"M Sykes","year":"1993","unstructured":"Sykes M . Novel approaches to the control of graft versus host disease. Curr Opin Immunol 1993; 5: 774\u2013781.","journal-title":"Curr Opin Immunol"},{"key":"BF1704874_CR15","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.4049\/jimmunol.155.5.2396","volume":"155","author":"V Rus","year":"1995","unstructured":"Rus V, Svetic A, Nguyen P et al. Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells. J Immunol 1995; 155: 2396\u20133406.","journal-title":"J Immunol"},{"key":"BF1704874_CR16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1006\/cimm.1996.0137","volume":"170","author":"KS Love","year":"1996","unstructured":"Love KS, Lakshmanan RR, Butterfield JH, Fox CC . IFN-gamma-stimulated enhancement of MHC class II antigen expression by the human mast cell line HMC-1. Cell Immunol 1996; 170: 85\u201390.","journal-title":"Cell Immunol"},{"key":"BF1704874_CR17","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.4049\/jimmunol.140.8.2556","volume":"140","author":"D Niederwieser","year":"1988","unstructured":"Niederwieser D, Aubock J, Troppmair J et al. IFN-mediated induction of MHC antigen expression on human keratinocytes and its influence on in vitro alloimmune responses. J Immunol 1988; 140: 2556\u20132564.","journal-title":"J Immunol"},{"key":"BF1704874_CR18","first-page":"15","volume-title":"Methods in Molecular Biology","author":"U Banning","year":"2003","unstructured":"Banning U, Korholz D . Intracellular detection of T-cell cytokines. Differentiation of TH1 and TH2 cells. In: Kiess W, Korholz D (eds). Methods in Molecular Biology. Humana Press: Totowa, New Jersey, Vol 215, 2003, pp 15\u201322."},{"key":"BF1704874_CR19","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1182\/blood-2001-11-0057","volume":"100","author":"A Urbano-Ispizua","year":"2002","unstructured":"Urbano-Ispizua A, Rozman C, Pimentel P et al. Risk factors for acute graft-versus-host disease in patients undergoing transplantation with CD34+ selected blood cells from HLA-identical siblings. Blood 2002; 100: 724\u2013727.","journal-title":"Blood"},{"key":"BF1704874_CR20","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1182\/blood.V98.7.2043","volume":"98","author":"C Kollman","year":"2001","unstructured":"Kollman C, Howe CW, Anasetti C et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 2001; 98: 2043\u20132051.","journal-title":"Blood"},{"key":"BF1704874_CR21","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1053\/bbmt.2001.v7.pm11760150","volume":"7","author":"CA Keever-Taylor","year":"2001","unstructured":"Keever-Taylor CA, Bredeson C, Loberiza FR et al. Analysis of risk factors for the development of GVHD after T cell-depleted allogeneic BMT: effect of HLA disparity, ABO incompatibility, and method of T-cell depletion. Biol Blood Marrow Transplant 2001; 7: 620\u2013630.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1704874_CR22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0301-472X(00)00677-9","volume":"29","author":"H Goker","year":"2001","unstructured":"Goker H, Haznedaroglu IC, Chao NJ . Acute graft-vs-host disease: pathobiology and management. Exp Hematol 2001; 29: 259\u2013277.","journal-title":"Exp Hematol"},{"key":"BF1704874_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.critrevonc.2004.05.008","volume":"51","author":"GL Banna","year":"2004","unstructured":"Banna GL, Aversa S, Sileni VC et al. Nonmyeloablative allogeneic stem cell transplantation (NST) after truly nonmyeloablative and reduced intensity conditioning regimens. Crit Rev Oncol 2004; 51: 171\u2013189.","journal-title":"Crit Rev Oncol"},{"key":"BF1704874_CR24","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1182\/blood.V99.11.4200","volume":"99","author":"Y Morishima","year":"2002","unstructured":"Morishima Y, Sasazuki T, Inoko H et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood 2002; 99: 4200\u20134206.","journal-title":"Blood"},{"key":"BF1704874_CR25","doi-asserted-by":"publisher","first-page":"9465","DOI":"10.1073\/pnas.95.16.9465","volume":"95","author":"J Eskdale","year":"1998","unstructured":"Eskdale J, Gallagher G, Verweij CL et al. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci USA 1998; 95: 9465\u20139470.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1704874_CR26","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1093\/intimm\/4.12.1389","volume":"4","author":"MT Bejarano","year":"1992","unstructured":"Bejarano MT, de Waal Malefyt R, Abrams JS et al. Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures. Int Immunol 1992; 4: 1389\u20131397.","journal-title":"Int Immunol"},{"key":"BF1704874_CR27","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1182\/blood.V90.11.4513","volume":"90","author":"D Korholz","year":"1997","unstructured":"Korholz D, Banning U, Bonig H et al. The role of interleukin-10 (IL-10) in IL-15-mediated T-cell responses. Blood 1997; 90: 4513\u20134521.","journal-title":"Blood"},{"key":"BF1704874_CR28","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1097\/00007890-199010000-00019","volume":"50","author":"D Niederwieser","year":"1990","unstructured":"Niederwieser D, Herold M, Woloszczuk W et al. Endogenous IFN-gamma during human bone marrow transplantation. Analysis of serum levels of interferon and interferon-dependent secondary messages. Transplantation 1990; 50: 620\u2013625.","journal-title":"Transplantation"},{"key":"BF1704874_CR29","first-page":"491","volume-title":"The Cytokine Handbook","author":"E De Maeyer","year":"1998","unstructured":"De Maeyer E, De Maeyer-Guignard J . Interferons. In: Thomson A (ed.). The Cytokine Handbook. Academic press: San Diego, 1998, pp 491\u2013516."},{"key":"BF1704874_CR30","first-page":"213","volume":"10","author":"PL Weiden","year":"1978","unstructured":"Weiden PL, Doney K, Storb R, Thomas ED . Anti-human thymocyte globulin for prophylaxis and treatment of graft-versus-host disease in recipients of allogeneic marrow graft. Transplant Proc 1978; 10: 213\u2013216.","journal-title":"Transplant Proc"},{"key":"BF1704874_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ajh.2830110102","volume":"11","author":"KC Doney","year":"1981","unstructured":"Doney KC, Weiden PL, Storb R, Thomas ED . Treatment of graft-versus-host disease in human allogeneic marrow graft recipients: a randomised trial comparing antithymocyte globulin and corticosteroids. Am J Hematol 1981; 11: 1\u20138.","journal-title":"Am J Hematol"},{"key":"BF1704874_CR32","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/00007890-198508000-00011","volume":"40","author":"HJ Deeg","year":"1985","unstructured":"Deeg HJ, Loughran Jr TP, Storb R et al. Treatment of acute graft-versus-host disease with antithymocyte globulin and cyclosporine with or without methylprednisolone. Transplantation 1985; 40: 162\u2013166.","journal-title":"Transplantation"},{"key":"BF1704874_CR33","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s002770050310","volume":"75","author":"MJ Dugan","year":"1997","unstructured":"Dugan MJ, DeFor TE, Steinbuch M et al. ATG plus corticosteroid therapy for acute graft-versus-host disease: predictors of response and survival. Ann Hematol 1997; 75: 41\u201346.","journal-title":"Ann Hematol"},{"key":"BF1704874_CR34","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S1083-8791(00)70036-X","volume":"6","author":"L Cragg","year":"2000","unstructured":"Cragg L, Blazar BR, Defor T et al. A randomised trial comparing prednisone with antithymocyte globulin\/prednisone as an initial systemic therapy for moderately severe acute graft-versus-host disease. Biol Blood Marrow Transplant 2000; 6: 441\u2013447.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1704874_CR35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1034\/j.1399-0012.2001.150301.x","volume":"15","author":"M Remberger","year":"2001","unstructured":"Remberger M, Aschan J, Barkholt L et al. Treatment of severe acute graft-versus-host disease with anti-thymocyte globulin. Clin Transplantation 2001; 15: 147\u2013153.","journal-title":"Clin Transplantation"},{"key":"BF1704874_CR36","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/(SICI)1096-911X(200001)34:1<39::AID-MPO7>3.0.CO;2-3","volume":"34","author":"H Bonig","year":"2000","unstructured":"Bonig H, Korholz D, Lex C et al. Monocyte deactivation and ist reversal in a patient with chemotherapy-induced leukopenia and severe systemic infection. Med Pediatr Oncol 2000; 34: 39\u201342.","journal-title":"Med Pediatr Oncol"},{"key":"BF1704874_CR37","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4049\/jimmunol.131.2.788","volume":"131","author":"GH Wong","year":"1983","unstructured":"Wong GH, Clark-Lewis I, McKimm-Breschkin L et al. Interferon-gamma induces enhanced expression of Ia and H-2 antigens on b lymphoid, macrophage, and myeloid cell lines. J Immunol 1983; 131: 788\u2013793.","journal-title":"J Immunol"},{"key":"BF1704874_CR38","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.4049\/jimmunol.166.5.2961","volume":"166","author":"T Ito","year":"2001","unstructured":"Ito T, Amakawa R, Inaba M et al. Differential regulation of human blood dendritic cell subsets by IFNs. J Immunol 2001; 166: 2961\u20132969.","journal-title":"J Immunol"},{"key":"BF1704874_CR39","unstructured":"Anderson BE, McNiff JM, Jain D et al. Distinct roles for donor- and host-derived antigen presenting cells and costimulatory molecules in murine chronic graft versus host disease: requirements depend on target organ. Blood First Edition Paper, prepublished online November 2, 2004, DOI 10. 1182\/blood-2004-08-3032."},{"key":"BF1704874_CR40","first-page":"391","volume-title":"The Cytokine Handbook","author":"WJ Storkus","year":"1998","unstructured":"Storkus WJ, Tahara H, Lotze MT . Interleukin-12. In: Thomson AW (ed.). The Cytokine Handbook. Academic Press: San Diego, CA, 1998, pp 391\u2013426."}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1704874","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704874.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1704874.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T01:51:09Z","timestamp":1682992269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1704874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,4,1]]}},"alternative-id":["BF1704874"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1704874","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,7]]},"assertion":[{"value":"30 January 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}