{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:25:21Z","timestamp":1792218321734,"version":"4.4.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2005,8,1]]},"DOI":"10.1038\/sj.bmt.1705039","type":"journal-article","created":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T09:10:18Z","timestamp":1118049018000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Total parenteral nutrition and hematopoietic stem cell transplantation: an expensive placebo?"],"prefix":"10.1038","volume":"36","author":[{"given":"L M","family":"Arfons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"BF1705039_CR1","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1056\/NEJM199403243301206","volume":"330","author":"JO Armitage","year":"1994","unstructured":"Armitage JO . Bone marrow transplantation. N Engl J Med 1994; 330: 827\u2013838.","journal-title":"N Engl J Med"},{"key":"BF1705039_CR2","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1097\/00007890-198743060-00012","volume":"43","author":"SA Weisdorf","year":"1987","unstructured":"Weisdorf SA, Lysne J, Wind D et al. Positive effect of prophylactic total parenteral nutrition on long-term outcome of bone marrow transplantation. Transplantation 1987; 43: 833\u2013838.","journal-title":"Transplantation"},{"key":"BF1705039_CR3","first-page":"3309","volume":"47","author":"DJ Szeluga","year":"1987","unstructured":"Szeluga DJ, Stuart RK, Brookmeyer R et al. Nutritional support of bone marrow transplant recipients: a prospective, randomized clinical trial comparing total parenteral nutrition to an enteral feeding program. Cancer Res 1987; 47: 3309\u20133316.","journal-title":"Cancer Res"},{"key":"BF1705039_CR4","first-page":"433","volume":"11","author":"M Muscaritoli","year":"1995","unstructured":"Muscaritoli M, Conversano L, Cangiano C et al. Biochemical changes may not accurately reflect changes in nutritional status after allogeneic bone marrow transplantation. Nutrition 1995; 11: 433\u2013436.","journal-title":"Nutrition"},{"key":"BF1705039_CR5","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1002\/1097-0142(19870415)59:8<1515::AID-CNCR2820590821>3.0.CO;2-D","volume":"59","author":"C Cheney","year":"1987","unstructured":"Cheney C, Gittere Abson K, Aker S et al. Body composition changes in marrow recipients receiving total parenteral nutrition. Cancer 1987; 59: 1515\u20131519.","journal-title":"Cancer"},{"key":"BF1705039_CR6","first-page":"273","volume":"45","author":"L Burkinshaw","year":"1973","unstructured":"Burkinshaw L, Jones PRM, Krupowicz DW . Observer error in skin fold thickness measurements. Human Biol 1973; 45: 273\u2013279.","journal-title":"Human Biol"},{"key":"BF1705039_CR7","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1093\/ajcn\/40.4.847","volume":"40","author":"D Szeluga","year":"1984","unstructured":"Szeluga D, Stuart RK, Utermohlen V et al. Nutritional assessment by isotope dilution analysis of body composition. Am J Clin Nutr 1984; 40: 847\u2013854.","journal-title":"Am J Clin Nutr"},{"issue":"Suppl. 5","key":"BF1705039_CR8","doi-asserted-by":"publisher","first-page":"42S","DOI":"10.1177\/014860718701100504","volume":"11","author":"HM Shizgal","year":"1987","unstructured":"Shizgal HM . Nutritional assessment with body composition. J Parent Ent Nutr 1987; 11 (Suppl. 5): 42S\u201347S.","journal-title":"J Parent Ent Nutr"},{"issue":"Suppl. 3","key":"BF1705039_CR9","first-page":"67","volume":"17","author":"HM Shizgal","year":"1990","unstructured":"Shizgal HM . Validation of the measurement of body composition from whole body bioelectric impedance. Infusionstherapie 1990; 17 (Suppl. 3): 67\u201374.","journal-title":"Infusionstherapie"},{"key":"BF1705039_CR10","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1002\/1097-0142(19891115)64:10<2045::AID-CNCR2820641013>3.0.CO;2-H","volume":"64","author":"POM Mulder","year":"1989","unstructured":"Mulder POM, Bouman JG, Gietema JA et al. Hyperalimentation in autologous bone marrow transplantation for solid tumors: comparison of total parenteral nutrition vs partial parenteral plus enteral nutrition. Cancer 1989; 64: 2045\u20132052.","journal-title":"Cancer"},{"key":"BF1705039_CR11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/0148607197021003157","volume":"21","author":"PM Charuhas","year":"1997","unstructured":"Charuhas PM, Fosberg KL, Bruemmer B et al. A double-blind randomized trial comparing outpatient parenteral nutrition with intravenous hydration: effect on resumption of oral intake after marrow transplantation. J Parent Ent Nutr 1997; 21: 157\u2013161.","journal-title":"J Parent Ent Nutr"},{"key":"BF1705039_CR12","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1172\/JCI101827","volume":"26","author":"CJ Smyth","year":"1946","unstructured":"Smyth CJ, Lasichak AG, Levey S . The effect of orally and intravenously administered amino acid mixtures on voluntary food consumption in normal men. J Clin Invest 1946; 26: 439\u2013445.","journal-title":"J Clin Invest"},{"key":"BF1705039_CR13","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1080\/07315724.1984.10720055","volume":"3","author":"K Sriram","year":"1984","unstructured":"Sriram K, Pinchcofsky G, Kaminski MV . Suppression of appetite by parenteral nutrition in humans. J Am Coll Nutr 1984; 3: 317\u2013323.","journal-title":"J Am Coll Nutr"},{"key":"BF1705039_CR14","first-page":"256","volume":"7","author":"MI Friedman","year":"1986","unstructured":"Friedman MI, Gil KM, Rothkopf MM et al. Postabsorptive control of food intake in humans. Appetite 1986; 7: 256 (abstract).","journal-title":"Appetite"},{"key":"BF1705039_CR15","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0899-9007(02)00779-7","volume":"18","author":"T \u00c7etin","year":"2002","unstructured":"\u00c7etin T, Arpaci F, Dere Y et al. Total parenteral nutrition delays platelet engraftment in patients who undergo autologous hematopoietic stem cell transplantation. Nutrition 2002; 18: 599\u2013603.","journal-title":"Nutrition"},{"key":"BF1705039_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0261-5614(90)90060-6","volume":"9","author":"M Lough","year":"1990","unstructured":"Lough M, Watkins R, Campbell M et al. Parenteral nutrition in bone marrow transplantation. Clin Nutr 1990; 9: 97\u2013101.","journal-title":"Clin Nutr"},{"key":"BF1705039_CR17","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/sj.bmt.1704204","volume":"32","author":"S Roberts","year":"2003","unstructured":"Roberts S, Miller J, Pineiro L, Jennings L . Total parenteral nutrition vs oral diet in autologous hematopoietic cell transplant recipients. Bone Marrow Transplant 2003; 32: 715\u2013721.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705039_CR18","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/j.jada.2004.06.024","volume":"104","author":"PM Sheean","year":"2004","unstructured":"Sheean PM, Braunschweig C, Rich E . The incidence of hyperglycemia in hematopoietic stem cell transplant recipients receiving total parenteral nutrition: a pilot study. J Am Diet Assoc 2004; 104: 1352\u20131360.","journal-title":"J Am Diet Assoc"},{"key":"BF1705039_CR19","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/1097-0142(19900701)66:1<62::AID-CNCR2820660113>3.0.CO;2-E","volume":"66","author":"VS Klimberg","year":"1990","unstructured":"Klimberg VS, Souba WW, Dolson DJ et al. Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer 1990; 66: 62\u201368.","journal-title":"Cancer"},{"key":"BF1705039_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0002-9610(05)80603-8","volume":"159","author":"VS Klimberg","year":"1990","unstructured":"Klimberg VS, Souba WW, Salloum RM et al. Intestinal glutamine metabolism after massive small bowel resection. Am J Surg 1990; 159: 27\u201332.","journal-title":"Am J Surg"},{"key":"BF1705039_CR21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10549-004-0783-4","volume":"88","author":"VK Todorova","year":"2004","unstructured":"Todorova VK, Harms SA, Kaufman Y et al. Effect of dietary glutamine in tumor glutathione levels and apoptosis-related proteins in DMBA-induced breast cancer of rats. Breast Cancer Res Treat 2004; 88: 247\u2013256.","journal-title":"Breast Cancer Res Treat"},{"key":"BF1705039_CR22","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/0140-6736(93)90939-E","volume":"341","author":"RM van der Hulst","year":"1993","unstructured":"van der Hulst RM, van Kreel BK . Glutamine and the preservation of gut integrity. Lancet 1993; 341: 1363\u20131365.","journal-title":"Lancet"},{"key":"BF1705039_CR23","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/S0899-9007(99)00213-0","volume":"15","author":"JK Shabert","year":"1999","unstructured":"Shabert JK, Winslow C, Lacey JM, Wilmore DW . Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition 1999; 15: 860\u2013864.","journal-title":"Nutrition"},{"key":"BF1705039_CR24","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/00000658-199802000-00022","volume":"227","author":"BJ Morlion","year":"1998","unstructured":"Morlion BJ, Stehle P, Wachtler P et al. Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: a randomized, double-blind controlled study. Ann Surg 1998; 227: 302\u2013308.","journal-title":"Ann Surg"},{"key":"BF1705039_CR25","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/S0140-6736(98)02007-8","volume":"352","author":"AP Houdijk","year":"1998","unstructured":"Houdijk AP, Rijnsburger ER, Jansen J et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 1998; 352: 772\u2013776.","journal-title":"Lancet"},{"key":"BF1705039_CR26","doi-asserted-by":"publisher","first-page":"821","DOI":"10.7326\/0003-4819-116-10-821","volume":"116","author":"TR Ziegler","year":"1992","unstructured":"Ziegler TR, Young LS, Benfell K et al. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. Ann Intern Med 1992; 116: 821\u2013828.","journal-title":"Ann Intern Med"},{"key":"BF1705039_CR27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1177\/0148607193017005407","volume":"17","author":"PR Schloerb","year":"1993","unstructured":"Schloerb PR, Amare M . Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications. J Parent Ent Nutr 1993; 17: 407\u2013413.","journal-title":"J Parent Ent Nutr"},{"key":"BF1705039_CR28","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/sj.bmt.1701317","volume":"22","author":"PM Anderson","year":"1998","unstructured":"Anderson PM, Ramsey NKC, Shu XO et al. Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation. Bone Marrow Transplant 1998; 22: 339\u2013344.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705039_CR29","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/sj.bmt.1703759","volume":"30","author":"R Pytl\u00edk","year":"2002","unstructured":"Pytl\u00edk R, Benes P, Patorkov\u00e1 M et al. Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study. Bone Marrow Transplant 2002; 30: 953\u2013961.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705039_CR30","first-page":"1229","volume":"85","author":"G Canovas","year":"2000","unstructured":"Canovas G, Le\u00f3n-Sanz M, G\u00f3mez P et al. Oral glutamine supplements in autologous hematopoietic transplant: impact on gastrointestinal toxicity and plasma protein levels. Haematologica 2000; 85: 1229\u20131230.","journal-title":"Haematologica"},{"key":"BF1705039_CR31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1177\/014860710002400261","volume":"24","author":"TM Coughlin Dickson","year":"2000","unstructured":"Coughlin Dickson TM, Wong RM, Negrin RS et al. Effect of oral glutamine supplementation during bone marrow transplantation. J Parent Ent Nutr 2000; 24: 61\u201366.","journal-title":"J Parent Ent Nutr"},{"key":"BF1705039_CR32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1177\/0148607199023003117","volume":"23","author":"PR Schloerb","year":"1999","unstructured":"Schloerb PR, Skikne BS . Oral and parenteral glutamine in bone marrow transplantation: a randomized, double-blind study. J Parent Ent Nutr 1999; 23: 117\u2013122.","journal-title":"J Parent Ent Nutr"},{"key":"BF1705039_CR33","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000061833","volume":"4","author":"P Lenssen","year":"2000","unstructured":"Lenssen P . Nutrition in hematopoietic stem cell transplantation. Nestl\u00e9 Nutrition Workshop Series Clinical and Performance Programme 2000; 4: 207\u2013222; discussion 222\u2013223.","journal-title":"Nestl\u00e9 Nutrition Workshop Series Clinical and Performance Programme"},{"key":"BF1705039_CR34","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0140-6736(80)90171-3","volume":"18","author":"GW Fischer","year":"1980","unstructured":"Fischer GW, Hunter KW, Wilson SR, Mease AD . Diminished bacterial defences with intralipid. Lancet 1980; 18: 819\u2013820.","journal-title":"Lancet"},{"key":"BF1705039_CR35","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1093\/ajcn\/67.5.927","volume":"67","author":"P Lenssen","year":"1998","unstructured":"Lenssen P, Bruemmer BA, Bowden RA et al. Intravenous lipid dose and incidence of bacteremia and fungemia in patients undergoing bone marrow transplantation. Am J Clin Nutr 1998; 67: 927\u2013933.","journal-title":"Am J Clin Nutr"},{"key":"BF1705039_CR36","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1097\/00007890-199809150-00011","volume":"66","author":"M Muscaritoli","year":"1998","unstructured":"Muscaritoli M, Conversano L, Torelli GF et al. Clinical and metabolic effects of different parenteral nutrition regimens in patients undergoing allogeneic bone marrow transplantation. Transplantation 1998; 66: 610\u2013616.","journal-title":"Transplantation"},{"key":"BF1705039_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1054\/clnu.2000.0151","volume":"20","author":"P Santos","year":"2001","unstructured":"Santos P, Louren\u00e7o R, Camilo ME et al. Parenteral nutrition and cyclosporine: do lipids make a difference? A prospective randomized crossover trial. Clin Nutr 2001; 20: 31\u201336.","journal-title":"Clin Nutr"},{"key":"BF1705039_CR38","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1056\/NEJMoa040125","volume":"351","author":"R Spielberger","year":"2004","unstructured":"Spielberger R, Stiff P, Bensinger W et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004; 351: 2590\u20132598.","journal-title":"N Engl J Med"},{"key":"BF1705039_CR39","first-page":"505","volume":"2","author":"DL Sigalet","year":"2001","unstructured":"Sigalet DL . ALX-0600 (NPS Allelix Corp). Curr Opin Investig Drugs 2001; 2: 505\u2013509.","journal-title":"Curr Opin Investig Drugs"},{"key":"BF1705039_CR40","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/sj.bmt.1701747","volume":"23","author":"JA Iestra","year":"1999","unstructured":"Iestra JA, Fibbe WE, Zwinderman AH et al. Parenteral nutrition following intensive cytotoxic therapy: an exploratory study on the need for parenteral nutrition after various treatment approaches for haematological malignancies. Bone Marrow Transplant 1999; 23: 933\u2013939.","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1705039","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1705039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1705039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:35:29Z","timestamp":1648082129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1705039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,6]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,8,1]]}},"alternative-id":["BF1705039"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1705039","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,6]]},"assertion":[{"value":"15 April 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}