{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:37:14Z","timestamp":1773308234247,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T00:00:00Z","timestamp":1140393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T00:00:00Z","timestamp":1140393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2006,4,1]]},"DOI":"10.1038\/sj.bmt.1705299","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T11:08:40Z","timestamp":1140433720000},"page":"641-649","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia"],"prefix":"10.1038","volume":"37","author":[{"given":"J R","family":"Passweg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W S","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Eapen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B M","family":"Camitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Gluckman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Hinterberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Hows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C W","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Pasquini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Schrezenmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Soci\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-J","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bredeson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,2,20]]},"reference":[{"key":"BF1705299_CR1","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1172\/JCI108680","volume":"59","author":"R Storb","year":"1977","unstructured":"Storb R, Prentice RL, Thomas ED . Treatment of aplastic anemia by marrow transplantation from HLA identical siblings. Prognostic factors associated with graft versus host disease and survival. J Clin Invest 1977; 59: 625\u2013632.","journal-title":"J Clin Invest"},{"key":"BF1705299_CR2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1182\/blood.V48.1.63.63","volume":"48","author":"BM Camitta","year":"1976","unstructured":"Camitta BM, Thomas ED, Nathan DG, Santos G, Gordon-Smith EC, Gale RP et al. Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality. Blood 1976; 48: 63\u201370.","journal-title":"Blood"},{"key":"BF1705299_CR3","first-page":"858","volume":"90","author":"JR Passweg","year":"1997","unstructured":"Passweg JR, Socie G, Hinterberger W, Bacigalupo A, Biggs JC, Camitta BM et al. Bone marrow transplantation for severe aplastic anemia: has outcome improved? Blood 1997; 90: 858\u2013864.","journal-title":"Blood"},{"key":"BF1705299_CR4","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1182\/blood.V92.8.2742","volume":"92","author":"A Stucki","year":"1998","unstructured":"Stucki A, Leisenring W, Sandmaier BM, Sanders J, Anasetti C, Storb R . Decreased rejection and improved survival of first and second marrow transplants for severe aplastic anemia (a 26-year retrospective analysis). Blood 1998; 92: 2742\u20132749.","journal-title":"Blood"},{"key":"BF1705299_CR5","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1182\/blood-2003-07-2546","volume":"103","author":"L Ades","year":"2004","unstructured":"Ades L, Mary JY, Robin M, Ferry C, Porcher R, Esperou H et al. Long-term outcome after bone marrow transplantation for severe aplastic anemia. Blood 2004; 103: 2490\u20132497.","journal-title":"Blood"},{"key":"BF1705299_CR6","first-page":"1690","volume":"96","author":"F Locatelli","year":"2000","unstructured":"Locatelli F, Bruno B, Zecca M, Van Lint MT, McCann S, Arcese W et al. Cyclosporin A and short-term methotrexate versus cyclosporin A as graft versus host disease prophylaxis in patients with severe aplastic anemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO\/EBMT randomized trial. Blood 2000; 96: 1690\u20131697.","journal-title":"Blood"},{"key":"BF1705299_CR7","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1046\/j.1365-2141.2003.04721.x","volume":"123","author":"JC Marsh","year":"2003","unstructured":"Marsh JC, Ball SE, Darbyshire P, Gordon-Smith EC, Keidan AJ, Martin A et al. Guidelines for the diagnosis and management of acquired aplastic anaemia. Br J Haematol 2003; 123: 782\u2013801.","journal-title":"Br J Haematol"},{"key":"BF1705299_CR8","first-page":"211","volume":"6","author":"A Locasciulli","year":"1990","unstructured":"Locasciulli A, van't Veer L, Bacigalupo A, Hows J, Van Lint MT, Gluckman E et al. Treatment with marrow transplantation or immunosuppression of childhood acquired severe aplastic anemia: a report from the EBMT SAA Working Party. Bone Marrow Transplant 1990; 6: 211\u2013217.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705299_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0037-1963(00)90031-3","volume":"37","author":"A Bacigalupo","year":"2000","unstructured":"Bacigalupo A, Brand R, Oneto R, Bruno B, Socie G, Passweg J et al. Treatment of acquired severe aplastic anemia: bone marrow transplantation compared with immunosuppressive therapy\u2014The European Group for Blood and Marrow Transplantation experience. Semin Hematol 2000; 37: 69\u201380.","journal-title":"Semin Hematol"},{"key":"BF1705299_CR10","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1182\/blood.V95.6.1931","volume":"95","author":"A Bacigalupo","year":"2000","unstructured":"Bacigalupo A, Bruno B, Saracco P, Di Bona E, Locasciulli A, Locatelli F et al. Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO\/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italiano Trapianti di Midolio Osseo (GITMO). Blood 2000; 95: 1931\u20131934.","journal-title":"Blood"},{"key":"BF1705299_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1159\/000041000","volume":"103","author":"A Bacigalupo","year":"2000","unstructured":"Bacigalupo A, Oneto R, Bruno B, Socie G, Passweg J, Locasciulli A et al. Current results of bone marrow transplantation in patients with acquired severe aplastic anemia. Report of the European Group for Blood and Marrow transplantation. On behalf of the Working Party on Severe Aplastic Anemia of the European Group for Blood and Marrow Transplantation. Acta Haematol 2000; 103: 19\u201325.","journal-title":"Acta Haematol"},{"key":"BF1705299_CR12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/00007890-197307000-00005","volume":"16","author":"B Speck","year":"1973","unstructured":"Speck B, Zwaan FE, van Rood JJ, Eernisse JG . Allogeneic bone marrow transplantation in a patient with aplastic anemia using a phenotypically HL-A-identical unrelated donor. Transplantation 1973; 16: 24\u201328.","journal-title":"Transplantation"},{"key":"BF1705299_CR13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/00007890-199601150-00012","volume":"61","author":"JL Wagner","year":"1996","unstructured":"Wagner JL, Deeg HJ, Seidel K, Anasetti C, Doney K, Sanders J et al. Bone marrow transplantation for severe aplastic anemia from genotypically HLA-nonidentical relatives. An update of the Seattle experience. Transplantation 1996; 61: 54\u201361.","journal-title":"Transplantation"},{"key":"BF1705299_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/BF01634000","volume":"31","author":"HP Lohrmann","year":"1975","unstructured":"Lohrmann HP, Dietrich M, Goldmann SF, Kristensen T, Fliedner TM, Abt C et al. Bone marrow transplantation for aplastic anaemia from a HL-A and MLC-identical unrelated donor. Blut 1975; 31: 347\u2013354.","journal-title":"Blut"},{"key":"BF1705299_CR15","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1097\/00007890-198306000-00010","volume":"35","author":"RJ Duquesnoy","year":"1983","unstructured":"Duquesnoy RJ, Zeevi A, Marrari M, Hackbarth S, Camitta B . Bone marrow transplantation for severe aplastic anemia using a phenotypically HLA-identical, SB-compatible unrelated donor. Transplantation 1983; 35: 566\u2013571.","journal-title":"Transplantation"},{"key":"BF1705299_CR16","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1182\/blood.V74.5.1852.1852","volume":"74","author":"B Camitta","year":"1989","unstructured":"Camitta B, Ash R, Menitove J, Murray K, Lawton C, Hunter J et al. Bone marrow transplantation for children with severe aplastic anemia: use of donors other than HLA-identical siblings. Blood 1989; 74: 1852\u20131857.","journal-title":"Blood"},{"key":"BF1705299_CR17","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1182\/blood.V68.6.1322.1322","volume":"68","author":"JM Hows","year":"1986","unstructured":"Hows JM, Yin JL, Marsh J, Swirsky D, Jones L, Apperley JF et al. Histocompatible unrelated volunteer donors compared with HLA nonidentical family donors in marrow transplantation for aplastic anemia and leukemia. Blood 1986; 68: 1322\u20131328.","journal-title":"Blood"},{"key":"BF1705299_CR18","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1056\/NEJM199303043280901","volume":"328","author":"NA Kernan","year":"1993","unstructured":"Kernan NA, Bartsch G, Ash RC, Beatty PG, Champlin R, Filipovich A et al. Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N Engl J Med 1993; 328: 593\u2013602.","journal-title":"N Engl J Med"},{"key":"BF1705299_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1046\/j.1365-2141.1996.d01-1772.x","volume":"94","author":"D Margolis","year":"1996","unstructured":"Margolis D, Camitta B, Pietryga D, Keever-Taylor C, Baxter-Lowe LA, Pierce K et al. Unrelated donor bone marrow transplantation to treat severe aplastic anaemia in children and young adults. Br J Haematol 1996; 94: 65\u201372.","journal-title":"Br J Haematol"},{"key":"BF1705299_CR20","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1046\/j.1365-2141.2001.02992.x","volume":"114","author":"S Kojima","year":"2001","unstructured":"Kojima S, Inaba J, Yoshimi A, Takahashi Y, Watanabe N, Kudo K et al. Unrelated donor marrow transplantation in children with severe aplastic anaemia using cyclophosphamide, anti-thymocyte globulin and total body irradiation. Br J Haematol 2001; 114: 706\u2013711.","journal-title":"Br J Haematol"},{"key":"BF1705299_CR21","first-page":"825","volume":"15","author":"D Przepiorka","year":"1995","unstructured":"Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 1995; 15: 825\u2013828.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705299_CR22","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S0889-8588(05)70111-8","volume":"13","author":"ME Flowers","year":"1999","unstructured":"Flowers ME, Kansu E, Sullivan KM . Pathophysiology and treatment of graft-versus-host disease. Hematol Oncol Clin N Am 1999; 13: 1091\u20131112, viii\u2013ix.","journal-title":"Hematol Oncol Clin N Am"},{"key":"BF1705299_CR23","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/sj.bmt.1703271","volume":"28","author":"JP Klein","year":"2001","unstructured":"Klein JP, Rizzo JD, Zhang MJ, Keiding N . Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part 2: Regression modeling. Bone Marrow Transplant 2001; 28: 1001\u20131011.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705299_CR24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"DR Cox","year":"1972","unstructured":"Cox DR . Regression models and life tables. J Roy Stat Soc B 1972; 34: 187\u2013220. Ref Type: Generic.","journal-title":"J Roy Stat Soc B"},{"key":"BF1705299_CR25","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1002\/(SICI)1097-0258(19990630)18:12<1489::AID-SIM140>3.0.CO;2-#","volume":"18","author":"PK Anderson","year":"1999","unstructured":"Anderson PK, Klein JP, Zhang MJ . Testing for centre effects in multi-centre survival studies: a Monte Carlo comparison of fixed and random effects tests. Stat Med 1999; 18: 1489\u20131500.","journal-title":"Stat Med"},{"key":"BF1705299_CR26","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1182\/blood.V100.3.799","volume":"100","author":"S Kojima","year":"2002","unstructured":"Kojima S, Matsuyama T, Kato S, Kigasawa H, Kobayashi R, Kikuta A et al. Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan Marrow Donor Program. Blood 2002; 100: 799\u2013803.","journal-title":"Blood"},{"key":"BF1705299_CR27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1053\/bbmt.1999.v5.pm10465104","volume":"5","author":"HJ Deeg","year":"1999","unstructured":"Deeg HJ, Seidel K, Casper J, Anasetti C, Davies S, Gajeweski JL et al. Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy. Biol Blood Marrow Transplant 1999; 5: 243\u2013252.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1705299_CR28","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1365-2141.2004.04857.x","volume":"125","author":"M Benesch","year":"2004","unstructured":"Benesch M, Urban C, Sykora KW, Schwinger W, Zintl F, Lackner H et al. Transplantation of highly purified CD34+ progenitor cells from alternative donors in children with refractory severe aplastic anaemia. Br J Haematol 2004; 125: 58\u201363.","journal-title":"Br J Haematol"},{"key":"BF1705299_CR29","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1053\/bbmt.2001.v7.pm11349807","volume":"7","author":"HJ Deeg","year":"2001","unstructured":"Deeg HJ, Amylon ID, Harris RE, Collins R, Beatty PG, Feig S et al. Marrow transplants from unrelated donors for patients with aplastic anemia: minimum effective dose of total body irradiation. Biol Blood Marrow Transplant 2001; 7: 208\u2013215.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1705299_CR30","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1182\/blood-2004-03-0803","volume":"104","author":"N Flomenberg","year":"2004","unstructured":"Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovich A, Horowitz M et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 2004; 104: 1923\u20131930.","journal-title":"Blood"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1705299","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1705299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1705299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T20:27:52Z","timestamp":1736281672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1705299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,20]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,4,1]]}},"alternative-id":["BF1705299"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1705299","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,20]]},"assertion":[{"value":"23 September 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}