{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:22:34Z","timestamp":1791566554417,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T00:00:00Z","timestamp":1186963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T00:00:00Z","timestamp":1186963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1038\/sj.bmt.1705811","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T15:44:35Z","timestamp":1187106275000},"page":"753-758","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Elevated lactate dehydrogenase is an adverse predictor of outcome in HLA-matched sibling bone marrow transplant for acute myelogenous leukemia"],"prefix":"10.1038","volume":"40","author":[{"given":"M","family":"Kalaycio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Rybicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Pohlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sweetenham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Andresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sobecks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Sekeres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Advani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Bolwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,8,13]]},"reference":[{"key":"BF1705811_CR1","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1002\/cncr.20945","volume":"103","author":"M Yanada","year":"2005","unstructured":"Yanada M, Matsuo K, Emi N, Naoe T . Efficacy of allogeneic hematopoietic stem cell transplantation depends on cytogenetic risk for acute myeloid leukemia in first disease remission. Cancer 2005; 103: 1652\u20131658.","journal-title":"Cancer"},{"key":"BF1705811_CR2","first-page":"2931","volume":"90","author":"A Ferrant","year":"1997","unstructured":"Ferrant A, Labopin M, Frassoni F, Prentice HG, Cahn JY, Blaise D et al. Karyotype in acute myeloblastic leukemia: prognostic significance for bone marrow transplantation in first remission: a European Group for Blood and Marrow Transplantation Study. Blood 1997; 90: 2931\u20132938.","journal-title":"Blood"},{"key":"BF1705811_CR3","first-page":"203","volume":"16","author":"RP Gale","year":"1995","unstructured":"Gale RP, Horowitz MM, Weiner RS, Ash RC, Atkinson K, Babu R et al. Impact of cytogenetic abnormalities on outcome of bone marrow transplants in acute myelogenous leukemia in first remission. Bone Marrow Transplant 1995; 16: 203\u2013208.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705811_CR4","first-page":"993","volume":"17","author":"S Keating","year":"1996","unstructured":"Keating S, Suciu S, de Witte T, Mandelli F, Willemze R, Resegotti L et al. Prognostic factors of patients with acute myeloid leukemia (AML) allografted in first complete remission: an analysis of the EORTC-GIMEMA AML 8A trial. The European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell\u2019 Adulto (GIMEMA) Leukemia Cooperative Groups. Bone Marrow Transplant 1996; 17: 993\u20131001.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705811_CR5","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1046\/j.1365-2141.1999.01713.x","volume":"107","author":"AP Grigg","year":"1999","unstructured":"Grigg AP, Szer J, Beresford J, Dodds A, Bradstock K, Durrant S et al. Factors affecting the outcome of allogeneic bone marrow transplantation for adult patients with refractory or relapsed acute leukaemia. Br J Haematol 1999; 107: 409\u2013418.","journal-title":"Br J Haematol"},{"key":"BF1705811_CR6","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/S0140-6736(00)02137-1","volume":"355","author":"F Frassoni","year":"2000","unstructured":"Frassoni F, Labopin M, Powles R, Mary JY, Arcese W, Bacigalupo A et al. Effect of centre on outcome of bone-marrow transplantation for acute myeloid leukaemia. Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation. Lancet 2000; 355: 1393\u20131398.","journal-title":"Lancet"},{"key":"BF1705811_CR7","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/sj.bmt.1702690","volume":"26","author":"M Michallet","year":"2000","unstructured":"Michallet M, Thomas X, Vernant JP, Kuentz M, Socie G, Esp\u00e9rou-Bourdeau H et al. Long-term outcome after allogeneic hematopoietic stem cell transplantation for advanced stage acute myeloblastic leukemia: a retrospective study of 379 patients reported to the Soci\u00e9t\u00e9 Fran\u00e7aise de Greffe de Moelle (SFGM). Bone Marrow Transplant 2000; 26: 1157\u20131163.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705811_CR8","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1182\/blood.V80.4.1090.1090","volume":"80","author":"JC Biggs","year":"1992","unstructured":"Biggs JC, Horowitz MM, Gale RP, Ash RC, Atkinson K, Helbig W et al. Bone marrow transplants may cure patients with acute leukemia never achieving remission with chemotherapy. Blood 1992; 80: 1090\u20131093.","journal-title":"Blood"},{"key":"BF1705811_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.bbmt.2005.06.004","volume":"12","author":"W Blum","year":"2006","unstructured":"Blum W, Bolwell BJ, Phillips G, Farag SS, Lin TS, Avalos BR et al. High disease burden is associated with poor outcomes for patients with acute myeloid leukemia not in remission who undergo unrelated donor cell transplantation. Biol Blood Marrow Transplant 2006; 12: 61\u201367.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1705811_CR10","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1182\/blood.V89.11.4226","volume":"89","author":"J Sierra","year":"1997","unstructured":"Sierra J, Storer B, Hansen JA, Bjerke JW, Martin PJ, Petersdorf EW et al. Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose. Blood 1997; 89: 4226\u20134235.","journal-title":"Blood"},{"key":"BF1705811_CR11","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1200\/JCO.2003.08.005","volume":"21","author":"T Haferlach","year":"2003","unstructured":"Haferlach T, Schoch C, Loffler H, Gassmann W, Kern W, Schnittger S et al. Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML Cooperative Group Studies 10.1200\/JCO.2003.08.00. J Clin Oncol 2003; 21: 256\u2013265.","journal-title":"J Clin Oncol"},{"key":"BF1705811_CR12","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1080\/10428190500353554","volume":"47","author":"R Abou-Jawde","year":"2006","unstructured":"Abou-Jawde R, Sobecks R, Pohlman B, Rybicki L, Advani A, Sekeres M et al. The role of post-remission chemotherapy for older patients with acute myelogenous leukemia. Leuk Lymphoma 2006; 47: 689\u2013695.","journal-title":"Leuk Lymphoma"},{"key":"BF1705811_CR13","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1046\/j.1365-2141.1996.00398.x","volume":"92","author":"F Ferrara","year":"1996","unstructured":"Ferrara F, Mirto S . Serum LDH as a predictor of clinical outcome in acute myelogenous leukaemia of the elderly. Br J Haematol 1996; 92: 627\u2013631.","journal-title":"Br J Haematol"},{"key":"BF1705811_CR14","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1182\/blood.V96.13.4075","volume":"96","author":"ML Slovak","year":"2000","unstructured":"Slovak ML, Kopecky KJ, Cassileth PA, Harrington DH, Theil KS, Mohamed A et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group\/Eastern Cooperative Oncology Group study. Blood 2000; 96: 4075\u20134083.","journal-title":"Blood"},{"key":"BF1705811_CR15","doi-asserted-by":"publisher","first-page":"4325","DOI":"10.1182\/blood-2002-03-0772","volume":"100","author":"JC Byrd","year":"2002","unstructured":"Byrd JC, Mrozek K, Dodge RK, Carroll AJ, Edwards CG, Arthur DC et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002; 100: 4325\u20134336.","journal-title":"Blood"},{"key":"BF1705811_CR16","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood.V92.7.2322","volume":"92","author":"D Grimwade","year":"1998","unstructured":"Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood 1998; 92: 2322\u20132333.","journal-title":"Blood"},{"key":"BF1705811_CR17","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/sj.bmt.1704867","volume":"35","author":"SS Farag","year":"2005","unstructured":"Farag SS, Bolwell BJ, Elder PJ, Kalaycio M, Lin T, Pohlman B et al. High-dose busulfan, cyclophosphamide, and etoposide does not improve outcome of allogeneic stem cell transplantation compared to BuCy2 in patients with acute myeloid leukemia. Bone Marrow Transplant 2005; 35: 653\u2013661.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705811_CR18","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/sj.bmt.1704647","volume":"34","author":"BJ Bolwell","year":"2004","unstructured":"Bolwell BJ, Sobecks R, Pohlman B, Andresen S, Rybicki L, Kuczkowski L et al. A prospective randomized trial comparing cyclosporine and short course methotrexate with cyclosporine and mycophenolate mofetil for GVHD prophylaxis in myeloablative allogeneic bone marrow transplantation. Bone Marrow Transplant 2004; 34: 621\u2013625.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705811_CR19","first-page":"38","volume":"39","author":"FE von Eyben","year":"2001","unstructured":"von Eyben FE, Blaabjerg O, Hyltoft-Petersen P, Madsen EL, Amato R, Liu F et al. Serum lactate dehydrogenase isoenzyme 1 and prediction of death in patients with metastatic testicular germ cell tumors. Clin Chemistry Lab Med 2001; 39: 38\u201344.","journal-title":"Clin Chemistry Lab Med"},{"key":"BF1705811_CR20","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1200\/JCO.1997.15.2.594","volume":"15","author":"Anonymous","year":"1997","unstructured":"Anonymous. International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol 1997; 15: 594\u2013603.","journal-title":"J Clin Oncol"},{"key":"BF1705811_CR21","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1182\/blood-2003-12-4434","volume":"104","author":"P Solal-Celigny","year":"2004","unstructured":"Solal-Celigny P, Roy P, Colombat P, White J, Armitage JO, Arranz-Saez R et al. Follicular lymphoma international prognostic index. Blood 2004; 104: 1258\u20131265.","journal-title":"Blood"},{"key":"BF1705811_CR22","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJM199309303291402","volume":"329","author":"Anonymous","year":"1993","unstructured":"Anonymous. A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med 1993; 329: 987\u2013994.","journal-title":"N Engl J Med"},{"key":"BF1705811_CR23","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/sj.bjc.6690080","volume":"79","author":"UN Lassen","year":"1999","unstructured":"Lassen UN, Osterlind K, Hirsch FR, Bergman B, Dombernowsky P, Hansen HH . Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression. Br J Cancer 1999; 79: 515\u2013519.","journal-title":"Br J Cancer"},{"key":"BF1705811_CR24","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/sj.bmt.1703525","volume":"29","author":"B Bolwell","year":"2002","unstructured":"Bolwell B, Kalaycio M, Sobecks R, Andresen A, McBee M, Kuczkowski L et al. Autologous hematopoietic cell transplantation for non-Hodgkin's lymphoma: 100 month follow-up. Bone Marrow Transplant 2002; 29: 673\u2013679.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705811_CR25","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/sj.bmt.1702433","volume":"25","author":"EA Copelan","year":"2000","unstructured":"Copelan EA, Penza SL, Pohlman B, Avalos BR, Goormastic M, Andresen S et al. Autotransplantation following busulfan, etoposide and cyclophosphamide in patients with non-Hodgkin's lymphoma. Bone Marrow Transplant 2000; 25: 1243\u20131248.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705811_CR26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/sj.bmt.1705388","volume":"38","author":"J Mehta","year":"2006","unstructured":"Mehta J, Gordon LI, Tallman MA, Winter JN, Evens AO, Frankfurt O et al. Does younger age affect the outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies beneficially? Bone Marrow Transplant 2006; 38: 95\u2013100.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705811_CR27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1365-2141.1986.tb05545.x","volume":"63","author":"K Atkinson","year":"1986","unstructured":"Atkinson K, Farrell C, Chapman G, Downs K, Penny R, Biggs J . Female marrow donors increase the risk of acute graft-versus-host disease: effect of donor age and parity and analysis of cell subpopulations in the donor marrow inoculum. Br J Haematol 1986; 63: 231\u2013239.","journal-title":"Br J Haematol"},{"key":"BF1705811_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0165-4608(94)90174-0","volume":"73","author":"GJ Swansbury","year":"1994","unstructured":"Swansbury GJ, Lawler SD, Alimena G, Arthur D, Berger R, Van den Berghe H et al. Long-term survival in acute myelogenous leukemia: a second follow-up of the Fourth International Workshop on Chromosomes in Leukemia. Cancer Genet Cytogenet 1994; 73: 1\u20137.","journal-title":"Cancer Genet Cytogenet"},{"key":"BF1705811_CR29","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1182\/blood-2002-01-0048","volume":"100","author":"S Couban","year":"2002","unstructured":"Couban S, Simpson DR, Barnett MJ, Bredeson C, Hubesch L, Howson-Jan K et al. A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies. Blood 2002; 100: 1525\u20131531.","journal-title":"Blood"},{"key":"BF1705811_CR30","first-page":"3702","volume":"95","author":"RE Champlin","year":"2000","unstructured":"Champlin RE, Schmitz N, Horowitz MM, Chapuis B, Chopra R, Cornelissen JJ et al. Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation. Blood 2000; 95: 3702\u20133709.","journal-title":"Blood"},{"key":"BF1705811_CR31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1056\/NEJM200101183440303","volume":"344","author":"WI Bensinger","year":"2001","unstructured":"Bensinger WI, Martin PJ, Storer B, Clift R, Forman SJ, Negrin R et al. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. N Engl J Med 2001; 344: 175\u2013181.","journal-title":"N Engl J Med"},{"key":"BF1705811_CR32","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s11912-002-0034-y","volume":"4","author":"M Sekeres","year":"2002","unstructured":"Sekeres M, Stone RM . Older adults with acute myeloid leukemia. Current Oncol Rep 2002; 4: 403\u2013409.","journal-title":"Current Oncol Rep"},{"key":"BF1705811_CR33","doi-asserted-by":"publisher","first-page":"7676","DOI":"10.1200\/JCO.2005.02.5940","volume":"23","author":"E Jourdan","year":"2005","unstructured":"Jourdan E, Boiron J-M, Dastugue N, Vey N, Marit G, Rigal-Huguet F et al. Early allogeneic stem-cell transplantation for young adults with acute myeloblastic leukemia in first complete remission: an intent-to-treat long-term analysis of the BGMT experience. J Clin Oncol 2005; 23: 7676\u20137684.","journal-title":"J Clin Oncol"},{"key":"BF1705811_CR34","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1182\/blood-2002-12-3714","volume":"102","author":"S Suciu","year":"2003","unstructured":"Suciu S, Mandelli F, de Witte T, Zittoun R, Gallo E, Labar B et al. Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC\/GIMEMA AML-10 trial. Blood 2003; 102: 1232\u20131240.","journal-title":"Blood"},{"key":"BF1705811_CR35","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1053\/bbmt.2002.v8.pm12234169","volume":"8","author":"Y Chalandon","year":"2002","unstructured":"Chalandon Y, Barnett MJ, Horsman DE, Conneally EA, Nantel SH, Nevill TJ et al. Influence of cytogenetic abnormalities on outcome after allogeneic bone marrow transplantation for acute myeloid leukemia in first complete remission. Biol Blood Marrow Transplant 2002; 8: 435\u2013443.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1705811_CR36","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.bbmt.2005.11.272","volume":"12","author":"R Obenchain","year":"2006","unstructured":"Obenchain R, Ruffner K, Stokes D, Wu W, Brandt S, Chinratanalab W et al. Allogeneic hematopoietic stem cell transplant (HSCT) in adults with acute myeloid leukemia (AML)\u2014a single program experience. Biol Blood Marrow Transplant 2006; 12: 88.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1705811_CR37","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1200\/JCO.1992.10.11.1723","volume":"10","author":"RA Clift","year":"1992","unstructured":"Clift RA, Buckner CD, Appelbaum FR, Schoch G, Petersen FB, Bensinger WI et al. Allogeneic marrow transplantation during untreated first relapse of acute myeloid leukemia. J Clin Oncol 1992; 10: 1723\u20131729.","journal-title":"J Clin Oncol"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1705811.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1705811","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1705811.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:46:37Z","timestamp":1648082797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1705811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,13]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["BF1705811"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1705811","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,13]]},"assertion":[{"value":"13 March 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}