{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:18:05Z","timestamp":1770481085831,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T00:00:00Z","timestamp":1193616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T00:00:00Z","timestamp":1193616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1038\/sj.bmt.1705897","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T10:43:53Z","timestamp":1193654633000},"page":"239-244","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Blood stem cell mobilization and collection in patients with chronic lymphocytic leukaemia: a nationwide analysis"],"prefix":"10.1038","volume":"41","author":[{"given":"E","family":"Jantunen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"It\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Siitonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kuittinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Heiskanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Koivunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Juvonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Silvennoinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nousiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Koistinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Volin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Remes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,10,29]]},"reference":[{"key":"BF1705897_CR1","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","volume":"343","author":"H D\u00f6hner","year":"2000","unstructured":"D\u00f6hner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberration and survival in chronic lymphocytic leukaemia. N Engl J Med 2000; 343: 1910\u20131916.","journal-title":"N Engl J Med"},{"key":"BF1705897_CR2","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","volume":"94","author":"TJ Hamblin","year":"1999","unstructured":"Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK . Unmutated Ig V\/(H) genes are associated with a more aggressive form of chronic lymphocytic leukaemia. Blood 1999; 94: 1848\u20131854.","journal-title":"Blood"},{"key":"BF1705897_CR3","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1056\/NEJM200012143432402","volume":"343","author":"KR Rai","year":"2000","unstructured":"Rai KR, Peterson BL, Appelbaum FR, Kolitz J, Elias L, Shepherd KL et al. Fludarabine compared with chlorambucil as primary therapy in patients with chronic lymphocyte leukaemia. N Engl J Med 2000; 343: 1750\u20131757.","journal-title":"N Engl J Med"},{"key":"BF1705897_CR4","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1182\/blood-2005-06-2395","volume":"107","author":"BF Eichhorst","year":"2006","unstructured":"Eichhorst BF, Busch R, Hopfinger G, Pasold R, Hensel M, Steinbrecher C et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first line therapy in younger patients with chronic lymphocytic leukaemia. Blood 2006; 107: 885\u2013891.","journal-title":"Blood"},{"key":"BF1705897_CR5","doi-asserted-by":"publisher","first-page":"7024","DOI":"10.1200\/JCO.2005.01.9950","volume":"23","author":"T Elter","year":"2005","unstructured":"Elter T, Borchmann P, Schul H, Reiser M, Trelle S, Schnell R et al. Fludabine combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukaemia: results of a phase II trial. J Clin Oncol 2005; 23: 7024\u20137031.","journal-title":"J Clin Oncol"},{"key":"BF1705897_CR6","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1182\/blood.V99.10.3554","volume":"99","author":"MJ Keating","year":"2002","unstructured":"Keating MJ, Flinn I, Jain V, Binet JL, Hillmen P, Byrd J et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine; results of a large international study. Blood 2002; 99: 3554\u20133561.","journal-title":"Blood"},{"key":"BF1705897_CR7","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1182\/blood-2003-05-1549","volume":"103","author":"P Dreger","year":"2004","unstructured":"Dreger P, Stilgenbauer S, Benner A, Ritgen M, Kr\u00f6ber A, Kneba M et al. The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukaemia: a risk-matched analysis based on the VH gene mutational status. Blood 2004; 103: 2850\u20132858.","journal-title":"Blood"},{"key":"BF1705897_CR8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1182\/blood-2004-01-0298","volume":"105","author":"DW Milligan","year":"2005","unstructured":"Milligan DW, Fernandes S, Dasgupta R, Davies FE, Matutes E, Fegan CD et al. Results of the MRC pilot study show autografting for younger patients with chronic lymphocytic leukemia is safe and achieves a high percentage of molecular responses. Blood 2005; 105: 397\u2013404.","journal-title":"Blood"},{"key":"BF1705897_CR9","doi-asserted-by":"publisher","first-page":"4389","DOI":"10.1182\/blood-2005-05-1778","volume":"106","author":"JG Gribben","year":"2005","unstructured":"Gribben JG, Zahrieh D, Stephans K, Bartlett-Pandite L, Alyea EP, Fisher DC et al. Autologous and allogeneic stem cell transplantation for poor-risk chronic lymphocytic leukemia. Blood 2005; 106: 4389\u20134396.","journal-title":"Blood"},{"key":"BF1705897_CR10","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1038\/sj.bmt.1705375","volume":"37","author":"E Jantunen","year":"2006","unstructured":"Jantunen E, It\u00e4l\u00e4 M, Siitonen T, Juvonen E, Koivunen E, Koistinen P et al. Autologous stem cell transplantation in patients with chronic lymphocytic leukaemia: the Finnish experience. Bone Marrow Transplant 2006; 37: 1093\u20131098.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705897_CR11","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/sj.bmt.1700730","volume":"19","author":"M It\u00e4l\u00e4","year":"1997","unstructured":"It\u00e4l\u00e4 M, Pelliniemi T-T, Rajam\u00e4ki A, Remes K . Autologous blood cell transplantation in B-CLL: response to chemotherapy prior to mobilisation predicts the stem cell yield. Bone Marrow Transplant 1997; 19: 647\u2013651.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705897_CR12","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1182\/blood-2003-05-1449","volume":"103","author":"O Tournilhac","year":"2004","unstructured":"Tournilhac O, Cazin B, Leprerre S, Divine M, Maloum K, Delmer A et al. Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood 2004; 103: 363\u2013365.","journal-title":"Blood"},{"key":"BF1705897_CR13","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990","volume":"87","author":"BD Cheson","year":"1996","unstructured":"Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O'Brien S et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990\u20134997.","journal-title":"Blood"},{"key":"BF1705897_CR14","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/sj.bmt.1701503","volume":"22","author":"R Scime","year":"1998","unstructured":"Scime R, Indovina A, Santoro A, Musso M, Olivieri A, Tringali S et al. PBSC mobilization, collection and positive selection in patients with chronic lymphocytic leukemia. Bone Marrow Transplant 1998; 22: 1159\u20131165.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705897_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/sj.leu.2403190","volume":"18","author":"M Montillo","year":"2004","unstructured":"Montillo M, Tedeschi A, Rossi V, Cairoli R, Pungoline E, Intropido L et al. Successful CD34+ cell mobilization by intermediate-dose Ara-C in chronic lymphocytic leukemia patients treated with sequential fludarabine and Campath-1H. Leukemia 2004; 18: 57\u201362.","journal-title":"Leukemia"},{"issue":"Suppl 1","key":"BF1705897_CR16","first-page":"S7","volume":"39","author":"L Sutton","year":"2007","unstructured":"Sutton L, Genet P, Tournilhac O, Divine M, Leblond V, Martin C et al. PBSC mobilization in CLL patients: impact of previous treatment with fludarabine. Bone Marrow Transplant 2007; 39 (Suppl 1): S7; abstract.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705897_CR17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1046\/j.1365-2141.1998.00960.x","volume":"103","author":"N Ketterer","year":"1998","unstructured":"Ketterer N, Salles G, Moullet I, Dumontet C, ElJaafari-Corbin A, Tremisi P et al. Factors associated with successful mobilisation of peripheral blood progenitor cells in 200 patients with lymphoid malignancies. Br J Haematol 1998; 103: 235\u2013242.","journal-title":"Br J Haematol"},{"key":"BF1705897_CR18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3109\/10428190009057639","volume":"37","author":"D Laszlo","year":"2000","unstructured":"Laszlo D, Galieni P, Raspadori D, Scalia G, Bigazzi C, Bocchia M et al. Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade lymphoma patients. Leuk Lymphoma 2000; 37: 157\u2013161.","journal-title":"Leuk Lymphoma"},{"key":"BF1705897_CR19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/sj.thj.6200061","volume":"1","author":"I Micallef","year":"2000","unstructured":"Micallef I, Apostolidis J, Rohatiner A, Wiggins C, Crawley CR, Foran JM et al. Factors which predict unsuccessful mobilisation of peripheral blood progenitor cells following G-CSF alone in patients with non-Hodgkin's lymphoma. Hematol J 2000; 1: 367\u2013373.","journal-title":"Hematol J"},{"key":"BF1705897_CR20","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1046\/j.1365-2141.2000.01900.x","volume":"108","author":"M Michallet","year":"2000","unstructured":"Michallet M, Thiebaut A, Dreger P, Remes K, Milpied N, Santini G et al. Peripheral blood stem cell (PBSC) mobilisation and transplantation after fludarabine therapy in chronic lymphocytic leukaemia (CLL): a report of the European Blood and Marrow Transplantation (EBMT) CLL subcommittee on behalf of the EBMT Chronic Leukaemias Working Party (CLWP). Br J Haematol 2000; 108: 595\u2013601.","journal-title":"Br J Haematol"},{"key":"BF1705897_CR21","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/s00277-005-1008-6","volume":"84","author":"D Lysak","year":"2005","unstructured":"Lysak D, Koza V, Steinerova K, Jindra P, Vozobulova V, Schutzova M . Mobilization of peripheral blood stem cells in CLL patients after front-line fludarabine treatment. Ann Hematol 2005; 84: 456\u2013461.","journal-title":"Ann Hematol"},{"key":"BF1705897_CR22","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1038\/sj.leu.2401201","volume":"12","author":"L Sutton","year":"1998","unstructured":"Sutton L, Maloum K, Gonzalez H, Zouabi H, Azar N, Boccacio C et al. Autologous hematopoietic stem cell transplantation for advanced B cell chronic lymphocytic leukaemia. Leukemia 1998; 12: 1699\u20131707.","journal-title":"Leukemia"},{"key":"BF1705897_CR23","first-page":"621","volume":"91","author":"J de la Rubia","year":"2006","unstructured":"de la Rubia J, Blade J, Lahuerta JJ, Ribera JM, Martinez R, Alegre A et al. Effect of chemotherapy with alkylating agents on the yield of CD34+ cells in patients with multiple myeloma. Results of the Spanish Myeloma Group (GEM) study. Haematologica 2006; 91: 621\u2013627.","journal-title":"Haematologica"},{"key":"BF1705897_CR24","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/sj.bmt.1705360","volume":"37","author":"E Jantunen","year":"2006","unstructured":"Jantunen E, Kuittinen T, Penttil\u00e4 K, Lehtonen P, Mahlam\u00e4ki E, Nousiainen T . High-dose melphalan (200\u2009mg\/m2) supported by autologous stem cell transplantation is safe and effective in elderly (\u2a7e65 years) myeloma patients: comparison with younger patients treated on the same protocol. Bone Marrow Transplant 2006; 37: 917\u2013922.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705897_CR25","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/sj.bmt.1705308","volume":"37","author":"F Lefrere","year":"2006","unstructured":"Lefrere F, Zohar S, Ghez D, Delarue R, Audat F, Suarez F et al. The VAD chemotherapy regimen plus a G-CSF dose of 10\u2009microg\/kg is as effective and less toxic than high-dose cyclophosphamide plus a G-CSF dose of 5\u2009microg\/kg for progenitor cell mobilization: results from a monocentric study of 82 patients. Bone Marrow Transplant 2006; 37: 725\u2013729.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705897_CR26","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1200\/JCO.1997.15.2.535","volume":"15","author":"MJ Watts","year":"1997","unstructured":"Watts MJ, Sullivan AM, Jamieson E, Pearce R, Fielding A, Devereux S et al. Progenitor cell mobilization after low-dose cyclophosphamide and granulocyte colony-stimulating factor: an analysis of progenitor-cell quantity and quality and factors predicting these parameters in 101 pretreated patients with malignant lymphoma. J Clin Oncol 1997; 15: 535\u2013546.","journal-title":"J Clin Oncol"},{"key":"BF1705897_CR27","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S1083-8791(00)70021-8","volume":"6","author":"KE Stockerl-Goldstein","year":"2000","unstructured":"Stockerl-Goldstein KE, Reddy SA, Horning SF, Blume KG, Chao NF, Hu WW et al. Favourable treatment outcome in non-Hodgkin's lymphoma patients with \u2018poor\u2019 mobilization of peripheral blood progenitor cells. Biol Blood Marrow Transplant 2000; 6: 506\u2013512.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BF1705897_CR28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/sj.bmt.1703653","volume":"30","author":"P Mollee","year":"2002","unstructured":"Mollee P, Pereira D, Nagy T, Song K, Saragosa R, Keating A et al. Cyclophosphamide, etoposide and G-CSF to mobilize peripheral blood stem cells for autologous stem cell transplantation in patients with lymphoma. Bone Marrow Transplant 2002; 30: 273\u2013278.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705897_CR29","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/sj.bmt.1704466","volume":"33","author":"T Kuittinen","year":"2004","unstructured":"Kuittinen T, Nousiainen T, Halonen P, Mahlam\u00e4ki E, Jantunen E . Prediction of mobilisation failure in patients with non-Hodgkin's lymphoma. Bone Marrow Transplant 2004; 33: 907\u2013912.","journal-title":"Bone Marrow Transplant"},{"issue":"Suppl 1","key":"BF1705897_CR30","first-page":"S152","volume":"39","author":"E Jantunen","year":"2007","unstructured":"Jantunen E, Lepp\u00e4 S, Kuittinen T, Keskinen L, Kuittinen O, Mokka M et al. (2007) Cyclophosphamide or disease-specific chemotherapy for progenitor cell mobilisation in patients with relapsed diffuse large B-cell lymphoma. Bone Marrow Transplant 2007; 39 (Suppl 1): S152; abstract.","journal-title":"Bone Marrow Transplant"},{"key":"BF1705897_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/sj.leu.2404441","volume":"21","author":"P Dreger","year":"2007","unstructured":"Dreger P, Corradini P, Kimby E, Michallet M, Milligan D, Schetelig J et al. Indications for allogeneic stem cell transplantation in chronic lymphocyte leukaemia: the EBMT transplant consensus. Leukemia 2007; 21: 12\u201317.","journal-title":"Leukemia"},{"key":"BF1705897_CR32","first-page":"1662","volume":"91","author":"M Brugiatelli","year":"2006","unstructured":"Brugiatelli M, Banini G, Barosi G, Lauria F, Liso V, Marchetti M et al. Management of chronic lymphocytic leukemia: practice guidelines from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation. Haematologica 2006; 91: 1662\u20131673.","journal-title":"Haematologica"},{"key":"BF1705897_CR33","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1182\/blood-2005-02-0468","volume":"106","author":"N Flomenberg","year":"2005","unstructured":"Flomenberg N, Devine SM, DiPersio JF, Liesveld JL, McCarty JM, Rowley SD et al. The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF. Blood 2005; 106: 1867\u20131874.","journal-title":"Blood"},{"issue":"Suppl 1","key":"BF1705897_CR34","first-page":"S41","volume":"39","author":"G Calandra","year":"2007","unstructured":"Calandra G, McCarty J, McGuirk J, Barlogie B, Crocker S-A, Badel K . AMD3100 plus G-CSF mobilizes the majority of non-Hodgkin lymphoma, multiple myeloma and Hodgkin's disease patients who failed prior mobilization with other regimens. Bone Marrow Transplant 2007; 39 (Suppl 1): S41; abstract.","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1705897.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1705897","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1705897.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:39:39Z","timestamp":1648082379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1705897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,29]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["BF1705897"],"URL":"https:\/\/doi.org\/10.1038\/sj.bmt.1705897","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,29]]},"assertion":[{"value":"26 June 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}