{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:28:35Z","timestamp":1759580915699},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1038\/sj.cdd.4400636","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T16:01:06Z","timestamp":1031155266000},"page":"59-69","source":"Crossref","is-referenced-by-count":18,"title":["Micro-environmental factors in the survival of human B-lymphoma cells"],"prefix":"10.1038","volume":"7","author":[{"given":"J M","family":"Levens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C D","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,3,6]]},"reference":[{"key":"BF4400636_CR1","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1126\/science.281.5381.1317","volume":"281","author":"G Evan","year":"1998","unstructured":"Evan G and Littlewood T . 1998 A matter of life and cell death. Science 281: 1317\u20131322","journal-title":"Science"},{"key":"BF4400636_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0092-8674(92)90123-T","volume":"69","author":"GI Evan","year":"1992","unstructured":"Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ and Hancock DC . 1992 Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119\u2013128.","journal-title":"Cell"},{"key":"BF4400636_CR3","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1002\/j.1460-2075.1994.tb06630.x","volume":"13","author":"EA Harrington","year":"1994","unstructured":"Harrington EA, Bennett MR, Fanidi A and Evan GI . 1994 C-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13: 3286\u20133295","journal-title":"EMBO J."},{"key":"BF4400636_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0065-230X(08)60470-4","volume":"55","author":"I Magrath","year":"1990","unstructured":"Magrath I . 1990 The pathogenesis of Burkitt's lymphoma. Adv. Cancer Res. 55: 133\u2013270","journal-title":"Adv. Cancer Res."},{"key":"BF4400636_CR5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4049\/jimmunol.139.1.313","volume":"139","author":"CD Gregory","year":"1987","unstructured":"Gregory CD, Tursz T, Edwards CF, Tetaud C, Talbot M, Caillou B, Rickinson AB and Lipinski M . 1987 Identification of a subset of normal B cells with a Burkitt's-lymphoma (BL)-like phenotype. J. Immunol. 139: 313\u2013318","journal-title":"J. Immunol."},{"key":"BF4400636_CR6","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1182\/blood.V88.9.3562.bloodjournal8893562","volume":"88","author":"CJ Chapman","year":"1996","unstructured":"Chapman CJ, Zhou JX, Gregory C, Rickinson AB and Stevenson FK . 1996 VH and VL gene analysis in sporadic Burkitts lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection. Blood 88: 3562\u20133568","journal-title":"Blood"},{"key":"BF4400636_CR7","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1002\/j.1460-2075.1987.tb02568.x","volume":"6","author":"M Rowe","year":"1987","unstructured":"Rowe M, Rowe DT, Gregory CD, Young LS, Farrell PJ, Rupani H and Rickinson AB . 1987 Differences in B-cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt lymphoma cells. EMBO J. 6: 2743\u20132751","journal-title":"EMBO J."},{"key":"BF4400636_CR8","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1099\/0022-1317-71-7-1481","volume":"71","author":"CD Gregory","year":"1990","unstructured":"Gregory CD, Rowe M and Rickinson AB . 1990 Different Epstein-Barr virus-B- cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line. J. Gen. Virol. 71: 1481\u20131495","journal-title":"J. Gen. Virol."},{"key":"BF4400636_CR9","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1002\/eji.1830210819","volume":"21","author":"YJ Liu","year":"1991","unstructured":"Liu YJ, Mason DY, Johnson GD, Abbot S, Gregory CD, Hardie DL, Gordon J and Maclennan ICM . 1991 Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur. J. Immunol. 21: 1905\u20131910","journal-title":"Eur. J. Immunol."},{"key":"BF4400636_CR10","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/0092-8674(91)90007-L","volume":"65","author":"S Henderson","year":"1991","unstructured":"Henderson S, Rowe M, Gregory C, Croom-Carter D, Wang F, Longnecker R, Kieff E and Rickinson A . 1991 Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 65: 1107\u20131115","journal-title":"Cell"},{"key":"BF4400636_CR11","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/349612a0","volume":"349","author":"CD Gregory","year":"1991","unstructured":"Gregory CD, Dive C, Henderson S, Smith CA, Williams GT, Gordon J and Rickinson AB . 1991 Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature 349: 612\u2013614","journal-title":"Nature"},{"key":"BF4400636_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1146\/annurev.iy.12.040194.001001","volume":"12","author":"ICM Maclennan","year":"1994","unstructured":"Maclennan ICM . 1994 Germinal-centers. Annu. Rev. Immunol. 12: 117\u2013139","journal-title":"Annu. Rev. Immunol."},{"key":"BF4400636_CR13","first-page":"3385","volume":"8","author":"AE Milner","year":"1993","unstructured":"Milner AE, Grand RJA, Waters CM and Gregory CD . 1993 Apoptosis in Burkitt lymphoma cells is driven by c-myc. Oncogene 8: 3385\u20133391","journal-title":"Oncogene"},{"key":"BF4400636_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/1097-0142(196103\/04)14:2<270::AID-CNCR2820140207>3.0.CO;2-Q","volume":"14","author":"GT O'Conor","year":"1961","unstructured":"O'Conor GT . 1961 Malignant lymphoma in African children. II. Pathological entity. Cancer 14: 270\u2013283","journal-title":"Cancer"},{"key":"BF4400636_CR15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/bjc.1963.8","volume":"17","author":"MA Epstein","year":"1963","unstructured":"Epstein MA and Herdson PB . 1963 Cellular degeneration associated with characteristic nuclear fine structure changes in the cells from two cases of Burkitt's malignant lymphoma syndrome. Br. J. Cancer 17: 56\u201358","journal-title":"Br. J. Cancer"},{"key":"BF4400636_CR16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/0014-2964(66)90052-1","volume":"2","author":"EH Cooper","year":"1966","unstructured":"Cooper EH, Frank GL and Wright DH . 1966 Cell proliferation in Burkitt tumours. Eur J. Cancer 2: 377\u2013384","journal-title":"Eur J. Cancer"},{"key":"BF4400636_CR17","first-page":"601","volume":"40","author":"C Berard","year":"1969","unstructured":"Berard C, O'Conor GT, Thomas LB and Torloni H . 1969 Histopathological definition of Burkitt's tumour. Bull. World Health Org. 40: 601\u2013607","journal-title":"Bull. World Health Org."},{"key":"BF4400636_CR18","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/sj.cdd.4400241","volume":"4","author":"SM Van den Eijnde","year":"1997","unstructured":"Van den Eijnde SM, Boshart L, Reutelingsperger CPM, De Zeeuw CI and Vermeij-Keers C . 1997 Phosphatidylserine plasma membrane asymmetry in vivo: A pancellular phenomenon which alters during apoptosis. Cell Death Differ. 4: 311\u2013316","journal-title":"Cell Death Differ."},{"key":"BF4400636_CR19","unstructured":"Savill J. . The innate immune system: recognition of apoptotic cells. In: Gregory CD (ed) Apoptosis and the Immune Response. New York: Wiley-Liss 1995 pp. 341\u2013369"},{"key":"BF4400636_CR20","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/ijc.2910570321","volume":"57","author":"CD Gregory","year":"1994","unstructured":"Gregory CD and Milner AE . 1994 Regulation of cell survival in Burkitt lymphoma: Implications from studies of apoptosis following cold-shock treatment. Int. J. Cancer 57: 419\u2013426","journal-title":"Int. J. Cancer"},{"key":"BF4400636_CR21","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1172\/JCI1112","volume":"101","author":"VA Fadok","year":"1998","unstructured":"Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY and Henson PM . 1998 Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-\u03b2, PGE2, and PAF. J. Clin. Invest. 101: 890\u2013898","journal-title":"J. Clin. Invest."},{"key":"BF4400636_CR22","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.4049\/jimmunol.153.7.2951","volume":"153","author":"H-S Kim","year":"1994","unstructured":"Kim H-S, Zhang XH and Choi YS . 1994 Activation and proliferation of follicular dendritic cell-like cells by activated T lymphocytes. J. Immunol. 153: 2951\u20132961","journal-title":"J. Immunol."},{"key":"BF4400636_CR23","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1093\/jnci\/77.3.681","volume":"77","author":"CM Rooney","year":"1986","unstructured":"Rooney CM, Gregory CD, Rowe M, Finerty S, Edwards C, Rupani H and Rickinson AB . 1986 Endemic Burkitt's lymphoma\u2013phenotypic analysis of tumor biopsy cells and of derived tumor cell lines. J. Natl. Cancer Inst. 77: 681\u2013687","journal-title":"J. Natl. Cancer Inst."},{"key":"BF4400636_CR24","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1084\/jem.182.5.1265","volume":"182","author":"P Garrone","year":"1995","unstructured":"Garrone P, Neidhardt EM, Garcia E, Galibert L, Vankooten C and Vanchereau J . 1995 Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J Exp. Med. 182: 1265\u20131273","journal-title":"J Exp. Med."},{"key":"BF4400636_CR25","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1002\/eji.1830241109","volume":"24","author":"PK Flora","year":"1994","unstructured":"Flora PK and Gregory CD . 1994 Recognition of apoptotic cells by human macrophages\u2013inhibition by a monocyte\/macrophage-specific monoclonal antibody. Eur. J. Immunol. 24: 2625\u20132632","journal-title":"Eur. J. Immunol."},{"key":"BF4400636_CR26","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1002\/eji.1830260941","volume":"26","author":"PK Flora","year":"1996","unstructured":"Flora PK, Devitt A, Johnson GD, Milner AE and Gregory CD . 1996 Bcl-2 delays macrophage engulfment of human B cells induced to undergo apoptosis. Eur. J. Immunol. 26: 2243\u20132247","journal-title":"Eur. J. Immunol."},{"key":"BF4400636_CR27","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/33169","volume":"392","author":"A Devitt","year":"1998","unstructured":"Devitt A, Moffatt OD, Raykundalia C, Capra JD, Simmons DL and Gregory CD . 1998 Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 392: 505\u2013509","journal-title":"Nature"},{"key":"BF4400636_CR28","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0065-230X(08)60484-4","volume":"56","author":"J Gordon","year":"1991","unstructured":"Gordon J and Cairns JA . 1991 Autocrine regulation of normal and malignant B lymphocytes. Adv. Cancer Res. 56: 313\u2013334","journal-title":"Adv. Cancer Res."},{"key":"BF4400636_CR29","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/358505a0","volume":"358","author":"JP Aubry","year":"1992","unstructured":"Aubry JP, Pochon S, Graber P, Jansen KU and Bonnefoy JY . 1992 CD21 is a ligand for CD23 and regulates IgE production. Nature 358: 505\u2013507","journal-title":"Nature"},{"key":"BF4400636_CR30","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1002\/eji.1830230432","volume":"23","author":"JY Bonnefoy","year":"1993","unstructured":"Bonnefoy JY, Henchoz S, Hardie D, Holder MJ and Gordon J . 1993 A subset of anti-CD21 antibodies promote the rescue of germinal center b-cells from apoptotis. Eur. J. Immunol. 23: 969\u2013972","journal-title":"Eur. J. Immunol."},{"key":"BF4400636_CR31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1182\/blood.V90.1.234","volume":"90","author":"LJ White","year":"1997","unstructured":"White LJ, Ozanne BW, Graber P, Aubry JP, Bonnefoy JY and Cushley W . 1997 Inhibition of apoptosis in a human pre-B-cell line by CD23 is mediated via a novel receptor. Blood 90: 234\u2013243","journal-title":"Blood"},{"key":"BF4400636_CR32","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.4049\/jimmunol.154.10.4996","volume":"154","author":"AC Grammer","year":"1995","unstructured":"Grammer AC, Bergman MC, Miura Y, Fujita K, Davis LS and Lipsky PE . 1995 The CD40 ligand expressed by human B cells costimulates B-cell responses. J. Immunol. 154: 4996\u20135010","journal-title":"J. Immunol."},{"key":"BF4400636_CR33","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/ijc.2910520424","volume":"52","author":"AE Milner","year":"1992","unstructured":"Milner AE, Johnson GD and Gregory CD . 1992 Prevention of programmed cell death in Burkitt lymphoma cell lines by bcl-2-dependent and bcl-2-independent mechanisms. Int. J. Cancer 52: 636\u2013644","journal-title":"Int. J. Cancer"},{"key":"BF4400636_CR34","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/bjc.1963.7","volume":"17","author":"DH Wright","year":"1963","unstructured":"Wright DH . 1963 Cytology and histochemistry of the Burkitt lymphoma. Br. J. Cancer 17: 50\u201355","journal-title":"Br. J. Cancer"},{"key":"BF4400636_CR35","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1002\/eji.1830230948","volume":"23","author":"MJ Holder","year":"1993","unstructured":"Holder MJ, Wang H, Milner AE, Casamayor M, Armitage R, Spriggs MK, Fanslow WC, MacLennan ICM, Gregory CD and Gordon J . 1993 Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction. Eur. J. Immunol. 23: 2368\u20132371","journal-title":"Eur. J. Immunol."},{"key":"BF4400636_CR36","first-page":"1939","volume":"57","author":"A Walker","year":"1997","unstructured":"Walker A, Taylor ST, Hickman JA and Dive C . 1997 Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells. Cancer Res. 57: 1939\u20131945","journal-title":"Cancer Res."},{"key":"BF4400636_CR37","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1182\/blood.V92.8.2830","volume":"92","author":"MP Baker","year":"1998","unstructured":"Baker MP, Eliopoulos AG, Young LS, Armitage RJ, Gregory CD and Gordon J . 1998 Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand. Blood 92: 2830\u20132843","journal-title":"Blood"},{"key":"BF4400636_CR38","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1084\/jem.182.5.1557","volume":"182","author":"EJ Schattner","year":"1995","unstructured":"Schattner EJ, Elkon KB, Yoo DH, Tumang J, Krammer PH, Crow MK and Friedman SM . 1995 CD40 ligation induces Apo-1\/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1\/Fas pathway. J. Exp. Med. 182: 1557\u20131565","journal-title":"J. Exp. Med."},{"key":"BF4400636_CR39","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1002\/(SICI)1521-4141(199910)29:10<3236::AID-IMMU3236>3.0.CO;2-T","volume":"29","author":"N McCloskey","year":"1999","unstructured":"McCloskey N, Pound JD, Holder MJ, Williams JM, Roberts LM, Lord JM and Gordon J . 1999 The extrafollicular-to-follicular transition of human B lymphocytes: induction of functional globotriaosylceramide (CD77) on high threshold occupancy of CD40. Eur. J. Immunol. 29: 3236\u20133244","journal-title":"Eur. J. Immunol."},{"key":"BF4400636_CR40","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/ijc.2910550327","volume":"55","author":"MH Falk","year":"1993","unstructured":"Falk MH, Hultner L, Milner A, Gregory CD and Bornkamm GW . 1993 Irradiated fibroblasts protect Burkitt-lymphoma cells from apoptosis by a mechanism independent of bcl-2. Int. J. Cancer 55: 485\u2013491","journal-title":"Int. J. Cancer"},{"key":"BF4400636_CR41","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1002\/(SICI)1097-0215(19980209)75:4<620::AID-IJC21>3.0.CO;2-B","volume":"75","author":"MH Falk","year":"1998","unstructured":"Falk MH, Meier T, Issels RD, Brielmeier M, Scheffer B and Bornkamm GW . 1998 Apoptosis in Burkitt lymphoma cells is prevented by promotion of cysteine uptake. Int. J. Cancer 75: 620\u2013625","journal-title":"Int. J. Cancer"},{"key":"BF4400636_CR42","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.4049\/jimmunol.153.7.3218","volume":"153","author":"SE Hall","year":"1994","unstructured":"Hall SE, Savill JS, Henson PM and Haslett C . 1994 Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose\/fucose-specific lectin. J. Immunol. 153: 3218\u20133227","journal-title":"J. Immunol."},{"key":"BF4400636_CR43","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/37022","volume":"390","author":"RE Voll","year":"1997","unstructured":"Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR and Girkontaite I . 1997 Immunosuppressive effects of apoptotic cells. Nature 390: 350\u2013351","journal-title":"Nature"},{"key":"BF4400636_CR44","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1182\/blood.V87.3.1147.bloodjournal8731147","volume":"87","author":"I Macdonald","year":"1996","unstructured":"Macdonald I, Wang H, Grand R, Armitage RJ, Fanslow WC, Gregory CD and Gordon J . 1996 Transforming growth factor-\u03b21 cooperates with anti-immunoglobulin for the induction of apoptosis in group I (biopsy-like) Burkitt lymphoma cell lines. Blood 87: 1147\u20131154","journal-title":"Blood"},{"key":"BF4400636_CR45","doi-asserted-by":"crossref","first-page":"998","DOI":"10.4049\/jimmunol.147.3.998","volume":"147","author":"A Kumar","year":"1991","unstructured":"Kumar A, Rogers T, Maizel A and Sharma S . 1991 Loss of transforming growth factor beta-1 receptors and its effects on the growth of EBV-transformed human B cells. J. Immunol. 147: 998\u20131006","journal-title":"J. Immunol."},{"key":"BF4400636_CR46","first-page":"460","volume":"76","author":"W Piacebello","year":"1991","unstructured":"Piacebello W, Severino A, Stacchini A and Aglietta M . 1991 Differential effect of transforming growth factor-beta-1 on the proliferation of human lymphoid and myeloid-leukemia cells. Haematologica 76: 460\u2013466","journal-title":"Haematologica"},{"key":"BF4400636_CR47","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1038\/sj.onc.1201355","volume":"15","author":"AE Milner","year":"1997","unstructured":"Milner AE, Grand RJA, Vaughan ATM, Armitage RJ and Gregory CD . 1997 Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following gamma-irradiation. Oncogene 15: 1815\u20131822","journal-title":"Oncogene"},{"key":"BF4400636_CR48","first-page":"373","volume":"13","author":"H Wang","year":"1997","unstructured":"Wang H, Grand RJA, Milner AE, Armitage RJ, Gordon J and Gregory CD . 1997 Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2: relationship to the cell-cycle and role of the retinoblastoma protein. Oncogene 13: 373\u2013379","journal-title":"Oncogene"},{"key":"BF4400636_CR49","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0167-4889(92)90048-G","volume":"1133","author":"C Dive","year":"1992","unstructured":"Dive C, Gregory CD, Phipps DJ, Evans DL, Milner AE and Wyllie AH . 1992 Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim. Biophys. Acta 1133: 275\u2013285","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4400636.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4400636","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4400636.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:15:03Z","timestamp":1684368903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4400636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["BF4400636"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4400636","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}