{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:44:50Z","timestamp":1790783090079,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2002,8,16]],"date-time":"2002-08-16T00:00:00Z","timestamp":1029456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1038\/sj.cdd.4401056","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T00:15:48Z","timestamp":1032308148000},"page":"956-962","source":"Crossref","is-referenced-by-count":77,"title":["Deoxyribonuclease II\u03b1 is required during the phagocytic phase of apoptosis and its loss causes perinatal lethality"],"prefix":"10.1038","volume":"9","author":[{"given":"R J","family":"Krieser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K S","family":"MacLea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Longnecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Fields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fiering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Eastman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,8,16]]},"reference":[{"key":"BF4401056_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/bjc.1972.33","volume":"26","author":"JFR Kerr","year":"1972","unstructured":"Kerr JFR, Wyllie AH, Currie AR . 1972 Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics Br. J. Cancer 26: 239\u2013257","journal-title":"Br. J. Cancer"},{"key":"BF4401056_CR2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0092-8674(00)81334-3","volume":"87","author":"ES Alnemri","year":"1996","unstructured":"Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J . 1996 Human ICE\/CED-3 protease nomenclature Cell 87: 171","journal-title":"Cell"},{"key":"BF4401056_CR3","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/0092-8674(94)90506-1","volume":"76","author":"MO Hengartner","year":"1994","unstructured":"Hengartner MO, Horvitz HR . 1994 C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2 Cell 76: 665\u2013676","journal-title":"Cell"},{"key":"BF4401056_CR4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/34112","volume":"391","author":"M Enari","year":"1998","unstructured":"Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S . 1998 A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Nature 391: 43\u201350","journal-title":"Nature"},{"key":"BF4401056_CR5","first-page":"1","volume":"1","author":"MC Peitsch","year":"1994","unstructured":"Peitsch MC, Polzar B, Tschopp J, Mannherz HG . 1994 About the involvement of deoxyribonuclease I in apoptosis Cell Death Different 1: 1\u20136","journal-title":"Cell Death Different"},{"key":"BF4401056_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/34214","volume":"391","author":"H Sakahira","year":"1998","unstructured":"Sakahira H, Enari M, Nagata S . 1998 Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis Nature 391: 96\u201399","journal-title":"Nature"},{"key":"BF4401056_CR7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1101\/gad.14.5.549","volume":"14","author":"D McIlroy","year":"2000","unstructured":"McIlroy D, Tanaka M, Sakahira H, Fukuyama H, Suzuki M, Yamamura K, Ohsawa Y, Uchiyama Y, Nagata S . 2000 An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes Genes & Dev. 14: 549\u2013558","journal-title":"Genes & Dev."},{"key":"BF4401056_CR8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1006\/bbrc.2000.3122","volume":"274","author":"J Zhang","year":"2000","unstructured":"Zhang J, Lee H, Lou DW, Bovin GP, Xu M . 2000 Lack of obvious 50 kilobase pair DNA fragments in DNA fragmentation factor 45-deficient thymocytes upon activation of apoptosis Biochem. Biophys. Res. Commun. 274: 225\u2013229","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF4401056_CR9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/76032","volume":"25","author":"M Napirei","year":"2000","unstructured":"Napirei M, Karsunky H, Zevnik B, Stephan H, Mannherz HG, Moroy T . 2000 Features of systemic lupus erythematosus in DNase1-deficient mice Nature Genet. 25: 177\u2013181","journal-title":"Nature Genet."},{"key":"BF4401056_CR10","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1006\/abbi.1993.1060","volume":"300","author":"MA Barry","year":"1993","unstructured":"Barry MA, Eastman A . 1993 Identification of deoxyribonuclease II as an endonuclease involved in apoptosis Arch. Biochem. Biophys. 300: 440\u2013450","journal-title":"Arch. Biochem. Biophys."},{"key":"BF4401056_CR11","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/0006-291X(92)90814-2","volume":"186","author":"MA Barry","year":"1992","unstructured":"Barry MA, Eastman A . 1992 Endonuclease activation during apoptosis: the role of cytosolic Ca2+ and pH Biochem. Biophys. Res. Commun. 186: 782\u2013789","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF4401056_CR12","doi-asserted-by":"publisher","first-page":"30909","DOI":"10.1074\/jbc.273.47.30909","volume":"273","author":"RJ Krieser","year":"1998","unstructured":"Krieser RJ, Eastman A . 1998 The cloning and expression of human deoxyribonuclease II: a possible role in apoptosis J. Biol. Chem. 273: 30909\u201330914","journal-title":"J. Biol. Chem."},{"key":"BF4401056_CR13","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0378-1119(00)00209-2","volume":"252","author":"RJ Krieser","year":"2000","unstructured":"Krieser RJ, Eastman A . 2000 Structure and chromosomal localization of the murine deoxyribonuclease II gene Gene 252: 155\u2013162","journal-title":"Gene"},{"key":"BF4401056_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0378-1119(01)00434-6","volume":"269","author":"RJ Krieser","year":"2001","unstructured":"Krieser RJ, MacLea KS, Park JP, Eastman A . 2001 The cloning, genomic structure, localization, and expression of human deoxyribonuclease II\u03b2 Gene 269: 205\u2013216","journal-title":"Gene"},{"key":"BF4401056_CR15","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1101\/gad.14.5.536","volume":"14","author":"YC Wu","year":"2000","unstructured":"Wu YC, Stanfield GM, Horvitz HR . 2000 NUC-1, a Caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis Genes & Dev. 14: 536\u2013548","journal-title":"Genes & Dev."},{"key":"BF4401056_CR16","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.1093\/nar\/27.20.4083","volume":"27","author":"D Shiokawa","year":"1999","unstructured":"Shiokawa D, Tanuma S . 1999 DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II Nucleic Acids Res. 27: 4083\u20134089","journal-title":"Nucleic Acids Res."},{"key":"BF4401056_CR17","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1126\/science.292.5521.1546","volume":"292","author":"K Kawane","year":"2001","unstructured":"Kawane K, Fukuyama H, Kondoh G, Takeda J, Ohsawa Y, Uchiyama Y, Nagata S . 2001 Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver Science 292: 1546\u20131549","journal-title":"Science"},{"key":"BF4401056_CR18","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1046\/j.1460-9568.1999.00477.x","volume":"11","author":"SM van den Eijnde","year":"1999","unstructured":"van den Eijnde SM, Lips J, Boshart L, Vermeij-Keers C, Marani E, Reutelingsperger CPM, De Zeeuw CI . 1999 Spatiotemporal distribution of dying neurons during early mouse development Eur. J. Neuroscience 11: 712\u2013724","journal-title":"Eur. J. Neuroscience"},{"key":"BF4401056_CR19","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1242\/dev.127.24.5245","volume":"127","author":"W Wood","year":"2000","unstructured":"Wood W, Turmaine M, Weber R, Camp V, Maki RA, McKercher SR, Martin P . 2000 Mesenchymal cells engulf and clear apoptotic footplate cells in macrophageless PU.1 null mouse embryos Development 127: 5245\u20135252","journal-title":"Development"},{"key":"BF4401056_CR20","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1074\/jbc.270.7.3203","volume":"270","author":"J Li","year":"1995","unstructured":"Li J, Eastman A . 1995 Apoptosis in an IL-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification: role of the Na+\/H+-antiport J. Biol. Chem. 270: 3203\u20133211","journal-title":"J. Biol. Chem."},{"key":"BF4401056_CR21","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/(SICI)1097-0320(19961201)25:4<349::AID-CYTO6>3.0.CO;2-8","volume":"25","author":"JE Reynolds","year":"1996","unstructured":"Reynolds JE, Li J, Eastman A . 1996 Detection of apoptosis by flow cytometry of cells simultaneously stained for intracellullar pH (carboxy SNARF-1) and membrane permeability (Hoechst 33342) Cytometry 25: 349\u2013357","journal-title":"Cytometry"},{"key":"BF4401056_CR22","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1002\/(SICI)1097-0185(19991001)256:2<208::AID-AR12>3.0.CO;2-R","volume":"256","author":"E Abdelwahid","year":"1999","unstructured":"Abdelwahid E, Pelliniemi LJ, Niinikoski H, Simell O, Tuominen J, Rahkonen O, Jokinen E . 1999 Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis Anat. Record 256: 208\u2013217","journal-title":"Anat. Record"},{"key":"BF4401056_CR23","doi-asserted-by":"publisher","first-page":"18857","DOI":"10.1074\/jbc.274.27.18857","volume":"274","author":"P Navarro","year":"1999","unstructured":"Navarro P, Valverde AM, Benito M, Lorenzo M . 1999 Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner J. Biol. Chem. 274: 18857\u201318863","journal-title":"J. Biol. Chem."},{"key":"BF4401056_CR24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1023\/A:1009692902805","volume":"5","author":"H-M Lorenz","year":"2000","unstructured":"Lorenz H-M, Herrmann M, Winkler T, Gaipl U, Kalden JR . 2000 Role of apoptosis in autoimmunity Apoptosis 5: 443\u2013449","journal-title":"Apoptosis"},{"key":"BF4401056_CR25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1006\/jaut.2000.0381","volume":"15","author":"S Schmidt-Acevedo","year":"2000","unstructured":"Schmidt-Acevedo S, Perez-Romano B, Ruiz-Arg\u00fcelles A . 2000 \u2018LE Cells\u2019 result from phagocytosis of apoptotic bodies induced by antinuclear antibodies J. Autoimmun. 15: 15\u201320","journal-title":"J. Autoimmun."},{"key":"BF4401056_CR26","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1006\/abio.1997.2496","volume":"255","author":"T Yasuda","year":"1998","unstructured":"Yasuda T, Takeshita H, Nakazato E, Nakajima T, Hosomi O, Nakashima Y, Kishi K . 1998 Activity measurement for deoxyribonucleases I and II with picogram sensitivity based on DNA\/SYBR Green I fluorescence Anal. Biochem. 255: 274\u2013276","journal-title":"Anal. Biochem."}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4401056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401056","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:19:11Z","timestamp":1684369151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4401056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,16]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["BF4401056"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4401056","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,16]]}}}