{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:21:20Z","timestamp":1791530480182,"version":"4.3.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2004,1,16]],"date-time":"2004-01-16T00:00:00Z","timestamp":1074211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1038\/sj.cdd.4401372","type":"journal-article","created":{"date-parts":[[2004,1,16]],"date-time":"2004-01-16T03:10:28Z","timestamp":1074222628000},"page":"468-478","source":"Crossref","is-referenced-by-count":26,"title":["A cytosolic source of calcium unveiled by hydrogen peroxide with relevance for epithelial cell death"],"prefix":"10.1038","volume":"11","author":[{"given":"J","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C X","family":"Bittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Humeres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V P","family":"Montecinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L F","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,1,16]]},"reference":[{"key":"BF4401372_CR1","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1074\/jbc.274.2.833","volume":"274","author":"PS Herson","year":"1999","unstructured":"Herson PS, Lee K, Pinnock RD, Hughes J and Ashford ML (1999) Hydrogen peroxide induces intracellular calcium overload by activation of a non-selective cation channel in an insulin-secreting cell line. J. Biol. Chem. 274: 833\u2013841","journal-title":"J. Biol. Chem."},{"key":"BF4401372_CR2","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S1095-6433(01)00438-X","volume":"130","author":"LF Barros","year":"2001","unstructured":"Barros LF, Hermosilla T and Castro J (2001) Necrotic volume increase and the early physiology of necrosis. Comp. Biochem. Physiol. A 130: 401\u2013409","journal-title":"Comp. Biochem. Physiol. A"},{"key":"BF4401372_CR3","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1152\/physrev.1999.79.2.609","volume":"79","author":"R Bolli","year":"1999","unstructured":"Bolli R and Marban E (1999) Molecular and cellular mechanisms of myocardial stunning. Physiol. Rev. 79: 609\u2013634","journal-title":"Physiol. Rev."},{"key":"BF4401372_CR4","doi-asserted-by":"publisher","first-page":"A7","DOI":"10.1038\/399a007","volume":"399","author":"JM Lee","year":"1999","unstructured":"Lee JM, Zipfel GJ and Choi DW (1999) The changing landscape of ischaemic brain injury mechanisms. Nature 399: A7\u201314","journal-title":"Nature"},{"key":"BF4401372_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1172\/JCI12035","volume":"109","author":"JS Braun","year":"2002","unstructured":"Braun JS, Sublett JE, Freyer D, Mitchell TJ, Cleveland JL, Tuomanen EI and Weber JR (2002) Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J. Clin. Invest. 109: 19\u201327","journal-title":"J. Clin. Invest."},{"key":"BF4401372_CR6","first-page":"824","volume":"56","author":"L Virag","year":"1999","unstructured":"Virag L, Scott GS, Antal-Szalmas P, O'Connor M, Ohshima H and Szabo C (1999) Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity. Mol. Pharmacol. 56: 824\u2013833","journal-title":"Mol. Pharmacol."},{"key":"BF4401372_CR7","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/1577","volume":"1","author":"AK Stout","year":"1998","unstructured":"Stout AK, Raphael HM, Kanterewicz BI, Klann E and Reynolds IJ (1998) Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat. Neurosci. 1: 366\u2013373","journal-title":"Nat. Neurosci."},{"key":"BF4401372_CR8","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1002\/hep.510290521","volume":"29","author":"AM Byrne","year":"1999","unstructured":"Byrne AM, Lemasters JJ and Nieminen AL (1999) Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced by tert-butylhydroperoxide in rat hepatocytes. Hepatology 29: 1523\u20131531","journal-title":"Hepatology"},{"key":"BF4401372_CR9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1242\/jcs.115.3.485","volume":"115","author":"JV Gerasimenko","year":"2002","unstructured":"Gerasimenko JV, Gerasimenko OV, Palejwala A, Tepikin AV, Petersen OH and Watson AJ (2002) Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore. J. Cell Sci. 115: 485\u2013497","journal-title":"J. Cell Sci."},{"key":"BF4401372_CR10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S1097-2765(01)00438-5","volume":"9","author":"Y Hara","year":"2002","unstructured":"Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K and Mori Y (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol. Cell 9: 163\u2013173","journal-title":"Mol. Cell"},{"key":"BF4401372_CR11","first-page":"F214","volume":"263","author":"N Ueda","year":"1992","unstructured":"Ueda N and Shah SV (1992) Role of intracellular calcium in hydrogen peroxide-induced renal tubular cell injury. Am. J. Physiol. 263: F214\u2013F221","journal-title":"Am. J. Physiol."},{"key":"BF4401372_CR12","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0003-9861(92)90671-I","volume":"297","author":"A Roveri","year":"1992","unstructured":"Roveri A, Coassin M, Maiorino M, Zamburlini A, van Amsterdam FT, Ratti E and Ursini F (1992) Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells. Arch. Biochem. Biophys. 297: 265\u2013270","journal-title":"Arch. Biochem. Biophys."},{"key":"BF4401372_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s002320010034","volume":"179","author":"JA Pariente","year":"2001","unstructured":"Pariente JA, Camello C, Camello PJ and Salido GM (2001) Release of calcium from mitochondrial and nonmitochondrial intracellular stores in mouse pancreatic acinar cells by hydrogen peroxide. J. Membr. Biol. 179: 27\u201335","journal-title":"J. Membr. Biol."},{"key":"BF4401372_CR14","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1053\/jhep.2001.20530","volume":"33","author":"LF Barros","year":"2001","unstructured":"Barros LF, Stutzin A, Calixto A, Catal\u00e1n M, Castro J, Hetz C and Hermosilla T (2001) Non-selective cation channels as effectors of free radical-induced rat liver cell necrosis. Hepatology 33: 114\u2013122","journal-title":"Hepatology"},{"key":"BF4401372_CR15","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S0161-5890(01)00108-0","volume":"38","author":"G Ermak","year":"2002","unstructured":"Ermak G and Davies KJ (2002) Calcium and oxidative stress: from cell signaling to cell death. Mol. Immunol. 38: 713\u2013721","journal-title":"Mol. Immunol."},{"key":"BF4401372_CR16","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/S0891-5849(00)00241-0","volume":"28","author":"H Wang","year":"2000","unstructured":"Wang H and Joseph JA (2000) Mechanisms of hydrogen peroxide-induced calcium dysregulation in PC12 cells. Free Radic. Biol. Med. 28: 1222\u20131231","journal-title":"Free Radic. Biol. Med."},{"key":"BF4401372_CR17","doi-asserted-by":"publisher","first-page":"26411","DOI":"10.1074\/jbc.M101101200","volume":"276","author":"TJ Collins","year":"2001","unstructured":"Collins TJ, Lipp P, Berridge MJ and Bootman MD (2001) Mitochondrial Ca(2+) uptake depends on the spatial and temporal profile of cytosolic Ca(2+) signals. J. Biol. Chem. 276: 26411\u201326420","journal-title":"J. Biol. Chem."},{"key":"BF4401372_CR18","doi-asserted-by":"publisher","first-page":"5298","DOI":"10.1093\/emboj\/17.18.5298","volume":"17","author":"P Pinton","year":"1998","unstructured":"Pinton P, Pozzan T and Rizzuto R (1998) The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum. EMBO J. 17: 5298\u20135308","journal-title":"EMBO J."},{"key":"BF4401372_CR19","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1126\/science.280.5370.1763","volume":"280","author":"R Rizzuto","year":"1998","unstructured":"Rizzuto R, Pinton P, Carrington W, Fay FS, Fogarty KE, Lifshitz LM, Tuft RA and Pozzan T (1998) Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science 280: 1763\u20131766","journal-title":"Science"},{"key":"BF4401372_CR20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0092-8674(00)80420-1","volume":"91","author":"MD Bootman","year":"1997","unstructured":"Bootman MD, Berridge MJ and Lipp P (1997) Cooking with calcium: the recipes for composing global signals from elementary events. Cell 91: 367\u2013373","journal-title":"Cell"},{"key":"BF4401372_CR21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1046\/j.1471-4159.1998.71010095.x","volume":"71","author":"S Tan","year":"1998","unstructured":"Tan S, Wood M and Maher P (1998) Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J. Neurochem. 71: 95\u2013105","journal-title":"J. Neurochem."},{"key":"BF4401372_CR22","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/sj.cdd.4401236","volume":"10","author":"LF Barros","year":"2003","unstructured":"Barros LF, Kanaseki T, Sabirov R, Morishima S, Castro J, Bittner CX, Maeno E, Ando-akatsuka Y and Okada Y (2003) Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency. Cell Death Differ. 10: 687\u2013697","journal-title":"Cell Death Differ."},{"key":"BF4401372_CR23","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/sj.cdd.4400851","volume":"8","author":"S Gobeil","year":"2001","unstructured":"Gobeil S, Boucher CC, Nadeau D and Poirier GG (2001) Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases. Cell Death Differ. 8: 588\u2013594","journal-title":"Cell Death Differ."},{"key":"BF4401372_CR24","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0021-9258(19)77928-9","volume":"263","author":"PA Hyslop","year":"1988","unstructured":"Hyslop PA, Hinshaw DB, Halsey Jr WA, Schraufstatter IU, Sauerheber RD, Spragg RG, Jackson JH and Cochrane CG (1988) Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J. Biol. Chem. 263: 1665\u20131675","journal-title":"J. Biol. Chem."},{"key":"BF4401372_CR25","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1161\/01.RES.78.4.564","volume":"78","author":"ML Wu","year":"1996","unstructured":"Wu ML, Tsai KL, Wang SM, Wu JC, Wang BS and Lee YT (1996) Mechanism of hydrogen peroxide and hydroxyl free radical-induced intracellular acidification in cultured rat cardiac myoblasts. Circ. Res. 78: 564\u2013572","journal-title":"Circ. Res."},{"key":"BF4401372_CR26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1006\/abbi.1994.1283","volume":"312","author":"GM Bartoli","year":"1994","unstructured":"Bartoli GM, Piccioni E, Agostara G, Calviello G and Palozza P (1994) Different mechanisms of tert-butyl hydroperoxide-induced lethal injury in normal and tumor thymocytes. Arch. Biochem. Biophys. 312: 81\u201387","journal-title":"Arch. Biochem. Biophys."},{"key":"BF4401372_CR27","doi-asserted-by":"publisher","first-page":"40955","DOI":"10.1074\/jbc.M106878200","volume":"276","author":"VH Guaiquil","year":"2001","unstructured":"Guaiquil VH, Vera JC and Golde DW (2001) Mechanism of vitamin C inhibition of cell death induced by oxidative stress in glutathione-depleted HL-60 cells. J. Biol. Chem. 276: 40955\u201340961","journal-title":"J. Biol. Chem."},{"key":"BF4401372_CR28","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1042\/bj20011856","volume":"364","author":"C Le Goffe","year":"2002","unstructured":"Le Goffe C, Vallette G, Charrier L, Candelon T, Bou-Hanna C, Bouhours JF and Laboisse CL (2002) Metabolic control of resistance of human epithelial cells to H2O2 and NO stresses. Biochem. J. 364: 349\u2013359","journal-title":"Biochem. J."},{"key":"BF4401372_CR29","doi-asserted-by":"publisher","first-page":"27694","DOI":"10.1074\/jbc.272.44.27694","volume":"272","author":"MJ Barrero","year":"1997","unstructured":"Barrero MJ, Montero M and Alvarez J (1997) Dynamics of [Ca2+] in the endoplasmic reticulum and cytoplasm of intact HeLa cells. A comparative study. J. Biol. Chem. 272: 27694\u201327699","journal-title":"J. Biol. Chem."},{"key":"BF4401372_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1469-7793.1999.001aa.x","volume":"516","author":"MR Duchen","year":"1999","unstructured":"Duchen MR (1999) Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J. Physiol. 516: 1\u201317","journal-title":"J. Physiol."},{"key":"BF4401372_CR31","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/S0960-9822(07)00565-9","volume":"8","author":"JV Gerasimenko","year":"1998","unstructured":"Gerasimenko JV, Tepikin AV, Petersen OH and Gerasimenko OV (1998) Calcium uptake via endocytosis with rapid release from acidifying endosomes. Curr. Biol. 8: 1335\u20131338","journal-title":"Curr. Biol."},{"key":"BF4401372_CR32","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1242\/jcs.115.3.599","volume":"115","author":"KA Christensen","year":"2002","unstructured":"Christensen KA, Myers JT and Swanson JA (2002) pH-dependent regulation of lysosomal calcium in macrophages. J. Cell Sci. 115: 599\u2013607","journal-title":"J. Cell Sci."},{"key":"BF4401372_CR33","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1042\/bj3560549","volume":"356","author":"F Antunes","year":"2001","unstructured":"Antunes F, Cadenas E and Brunk UT (2001) Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture. Biochem. J. 356: 549\u2013555","journal-title":"Biochem. J."},{"key":"BF4401372_CR34","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1042\/bj3590335","volume":"359","author":"K Kagedal","year":"2001","unstructured":"Kagedal K, Zhao M, Svensson I and Brunk UT (2001) Sphingosine induced apoptosis is dependent on lysosomal proteases. Biochem. J. 359: 335\u2013343","journal-title":"Biochem. J."},{"key":"BF4401372_CR35","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1006\/abbi.1993.1206","volume":"302","author":"DS Kaufman","year":"1993","unstructured":"Kaufman DS, Goligorsky MS, Nord EP and Graber ML (1993) Perturbation of cell pH regulation by H2O2 in renal epithelial cells. Arch. Biochem. Biophys. 302: 245\u2013254","journal-title":"Arch. Biochem. Biophys."},{"key":"BF4401372_CR36","doi-asserted-by":"publisher","first-page":"6512","DOI":"10.1523\/JNEUROSCI.21-17-06512.2001","volume":"21","author":"M Chen","year":"2001","unstructured":"Chen M and Simard JM (2001) Cell swelling and a nonselective cation channel regulated by internal Ca2+ and ATP in native reactive astrocytes from adult rat brain. J. Neurosci. 21: 6512\u20136521","journal-title":"J. Neurosci."},{"key":"BF4401372_CR37","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1042\/bj2970209","volume":"297","author":"TN Doan","year":"1994","unstructured":"Doan TN, Gentry DL, Taylor AA and Elliott SJ (1994) Hydrogen peroxide activates agonist-sensitive Ca(2+)-flux pathways in canine venous endothelial cells. Biochem. J. 297: 209\u2013215","journal-title":"Biochem. J."},{"key":"BF4401372_CR38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0014-5793(97)01456-7","volume":"419","author":"H Sauer","year":"1997","unstructured":"Sauer H, Diedershagen H, Hescheler J and Wartenberg M (1997) Calcium-dependence of hydrogen peroxide-induced c-fos expression and growth stimulation of multicellular prostate tumor spheroids. FEBS Lett. 419: 201\u2013205","journal-title":"FEBS Lett."},{"key":"BF4401372_CR39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1177\/107424849900400107","volume":"4","author":"X Wang","year":"1999","unstructured":"Wang X, Takeda S, Mochizuki S, Jindal R and Dhalla NS (1999) Mechanisms of hydrogen peroxide-induced increase in intracellular calcium in cardiomyocytes. J. Cardiovasc. Pharmacol. Ther. 4: 41\u201348","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"BF4401372_CR40","doi-asserted-by":"publisher","first-page":"23477","DOI":"10.1074\/jbc.M108676200","volume":"277","author":"JT Colston","year":"2002","unstructured":"Colston JT, Chandrasekar B and Freeman GL (2002) A novel peroxide-induced calcium transient regulates interleukin-6 expression in cardiac-derived fibroblasts. J. Biol. Chem. 277: 23477\u201323483","journal-title":"J. Biol. Chem."},{"key":"BF4401372_CR41","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1007\/BF00374916","volume":"424","author":"JB Parys","year":"1993","unstructured":"Parys JB, Missiaen L, De Smedt H, Droogmans G and Casteels R (1993) Bell-shaped activation of inositol-1,4,5-trisphosphate-induced Ca2+ release by thimerosal in permeabilized A7r5 smooth-muscle cells. Pflugers Arch. 424: 516\u2013522","journal-title":"Pflugers Arch."},{"key":"BF4401372_CR42","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0143-4160(96)90086-X","volume":"20","author":"L Karhapaa","year":"1996","unstructured":"Karhapaa L, Titievsky A, Kaila K and Tornquist K (1996) Redox modulation of calcium entry and release of intracellular calcium by thimerosal in GH4C1 pituitary cells. Cell Calcium 20: 447\u2013457","journal-title":"Cell Calcium"},{"key":"BF4401372_CR43","doi-asserted-by":"publisher","first-page":"25557","DOI":"10.1074\/jbc.270.43.25557","volume":"270","author":"TG Favero","year":"1995","unstructured":"Favero TG, Zable AC and Abramson JJ (1995) Hydrogen peroxide stimulates the Ca2+ release channel from skeletal muscle sarcoplasmic reticulum. J. Biol. Chem. 270: 25557\u201325563","journal-title":"J. Biol. Chem."},{"key":"BF4401372_CR44","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/978-1-4613-1143-0_21","volume-title":"Molecular Biology of Membrane Transport Disorders","author":"WR Busa","year":"1996","unstructured":"Busa WR (1996) Regulation of intracellular free calcium. In Molecular Biology of Membrane Transport Disorders, Schultz SG, Andreoli TE, Brown AM, Fambrough DM, Hoffman JF, Welsh MJ, eds (New York: Plenum Press) pp. 427\u2013446"},{"key":"BF4401372_CR45","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1172\/JCI114472","volume":"85","author":"IU Schraufstatter","year":"1990","unstructured":"Schraufstatter IU, Browne K, Harris A, Hyslop PA, Jackson JH, Quehenberger O and Cochrane CG (1990) Mechanisms of hypochlorite injury of target cells. J. Clin. Invest. 85: 554\u2013562","journal-title":"J. Clin. Invest."},{"key":"BF4401372_CR46","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1073\/pnas.78.1.210","volume":"78","author":"JM Albrich","year":"1981","unstructured":"Albrich JM, McCarthy CA and Hurst JK (1981) Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase. Proc. Natl. Acad. Sci. USA 78: 210\u2013214","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF4401372_CR47","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1006\/abbi.2001.2691","volume":"397","author":"JR Kim","year":"2002","unstructured":"Kim JR, Kwon KS, Yoon HW, Lee SR and Rhee SG (2002) Oxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cells. Arch. Biochem. Biophys. 397: 414\u2013423","journal-title":"Arch. Biochem. Biophys."},{"key":"BF4401372_CR48","doi-asserted-by":"publisher","first-page":"C461","DOI":"10.1152\/ajpcell.00167.2001","volume":"282","author":"MA Soto","year":"2002","unstructured":"Soto MA, Gonzalez C, Lissi E, Vergara C and Latorre R (2002) Ca(2+)-activated K+ channel inhibition by reactive oxygen species. Am. J. Physiol. Cell Physiol. 282: C461\u2013C471","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"BF4401372_CR49","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0197-0186(98)00013-8","volume":"33","author":"CJ Fowler","year":"1998","unstructured":"Fowler CJ, Ando Y and Tiger G (1998) Comparison of the effects of hydrogen peroxide, 4-hydroxy-2-nonenal and beta-amyloid (25\u201335) upon calcium signalling. Neurochem. Int. 33: 161\u2013172","journal-title":"Neurochem. Int."},{"key":"BF4401372_CR50","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1172\/JCI113241","volume":"80","author":"CF Nathan","year":"1987","unstructured":"Nathan CF (1987) Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J. Clin. Invest. 80: 1550\u20131560","journal-title":"J. Clin. Invest."},{"key":"BF4401372_CR51","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S1011-1344(01)00235-4","volume":"64","author":"KU Schallreuter","year":"2001","unstructured":"Schallreuter KU and Wood JM (2001) Thioredoxin reductase \u2013 its role in epidermal redox status. J. Photochem. Photobiol. B 64: 179\u2013184","journal-title":"J. Photochem. Photobiol. B"},{"key":"BF4401372_CR52","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1128\/IAI.68.7.3990-3997.2000","volume":"68","author":"CD Pericone","year":"2000","unstructured":"Pericone CD, Overweg K, Hermans PW and Weiser JN (2000) Inhibitory and bactericidal effects of hydrogen peroxide production by Streptococcus pneumoniae on other inhabitants of the upper respiratory tract. Infect. Immun. 68: 3990\u20133997","journal-title":"Infect. Immun."},{"key":"BF4401372_CR53","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1126\/science.270.5234.296","volume":"270","author":"M Sundaresan","year":"1995","unstructured":"Sundaresan M, Yu ZX, Ferrans VJ, Irani K and Finkel T (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270: 296\u2013299","journal-title":"Science"},{"key":"BF4401372_CR54","doi-asserted-by":"publisher","first-page":"21388","DOI":"10.1074\/jbc.272.34.21388","volume":"272","author":"A Quillet-Mary","year":"1997","unstructured":"Quillet-Mary A, Jaffrezou JP, Mansat V, Bordier C, Naval J and Laurent G (1997) Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem. 272: 21388\u201321395","journal-title":"J. Biol. Chem."},{"key":"BF4401372_CR55","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1042\/bj3630483","volume":"363","author":"S Mueller","year":"2002","unstructured":"Mueller S, Weber A, Fritz R, Mutze S, Rost D, Walczak H, Volkl A and Stremmel W (2002) Sensitive and real-time determination of H2O2 release from intact peroxisomes. Biochem. J. 363: 483\u2013491","journal-title":"Biochem. J."},{"key":"BF4401372_CR56","doi-asserted-by":"publisher","first-page":"7166","DOI":"10.1093\/emboj\/16.23.7166","volume":"16","author":"P Lipp","year":"1997","unstructured":"Lipp P, Thomas D, Berridge MJ and Bootman MD (1997) Nuclear calcium signalling by individual cytoplasmic calcium puffs. EMBO J. 16: 7166\u20137173","journal-title":"EMBO J."},{"key":"BF4401372_CR57","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/27686","volume":"395","author":"T Nguyen","year":"1998","unstructured":"Nguyen T, Chin WC and Verdugo P (1998) Role of Ca2+\/K+ ion exchange in intracellular storage and release of Ca2+. Nature 395: 908\u2013912","journal-title":"Nature"},{"key":"BF4401372_CR58","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0006-3495(99)77214-0","volume":"76","author":"RC Scaduto Jr","year":"1999","unstructured":"Scaduto Jr RC and Grotyohann LW (1999) Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys. J. 76: 469\u2013477","journal-title":"Biophys. J."},{"key":"BF4401372_CR59","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1113\/jphysiol.2001.012806","volume":"538","author":"SK Inglis","year":"2002","unstructured":"Inglis SK, Finlay L, Ramminger SJ, Richard K, Ward MR, Wilson SM and Olver RE (2002) Regulation of intracellular pH in Calu-3 human airway cells. J. Physiol. 538: 527\u2013539","journal-title":"J. Physiol."},{"key":"BF4401372_CR60","doi-asserted-by":"publisher","first-page":"C883","DOI":"10.1152\/ajpcell.1998.274.4.C883","volume":"274","author":"TN Nagaraja","year":"1998","unstructured":"Nagaraja TN and Brookes N (1998) Intracellular acidification induced by passive and active transport of ammonium ions in astrocytes. Am. J. Physiol. 274: C883\u2013C891","journal-title":"Am. J. Physiol."}],"container-title":["Cell Death &amp; Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4401372.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401372","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401372.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T20:22:22Z","timestamp":1684354942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4401372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,16]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["BF4401372"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4401372","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,16]]}}}