{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:36:18Z","timestamp":1791196578669,"version":"4.1.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Death Differ"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1038\/sj.cdd.4401535","type":"journal-article","created":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T11:47:15Z","timestamp":1103543235000},"page":"S193-S206","source":"Crossref","is-referenced-by-count":132,"title":["Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies"],"prefix":"10.1038","volume":"11","author":[{"given":"S","family":"Inoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"MacFarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M C","family":"Wheat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J S","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G M","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,12,20]]},"reference":[{"key":"BF4401535_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1006\/excr.2000.4835","volume":"256","author":"SB Bratton","year":"2000","unstructured":"Bratton SB, MacFarlane M, Cain K and Cohen GM (2000) Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp. Cell. Res. 256: 27\u201333","journal-title":"Exp. Cell. Res."},{"key":"BF4401535_CR2","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0002-9440(10)64779-7","volume":"157","author":"JC Reed","year":"2000","unstructured":"Reed JC (2000) Mechanisms of apoptosis. Am. J. Pathol. 157: 1415\u20131430","journal-title":"Am. J. Pathol."},{"key":"BF4401535_CR3","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/0092-8674(95)90071-3","volume":"81","author":"AM Chinnaiyan","year":"1995","unstructured":"Chinnaiyan AM, O'Rourke K, Tewari M and Dixit VM (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505\u2013512","journal-title":"Cell"},{"key":"BF4401535_CR4","doi-asserted-by":"publisher","first-page":"5579","DOI":"10.1002\/j.1460-2075.1995.tb00245.x","volume":"14","author":"FC Kischkel","year":"1995","unstructured":"Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH and Peter ME (1995) Cytotoxicity-dependent APO-1 (Fas\/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14: 5579\u20135588","journal-title":"EMBO J."},{"key":"BF4401535_CR5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/35008667","volume":"2","author":"JL Bodmer","year":"2000","unstructured":"Bodmer JL, Holler N, Reynard S, Vinciguerra P, Schneider P, Juo P, Blenis J and Tschopp J (2000) TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat. Cell. Biol. 2: 241\u2013243","journal-title":"Nat. Cell. Biol."},{"key":"BF4401535_CR6","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S1074-7613(00)80212-5","volume":"12","author":"FC Kischkel","year":"2000","unstructured":"Kischkel FC, Lawrence DA, Chuntharapai A, Schow P, Kim KJ and Ashkenazi A (2000) Apo2L\/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 12: 611\u2013620","journal-title":"Immunity"},{"key":"BF4401535_CR7","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S1074-7613(00)80211-3","volume":"12","author":"MR Sprick","year":"2000","unstructured":"Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J, Krammer PH and Walczak H (2000) FADD\/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12: 599\u2013609","journal-title":"Immunity"},{"key":"BF4401535_CR8","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S0092-8674(00)81265-9","volume":"85","author":"MP Boldin","year":"1996","unstructured":"Boldin MP, Goncharov TM, Goltsev YV and Wallach D (1996) Involvement of MACH, a novel MORT1\/FADD-interacting protease, in Fas\/APO-1- and TNF receptor-induced cell death. Cell 85: 803\u2013815","journal-title":"Cell"},{"key":"BF4401535_CR9","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0092-8674(00)81266-0","volume":"85","author":"M Muzio","year":"1996","unstructured":"Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME and Dixit VM (1996) FLICE, a novel FADD-homologous ICE\/CED-3-like protease, is recruited to the CD95 (Fas\/APO-1) death-inducing signaling complex. Cell 85: 817\u2013827","journal-title":"Cell"},{"key":"BF4401535_CR10","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1016\/S0960-9822(02)70791-4","volume":"6","author":"SA Marsters","year":"1996","unstructured":"Marsters SA, Sheridan JP, Donahue CJ, Pitti RM, Gray CL, Goddard AD, Bauer KD and Ashkenazi A (1996) Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B. Curr. Biol. 6: 1669\u20131676","journal-title":"Curr. Biol."},{"key":"BF4401535_CR11","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/1074-7613(95)90057-8","volume":"3","author":"SR Wiley","year":"1995","unstructured":"Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA and Goodwin RG (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3: 673\u2013682","journal-title":"Immunity"},{"key":"BF4401535_CR12","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/5517","volume":"5","author":"H Walczak","year":"1999","unstructured":"Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, Smith C, Smolak P, Goodwin RG, Rauch CT, Schuh JC and Lynch DH (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med. 5: 157\u2013163","journal-title":"Nat. Med."},{"key":"BF4401535_CR13","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","volume":"281","author":"A Ashkenazi","year":"1998","unstructured":"Ashkenazi A and Dixit VM (1998) Death receptors: signaling and modulation. Science 281: 1305\u20131308","journal-title":"Science"},{"key":"BF4401535_CR14","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/40657","volume":"388","author":"M Irmler","year":"1997","unstructured":"Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE and Tschopp J (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388: 190\u2013195","journal-title":"Nature"},{"key":"BF4401535_CR15","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1074\/jbc.274.3.1541","volume":"274","author":"C Scaffidi","year":"1999","unstructured":"Scaffidi C, Schmitz I, Krammer PH and Peter ME (1999) The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem. 274: 1541\u20131548","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR16","doi-asserted-by":"publisher","first-page":"20633","DOI":"10.1074\/jbc.M101780200","volume":"276","author":"A Krueger","year":"2001","unstructured":"Krueger A, Schmitz I, Baumann S, Krammer PH and Kirchhoff S (2001) Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J. Biol. Chem. 276: 20633\u201320640","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR17","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1182\/blood.V91.8.2875.2875_2875_2885","volume":"91","author":"J Plumas","year":"1998","unstructured":"Plumas J, Jacob MC, Chaperot L, Molens JP, Sotto JJ and Bensa JC (1998) Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas\/Apo-1)-mediated apoptosis. Blood 91: 2875\u20132885","journal-title":"Blood"},{"key":"BF4401535_CR18","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1038\/sj.leu.2400815","volume":"11","author":"L Xerri","year":"1997","unstructured":"Xerri L, Devilard E, Hassoun J, Haddad P and Birg F (1997) Malignant and reactive cells from human lymphomas frequently express Fas ligand but display a different sensitivity to Fas-mediated apoptosis. Leukemia 11: 1868\u20131877","journal-title":"Leukemia"},{"key":"BF4401535_CR19","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/bjc.1998.469","volume":"78","author":"L Xerri","year":"1998","unstructured":"Xerri L, Bouabdallah R, Devilard E, Hassoun J, Stoppa AM and Birg F (1998) Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation. Br. J. Cancer 78: 225\u2013232","journal-title":"Br. J. Cancer"},{"key":"BF4401535_CR20","doi-asserted-by":"publisher","first-page":"6809","DOI":"10.1038\/sj.onc.1205853","volume":"21","author":"M MacFarlane","year":"2002","unstructured":"MacFarlane M, Harper N, Snowden RT, Dyer MJ, Barnett GA, Pringle JH and Cohen GM (2002) Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene 21: 6809\u20136818","journal-title":"Oncogene"},{"key":"BF4401535_CR21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1046\/j.1365-2141.1997.422688.x","volume":"97","author":"D Wang","year":"1997","unstructured":"Wang D, Freeman GJ, Levine H, Ritz J and Robertson MJ (1997) Role of the CD40 and CD95 (APO-1\/Fas) antigens in the apoptosis of human B-cell malignancies. Br. J. Haematol. 97: 409\u2013417","journal-title":"Br. J. Haematol."},{"key":"BF4401535_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1044-579X(02)00131-1","volume":"13","author":"N Ozoren","year":"2003","unstructured":"Ozoren N and El-Deiry WS (2003) Cell surface death receptor signaling in normal and cancer cells. Semin. Cancer Biol. 13: 135\u2013147","journal-title":"Semin. Cancer Biol."},{"key":"BF4401535_CR23","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1023\/A:1020039225764","volume":"7","author":"H Wajant","year":"2002","unstructured":"Wajant H, Pfizenmaier K and Scheurich P (2002) TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy. Apoptosis 7: 449\u2013459","journal-title":"Apoptosis"},{"key":"BF4401535_CR24","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nrd772","volume":"1","author":"RW Johnstone","year":"2002","unstructured":"Johnstone RW (2002) Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. Drug Discov. 1: 287\u2013299","journal-title":"Nat. Rev. Drug Discov."},{"key":"BF4401535_CR25","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/35106079","volume":"1","author":"P Marks","year":"2001","unstructured":"Marks P, Rifkind RA, Richon VM, Breslow R, Miller T and Kelly WK (2001) Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer 1: 194\u2013202","journal-title":"Nat. Rev. Cancer"},{"key":"BF4401535_CR26","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/00062752-200207000-00010","volume":"9","author":"A Melnick","year":"2002","unstructured":"Melnick A and Licht JD (2002) Histone deacetylases as therapeutic targets in hematologic malignancies. Curr. Opin. Hematol. 9: 322\u2013332","journal-title":"Curr. Opin. Hematol."},{"key":"BF4401535_CR27","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1182\/blood-2002-12-3794","volume":"102","author":"JL Aron","year":"2003","unstructured":"Aron JL, Parthun MR, Marcucci G, Kitada S, Mone AP, Davis ME, Shen T, Murphy T, Wickham J, Kanakry C, Lucas DM, Reed JC, Grever MR and Byrd JC (2003) Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. Blood 102: 652\u2013658","journal-title":"Blood"},{"key":"BF4401535_CR28","doi-asserted-by":"publisher","first-page":"12579","DOI":"10.1074\/jbc.M213093200","volume":"278","author":"C Henderson","year":"2003","unstructured":"Henderson C, Mizzau M, Paroni G, Maestro R, Schneider C and Brancolini C (2003) Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). J. Biol. Chem. 278: 12579\u201312589","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR29","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1074\/jbc.M106699200","volume":"277","author":"SH Kwon","year":"2002","unstructured":"Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW and Han JW (2002) Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas\/Fas ligand expression in human acute promyelocytic leukemia cells. J. Biol. Chem. 277: 2073\u20132080","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR30","doi-asserted-by":"publisher","first-page":"10833","DOI":"10.1073\/pnas.191208598","volume":"98","author":"AA Ruefli","year":"2001","unstructured":"Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ and Johnstone RW (2001) The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc. Natl. Acad. Sci. USA 98: 10833\u201310838","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF4401535_CR31","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1038\/sj.cdd.4400914","volume":"8","author":"D Bernhard","year":"2001","unstructured":"Bernhard D, Skvortsov S, Tinhofer I, Hubl H, Greil R, Csordas A and Kofler R (2001) Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts. Cell Death Differ. 8: 1014\u20131021","journal-title":"Cell Death Differ."},{"key":"BF4401535_CR32","first-page":"4392","volume":"59","author":"RD Glick","year":"1999","unstructured":"Glick RD, Swendeman SL, Coffey DC, Rifkind RA, Marks PA, Richon VM and La Quaglia MP (1999) Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95\/CD95 ligand expression in human neuroblastoma. Cancer Res. 59: 4392\u20134399","journal-title":"Cancer Res."},{"key":"BF4401535_CR33","doi-asserted-by":"publisher","first-page":"4055","DOI":"10.1182\/blood-2002-11-3514","volume":"101","author":"N Mitsiades","year":"2003","unstructured":"Mitsiades N, Mitsiades CS, Richardson PG, McMullan C, Poulaki V, Fanourakis G, Schlossman R, Chauhan D, Munshi NC, Hideshima T, Richon VM, Marks PA and Anderson KC (2003) Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood 101: 4055\u20134062","journal-title":"Blood"},{"key":"BF4401535_CR34","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.bbrc.2003.12.074","volume":"314","author":"J Neuzil","year":"2004","unstructured":"Neuzil J, Swettenham E and Gellert N (2004) Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation. Biochem. Biophys. Res. Commun. 314: 186\u2013191","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF4401535_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1067\/msy.2001.115897","volume":"130","author":"A Hernandez","year":"2001","unstructured":"Hernandez A, Thomas R, Smith F, Sandberg J, Kim S, Chung DH and Evers BM (2001) Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis. Surgery 130: 265\u2013272","journal-title":"Surgery"},{"key":"BF4401535_CR36","first-page":"521","volume":"9","author":"H Inoue","year":"2002","unstructured":"Inoue H, Shiraki K, Ohmori S, Sakai T, Deguchi M, Yamanaka T, Okano H and Nakano T (2002) Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. Int. J. Mol. Med. 9: 521\u2013525","journal-title":"Int. J. Mol. Med."},{"key":"BF4401535_CR37","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1046\/j.1365-2141.1997.4393250.x","volume":"99","author":"V Snell","year":"1997","unstructured":"Snell V, Clodi K, Zhao S, Goodwin R, Thomas EK, Morris SW, Kadin ME, Cabanillas F, Andreeff M and Younes A (1997) Activity of TNF-related apoptosis-inducing ligand (TRAIL) in haematological malignancies. Br. J. Haematol. 99: 618\u2013624","journal-title":"Br. J. Haematol."},{"key":"BF4401535_CR38","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1182\/blood.V94.4.1401","volume":"94","author":"JC Byrd","year":"1999","unstructured":"Byrd JC, Shinn C, Ravi R, Willis CR, Waselenko JK, Flinn IW, Dawson NA and Grever MR (1999) Depsipeptide (FR901228): a novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells. Blood 94: 1401\u20131408","journal-title":"Blood"},{"key":"BF4401535_CR39","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/82741","volume":"1","author":"RS Hotchkiss","year":"2000","unstructured":"Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ, Klender P, Xanthoudakis S, Roy S, Black C, Grimm E, Aspiotis R, Han Y, Nicholson DW and Karl IE (2000) Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat. Immunol. 1: 496\u2013501","journal-title":"Nat. Immunol."},{"key":"BF4401535_CR40","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S1097-2765(00)80095-7","volume":"1","author":"SM Srinivasula","year":"1998","unstructured":"Srinivasula SM, Ahmad M, Fernandes-Alnemri T and Alnemri ES (1998) Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell 1: 949\u2013957","journal-title":"Mol. Cell"},{"issue":"Part 1","key":"BF4401535_CR41","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1042\/bj3480093","volume":"348","author":"M MacFarlane","year":"2000","unstructured":"MacFarlane M, Cohen GM and Dickens M (2000) JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation. Biochem. J. 348 (Part 1): 93\u2013101","journal-title":"Biochem. J."},{"key":"BF4401535_CR42","doi-asserted-by":"publisher","first-page":"14486","DOI":"10.1073\/pnas.93.25.14486","volume":"93","author":"SM Srinivasula","year":"1996","unstructured":"Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G and Alnemri ES (1996) Molecular ordering of the Fas-apoptotic pathway: the Fas\/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3\/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. USA 93: 14486\u201314491","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF4401535_CR43","first-page":"793","volume":"15","author":"B Bonavida","year":"1999","unstructured":"Bonavida B, Ng CP, Jazirehi A, Schiller G and Mizutani Y (1999) Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: the trail to non-toxic cancer therapeutics (review). Int. J. Oncol. 15: 793\u2013802","journal-title":"Int. J. Oncol."},{"key":"BF4401535_CR44","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2174\/1568011033482404","volume":"3","author":"S Fulda","year":"2003","unstructured":"Fulda S and Debatin KM (2003) Death receptor signaling in cancer therapy. Curr. Med. Chem. Anti-Cancer Agents 3: 253\u2013262","journal-title":"Curr. Med. Chem. Anti-Cancer Agents"},{"key":"BF4401535_CR45","doi-asserted-by":"publisher","first-page":"8247","DOI":"10.1128\/MCB.21.24.8247-8254.2001","volume":"21","author":"A Krueger","year":"2001","unstructured":"Krueger A, Baumann S, Krammer PH and Kirchhoff S (2001) FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol. Cell. Biol. 21: 8247\u20138254","journal-title":"Mol. Cell. Biol."},{"key":"BF4401535_CR46","doi-asserted-by":"publisher","first-page":"34743","DOI":"10.1074\/jbc.M105693200","volume":"276","author":"N Harper","year":"2001","unstructured":"Harper N, Farrow SN, Kaptein A, Cohen GM and MacFarlane M (2001) Modulation of tumor necrosis factor apoptosis-inducing ligand-induced NF-kappa B activation by inhibition of apical caspases. J. Biol. Chem. 276: 34743\u201334752","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR47","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nm0302-274","volume":"8","author":"H LeBlanc","year":"2002","unstructured":"LeBlanc H, Lawrence D, Varfolomeev E, Totpal K, Morlan J, Schow P, Fong S, Schwall R, Sinicropi D and Ashkenazi A (2002) Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. Nat. Med. 8: 274\u2013281","journal-title":"Nat. Med."},{"key":"BF4401535_CR48","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1101\/gad.949602","volume":"16","author":"Y Deng","year":"2002","unstructured":"Deng Y, Lin Y and Wu X (2002) TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac\/DIABLO. Genes Dev. 16: 33\u201345","journal-title":"Genes Dev."},{"key":"BF4401535_CR49","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0002-9440(10)64557-9","volume":"157","author":"LA O'Reilly","year":"2000","unstructured":"O'Reilly LA, Cullen L, Visvader J, Lindeman GJ, Print C, Bath ML, Huang DC and Strasser A (2000) The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells. Am. J. Pathol. 157: 449\u2013461","journal-title":"Am. J. Pathol."},{"key":"BF4401535_CR50","first-page":"11","volume":"25","author":"JC Reed","year":"1998","unstructured":"Reed JC (1998) Molecular biology of chronic lymphocytic leukemia. Semin. Oncol. 25: 11\u201318","journal-title":"Semin. Oncol."},{"key":"BF4401535_CR51","first-page":"1227","volume":"9","author":"P Panayiotidis","year":"1995","unstructured":"Panayiotidis P, Ganeshaguru K, Foroni L and Hoffbrand AV (1995) Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. Leukemia 9: 1227\u20131232","journal-title":"Leukemia"},{"key":"BF4401535_CR52","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1158\/0008-5472.CAN-03-2629","volume":"64","author":"F Guo","year":"2004","unstructured":"Guo F, Sigua C, Tao J, Bali P, George P, Li Y, Wittmann S, Moscinski L, Atadja P and Bhalla K (2004) Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L\/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells. Cancer Res. 64: 2580\u20132589","journal-title":"Cancer Res."},{"key":"BF4401535_CR53","first-page":"1273","volume":"2","author":"RR Rosato","year":"2003","unstructured":"Rosato RR, Almenara JA, Dai Y and Grant S (2003) Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells. Mol. Cancer Ther. 2: 1273\u20131284","journal-title":"Mol. Cancer Ther."},{"key":"BF4401535_CR54","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1093\/jnci\/94.7.504","volume":"94","author":"X Yu","year":"2002","unstructured":"Yu X, Guo ZS, Marcu MG, Neckers L, Nguyen DM, Chen GA and Schrump DS (2002) Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228. J. Natl. Cancer Inst. 94: 504\u2013513","journal-title":"J. Natl. Cancer Inst."},{"key":"BF4401535_CR55","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S1097-2765(04)00094-2","volume":"13","author":"HY Cohen","year":"2004","unstructured":"Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM and Sinclair DA (2004) Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol. Cell 13: 627\u2013638","journal-title":"Mol. Cell"},{"key":"BF4401535_CR56","doi-asserted-by":"publisher","first-page":"6564","DOI":"10.4049\/jimmunol.166.11.6564","volume":"166","author":"AS Varadhachary","year":"2001","unstructured":"Varadhachary AS, Edidin M, Hanlon AM, Peter ME, Krammer PH and Salgame P (2001) Phosphatidylinositol 3\u2032-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95. J. Immunol. 166: 6564\u20136569","journal-title":"J. Immunol."},{"key":"BF4401535_CR57","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1128\/MCB.22.1.207-220.2002","volume":"22","author":"A Algeciras-Schimnich","year":"2002","unstructured":"Algeciras-Schimnich A, Shen L, Barnhart BC, Murmann AE, Burkhardt JK and Peter ME (2002) Molecular ordering of the initial signaling events of CD95. Mol. Cell. Biol. 22: 207\u2013220","journal-title":"Mol. Cell. Biol."},{"key":"BF4401535_CR58","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1182\/blood-2002-04-1174","volume":"100","author":"IM Pedersen","year":"2002","unstructured":"Pedersen IM, Kitada S, Schimmer A, Kim Y, Zapata JM, Charboneau L, Rassenti L, Andreeff M, Bennett F, Sporn MB, Liotta LD, Kipps TJ and Reed JC (2002) The triterpenoid CDDO induces apoptosis in refractory CLL B cells. Blood 100: 2965\u20132972","journal-title":"Blood"},{"key":"BF4401535_CR59","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","volume":"286","author":"P Bouillet","year":"1999","unstructured":"Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM and Strasser A (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735\u20131738","journal-title":"Science"},{"key":"BF4401535_CR60","doi-asserted-by":"publisher","first-page":"18811","DOI":"10.1074\/jbc.M301010200","volume":"278","author":"R Ley","year":"2003","unstructured":"Ley R, Balmanno K, Hadfield K, Weston C and Cook SJ (2003) Activation of the ERK1\/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J. Biol. Chem. 278: 18811\u201318816","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR61","first-page":"1583","volume":"62","author":"R Ravi","year":"2002","unstructured":"Ravi R and Bedi A (2002) Requirement of BAX for TRAIL\/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). Cancer Res. 62: 1583\u20131587","journal-title":"Cancer Res."},{"key":"BF4401535_CR62","doi-asserted-by":"publisher","first-page":"11345","DOI":"10.1074\/jbc.M109893200","volume":"277","author":"XM Sun","year":"2002","unstructured":"Sun XM, Bratton SB, Butterworth M, MacFarlane M and Cohen GM (2002) Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac\/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J. Biol. Chem. 277: 11345\u201311351","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR63","doi-asserted-by":"publisher","first-page":"25534","DOI":"10.1074\/jbc.M303399200","volume":"278","author":"N Harper","year":"2003","unstructured":"Harper N, Hughes M, MacFarlane M and Cohen GM (2003) Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J. Biol. Chem. 278: 25534\u201325541","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR64","doi-asserted-by":"publisher","first-page":"25417","DOI":"10.1074\/jbc.272.41.25417","volume":"272","author":"M MacFarlane","year":"1997","unstructured":"MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM and Alnemri ES (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. 272: 25417\u201325420","journal-title":"J. Biol. Chem."},{"key":"BF4401535_CR65","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.4049\/jimmunol.162.5.2597","volume":"162","author":"TS Griffith","year":"1999","unstructured":"Griffith TS, Rauch CT, Smolak PJ, Waugh JY, Boiani N, Lynch DH, Smith CA, Goodwin RG and Kubin MZ (1999) Functional analysis of TRAIL receptors using monoclonal antibodies. J. Immunol. 162: 2597\u20132605","journal-title":"J. Immunol."},{"key":"BF4401535_CR66","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/sj.cdd.4400370","volume":"5","author":"DM Rasper","year":"1998","unstructured":"Rasper DM, Vaillancourt JP, Hadano S, Houtzager VM, Seiden I, Keen SL, Tawa P, Xanthoudakis S, Nasir J, Martindale D, Koop BF, Peterson EP, Thornberry NA, Huang J, MacPherson DP, Black SC, Hornung F, Lenardo MJ, Hayden MR, Roy S and Nicholson DW (1998) Cell death attenuation by \u2018Usurpin\u2019, a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Cell Death Differ. 5: 271\u2013288","journal-title":"Cell Death Differ."},{"key":"BF4401535_CR67","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1038\/sj.leu.2403088","volume":"17","author":"RT Snowden","year":"2003","unstructured":"Snowden RT, Sun XM, Dyer MJ and Cohen GM (2003) Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1. Leukemia 17: 1981\u20131989","journal-title":"Leukemia"},{"key":"BF4401535_CR68","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1074\/jbc.274.8.5053","volume":"274","author":"XM Sun","year":"1999","unstructured":"Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR and Cohen GM (1999) Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J. Biol. Chem. 274: 5053\u20135060","journal-title":"J. Biol. Chem."}],"container-title":["Cell Death & Differentiation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/4401535.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401535","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/4401535.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:24:42Z","timestamp":1684369482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4401535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":68,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["BF4401535"],"URL":"https:\/\/doi.org\/10.1038\/sj.cdd.4401535","relation":{},"ISSN":["1350-9047","1476-5403"],"issn-type":[{"value":"1350-9047","type":"print"},{"value":"1476-5403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}