{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:28:49Z","timestamp":1780320529109,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharmacol Ther"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1038\/sj.clpt.6100330","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T12:25:57Z","timestamp":1187785557000},"page":"601-606","source":"Crossref","is-referenced-by-count":41,"title":["Lopinavir\u2013Ritonavir Dramatically Affects the Pharmacokinetics of Irinotecan in HIV Patients With Kaposi\u2019s Sarcoma"],"prefix":"10.1111","volume":"83","author":[{"given":"G","family":"Corona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Vaccher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sandron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Sartor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Tirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Toffoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,22]]},"reference":[{"key":"6100330-bib1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0959-8049(01)00120-4","volume":"37","author":"Dal Maso L","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"6100330-bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.qai.0000233310.90484.16","volume":"43","author":"Palella F.J.","year":"2006","journal-title":"J. Acquir. Immune Defic. Syndr"},{"key":"6100330-bib3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1470-2045(03)01192-6","volume":"4","author":"Sgadari C","year":"2003","journal-title":"Lancet Oncol"},{"key":"6100330-bib4","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1158\/0008-5472.CAN-03-2677","volume":"64","author":"Ikezoe T.","year":"2004","journal-title":"Cancer Res"},{"key":"6100330-bib5","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm0703-867","volume":"9","author":"Pomerantz R.J","year":"2003","journal-title":"Nat. Med"},{"key":"6100330-bib6","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1056\/NEJM199804303381808","volume":"338","author":"Flexner C","year":"1998","journal-title":"N. Engl. J. Med"},{"key":"6100330-bib7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1124\/mol.56.2.383","volume":"56","author":"Gutmann H","year":"1999","journal-title":"Mol. Pharmacol"},{"key":"6100330-bib8","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.bcp.2007.01.027","volume":"73","author":"Storch C.H","year":"2007","journal-title":"Biochem. Pharmacol"},{"key":"6100330-bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00003088-200342030-00002","volume":"42","author":"de Maat M.M","year":"2003","journal-title":"Clin. Pharmacokinet"},{"key":"6100330-bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/01.qco.0000200295.30285.13","volume":"19","author":"Bower M","year":"2006","journal-title":"Curr. Opin. Infect. Dis"},{"key":"6100330-bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/1097-0142(20010101)91:1<155::AID-CNCR20>3.0.CO;2-B","volume":"91","author":"Vaccher E.","year":"2001","journal-title":"Cancer"},{"key":"6100330-bib12","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2165\/00003088-200241140-00004","volume":"41","author":"Fichtenbaum C.J","year":"2002","journal-title":"Clin. Pharmacokinet"},{"key":"6100330-bib13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s002800051025","volume":"45","author":"Fumagalli L.","year":"2000","journal-title":"Cancer Chemother. Pharmacol"},{"key":"6100330-bib14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s002800050932","volume":"43","author":"Nannan P.V.","year":"1999","journal-title":"Cancer Chemother. Pharmacol"},{"key":"6100330-bib15","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/annonc\/mdh464","volume":"15","author":"Toffoli G.","year":"2004","journal-title":"Ann. Oncol"},{"key":"6100330-bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2165\/00003088-200544020-00001","volume":"44","author":"Antoniou T","year":"2005","journal-title":"Clin. Pharmacokinet"},{"key":"6100330-bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2165\/00003088-200443050-00003","volume":"43","author":"King J.R","year":"2004","journal-title":"Clin. Pharmacokinet"},{"key":"6100330-bib18","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2165\/00003495-200666090-00012","volume":"66","author":"Oldfield V","year":"2006","journal-title":"Drugs"},{"key":"6100330-bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ctrv.2006.07.001","volume":"32","author":"Fuchs C","year":"2006","journal-title":"Cancer Treat. Rev"},{"key":"6100330-bib20","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1097\/01.aids.0000189855.06194.ce","volume":"19","author":"Vaccher E","year":"2005","journal-title":"AIDS"},{"key":"6100330-bib21","first-page":"2182","volume":"7","author":"Mathijssen R.H.","year":"2001","journal-title":"Clin. Cancer Res"},{"key":"6100330-bib22","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1200\/JCO.2002.08.177","volume":"20","author":"Kehrer D.F","year":"2002","journal-title":"J. Clin. Oncol"},{"key":"6100330-bib23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0090-9556(24)15060-X","volume":"28","author":"Slatter J.G.","year":"2000","journal-title":"Drug Metab. Dispos"},{"key":"6100330-bib24","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0006-2952(99)00026-X","volume":"57","author":"Drewe J","year":"1999","journal-title":"Biochem. Pharmacol"},{"key":"6100330-bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.tpj.6500072","volume":"2","author":"Iyer L.","year":"2002","journal-title":"Pharmacogenomics J"},{"key":"6100330-bib26","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1124\/dmd.105.005447","volume":"33","author":"Zhang D","year":"2005","journal-title":"Drug Metab. Dispos"},{"key":"6100330-bib27","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1086\/466531","volume":"192","author":"Rotger M.","year":"2005","journal-title":"J. Infect. Dis"},{"key":"6100330-bib28","doi-asserted-by":"crossref","first-page":"12671","DOI":"10.1073\/pnas.231140698","volume":"98","author":"Zucker S.D.","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"6100330-bib29","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2217\/14622416.7.8.1211","volume":"7","author":"Innocenti F","year":"2006","journal-title":"Pharmacogenomics"},{"key":"6100330-bib30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.clpt.2004.01.010","volume":"75","author":"Sai K.","year":"2004","journal-title":"Clin. Pharmacol. Ther"},{"key":"6100330-bib31","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1200\/JCO.2005.05.5400","volume":"24","author":"Toffoli G.","year":"2006","journal-title":"J. Clin. Oncol"},{"key":"6100330-bib32","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1200\/JCO.1993.11.5.909","volume":"11","author":"Shimada Y.","year":"1993","journal-title":"J. Clin. Oncol"},{"key":"6100330-bib33","unstructured":""},{"key":"6100330-bib34","first-page":"531","volume":"67","author":"Krigel R.L","year":"1983","journal-title":"Cancer Treat. Rep"},{"key":"6100330-bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6","volume":"47","author":"Miller A.B","year":"1981","journal-title":"Cancer"},{"key":"6100330-bib36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1517\/17425255.1.3.473","volume":"1","author":"Ma Q.","year":"2005","journal-title":"Expert Opin. Drug Metab. Toxicol"},{"key":"6100330-bib37","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1200\/JCO.1996.14.11.2959","volume":"14","author":"Saltz L.B.","year":"1996","journal-title":"J. Clin. Oncol"}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T09:49:41Z","timestamp":1737366581000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1038\/sj.clpt.6100330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,22]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,8,22]]},"published-print":{"date-parts":[[2008,4]]}},"alternative-id":["6100330"],"URL":"https:\/\/doi.org\/10.1038\/sj.clpt.6100330","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1092139.545519","asserted-by":"object"}]},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,22]]}}}