{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:55:31Z","timestamp":1793033731476,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharmacol Ther"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1038\/sj.clpt.6100400","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T03:15:53Z","timestamp":1193195753000},"page":"761-769","source":"Crossref","is-referenced-by-count":2261,"title":["Nanoparticles in Medicine: Therapeutic Applications and Developments"],"prefix":"10.1111","volume":"83","author":[{"given":"L","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FX","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AZ","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RS","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OC","family":"Farokhzad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,24]]},"reference":[{"key":"6100400-bib1","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.addr.2006.09.011","volume":"58","author":"Farokhzad O.C.","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"6100400-bib2","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1002\/ijc.22709","volume":"120","author":"Liu Y.","year":"2007","journal-title":"Int. J. Cancer"},{"key":"6100400-bib3","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.addr.2004.02.014","volume":"56","author":"Brannon-Peppas L.","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"6100400-bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.nano.2005.03.002","volume":"1","author":"Kawasaki E.S.","year":"2005","journal-title":"Nanomedicine"},{"key":"6100400-bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/10611860701231810","volume":"15","author":"Emerich D.F.","year":"2007","journal-title":"J. Drug Target."},{"key":"6100400-bib6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2174\/138945006777435245","volume":"7","author":"Groneberg D.A.","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"6100400-bib7","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nbt1006-1211","volume":"24","author":"Wagner V.","year":"2006","journal-title":"Nat. Biotech."},{"key":"6100400-bib8","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1021\/nl052455y","volume":"6","author":"Zhang L.","year":"2006","journal-title":"Nano Lett."},{"key":"6100400-bib9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","volume":"4","author":"Torchilin V.P.","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"6100400-bib10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0163-7827(03)00033-X","volume":"42","author":"Moghimi S.M.","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"6100400-bib11","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1200\/JCO.1998.16.7.2445","volume":"16","author":"Northfelt D.W.","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"6100400-bib12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrc1958","volume":"6","author":"Duncan R.","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"6100400-bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijpharm.2003.09.050","volume":"277","author":"Tanaka T.","year":"2004","journal-title":"Int. J. Pharm."},{"key":"6100400-bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCULATIONAHA.106.619056","volume":"114","author":"Deguchi J.-O.","year":"2006","journal-title":"Circulation"},{"key":"6100400-bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0169-409X(02)00021-2","volume":"54","author":"Davis F.F.","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"6100400-bib16","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1200\/JCO.2005.08.002","volume":"23","author":"Harries M.","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"6100400-bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0169-409X(97)00136-1","volume":"32","author":"Woodle M.C.","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"6100400-bib18","first-page":"7190","volume":"62","author":"Sapra P.","year":"2002","journal-title":"Cancer Res."},{"key":"6100400-bib19","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.addr.2003.10.038","volume":"56","author":"Simoes S.","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"6100400-bib20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/sj.bjc.6601922","volume":"91","author":"Bissett D.","year":"2004","journal-title":"Br. J. Cancer"},{"key":"6100400-bib21","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1158\/1078-0432.CCR-05-0720","volume":"11","author":"Hoekstra R.","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"6100400-bib22","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1166\/jnn.2006.440","volume":"6","author":"Tiwari S.B.","year":"2006","journal-title":"J. Nanosci. Nanotechnol."},{"key":"6100400-bib23","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1021\/mp050023q","volume":"2","author":"McCarthy T.D.","year":"2005","journal-title":"Mol. Pharm."},{"key":"6100400-bib24","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.mt.6300029","volume":"15","author":"Seiler M.P.","year":"2007","journal-title":"Mol. Ther."},{"key":"6100400-bib25","first-page":"14","volume":"2","author":"Gu F.X.","year":"2007","journal-title":"Nano Today"},{"key":"6100400-bib26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1023\/A:1022608321861","volume":"20","author":"Fonseca M.J.","year":"2003","journal-title":"Pharm. Res."},{"key":"6100400-bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/10611860500206674","volume":"13","author":"Schnyder A.","year":"2005","journal-title":"J. Drug Target."},{"key":"6100400-bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0168-3659(02)00009-3","volume":"82","author":"Kabanov A.V.","year":"2002","journal-title":"J. Control. Release"},{"key":"6100400-bib29","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ejpb.2006.10.022","volume":"65","author":"Wong H.L.","year":"2007","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"6100400-bib30","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1021\/bm0501454","volume":"6","author":"Arifin D.R.","year":"2005","journal-title":"Biomacromolecules"},{"key":"6100400-bib31","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1073\/pnas.0601755103","volume":"103","author":"Farokhzad O.C.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"6100400-bib32","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1158\/1078-0432.CCR-05-2318","volume":"12","author":"Raffaghello L.","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"6100400-bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11095-006-9132-0","volume":"24","author":"Torchilin V.P.","year":"2007","journal-title":"Pharm. Res."},{"key":"6100400-bib34","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/cmdc.200700121","volume":"2","author":"Zhang L.","year":"2007","journal-title":"Chem. Med. Chem."},{"key":"6100400-bib35","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1158\/0008-5472.CAN-04-3921","volume":"65","author":"Kukowska-Latallo J.F.","year":"2005","journal-title":"Cancer Res."},{"key":"6100400-bib36","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s11095-005-9396-9","volume":"23","author":"Bhadra D.","year":"2006","journal-title":"Pharm. Res."},{"key":"6100400-bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10611860600965914","volume":"15","author":"Dutta T.","year":"2007","journal-title":"J. Drug Target."},{"key":"6100400-bib38","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1158\/0008-5472.CAN-06-2066","volume":"66","author":"Morgan M.T.","year":"2006","journal-title":"Cancer Res."},{"key":"6100400-bib39","first-page":"1917","volume":"9","author":"Wosikowski K.","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"6100400-bib40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2006.06.001","volume":"173","author":"Xie Y.L.","year":"2006","journal-title":"Behav. Brain Res."},{"key":"6100400-bib41","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s11095-006-9203-2","volume":"24","author":"Chavanpatil M.D.","year":"2007","journal-title":"Pharm. Res."},{"key":"6100400-bib42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.biomaterials.2005.05.028","volume":"27","author":"Hyung Park J.","year":"2006","journal-title":"Biomaterials"},{"key":"6100400-bib43","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1021\/bm025740+","volume":"4","author":"Raja K.S.","year":"2003","journal-title":"Biomacromolecules"},{"key":"6100400-bib44","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1021\/nl0500555","volume":"6","author":"Everts M.","year":"2006","journal-title":"Nano Lett."},{"key":"6100400-bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11060-005-9059-z","volume":"78","author":"Jordan A.","year":"2006","journal-title":"J. Neurooncol."},{"key":"6100400-bib46","doi-asserted-by":"crossref","first-page":"S2893","DOI":"10.1088\/0953-8984\/18\/38\/S24","volume":"18","author":"Jurgons R.","year":"2006","journal-title":"J. Phys. Condens. Matter"},{"key":"6100400-bib47","doi-asserted-by":"crossref","first-page":"13549","DOI":"10.1073\/pnas.2232479100","volume":"100","author":"Hirsch L.R.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"6100400-bib48","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/ja0343095","volume":"125","author":"Roy I.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"6100400-bib49","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1021\/ja060367p","volume":"128","author":"Huo Q.","year":"2006","journal-title":"J. Am. Chem. Soc."}],"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:13:31Z","timestamp":1699344811000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1038\/sj.clpt.6100400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,24]]},"references-count":49,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2007,10,24]]},"published-print":{"date-parts":[[2008,5]]}},"alternative-id":["6100400"],"URL":"https:\/\/doi.org\/10.1038\/sj.clpt.6100400","relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,24]]}}}