{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:44:49Z","timestamp":1769125489874,"version":"3.49.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2004,4,7]],"date-time":"2004-04-07T00:00:00Z","timestamp":1081296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,4,7]],"date-time":"2004-04-07T00:00:00Z","timestamp":1081296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2004,10,1]]},"DOI":"10.1038\/sj.ejcn.1601975","type":"journal-article","created":{"date-parts":[[2004,4,7]],"date-time":"2004-04-07T09:58:23Z","timestamp":1081331903000},"page":"1359-1364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Hair as a biopsy material: trace element data on one man over two decades"],"prefix":"10.1038","volume":"58","author":[{"given":"L M","family":"Klevay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Christopherson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T R","family":"Shuler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,4,7]]},"reference":[{"key":"BF1601975_CR1","volume-title":"Cardiovascular Diseases and Trace Elements","author":"TG Aalbers","year":"1984","unstructured":"Aalbers TG (1984): Cardiovascular Diseases and Trace Elements. Dieren: Drukkerij Blok en Zonen."},{"key":"BF1601975_CR2","first-page":"2.14, 2.22","volume-title":"Flow Injection Mercury\/hydride Analyses. Recommended Analytical Conditions and General Information","author":"Anon","year":"1996","unstructured":"Anon (1996): Flow Injection Mercury\/hydride Analyses. Recommended Analytical Conditions and General Information, pp. 2.14, 2.22. Ueberlingen, FRG: Bodenseewerk Perkin-Elmer Gmbh."},{"key":"BF1601975_CR3","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1001\/jama.1985.03360080053028","volume":"254","author":"S Barrett","year":"1985","unstructured":"Barrett S (1985): Commercial hair analysis. Science or scam? JAMA 254, 1041\u20131045.","journal-title":"JAMA"},{"key":"BF1601975_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1001\/archinte.1980.00330130075019","volume":"140","author":"WB Bean","year":"1980","unstructured":"Bean WB (1980): Nail growth. Thirty-five years of observation. Arch. Intern. Med. 140, 73\u201376.","journal-title":"Arch. Intern. Med."},{"key":"BF1601975_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/BF02784088","volume":"52","author":"A Bertazzo","year":"1996","unstructured":"Bertazzo A, Costa C, Biasiolo M, Allegri G, Cirrincione G & Presti G (1996): Determination of copper and zinc levels in human hair: influence of sex, age, and hair pigmentation. Biol. Trace Elem. Res. 52, 37\u201353.","journal-title":"Biol. Trace Elem. Res."},{"key":"BF1601975_CR6","volume-title":"Time Series Analysis: Forecasting and Control","author":"GEP Box","year":"1976","unstructured":"Box GEP & Jenkins GM (1976): Time Series Analysis: Forecasting and Control. San Francisco: Holden-Day."},{"key":"BF1601975_CR7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/clinchem\/41.2.284","volume":"41","author":"VJ Bush","year":"1995","unstructured":"Bush VJ, Moyer TP, Batts KP & Parisi JE (1995): Essential and toxic element concentrations in fresh and formalin-fixed human autopsy tissues. Clin. Chem. 41, 284\u2013294.","journal-title":"Clin. Chem."},{"key":"BF1601975_CR8","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1093\/clinchem\/34.11.2253","volume":"34","author":"P Chappuis","year":"1988","unstructured":"Chappuis P, Duhaux L, Paolaggi F, de Vernejoul MC & Rousselet F (1988): Analytical problems encountered in determining aluminum status from hair in controls and hemodialyzed patients. Clin. Chem. 34, 2253\u20132255.","journal-title":"Clin. Chem."},{"key":"BF1601975_CR9","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/BF02992730","volume":"26\u201327","author":"YD Cheng","year":"1990","unstructured":"Cheng YD, Zhuang GS, Tan MG, Zhi M & Zhou W (1990): Study of correlation of Se content in human hair and internal organs by INAA. Biol. Trace Elem. Res. 26\u201327, 737\u2013741.","journal-title":"Biol. Trace Elem. Res."},{"key":"BF1601975_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0015-7368(71)70621-5","volume":"11","author":"R Cornelis","year":"1971","unstructured":"Cornelis R & Speecke A (1971): Neutron activation analysis of human hair collected at regular intervals for 25 years. J. Forensic Sci. Soc. 11, 29\u201346.","journal-title":"J. Forensic Sci. Soc."},{"key":"BF1601975_CR11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/clinchem\/21.4.603","volume":"21","author":"JP Creason","year":"1975","unstructured":"Creason JP, Hinners TA, Bumgarner JE & Pinkerton C (1975): Trace elements in hair, as related to exposure in metropolitan New York. Clin. Chem. 21, 603\u2013612.","journal-title":"Clin. Chem."},{"key":"BF1601975_CR12","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1093\/ajcn\/30.12.2047","volume":"30","author":"SB Deeming","year":"1977","unstructured":"Deeming SB & Weber CW (1977): Evaluation of hair analysis for determination of zinc status using rats. Am. J. Clin. Nutr. 30, 2047\u20132052.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601975_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/BF02917419","volume":"22","author":"ES DiPietro","year":"1989","unstructured":"DiPietro ES, Phillips DL, Paschal DC & Neese JW (1989): Determination of trace elements in human hair. Reference intervals for 28 elements in nonoccupationally exposed adults in the US and effects of hair treatments. Biol. Trace Elem. Res. 22, 83\u2013100.","journal-title":"Biol. Trace Elem. Res."},{"key":"BF1601975_CR14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0946-672X(02)80005-0","volume":"16","author":"G Drasch","year":"2002","unstructured":"Drasch G & Roider G (2002): Assessment of hair mineral analysis commercially offered in Germany. J. Trace Elem. Med. Biol. 16, 27\u201331.","journal-title":"J. Trace Elem. Med. Biol."},{"key":"BF1601975_CR15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/BF02783970","volume":"62","author":"ME Druyan","year":"1998","unstructured":"Druyan ME, Bass D, Puchyr R, Urek K, Quig D, Harmon E & Marquardt W (1998): Determination of reference ranges for elements in human scalp hair. Biol. Trace Elem. Res. 62, 183\u2013197.","journal-title":"Biol. Trace Elem. Res."},{"key":"BF1601975_CR16","first-page":"161","volume":"6","author":"CD Hunt","year":"1989","unstructured":"Hunt CD & Shuler TR (1989): Open-vessel, wet-ash, low-temperature digestion of biological materials for inductively coupled argon plasma spectroscopy (ICAP) analysis of boron and other elements. J. Micronutr. Anal. 6, 161\u2013174.","journal-title":"J. Micronutr. Anal."},{"key":"BF1601975_CR17","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1093\/ajcn\/31.3.477","volume":"31","author":"RA Jacob","year":"1978","unstructured":"Jacob RA, Klevay LM & Logan Jr GM (1978): Hair as a biopsy material. V. Hair metal as an index of hepatic metal in rats: copper and zinc. Am. J. Clin. Nutr. 31, 477\u2013480.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601975_CR18","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1093\/ajcn\/23.9.1194","volume":"23","author":"LM Klevay","year":"1970","unstructured":"Klevay LM (1970a): Hair as a biopsy material II. Assessment of copper nutriture. Am. J. Clin. Nutr. 23, 1194\u20131202.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601975_CR19","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1093\/ajcn\/23.3.284","volume":"23","author":"LM Klevay","year":"1970","unstructured":"Klevay LM (1970b): Hair as a biopsy material. I. Assessment of zinc nutriture. Am. J. Clin. Nutr. 23, 284\u2013289.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601975_CR20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/00039896.1973.10666250","volume":"26","author":"LM Klevay","year":"1973","unstructured":"Klevay LM (1973): Hair as a biopsy material. 3. Assessment of environmental lead exposure. Arch. Environ. Health 26, 169\u2013172.","journal-title":"Arch. Environ. Health"},{"key":"BF1601975_CR21","first-page":"11","volume-title":"Proceedings of the International Conference on Feed Additives","author":"LM Klevay","year":"1981","unstructured":"Klevay LM (1981a): Hair as a biopsy material in the assessment of trace element exposure. Proceedings of the International Conference on Feed Additives. Budapest. ed. S. Szentmihalyi, 3, pp. 11\u201318."},{"key":"BF1601975_CR22","first-page":"371","volume":"23","author":"LM Klevay","year":"1981","unstructured":"Klevay LM (1981b): Hair as a biopsy material. VI. Hair copper as an index of copper in heart and kidney of rats. Nutr. Rep. Int. 23, 371\u2013376.","journal-title":"Nutr. Rep. Int."},{"key":"BF1601975_CR23","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/ajcn\/46.2.233","volume":"46","author":"LM Klevay","year":"1987","unstructured":"Klevay LM, Bistrian BR, Fleming CR & Neumann CG (1987): Hair analysis in clinical and experimental medicine. Am. J. Clin. Nutr. 46, 233\u2013236.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601975_CR24","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S1382-6689(01)00095-3","volume":"11","author":"LM Klevay","year":"2002","unstructured":"Klevay LM, Christopherson DM & Shuler TR (2002): Lead in hair and gasoline. Environ. Toxicol. Pharmacol. 11, 141\u2013142.","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"BF1601975_CR25","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0048-9697(90)90060-8","volume":"95","author":"M Leotsinidis","year":"1990","unstructured":"Leotsinidis M & Kondakis X (1990): Trace metals in scalp hair of Greek agricultural workers. Sci. Total Environ. 95, 149\u2013156.","journal-title":"Sci. Total Environ."},{"key":"BF1601975_CR26","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1080\/00039896.1968.10665346","volume":"17","author":"K Liebscher","year":"1968","unstructured":"Liebscher K & Smith H (1968): Essential and nonessential trace elements. A method of determining whether an element is essential or nonessential in human tissue. Arch. Environ. Health 17, 881\u2013890.","journal-title":"Arch. Environ. Health"},{"key":"BF1601975_CR27","first-page":"160","volume":"9","author":"F Marumo","year":"1979","unstructured":"Marumo F, Tsukamoto Y, Iwanami S, Kishimoto T & Yamagami S (1979): Effects of hemofiltration and hemodialysis on contents of trace elements in hair, nails and plasma of patients with chronic renal failure. Proc. Clin. Dial. Transplant. Forum 9, 160\u2013164.","journal-title":"Proc. Clin. Dial. Transplant. Forum"},{"key":"BF1601975_CR28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0048-9697(86)90259-7","volume":"54","author":"J Moon","year":"1986","unstructured":"Moon J, Smith TJ, Tamaro S, Enarson D, Fadl S, Davison AJ & Weldon L (1986): Trace metals in scalp hair of children and adults in three Alberta Indian villages. Sci. Total Environ. 54, 107\u2013125.","journal-title":"Sci. Total Environ."},{"key":"BF1601975_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0048-9697(88)90280-X","volume":"76","author":"Y Muramatsu","year":"1988","unstructured":"Muramatsu Y & Parr RM (1988): Concentrations of some trace elements in hair, liver and kidney from autopsy subjects\u2014relationship between hair and internal organs. Sci. Total Environ. 76, 29\u201340.","journal-title":"Sci. Total Environ."},{"key":"BF1601975_CR30","first-page":"83","volume":"55","author":"H Mussalo-Rauhamaa","year":"1996","unstructured":"Mussalo-Rauhamaa H, Kantola M, Seppanen K, Soininen L & Koivusalo M (1996): Trends in the concentrations of mercury, copper, zinc and selenium in inhabitants of north-eastern Finnish Lapland in 1982\u20131991. A pilot study. Arctic Med. Res. 55, 83\u201391.","journal-title":"Arctic Med. Res."},{"key":"BF1601975_CR31","first-page":"18","volume":"300","author":"J Neve","year":"1980","unstructured":"Neve J, Haucoq M & Molle L (1980): Critical study of some wet digestion methods for the decomposition of biological materials for the determination of total Se and Se(VI). Mickrochim Acta 300, 18.","journal-title":"Mickrochim Acta"},{"key":"BF1601975_CR32","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1080\/0002889758507239","volume":"36","author":"UG Oleru","year":"1975","unstructured":"Oleru UG (1975): Epidemiological implications of environmental cadmium. I. The probable utility of human hair for occupational trace metal (cadmium) screening. Am. Ind. Hyg. Assoc. J. 36, 229\u2013233.","journal-title":"Am. Ind. Hyg. Assoc. J."},{"key":"BF1601975_CR33","first-page":"245","volume":"60","author":"HM Perry Jr","year":"1962","unstructured":"Perry Jr HM, Tipton IH, Schroeder HA & Cook MJ (1962): Variability in the metal content of human organs. J. Lab. Clin. Med. 60, 245\u2013253.","journal-title":"J. Lab. Clin. Med."},{"key":"BF1601975_CR34","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1080\/00039896.1971.10665986","volume":"23","author":"HG Petering","year":"1971","unstructured":"Petering HG, Yeager DW & Witherup SO (1971): Trace metal content of hair. I. Zinc and copper content of human hair in relation to age and sex. Arch. Environ. Health 23, 202\u2013207.","journal-title":"Arch. Environ. Health"},{"key":"BF1601975_CR35","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/00039896.1973.10666389","volume":"27","author":"HG Petering","year":"1973","unstructured":"Petering HG, Yeager DW & Witherup SO (1973): Trace metal content of hair. II. Cadmium and lead of human hair in relation to age and sex. Arch. Environ. Health 27, 327\u2013330.","journal-title":"Arch. Environ. Health"},{"key":"BF1601975_CR36","unstructured":"SAS (1999): SAS\/STAT 8.0. Cary, NC: SAS Institute, Inc."},{"key":"BF1601975_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/jid.1969.110","volume":"53","author":"HA Schroeder","year":"1969","unstructured":"Schroeder HA & Nason AP (1969): Trace metals in human hair. J. Invest. Dermatol. 53, 71\u201378.","journal-title":"J. Invest. Dermatol."},{"key":"BF1601975_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1001\/jama.285.1.67","volume":"285","author":"S Seidel","year":"2001","unstructured":"Seidel S, Kreutzer R, Smith D, McNeel S & Gilliss D (2001): Assessment of commercial laboratories performing hair mineral analysis. JAMA 285, 67\u201372.","journal-title":"JAMA"},{"key":"BF1601975_CR39","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0048-9697(87)90213-0","volume":"67","author":"KP Shrestha","year":"1987","unstructured":"Shrestha KP & Oswaldo A (1987): Trace elements in hair of epileptic and normal subjects. Sci. Total Environ. 67, 215\u2013225.","journal-title":"Sci. Total Environ."},{"key":"BF1601975_CR40","first-page":"206","volume-title":"Biometry The principles and practice of statistics in biological research","author":"RR Sokal","year":"1969","unstructured":"Sokal RR & Rohlf FJ (1969): Biometry The principles and practice of statistics in biological research, pp. 206\u2013213. San Francisco, CA: W.H. Freeman & Co."},{"key":"BF1601975_CR41","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1080\/00984109708984035","volume":"51","author":"AK Srivastava","year":"1997","unstructured":"Srivastava AK, Gupta BN, Bihari V, Gaur JS & Mathur N (1997): Hair selenium as a monitoring tool for occupational exposures in relation to clinical profile. J. Toxicol. Environ. Health 51, 437\u2013445.","journal-title":"J. Toxicol. Environ. Health"},{"key":"BF1601975_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF02916815","volume":"40","author":"A Sturaro","year":"1994","unstructured":"Sturaro A, Parvoli G, Doretti L, Allegri G & Costa C (1994): The influence of color, age, and sex on the content of zinc, copper, nickel, manganese, and lead in human hair. Biol. Trace Elem. Res. 40, 1\u20138.","journal-title":"Biol. Trace Elem. Res."},{"key":"BF1601975_CR43","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0048-9697(82)90056-0","volume":"24","author":"S Thimaya","year":"1982","unstructured":"Thimaya S & Ganapathy SN (1982): Selenium in human hair in relation to age, diet, pathological condition and serum levels. Sci. Total Environ. 24, 41\u201349.","journal-title":"Sci. Total Environ."},{"key":"BF1601975_CR44","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1126\/science.178.4056.69","volume":"178","author":"D Weiss","year":"1972","unstructured":"Weiss D, Whitten B & Leddy D (1972): Lead content of human hair (1871\u20131971). Science 178, 69\u201370.","journal-title":"Science"},{"key":"BF1601975_CR45","first-page":"485","volume":"198","author":"M Wilhelm","year":"1996","unstructured":"Wilhelm M & Idel H (1996): Hair analysis in environmental medicine. Zentralbl. Hyg. Umweltmed. 198, 485\u2013501.","journal-title":"Zentralbl. Hyg. Umweltmed."},{"key":"BF1601975_CR46","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0048-9697(90)90330-W","volume":"92","author":"M Wilhelm","year":"1990","unstructured":"Wilhelm M, Ohnesorge FK & Hotzel D (1990): Cadmium, copper, lead, and zinc concentrations in human scalp and pubic hair. Sci. Total Environ. 92, 199\u2013206.","journal-title":"Sci. Total Environ."},{"key":"BF1601975_CR47","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0048-9697(90)90217-I","volume":"99","author":"J Yoshinaga","year":"1990","unstructured":"Yoshinaga J, Imai H, Nakazawa M, Suzuki T & Morita M (1990): Lack of significantly positive correlations between elemental concentrations in hair and in organs. Sci. Total Environ. 99, 125\u2013135.","journal-title":"Sci. Total Environ."},{"key":"BF1601975_CR48","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/BF02992729","volume":"26-27","author":"GS Zhuang","year":"1990","unstructured":"Zhuang GS, Wang YS, Tan MG, Zhi M, Pan WQ & Cheng YD (1990): Preliminary study of the distribution of the toxic elements As, Cd, and Hg in human hair and tissues by RNAA. Biol. Trace Elem. Res. 26-27, 729\u2013736.","journal-title":"Biol. Trace Elem. Res."}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1601975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1601975","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1601975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T16:09:27Z","timestamp":1648224567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1601975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,7]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10,1]]}},"alternative-id":["BF1601975"],"URL":"https:\/\/doi.org\/10.1038\/sj.ejcn.1601975","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,7]]},"assertion":[{"value":"24 March 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2004","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}