{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:58:41Z","timestamp":1787003921144,"version":"build-2736575974"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T00:00:00Z","timestamp":1085529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T00:00:00Z","timestamp":1085529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2004,11,1]]},"DOI":"10.1038\/sj.ejcn.1601998","type":"journal-article","created":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T05:13:24Z","timestamp":1085548404000},"page":"1498-1504","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Reduced production of immunoregulatory cytokines in vitamin A- and zinc-deficient Indonesian infants"],"prefix":"10.1038","volume":"58","author":[{"given":"F T","family":"Wieringa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Dijkhuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C E","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"van der Ven-Jongekrijg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Muhilal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W M","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,5,26]]},"reference":[{"key":"BF1601998_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(95)91157-X","volume":"345","author":"CJ Bates","year":"1995","unstructured":"Bates CJ (1995): Vitamin A. Lancet 345, 31\u201335.","journal-title":"Lancet"},{"key":"BF1601998_CR2","unstructured":"Beaton GH, Martorell R, L\u2019Abbe KA, Edmonston B, McCabe GP, Ross AC & Harvey B (1992): Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. Final report to CIDA, University of Toronto, Canada."},{"key":"BF1601998_CR3","first-page":"E1002","volume":"272","author":"FW Beck","year":"1997","unstructured":"Beck FW, Prasad AS, Kaplan J, Fitzgerald JT & Brewer GJ (1997): Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am. J. Physiol. 272, E1002\u2013E1007.","journal-title":"Am. J. Physiol."},{"key":"BF1601998_CR4","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1093\/ajcn\/72.6.1516","volume":"72","author":"ZA Bhutta","year":"2000","unstructured":"Bhutta ZA, Bird SM, Black RE, Brown KH, Meeks Gardner J, Hidayat A, Khatun F, Martorell R, Ninh NX, Penny ME, Rosado JL, Roy SK, Ruel M, Sazawal S & Shankar AH (2000): Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am. J. Clin. Nutr. 72, 1516\u20131522.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601998_CR5","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1093\/jn\/120.10.1264","volume":"120","author":"TA Bowman","year":"1990","unstructured":"Bowman TA, Goonewardene IM, Pasatiempo AM, Ross AC & Taylor CE (1990): Vitamin A deficiency decreases natural killer cell activity and interferon production in rats. J. Nutr. 120, 1264\u20131273.","journal-title":"J. Nutr."},{"key":"BF1601998_CR6","doi-asserted-by":"publisher","first-page":"425S","DOI":"10.1093\/ajcn\/68.2.425S","volume":"68","author":"KH Brown","year":"1998","unstructured":"Brown KH (1998): Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries. Am. J. Clin. Nutr. 68, 425S\u2013429S.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601998_CR7","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.4049\/jimmunol.152.4.1515","volume":"152","author":"MT Cantorna","year":"1994","unstructured":"Cantorna MT, Nashold FE & Hayes CE (1994): In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. J. Immunol. 152, 1515\u20131522.","journal-title":"J. Immunol."},{"key":"BF1601998_CR8","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/ajcn\/73.4.786","volume":"73","author":"MA Dijkhuizen","year":"2001","unstructured":"Dijkhuizen MA, Wieringa FT, West CE, Muherdiyantiningsih & Muhilal (2001): Concurrent micronutrient deficiencies in lactating mothers and their infants in Indonesia. Am. J. Clin. Nutr. 73, 786\u2013791.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601998_CR9","first-page":"55","volume-title":"Bioavailability of micronutrients and minor dietary compounds. Metabolic and technological aspects.","author":"MA Dijkhuizen","year":"2003","unstructured":"Dijkhuizen MA, Wieringa FT, West CE & Van Wouwe JP (2003): The role of zinc as a nutrient and its significance for health. In Bioavailability of micronutrients and minor dietary compounds. Metabolic and technological aspects. Eds. Pilar Vaquero M, Garcia-Arias T, Carbajal A & Sanchez-Muniz FJ, Trivandrum (Kerala), India: Research Signpost,. Chapter 5, pp 55\u201368."},{"key":"BF1601998_CR10","first-page":"272","volume":"84","author":"C Driessen","year":"1995","unstructured":"Driessen C, Hirv K, Kirchner H & Rink L (1995): Zinc regulates cytokine induction by superantigens and lipopolysaccharide. Immunology 84, 272\u2013277.","journal-title":"Immunology"},{"key":"BF1601998_CR11","unstructured":"FAO\/WHO (1992): International conference on nutrition. World declaration and plan of action. FAO: Rome."},{"key":"BF1601998_CR12","volume-title":"Principles of Nutritional Assessment","author":"RS Gibson","year":"1990","unstructured":"Gibson RS (1990): Principles of Nutritional Assessment. Oxford: Oxford University Press."},{"key":"BF1601998_CR13","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/jcb.10166","volume":"85","author":"D Hatakeyama","year":"2002","unstructured":"Hatakeyama D, Kozawa O, Otsuka T, Shibata T & Uematsu T (2002): Zinc suppresses IL-6 synthesis by prostaglandin F2alpha in osteoblasts:inhibition of phospholipase C and phospholipase D. J. Cell Biochem. 85, 621\u2013628.","journal-title":"J. Cell Biochem."},{"key":"BF1601998_CR14","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1084\/jem.160.1.310","volume":"160","author":"C Huber","year":"1984","unstructured":"Huber C, Batchelor JR, Fuchs D, Hausen A, Lang A, Niederwieser D, Reibnegger G, Swetly P, Troppmair J & Wachter H (1984): Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J. Exp. Med. 160, 310\u2013316.","journal-title":"J. Exp. Med."},{"key":"BF1601998_CR15","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1182\/blood.V87.12.5144.bloodjournal87125144","volume":"87","author":"PM Jansen","year":"1996","unstructured":"Jansen PM, van der Pouw Kraan TC, de Jong IW, van Mierlo G, Wijdenes J, Chang AA, Aarden LA, Taylor FBJ & Hack CE (1996): Release of interleukin-12 in experimental Escherichia coli septic shock in baboons: relation to plasma levels of interleukin- 10 and interferon-gamma. Blood 87, 5144\u20135151.","journal-title":"Blood"},{"key":"BF1601998_CR16","first-page":"616","volume":"9","author":"J Jason","year":"2002","unstructured":"Jason J, Archibald LK, Nwanyanwu OC, Sowell AL, Buchanan I, Larned J, Bell M, Kazembe PN, Dobbie H & Jarvis WR (2002): Vitamin A levels and immunity in humans. Clin. Diagn. Lab. Immunol. 9, 616\u2013621.","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"BF1601998_CR17","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/ajcn\/73.2.356","volume":"73","author":"NM Lowe","year":"2001","unstructured":"Lowe NM, Shames DM, Woodhouse LR, Matel JS, Roehl R, Saccomani MP, Toffolo G, Cobelli C & King JC (2001): A compartmental model of zinc metabolism in healthy women using oral and intervenous stable isotope tracers. Am. J. Clin. Nutr. 73, 356\u2013358.","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601998_CR18","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0952-7915(98)80163-5","volume":"10","author":"H Okamura","year":"1998","unstructured":"Okamura H, Kashiwamura S, Tsutsui H, Yoshimoto T & Nakanishi K (1998): Regulation of interferon-gamma production by IL-12 and IL-18. Curr. Opin. Immunol 10, 259\u2013264.","journal-title":"Curr. Opin. Immunol"},{"key":"BF1601998_CR19","doi-asserted-by":"publisher","first-page":"616S","DOI":"10.1093\/jn\/131.2.616S","volume":"131","author":"SJ Oppenheimer","year":"2001","unstructured":"Oppenheimer SJ (2001): Iron and its relation to immunity and infectious disease. J. Nutr. 131, 616S\u2013635S.","journal-title":"J. Nutr."},{"key":"BF1601998_CR20","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1096\/fasebj.10.9.8801180","volume":"10","author":"AC Ross","year":"1996","unstructured":"Ross AC & Stephensen CB (1996): Vitamin A and retinoids in antiviral responses. FASEB. J. 10, 979\u2013985.","journal-title":"FASEB. J."},{"key":"BF1601998_CR21","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1093\/clinids\/19.3.489","volume":"19","author":"RD Semba","year":"1994","unstructured":"Semba RD (1994): Vitamin A, immunity, and infection. Clin. Infect. Dis. 19, 489\u2013499.","journal-title":"Clin. Infect. Dis."},{"key":"BF1601998_CR22","doi-asserted-by":"publisher","first-page":"447(S)","DOI":"10.1093\/ajcn\/68.2.447S","volume":"68","author":"AH Shankar","year":"1998","unstructured":"Shankar AH & Prasad AS (1998): Zinc and immune function: the biological basis of altered resistance to infection. Am. J. Clin. Nutr. 68, 447(S)\u2013463(S).","journal-title":"Am. J. Clin. Nutr."},{"key":"BF1601998_CR23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0022-1759(98)00192-6","volume":"222","author":"R van Crevel","year":"1999","unstructured":"van Crevel R, van der Ven J, Netea MG, de Lange W, Kullberg BJ & Van der Meer JWM (1999): Disease-specific ex vivo stimulation of whole blood for cytokine production: applications in the study of tuberculosis. J. Immunol. Meth. 222, 145\u2013153.","journal-title":"J. Immunol. Meth."},{"key":"BF1601998_CR24","first-page":"581","volume":"80","author":"U Wiedermann","year":"1993","unstructured":"Wiedermann U, Hanson LA, Kahu H & Dahlgren UI (1993): Aberrant T-cell function in vitro and impaired T-cell dependent antibody response in vivo in vitamin A-deficient rats. Immunology 80, 581\u2013586.","journal-title":"Immunology"},{"key":"BF1601998_CR25","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1093\/jn\/131.10.3061","volume":"132","author":"FT Wieringa","year":"2002","unstructured":"Wieringa FT, Dijkhuizen MA, West CE, Northrop-Clewes CA & Muhilal (2002): Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants. J. Nutr. 132, 3061\u20133066.","journal-title":"J. Nutr."}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1601998.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1601998","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1601998.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T19:14:36Z","timestamp":1734376476000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1601998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,26]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11,1]]}},"alternative-id":["BF1601998"],"URL":"https:\/\/doi.org\/10.1038\/sj.ejcn.1601998","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,26]]},"assertion":[{"value":"17 October 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2004","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2004","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2004","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}