{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:15:18Z","timestamp":1790709318321,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T00:00:00Z","timestamp":1185321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T00:00:00Z","timestamp":1185321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Nutr"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1038\/sj.ejcn.1602848","type":"journal-article","created":{"date-parts":[[2007,7,26]],"date-time":"2007-07-26T13:25:26Z","timestamp":1185456326000},"page":"1294-1301","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["\u03b1-Lactalbumin-rich infant formula fed to healthy term infants in a multicenter study: plasma essential amino acids and gastrointestinal tolerance"],"prefix":"10.1038","volume":"62","author":[{"given":"A M","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B J","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E L","family":"Lien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Pramuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Trabulsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,7,25]]},"reference":[{"key":"BF1602848_CR1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1080\/07315724.2000.10718943","volume":"19","author":"C Agostini","year":"2000","unstructured":"Agostini C, Carratu B, Boniglia C, Riva E, Sanzini E (2000). Free amino acid content in standard infant formulas: comparison with human milk. J Am Coll Nutr 19, 434\u2013438.","journal-title":"J Am Coll Nutr"},{"key":"BF1602848_CR2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/S0899-9007(02)00752-9","volume":"18","author":"PA Alarcon","year":"2002","unstructured":"Alarcon PA, Tressler RL, Mulvaney A, Lam W, Comer GM (2002). Gastrointestinal tolerance of a new infant milk formula in healthy babies: an international study conducted in 17 countries. Nutrition 18, 484\u2013489.","journal-title":"Nutrition"},{"key":"BF1602848_CR3","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0021-9258(18)96104-1","volume":"242","author":"U Brodbeck","year":"1967","unstructured":"Brodbeck U, Denton WL, Tanahashi N, Ebner KE (1967). The isolation and identification of the B protein of lactose synthetase as alpha-lactalbumin. J Biol Chem 242, 1391\u20131397.","journal-title":"J Biol Chem"},{"key":"BF1602848_CR4","first-page":"5119","volume":"50","author":"KG Dewey","year":"1996","unstructured":"Dewey KG, Beaton G, Fjeld C, Lonnerdal B, Reeds P (1996). Protein requirements of infants and children. Eur J Clin Nutr 50, 5119\u20135150.","journal-title":"Eur J Clin Nutr"},{"key":"BF1602848_CR5","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1093\/ajcn\/46.5.736","volume":"46","author":"MJ Dibley","year":"1987","unstructured":"Dibley MJ, Goldsby JB, Staehling NW, Trowbridge FL (1987). Development of normalized curves for the international growth reference: historical and technical considerations. Am J Clin Nutr 46, 736\u2013748.","journal-title":"Am J Clin Nutr"},{"key":"BF1602848_CR6","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1097\/00005176-199205000-00014","volume":"14","author":"A Fazzolari-Nesci","year":"1992","unstructured":"Fazzolari-Nesci A, Domianello D, Sotera V, Raiha NCR (1992). Tryptophan fortification of adapted formula increases plasma tryptophan concentrations to levels not different from those found in breast-fed infants. J Pediatr Gastroenterol Nutr 14, 456\u2013459.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BF1602848_CR7","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1093\/ajcn\/56.6.1004","volume":"56","author":"RM Hanning","year":"1992","unstructured":"Hanning RM, Paes B, Atkinson SA (1992). Protein metabolism and growth of term infants in response to a reduced-protein, 40:60 whey:casein formula with added tryptophan. Am J Clin Nutr 56, 1004\u20131011.","journal-title":"Am J Clin Nutr"},{"key":"BF1602848_CR8","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1111\/j.1651-2227.1996.tb14210.x","volume":"85","author":"W Heine","year":"1996","unstructured":"Heine W, Radke M, Wutzke KD, Peters E, Kundt G (1996). Alpha-lactalbumin-enriched low-protein infant formulas: a comparison to breast milk feeding. Acta Paediatr 85, 1024\u20131028.","journal-title":"Acta Paediatr"},{"key":"BF1602848_CR9","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/jn\/121.3.277","volume":"121","author":"WE Heine","year":"1991","unstructured":"Heine WE, Klein PD, Reeds PJ (1991). The importance of alpha-lactalbumin in infant nutrition. J Nutr 121, 277\u2013283.","journal-title":"J Nutr"},{"key":"BF1602848_CR10","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jnutbio.2003.10.009","volume":"15","author":"JG Jackson","year":"2004","unstructured":"Jackson JG, Janszen DB, Lonnerdal B, Lien EL, Pramuk KP, Kuhlman CF (2004). A multinational study of alpha-lactalbumin concentrations in human milk. J Nutr Biochem 15, 517\u2013521.","journal-title":"J Nutr Biochem"},{"key":"BF1602848_CR11","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/S0022-3476(87)80394-3","volume":"110","author":"LM Janas","year":"1987","unstructured":"Janas LM, Picciano MF, Hathch TF (1987). Indices of protein metabolism in term infants fed either human milk or formulas with reduced protein concentration and various whey\/casein ratios. J Pediatr 110, 838\u2013848.","journal-title":"J Pediatr"},{"key":"BF1602848_CR12","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/00005176-199803000-00011","volume":"26","author":"PM Karlsland Akeson","year":"1998","unstructured":"Karlsland Akeson PM, Axelsson IEM, Raiha NCR (1998). Protein and amino acid metabolism in three-to twelve-month old infants fed human milk or formulas with varying protein concentrations. J Pediatr Gastroenterol Nutr 26, 297\u2013304.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BF1602848_CR13","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1093\/ajcn\/77.5.1261","volume":"77","author":"SL Kelleher","year":"2003","unstructured":"Kelleher SL, Chatterton D, Nielsen K, Lonnerdal B (2003). Glycomacropeptide and alpha-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J Clin Nutr 77, 1261\u20131268.","journal-title":"Am J Clin Nutr"},{"key":"BF1602848_CR14","volume-title":"Advance data from vital and health statistics; no. 314","author":"RJ Kuczmarski","year":"2000","unstructured":"Kuczmarski RJ, Ogden CL, Grummer-Strawn LM et al. (2000). CDC growth charts: United States. Advance data from vital and health statistics; no. 314. Hyattsville, Maryland: National Center for Health Statistics."},{"key":"BF1602848_CR15","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1093\/clinchem\/43.12.2397","volume":"43","author":"N Lepage","year":"1997","unstructured":"Lepage N, McDonald N, Dallaire L, Lambert M (1997). Age-specific distribution of plasma amino acid concentrations in a healthy pediatric population. Clin Chem 43, 2397\u20132402.","journal-title":"Clin Chem"},{"issue":"Suppl","key":"BF1602848_CR16","doi-asserted-by":"publisher","first-page":"1555S","DOI":"10.1093\/ajcn\/77.6.1555S","volume":"77","author":"EL Lien","year":"2003","unstructured":"Lien EL (2003). Infant formulas with increased concentrations of alpha-lactalbumin. Am J Clin Nutr 77 (Suppl), 1555S\u20131558S.","journal-title":"Am J Clin Nutr"},{"key":"BF1602848_CR17","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/00005176-200402000-00013","volume":"38","author":"EL Lien","year":"2004","unstructured":"Lien EL, Davis AM, multi-center group (2004). Growth and safety of a reduced protein formula enriched with bovine alpha-lactalbumin in term infants. J Pediatr Gastroenterol Nutr 38, 170\u2013176.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BF1602848_CR18","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.1542\/peds.103.1.e7","volume":"103","author":"B Lloyd","year":"1999","unstructured":"Lloyd B, Halter RJ, Kuchan MJ, Bags GE, Ryan AS, Masor ML (1999). Formula tolerance in post-breastfed and exclusively formula-fed infants. Pediatrics 103, E7.","journal-title":"Pediatrics"},{"key":"BF1602848_CR19","first-page":"53","volume-title":"Protein Metabolism During Infancy","author":"B Lonnerdal","year":"1994","unstructured":"Lonnerdal B (1994). Digestibility and absorption of protein in infants. In: Raiha NCR (ed.), Protein Metabolism During Infancy. Raven Press: Vevey 33, pp 53\u201365."},{"key":"BF1602848_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.1651-2227.1990.tb11454.x","volume":"79","author":"B Lonnerdal","year":"1990","unstructured":"Lonnerdal B, Chen CL (1990). Effects of formula protein level and ratio on infant growth, plasma amino acids and serum trace elements. Acta Paediatr Scand 79, 257\u2013265.","journal-title":"Acta Paediatr Scand"},{"key":"BF1602848_CR21","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1093\/jn\/115.9.1209","volume":"115","author":"B Lonnerdal","year":"1985","unstructured":"Lonnerdal B, Glazier C (1985). Calcium binding by alpha-lactalbumin in human milk and bovine. J Nutr 115, 1209\u20131216.","journal-title":"J Nutr"},{"key":"BF1602848_CR22","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1093\/ajcn\/68.2.350","volume":"68","author":"B Lonnerdal","year":"1998","unstructured":"Lonnerdal B, Hernell O (1998). Effects of feeding ultrahigh-temperature (UHT)-treated infant formula with different protein concentrations or powdered formula, as compared with breast-feeding, on plasma amino acids, hematology, and trace element status. Am J Clin Nutr 68, 350\u2013356.","journal-title":"Am J Clin Nutr"},{"key":"BF1602848_CR23","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1301\/nr.2003.sept.295-305","volume":"61","author":"B Lonnerdal","year":"2003","unstructured":"Lonnerdal B, Lien E (2003). Nutritional and physiologic significance of alpha-lactalbumin in infants. Nutr Rev 61, 295\u2013305.","journal-title":"Nutr Rev"},{"key":"BF1602848_CR24","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1093\/ajcn\/50.4.778","volume":"50","author":"M Pamblanco","year":"1989","unstructured":"Pamblanco M, Portoles M, Paredes C, Ten A, Comin J (1989). Free amino acids in preterm and term milk from mothers delivering appropriate- or small-for-gestational-age infants. Am J Clin Nutr 50, 778\u2013781.","journal-title":"Am J Clin Nutr"},{"key":"BF1602848_CR25","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/00005176-198910000-00015","volume":"9","author":"TA Picone","year":"1989","unstructured":"Picone TA, Benson JD, Moro G, Minoli I, Fulconis F, Rassin DK et al. (1989). Growth, serum biochemistries, amino acids of term infants fed formulas with amino acid and protein concentrations similar to human milk. J Pediatr Gastroenterol Nutr 9, 351\u2013360.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BF1602848_CR26","doi-asserted-by":"crossref","first-page":"19292","DOI":"10.1016\/S0021-9258(19)36512-3","volume":"268","author":"J Ren","year":"1993","unstructured":"Ren J, Stuart DI, Acharya KR (1993). Alpha-lactalbumin possesses a distinct zinc binding site. J Biol Chem 268, 19292\u201319298.","journal-title":"J Biol Chem"},{"key":"BF1602848_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/17450399509381825","volume":"48","author":"A Rerat","year":"1995","unstructured":"Rerat A (1995). Nutritional value of protein hydrolysis products (oligopeptides and free amino acids) as a consequence of absorption and metabolism kinetics Arch. Tierernahr 48, 23\u201336.","journal-title":"Tierernahr"},{"key":"BF1602848_CR28","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/00005176-199703000-00017","volume":"24","author":"S Rudolff","year":"1997","unstructured":"Rudolff S, Kunz C (1997). Protein and non-protein nitrogen components in human milk, bovine milk, and infant formula: quantitative and qualitative aspects of infant nutrition. J Pediatr Gastroenterol Nutr 24, 328\u2013344.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BF1602848_CR29","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/ajcn\/30.4.499","volume":"30","author":"U Svangerb","year":"1977","unstructured":"Svangerb U, Gebre-Medhin M, Ljungqvist B, Olson M (1977). Breast milk composition in Ethiopian and Swedish mothers: III Amino acid and other nitrogenous substances. Am J Clin Nutr 30, 499\u2013507.","journal-title":"Am J Clin Nutr"},{"key":"BF1602848_CR30","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/1097-4652(200102)186:2<251::AID-JCP1027>3.0.CO;2-F","volume":"186","author":"U Wenzel","year":"2001","unstructured":"Wenzel U, Meissner B, Doring F, Daniel H (2001). PEPT1-mediated uptake of dipeptides enhances the intestinal absorption of amino acids via transport system b(0,+). J Cell Physiol 186, 251\u2013259.","journal-title":"J Cell Physiol"},{"key":"BF1602848_CR31","unstructured":"World Health Organization Global Strategy for Infant and Young-Child Feeding (2003). Fifty-fourth WHA a54\/INF.DOC\/4 (Resolution WHA 54.2)."}],"container-title":["European Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1602848","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1602848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1602848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T21:44:59Z","timestamp":1648158299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1602848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,25]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["BF1602848"],"URL":"https:\/\/doi.org\/10.1038\/sj.ejcn.1602848","relation":{},"ISSN":["0954-3007","1476-5640"],"issn-type":[{"value":"0954-3007","type":"print"},{"value":"1476-5640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,25]]},"assertion":[{"value":"15 November 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}