{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:48:51Z","timestamp":1761216531534},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2002,8,13]],"date-time":"2002-08-13T00:00:00Z","timestamp":1029196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1038\/sj.ejhg.5200842","type":"journal-article","created":{"date-parts":[[2002,9,3]],"date-time":"2002-09-03T19:06:56Z","timestamp":1031080016000},"page":"539-546","source":"Crossref","is-referenced-by-count":38,"title":["A genome scan for loci influencing anti-atherogenic serum bilirubin levels"],"prefix":"10.1038","volume":"10","author":[{"given":"Florian","family":"Kronenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Coon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Gutin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Abkevich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis G","family":"Ballinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,8,13]]},"reference":[{"key":"BF5200842_CR1","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/clinchem\/46.11.1723","volume":"46","author":"M Mayer","year":"2000","unstructured":"Mayer M . Association of serum bilirubin concentration with risk of coronary artery disease Clin Chem 2000 46: 1723\u20131727","journal-title":"Clin Chem"},{"key":"BF5200842_CR2","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1126\/science.3029864","volume":"235","author":"R Stocker","year":"1987","unstructured":"Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN . Bilirubin is an antioxidant of possible physiological importance Science 1987 235: 1043\u20131046","journal-title":"Science"},{"key":"BF5200842_CR3","doi-asserted-by":"publisher","first-page":"5918","DOI":"10.1073\/pnas.84.16.5918","volume":"84","author":"R Stocker","year":"1987","unstructured":"Stocker R, Glazer AN, Ames BN . Antioxidant activity of albumin-bound bilirubin Proc Natl Acad Sci USA 1987 84: 5918\u20135922","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF5200842_CR4","doi-asserted-by":"crossref","first-page":"16712","DOI":"10.1016\/S0021-9258(19)89449-8","volume":"269","author":"J Neuzil","year":"1994","unstructured":"Neuzil J, Stocker R . Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation J Biol Chem 1994 269: 16712\u201316719","journal-title":"J Biol Chem"},{"key":"BF5200842_CR5","first-page":"233","volume":"12","author":"LB Dudnik","year":"1998","unstructured":"Dudnik LB, Khrapova NG . Characterization of bilirubin inhibitory properties in free radical oxidation reactions Membr Cell Biol 1998 12: 233\u2013240","journal-title":"Membr Cell Biol"},{"key":"BF5200842_CR6","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/0006-2952(95)02395-X","volume":"51","author":"TW Wu","year":"1996","unstructured":"Wu TW, Fung KP, Wu J, Yang CC, Weisel RD . Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins Biochem Pharmacol 1996 51: 859\u2013862","journal-title":"Biochem Pharmacol"},{"key":"BF5200842_CR7","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1073\/pnas.96.5.2445","volume":"96","author":"S Dore","year":"1999","unstructured":"Dore S, Takahashi M, Ferris CD, Hester LD, Guastella D, Snyder SH . Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury Proc Natl Acad Sci USA 1999 96: 2445\u20132450","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF5200842_CR8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1139\/o91-102","volume":"69","author":"TW Wu","year":"1991","unstructured":"Wu TW, Wu J, Li RK, Mickle D, Carey D . Albumin-bound bilirubins protect human ventricular myocytes against oxyradical damage Biochem Cell Biol 1991 69: 683\u2013688","journal-title":"Biochem Cell Biol"},{"key":"BF5200842_CR9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0008-6363(98)00278-8","volume":"41","author":"RC Siow","year":"1999","unstructured":"Siow RC, Sato H, Mann GE . Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovasc Res 1999 41: 385\u2013394","journal-title":"Cardiovasc Res"},{"key":"BF5200842_CR10","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1161\/01.ATV.17.5.969","volume":"17","author":"M Mietus-Snyder","year":"1997","unstructured":"Mietus-Snyder M, Friera A, Glass CK, Pitas RE . Regulation of scavenger receptor expression in smooth muscle cells by protein kinase C: a role for oxidative stress Arterioscler Thromb Vasc Biol 1997 17: 969\u2013978","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BF5200842_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0009-8981(93)90066-D","volume":"223","author":"Y Amit","year":"1993","unstructured":"Amit Y, Boneh A . Bilirubin inhibits protein kinase C activity and protein kinase C-mediated phosphorylation of endogenous substrates in human skin fibroblasts Clin Chim Acta 1993 223: 103\u2013111","journal-title":"Clin Chim Acta"},{"key":"BF5200842_CR12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/clinchem\/40.1.18","volume":"40","author":"HA Schwertner","year":"1994","unstructured":"Schwertner HA, Jackson WG, Tolan G . Association of low serum concentration of bilirubin with increased risk of coronary artery disease Clin Chem 1994 40: 18\u201323","journal-title":"Clin Chem"},{"key":"BF5200842_CR13","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1161\/01.ATV.16.8.912","volume":"16","author":"SC Hunt","year":"1996","unstructured":"Hunt SC, Wu LL, Hopkins PN, Williams RR . Evidence for a major gene elevating serum bilirubin concentration in Utah pedigrees Arterioscler Thromb Vasc Biol 1996 16: 912\u2013917","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BF5200842_CR14","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S0021-9150(00)00420-2","volume":"154","author":"SC Hunt","year":"2001","unstructured":"Hunt SC, Kronenberg F, Eckfeldt JH, Hopkins PN, Myers RH, Heiss G . Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: The NHLBI Family Heart Study Atherosclerosis 2001 154: 747\u2013754","journal-title":"Atherosclerosis"},{"key":"BF5200842_CR15","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/clinchem\/41.10.1504","volume":"41","author":"LH Breimer","year":"1995","unstructured":"Breimer LH, Wannamethee G, Ebrahim S, Shaper AG . Serum bilirubin and risk of ischemic heart disease in middle-aged British men Clin Chem 1995 41: 1504\u20131508","journal-title":"Clin Chem"},{"key":"BF5200842_CR16","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1161\/01.ATV.16.2.250","volume":"16","author":"PN Hopkins","year":"1996","unstructured":"Hopkins PN, Wu LL, Hunt SC, James BC, Vincent GM, Williams RR . Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease Arterioscler Thromb Vasc Biol 1996 16: 250\u2013255","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BF5200842_CR17","first-page":"185","volume":"27","author":"SS Levinson","year":"1997","unstructured":"Levinson SS . Relationship between bilirubin, apolipoprotein B, and coronary artery disease Ann Clin Lab Sci 1997 27: 185\u2013192","journal-title":"Ann Clin Lab Sci"},{"key":"BF5200842_CR18","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/S0002-9149(01)01494-1","volume":"87","author":"L Djousse","year":"2001","unstructured":"Djousse L, Levy D, Cupples LA, Evans JC, D'Agostino RB, Ellison RC . Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study Am J Cardiol 2001 87: 1196\u20131200","journal-title":"Am J Cardiol"},{"key":"BF5200842_CR19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0021-9150(97)06088-7","volume":"131","author":"M Madhavan","year":"1997","unstructured":"Madhavan M, Wattigney WA, Srinivasan SR, Berenson GS . Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults Atherosclerosis 1997 131: 107\u2013113","journal-title":"Atherosclerosis"},{"key":"BF5200842_CR20","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1086\/302945","volume":"66","author":"EN Kort","year":"2000","unstructured":"Kort EN, Ballinger DG, Ding W et al. Evidence of linkage of familial hypoalphalipoproteinemia to a novel locus on chromosome 11q23 Am J Hum Genet 2000 66: 1845\u20131856","journal-title":"Am J Hum Genet"},{"key":"BF5200842_CR21","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.2105\/AJPH.78.10.1283","volume":"78","author":"RR Williams","year":"1988","unstructured":"Williams RR, Hunt SC, Barlow GK et al. Health family trees: a tool for finding and helping young family members of coronary and cancer prone pedigrees in Texas and Utah Am J Public Health 1988 78: 1283\u20131286","journal-title":"Am J Public Health"},{"key":"BF5200842_CR22","first-page":"1037","volume-title":"Fundamentals of Clinical Chemistry","author":"JI Routh","year":"1976","unstructured":"Routh JI . Liver Function in Tietz NW (ed) Fundamentals of Clinical Chemistry Philadelphia: WB Saunders 1976 pp 1037\u20131040"},{"key":"BF5200842_CR23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1086\/301904","volume":"63","author":"JR O'Connell","year":"1998","unstructured":"O'Connell JR, Weeks DE . PedCheck: A program for identification of genotype incompatibilities in linkage analysis Am J Hum Genet 1998 63: 259\u2013266","journal-title":"Am J Hum Genet"},{"key":"BF5200842_CR24","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1073\/pnas.84.8.2363","volume":"84","author":"ES Lander","year":"1987","unstructured":"Lander ES, Green P . Construction of multilocus genetic linkage maps in humans Proc Natl Acad Sci USA 1987 84: 2363\u20132367","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF5200842_CR25","unstructured":"Hasstedt SJ.PAP . pedigree analysis package, rev. 4 Salt Lake City, Utah: Department of Human Genetics, University of Utah 1993"},{"key":"BF5200842_CR26","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1086\/302797","volume":"66","author":"HH G\u00f6ring","year":"2000","unstructured":"G\u00f6ring HH, Terwilliger JD . Linkage analysis in the presence of errors I: complex-valued recombination fractions and complex phenotypes Am J Hum Genet 2000 66: 1095\u20131106","journal-title":"Am J Hum Genet"},{"key":"BF5200842_CR27","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1023\/A:1008947712763","volume":"10","author":"A Thomas","year":"2000","unstructured":"Thomas A, Gutin A, Abkevich V, Bansal A . Multilocus linkage analysis by blocked Gibbs sampling Statistics Comput 2000 10: 259\u2013269","journal-title":"Statistics Comput"},{"issue":"Suppl 1","key":"BF5200842_CR28","doi-asserted-by":"publisher","first-page":"S461","DOI":"10.1002\/gepi.2001.21.s1.s461","volume":"21","author":"NJ Camp","year":"2001","unstructured":"Camp NJ, Gutin A, Abkevich V, Farnham JM, Cannon-Albright L, Thomas A . A new nonparametric linkage statistic for mapping both qualitative and quantitative trait loci Genet Epidemiol 2001 21 Suppl 1: S461\u2013S466","journal-title":"Genet Epidemiol"},{"key":"BF5200842_CR29","first-page":"1347","volume":"58","author":"L Kruglyak","year":"1996","unstructured":"Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES . Parametric and nonparametric linkage analysis: a unified multipoint approach Am J Hum Genet 1996 58: 1347\u20131363","journal-title":"Am J Hum Genet"},{"key":"BF5200842_CR30","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1086\/340670","volume":"70","author":"S Stone","year":"2002","unstructured":"Stone S, Abkevich V, Hunt SC et al. A major predisposition locus for severe obesity, at 4p15-p14 Am J Hum Genet 2002 70: 1459\u20131468","journal-title":"Am J Hum Genet"},{"key":"BF5200842_CR31","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0021-9150(97)00232-3","volume":"136","author":"HA Schwertner","year":"1998","unstructured":"Schwertner HA . Association of smoking and low serum bilirubin antioxidant concentrations Atherosclerosis 1998 136: 383\u2013387","journal-title":"Atherosclerosis"},{"key":"BF5200842_CR32","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1515\/CCLM.2000.078","volume":"38","author":"D Cerne","year":"2000","unstructured":"Cerne D, Ledinski G, Kager G, Greilberger J, Wang X, Jurgens G . Comparison of laboratory parameters as risk factors for the presence and the extent of coronary or carotid atherosclerosis: the significance of apolipoprotein B to apolipoprotein all ratio Clin Chem Lab Med 2000 38: 529\u2013538","journal-title":"Clin Chem Lab Med"},{"key":"BF5200842_CR33","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1023\/A:1013794407325","volume":"12","author":"EH Temme","year":"2001","unstructured":"Temme EH, Zhang J, Schouten EG, Kesteloot H . Serum bilirubin and 10-year mortality risk in a Belgian population Cancer Causes Control 2001 12: 887\u2013894","journal-title":"Cancer Causes Control"},{"key":"BF5200842_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/bbrc.1995.2248","volume":"214","author":"P Vigne","year":"1995","unstructured":"Vigne P, Feolde E, Ladoux A, Duval D, Frelin C . Contributions of NO synthase and heme oxygenase to cGMP formation by cytokine and hemin treated brain capillary endothelial cells Biochem Biophys Res Commun 1995 214: 1\u20135","journal-title":"Biochem Biophys Res Commun"},{"key":"BF5200842_CR35","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0014-5793(95)00650-X","volume":"368","author":"RC Siow","year":"1995","unstructured":"Siow RC, Ishii T, Sato H et al. Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells FEBS Lett 1995 368: 239\u2013242","journal-title":"FEBS Lett"},{"key":"BF5200842_CR36","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/0014-5793(92)80508-E","volume":"303","author":"G Paganga","year":"1992","unstructured":"Paganga G, Rice-Evans C, Rule R, Leake D . The interaction between ruptured erythrocytes and low-density lipoproteins FEBS Lett 1992 303: 154\u2013158","journal-title":"FEBS Lett"},{"key":"BF5200842_CR37","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0304-4165(93)90013-X","volume":"1158","author":"T Nakagami","year":"1993","unstructured":"Nakagami T, Toyomura K, Kinoshita T, Morisawa S . A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin Biochim Biophys Acta 1993 1158: 189\u2013193","journal-title":"Biochim Biophys Acta"},{"key":"BF5200842_CR38","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nm0196-87","volume":"2","author":"D Willis","year":"1996","unstructured":"Willis D, Moore AR, Frederick R, Willoughby DA . Heme oxygenase: a novel target for the modulation of the inflammatory response Nat Med 1996 2: 87\u201390","journal-title":"Nat Med"},{"key":"BF5200842_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1469-1809.1990.tb00356.x","volume":"54","author":"D Harding","year":"1990","unstructured":"Harding D, Jeremiah SJ, Povey S, Burchell B . Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1 Ann Hum Genet 1990 54: 17\u201321","journal-title":"Ann Hum Genet"},{"key":"BF5200842_CR40","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/hep.1840150531","volume":"15","author":"PJ Bosma","year":"1992","unstructured":"Bosma PJ, Chowdhury NR, Goldhoorn BG et al. Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I Hepatology 1992 15: 941\u2013947","journal-title":"Hepatology"},{"key":"BF5200842_CR41","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1172\/JCI115829","volume":"90","author":"JK Ritter","year":"1992","unstructured":"Ritter JK, Yeatman MT, Ferreira P, Owens IS . Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient J Clin Invest 1992 90: 150\u2013155","journal-title":"J Clin Invest"},{"key":"BF5200842_CR42","first-page":"722","volume":"53","author":"N Moghrabi","year":"1993","unstructured":"Moghrabi N, Clarke DJ, Burchell B, Boxer M . Cosegregation of intragenic markers with a novel mutation that causes Crigler-Najjar syndrome type I: implication in carrier detection and prenatal diagnosis Am J Hum Genet 1993 53: 722\u2013729","journal-title":"Am J Hum Genet"},{"key":"BF5200842_CR43","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/0016-5085(93)90029-C","volume":"105","author":"PJ Bosma","year":"1993","unstructured":"Bosma PJ, Goldhoorn B, Oude Elferink RP, Sinaasappel M, Oostra BA, Jansen PL . A mutation in bilirubin uridine 5\u2032-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type II Gastroenterology 1993 105: 216\u2013220","journal-title":"Gastroenterology"},{"key":"BF5200842_CR44","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1006\/geno.1993.1451","volume":"18","author":"N Moghrabi","year":"1993","unstructured":"Moghrabi N, Clarke DJ, Boxer M, Burchell B . Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2 Genomics 1993 18: 171\u2013173","journal-title":"Genomics"},{"key":"BF5200842_CR45","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1136\/jmg.12.2.152","volume":"12","author":"D Owens","year":"1975","unstructured":"Owens D, Evans J . Population studies on Gilbert's syndrome J Med Genet 1975 12: 152\u2013156","journal-title":"J Med Genet"},{"key":"BF5200842_CR46","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S0140-6736(77)92226-7","volume":"1","author":"A Bailey","year":"1977","unstructured":"Bailey A, Robinson D, Dawson AM . Does Gilbert's disease exist? Lancet 1977 1: 931\u2013933","journal-title":"Lancet"},{"key":"BF5200842_CR47","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1055\/s-2008-1068222","volume":"112","author":"A Sieg","year":"1987","unstructured":"Sieg A, Arab L, Schlierf G, Stiehl A, Kommerell B . Die Pr\u00e4valenz des Gilbert-Syndroms in Deutschland Dtsch Med Wochenschr 1987 112: 1206\u20131208","journal-title":"Dtsch Med Wochenschr"},{"key":"BF5200842_CR48","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0009-8981(97)00167-8","volume":"266","author":"DJ Clarke","year":"1997","unstructured":"Clarke DJ, Moghrabi N, Monaghan G et al. Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias Clin Chim Acta 1997 266: 63\u201374","journal-title":"Clin Chim Acta"},{"key":"BF5200842_CR49","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","volume":"333","author":"PJ Bosma","year":"1995","unstructured":"Bosma PJ, Chowdhury JR, Bakker C et al. The genetic basis of the reduced expression of bilirubin UDP- glucuronosyltransferase 1 in Gilbert's syndrome N Engl J Med 1995 333: 1171\u20131175","journal-title":"N Engl J Med"},{"key":"BF5200842_CR50","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/S0140-6736(96)91273-8","volume":"347","author":"G Monaghan","year":"1996","unstructured":"Monaghan G, Ryan M, Seddon R, Hume R, Burchell B . Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome Lancet 1996 347: 578\u2013581","journal-title":"Lancet"},{"key":"BF5200842_CR51","first-page":"106","volume":"84","author":"A Iolascon","year":"1999","unstructured":"Iolascon A, Faienza MF, Centra M, Storelli S, Zelante L, Savoia A . (TA)8 allele in the UGT1A1 gene promoter of a Caucasian with Gilbert's syndrome Haematologica 1999 84: 106\u2013109","journal-title":"Haematologica"},{"key":"BF5200842_CR52","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0021-9150(01)00601-3","volume":"160","author":"L Vitek","year":"2002","unstructured":"Vitek L, Jirsa M, Brodanova M et al. Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels Atherosclerosis 2002 160: 449\u2013456","journal-title":"Atherosclerosis"},{"key":"BF5200842_CR53","doi-asserted-by":"crossref","first-page":"7774","DOI":"10.1016\/S0021-9258(20)89517-9","volume":"266","author":"JJ Cali","year":"1991","unstructured":"Cali JJ, Russell DW . Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis J Biol Chem 1991 266: 7774\u20137778","journal-title":"J Biol Chem"},{"key":"BF5200842_CR54","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1034\/j.1399-0004.2001.590205.x","volume":"59","author":"M Samuels","year":"2001","unstructured":"Samuels M, Forbey K, Reid J et al. Identification of a common variant in the lipoprotein lipase gene in a large Utah kindred ascertained for coronary heart disease: the \u221293G\/D9N variant predisposes to low HDL-C\/high triglycerides Clin Genet 2001 59: 88\u201398","journal-title":"Clin Genet"},{"key":"BF5200842_CR55","first-page":"3187","volume":"84","author":"JE Hixson","year":"1999","unstructured":"Hixson JE, Almasy L, Cole S et al. Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene, POMC J Clin Endocrinol Metab 1999 84: 3187\u20133191","journal-title":"J Clin Endocrinol Metab"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/5200842","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/5200842.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/5200842.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T01:28:39Z","timestamp":1684373319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/5200842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,13]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["BF5200842"],"URL":"https:\/\/doi.org\/10.1038\/sj.ejhg.5200842","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,13]]}}}