{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:18:43Z","timestamp":1789996723899,"version":"4.0.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T00:00:00Z","timestamp":1159315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Hum Genet"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1038\/sj.ejhg.5201722","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T11:28:05Z","timestamp":1159356485000},"page":"23-28","source":"Crossref","is-referenced-by-count":51,"title":["Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias"],"prefix":"10.1038","volume":"15","author":[{"given":"Taiji","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyue","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senkai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,9,27]]},"reference":[{"key":"BF5201722_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1432-0436.1999.6420115.x","volume":"64","author":"EA Kurzrock","year":"1999","unstructured":"Kurzrock EA, Baskin LS, Cunha GR : Ontogeny of the male urethra: theory of endodermal differentiation. Differentiation 1999; 64: 115\u2013122.","journal-title":"Differentiation"},{"key":"BF5201722_CR2","doi-asserted-by":"publisher","first-page":"6695","DOI":"10.1210\/jc.2005-0446","volume":"90","author":"HT Thai","year":"2005","unstructured":"Thai HT, Kalbasi M, Lagerstedt K, Frisen L, Kockum I, Nordenskjold A : The Valine allele of the V89L polymorphism in the five-alpha reductase gene confers a reduced risk for hypospadias. J Clin Endocrinol Metab 2005; 90: 6695\u20136698.","journal-title":"J Clin Endocrinol Metab"},{"key":"BF5201722_CR3","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/S0022-5347(05)67861-5","volume":"163","author":"LS Baskin","year":"2000","unstructured":"Baskin LS : Hypospadias and urethral development. J Urol 2000; 163: 951\u2013956.","journal-title":"J Urol"},{"key":"BF5201722_CR4","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/sj.ejhg.5201232","volume":"12","author":"Y Wang","year":"2004","unstructured":"Wang Y, Li Q, Xu J et al: Mutation analysis of five candidate genes in Chinese patients with hypospadias. Eur J Hum Genet 2004; 12: 706\u2013712.","journal-title":"Eur J Hum Genet"},{"key":"BF5201722_CR5","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/(SICI)1096-8628(19991126)87:3<221::AID-AJMG5>3.0.CO;2-#","volume":"87","author":"LF Ferraz","year":"1999","unstructured":"Ferraz LF, Mathias Baptista MT, Maciel-Guerra AT, Junior GG, Hackel C : New frameshift mutation in the 5alpha-reductase type 2 gene in a Brazilian patient with 5alpha-reductase deficiency. Am J Med Genet 1999; 87: 221\u2013225.","journal-title":"Am J Med Genet"},{"key":"BF5201722_CR6","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1080\/00365590310014517","volume":"37","author":"B Utsch","year":"2003","unstructured":"Utsch B, Kaya A, Ozburun A, Lentze MJ, Albers N, Ludwig M : Exclusion of WTAP and HOXA13 as candidates genes for isolated hypospadias. Scan J Urol Nephrol 2003; 37: 498\u2013501.","journal-title":"Scan J Urol Nephrol"},{"key":"BF5201722_CR7","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nrg1083","volume":"4","author":"HS Stadler","year":"2003","unstructured":"Stadler HS : Modelling genitourinary defects in mice: an emerging genetic and developmental system. Nat Rev Genet 2003; 4: 478\u2013482.","journal-title":"Nat Rev Genet"},{"key":"BF5201722_CR8","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1242\/dev.127.11.2471","volume":"127","author":"R Haraguchi","year":"2000","unstructured":"Haraguchi R, Suzuki K, Murakami R et al: Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation. Development 2000; 127: 2471\u20132479.","journal-title":"Development"},{"key":"BF5201722_CR9","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1046\/j.1525-142X.2002.01068.x","volume":"4","author":"C Podlasek","year":"2002","unstructured":"Podlasek C, Houston J, McKenna KE, McVary KT : Posterior Hox gene expression in developing genitalia. Evol Dev 2002; 4: 142\u2013163.","journal-title":"Evol Dev"},{"key":"BF5201722_CR10","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1242\/dev.128.21.4241","volume":"128","author":"R Haraguchi","year":"2001","unstructured":"Haraguchi R, Mo R, Hui C et al: Unique functions of Sonic hedgehog signaling during external genitalia development. Development 2001; 128: 4241\u20134250.","journal-title":"Development"},{"key":"BF5201722_CR11","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1242\/dev.00530","volume":"130","author":"EA Morgan","year":"2003","unstructured":"Morgan EA, Nguyen SB, Scottv V, Stadler HS : Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development 2003; 130: 3095\u20133109.","journal-title":"Development"},{"key":"BF5201722_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4419-8995-6_1","volume":"545","author":"LS Baskin","year":"2004","unstructured":"Baskin LS : Hypospadias. Adv Exp Med Biol 2004; 545: 3\u201322.","journal-title":"Adv Exp Med Biol"},{"key":"BF5201722_CR13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1046\/j.1523-1747.1998.00092.x","volume":"110","author":"EJ Stelnicki","year":"1998","unstructured":"Stelnicki EJ, Komuves LG, Kwong AO et al: HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development. J Invest Dermatol 1998; 110: 110\u2013115.","journal-title":"J Invest Dermatol"},{"key":"BF5201722_CR14","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I","volume":"218","author":"LG Komuves","year":"2000","unstructured":"Komuves LG, Shen WF, Kwong A et al: Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation. Dev Dyn 2000; 218: 636\u2013647.","journal-title":"Dev Dyn"},{"key":"BF5201722_CR15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1242\/dev.105.3.639","volume":"105","author":"SE Wedden","year":"1989","unstructured":"Wedden SE, Pang K, Eichele G : Expression pattern of homeobox-containing genes during chick embryogenesis. Development 1989; 105: 639\u2013650.","journal-title":"Development"},{"key":"BF5201722_CR16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1242\/dev.112.3.807","volume":"112","author":"K Schughart","year":"1991","unstructured":"Schughart K, Bieberich CJ, Eid R, Ruddle FH : A regulatory region from the mouse Hox-2.2 promoter directs gene expression into developing limbs. Development 1991; 112: 807\u2013811.","journal-title":"Development"}],"container-title":["European Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/5201722.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/5201722","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/5201722.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T01:37:25Z","timestamp":1684373845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/5201722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,27]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["BF5201722"],"URL":"https:\/\/doi.org\/10.1038\/sj.ejhg.5201722","relation":{},"ISSN":["1018-4813","1476-5438"],"issn-type":[{"value":"1018-4813","type":"print"},{"value":"1476-5438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,27]]}}}