{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T09:58:59Z","timestamp":1793699939779,"version":"4.5.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"20","license":[{"start":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T00:00:00Z","timestamp":1095897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T00:00:00Z","timestamp":1095897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2004,10,13]]},"DOI":"10.1038\/sj.emboj.7600386","type":"journal-article","created":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T06:22:02Z","timestamp":1095920522000},"page":"4018-4028","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":579,"title":["Endoglin promotes endothelial cell proliferation and TGF\u2010\u03b2\/ALK1 signal transduction"],"prefix":"10.1038","volume":"23","author":[{"given":"Franck","family":"Lebrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Jos\u00e9","family":"Goumans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Jonker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita LC","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Valdimarsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midory","family":"Thorikay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mummery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter ten","family":"Dijke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,9,23]]},"reference":[{"key":"BFEMBJ7600386_CR1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/dbio.1999.9534","volume":"217","author":"HM Arthur","year":"2000","unstructured":"Arthur HM, Ure J, Smith AJ, Renforth G, Wilson DI, Torsney E, Charlton R, Parums DV, Jowett T, Marchuk DA, Burn J, Diamond AG (2000) Endoglin, an ancillary TGF\u2010\u03b2 receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol 217: 42\u201353","journal-title":"Dev Biol"},{"key":"BFEMBJ7600386_CR2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1074\/jbc.274.2.584","volume":"274","author":"NP Barbara","year":"1999","unstructured":"Barbara NP, Wrana JL, Letarte M (1999) Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor\u2010\u03b2 superfamily. J Biol Chem 274: 584\u2013594","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600386_CR3","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI8088","volume":"104","author":"A Bourdeau","year":"1999","unstructured":"Bourdeau A, Dumont DJ, Letarte M (1999) A murine model of hereditary hemorrhagic telangiectasia. J Clin Invest 104: 1343\u20131351","journal-title":"J Clin Invest"},{"key":"BFEMBJ7600386_CR4","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/1523-1747.ep12555569","volume":"95","author":"IM Braverman","year":"1990","unstructured":"Braverman IM, Keh A, Jacobson BS (1990) Ultrastructure, three\u2010dimensional organization of the telangiectases of hereditary hemorrhagic telangiectasia. J Invest Dermatol 95: 422\u2013427","journal-title":"J Invest Dermatol"},{"key":"BFEMBJ7600386_CR5","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1128\/MCB.15.3.1573","volume":"15","author":"J Carcamo","year":"1995","unstructured":"Carcamo J, Zentella A, Massagu\u00e9 J (1995) Disruption of transforming growth factor\u2010\u03b2 signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol Cell Biol 15: 1573\u20131581","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7600386_CR6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/74651","volume":"6","author":"P Carmeliet","year":"2000","unstructured":"Carmeliet P (2000) Mechanisms of angiogenesis and arteriogenesis. Nat Med 6: 389\u2013395","journal-title":"Nat Med"},{"key":"BFEMBJ7600386_CR7","doi-asserted-by":"crossref","first-page":"19027","DOI":"10.1016\/S0021-9258(18)41732-2","volume":"267","author":"S Cheifetz","year":"1992","unstructured":"Cheifetz S, Bellon T, Cales C, Vera S, Bernabeu C, Massagu\u00e9 J, Letarte M (1992) Endoglin is a component of the transforming growth factor\u2010\u03b2 receptor system in human endothelial cells. J Biol Chem 267: 19027\u201319030","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600386_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.1095","volume":"188","author":"E Fonsatti","year":"2001","unstructured":"Fonsatti E, Del Vecchio L, Altomonte M, Sigalotti L, Nicotra MR, Coral S, Natali PG, Maio M (2001) Endoglin: an accessory component of the TGF\u2010\u03b2\u2010binding receptor\u2010complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies. J Cell Physiol 188: 1\u20137","journal-title":"J Cell Physiol"},{"key":"BFEMBJ7600386_CR9","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1073\/pnas.91.15.7291","volume":"91","author":"C Garlanda","year":"1994","unstructured":"Garlanda C, Parravicini C, Sironi M, De Rossi M, Wainstok de Calmanovici R, Carozzi F, Bussolino F, Colotta F, Mantovani A, Vecchi A (1994) Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle\u2010sized T antigen: implications for pathogenesis of opportunistic vascular tumors. Proc Natl Acad Sci USA 91: 7291\u20137295","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600386_CR10","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.4049\/jimmunol.141.6.1925","volume":"141","author":"A Gougos","year":"1988","unstructured":"Gougos A, Letarte M (1988) Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre\u2010B leukemic cell line. J Immunol 141: 1925\u20131933","journal-title":"J Immunol"},{"key":"BFEMBJ7600386_CR11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/intimm\/4.1.83","volume":"4","author":"A Gougos","year":"1992","unstructured":"Gougos A, St Jacques S, Greaves A, O'Connell PJ, d'Apice AJ, Buhring HJ, Bernabeu C, van Mourik JA, Letarte M (1992) Identification of distinct epitopes of endoglin, an RGD\u2010containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts. Int Immunol 4: 83\u201392","journal-title":"Int Immunol"},{"key":"BFEMBJ7600386_CR12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S1097-2765(03)00386-1","volume":"12","author":"M\u2010J Goumans","year":"2003","unstructured":"Goumans M\u2010J, Valdimarsdottir G, Itoh S, Lebrin F, Larsson J, Mummery C, Karlsson S, ten Dijke P (2003) Activin receptor\u2010like kinase (ALK)1 is an antagonistic mediator of lateral TGF\u2010\u03b2\/ALK5 signaling. Mol Cell 12: 817\u2013828","journal-title":"Mol Cell"},{"key":"BFEMBJ7600386_CR13","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/emboj\/21.7.1743","volume":"21","author":"M\u2010J Goumans","year":"2002","unstructured":"Goumans M\u2010J, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P (2002) Balancing the activation state of the endothelium via two distinct TGF\u2010\u03b2 type I receptors. EMBO J 21: 1743\u20131753","journal-title":"EMBO J"},{"key":"BFEMBJ7600386_CR14","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1242\/dev.126.16.3473","volume":"126","author":"M\u2010J Goumans","year":"1999","unstructured":"Goumans M\u2010J, Zwijsen A, van Rooijen MA, Huylebroeck D, Roelen BA, Mummery CL (1999) Transforming growth factor\u2010\u03b2 signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice. Development 126: 3473\u20133483","journal-title":"Development"},{"key":"BFEMBJ7600386_CR15","doi-asserted-by":"crossref","first-page":"29197","DOI":"10.1074\/jbc.M111991200","volume":"277","author":"M Guerrero\u2010Esteo","year":"2002","unstructured":"Guerrero\u2010Esteo M, Sanchez\u2010Elsner T, Letamendia A, Bernabeu C (2002) Extracellular cytoplasmic domains of endoglin interact with the transforming growth factor\u2010\u03b2 receptors I and II. J Biol Chem 277: 29197\u201329209","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600386_CR16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","volume":"390","author":"C\u2010H Heldin","year":"1997","unstructured":"Heldin C\u2010H, Miyazono K, ten Dijke P (1997) TGF\u2010\u03b2 signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465\u2013471","journal-title":"Nature"},{"key":"BFEMBJ7600386_CR17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng0696-189","volume":"13","author":"DW Johnson","year":"1996","unstructured":"Johnson DW, Berg JN, Baldwin MA, Gallione CJ, Marondel I, Yoon SJ, Stenzel TT, Speer M, Pericak\u2010Vance MA, Diamond A, Guttmacher AE, Jackson CE, Attisano L, Kucherlapati R, Porteous ME, Marchuk DA (1996) Mutations in the activin receptor\u2010like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet 13: 189\u2013195","journal-title":"Nat Genet"},{"key":"BFEMBJ7600386_CR18","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1074\/jbc.M111023200","volume":"277","author":"O Korchynskyi","year":"2002","unstructured":"Korchynskyi O, ten Dijke P (2002) Identification and functional characterization of distinct critically important bone morphogenetic protein\u2010specific response elements in the Id1 promoter. J Biol Chem 277: 4883\u20134891","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600386_CR19","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1093\/emboj\/20.7.1663","volume":"20","author":"J Larsson","year":"2001","unstructured":"Larsson J, Goumans M\u2010J, Sjostrand LJ, van Rooijen MA, Ward D, Leveen P, Xu X, ten Dijke P, Mummery CL, Karlsson S (2001) Abnormal angiogenesis but intact hematopoietic potential in TGF\u2010\u03b2 type I receptor\u2010deficient mice. EMBO J 20: 1663\u20131673","journal-title":"EMBO J"},{"key":"BFEMBJ7600386_CR20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/eji.1830220216","volume":"22","author":"P Lastres","year":"1992","unstructured":"Lastres P, Bellon T, Cabanas C, Sanchez\u2010Madrid F, Acevedo A, Gougos A, Letarte M, Bernabeu C (1992) Regulated expression on human macrophages of endoglin, an Arg\u2010Gly\u2010Asp\u2010containing surface antigen. Eur J Immunol 22: 393\u2013397","journal-title":"Eur J Immunol"},{"key":"BFEMBJ7600386_CR21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.133.5.1109","volume":"133","author":"P Lastres","year":"1996","unstructured":"Lastres P, Letamendia A, Zhang H, Rius C, Almendro N, Raab U, Lopez LA, Langa C, Fabra A, Letarte M, Bernabeu C (1996) Endoglin modulates cellular responses to TGF\u2010\u03b21. J Cell Biol 133: 1109\u20131121","journal-title":"J Cell Biol"},{"key":"BFEMBJ7600386_CR22","doi-asserted-by":"crossref","first-page":"33011","DOI":"10.1074\/jbc.273.49.33011","volume":"273","author":"A Letamendia","year":"1998","unstructured":"Letamendia A, Lastres P, Botella LM, Raab U, Langa C, Velasco B, Attisano L, Bernabeu C (1998) Role of endoglin in cellular responses to transforming growth factor\u2010\u03b2. A comparative study with betaglycan. J Biol Chem 273: 33011\u201333019","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600386_CR23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1096\/fasebj.14.1.55","volume":"14","author":"C Li","year":"2000","unstructured":"Li C, Hampson IN, Hampson L, Kumar P, Bernabeu C, Kumar S (2000) CD105 antagonizes the inhibitory signaling of transforming growth factor\u2010\u03b21 on human vascular endothelial cells. FASEB J 14: 55\u201364","journal-title":"FASEB J"},{"key":"BFEMBJ7600386_CR24","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1126\/science.284.5419.1534","volume":"284","author":"DY Li","year":"1999","unstructured":"Li DY, Sorensen LK, Brooke BS, Urness LD, Davis EC, Taylor DG, Boak BB, Wendel DP (1999) Defective angiogenesis in mice lacking endoglin. Science 284: 1534\u20131537","journal-title":"Science"},{"key":"BFEMBJ7600386_CR25","doi-asserted-by":"crossref","first-page":"26750","DOI":"10.1074\/jbc.270.45.26750","volume":"270","author":"JM Li","year":"1995","unstructured":"Li JM, Nichols MA, Chandrasekharan S, Xiong Y, Wang XF (1995) Transforming growth factor \u03b2 activates the promoter of cyclin\u2010dependent kinase inhibitor p15ink4B through an Sp1 consensus site. J Biol Chem 270: 26750\u201326753","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600386_CR26","doi-asserted-by":"crossref","first-page":"9984","DOI":"10.1074\/jbc.274.15.9984","volume":"274","author":"A Lux","year":"1999","unstructured":"Lux A, Attisano L, Marchuk DA (1999) Assignment of transforming growth factor\u2010\u03b21 and \u03b23 and a third new ligand to the type I receptor ALK\u20101. J Biol Chem 274: 9984\u20139992","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600386_CR27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng1294-345","volume":"8","author":"KA McAllister","year":"1994","unstructured":"McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, Helmbold EA, Markel DS, McKinnon WC, Murrell J, McCormick MK, Pericak\u2010Vance MA, Heutink P, Oostra BA, Haitjema T, Westerman CJJ, Porteous ME, Guttmacher AE, Letarte M, Marchuk DA (1994) Endoglin, a TGF\u2010\u03b2 binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet 8: 345\u2013351","journal-title":"Nat Genet"},{"key":"BFEMBJ7600386_CR28","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/(SICI)1097-0215(19990517)81:4<568::AID-IJC11>3.0.CO;2-X","volume":"81","author":"DW Miller","year":"1999","unstructured":"Miller DW, Graulich W, Karges B, Stahl S, Ernst M, Ramaswamy A, Sedlacek HH, Muller R, Adamkiewicz J (1999) Elevated expression of endoglin, a component of the TGF\u2010\u03b2\u2010receptor complex, correlates with proliferation of tumor endothelial cells. Int J Cancer 81: 568\u2013572","journal-title":"Int J Cancer"},{"key":"BFEMBJ7600386_CR29","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1093\/emboj\/16.17.5353","volume":"16","author":"A Nakao","year":"1997","unstructured":"Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P (1997) TGF\u2010\u03b2 receptor\u2010mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16: 5353\u20135362","journal-title":"EMBO J"},{"key":"BFEMBJ7600386_CR30","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1073\/pnas.97.6.2626","volume":"97","author":"SP Oh","year":"2000","unstructured":"Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E (2000) Activin receptor\u2010like kinase 1 modulates transforming growth factor\u2010\u03b21 signaling in the regulation of angiogenesis. Proc Natl Acad Sci USA 97: 2626\u20132631","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600386_CR31","doi-asserted-by":"crossref","first-page":"29244","DOI":"10.1074\/jbc.M909467199","volume":"275","author":"K Pardali","year":"2000","unstructured":"Pardali K, Kurisaki A, Mor\u00e9n A, ten Dijke P, Kardassis D, Moustakas A (2000) Role of Smad proteins and transcription factor Sp1 in p21Waf\/Cip1 regulation by transforming growth factor\u2010\u03b2. J Biol Chem 275: 29244\u201329256","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600386_CR32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1359-6101(96)00048-2","volume":"8","author":"MS Pepper","year":"1997","unstructured":"Pepper MS (1997) Transforming growth factor\u2010\u03b2: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev 8: 21\u201343","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFEMBJ7600386_CR33","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1096\/fasebj.13.15.2105","volume":"13","author":"E Piek","year":"1999","unstructured":"Piek E, Heldin C\u2010H, ten Dijke P (1999) Specificity, diversity, and regulation in TGF\u2010\u03b2 superfamily signaling. FASEB J 13: 2105\u20132124","journal-title":"FASEB J"},{"key":"BFEMBJ7600386_CR34","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","volume":"386","author":"W Risau","year":"1997","unstructured":"Risau W (1997) Mechanisms of angiogenesis. Nature 386: 671\u2013674","journal-title":"Nature"},{"key":"BFEMBJ7600386_CR35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1046\/j.1365-2141.1996.d01-1698.x","volume":"93","author":"MM Robledo","year":"1996","unstructured":"Robledo MM, Hidalgo A, Lastres P, Arroyo AG, Bernabeu C, Sanchez\u2010Madrid F, Teixido J (1996) Characterization of TGF\u2010\u03b21\u2010binding proteins in human bone marrow stromal cells. Br J Haematol 93: 507\u2013514","journal-title":"Br J Haematol"},{"key":"BFEMBJ7600386_CR36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ijc.11551","volume":"108","author":"X She","year":"2004","unstructured":"She X, Matsuno F, Harada N, Tsai H, Seon BK (2004) Synergy between anti\u2010endoglin (CD105) monoclonal antibodies and TGF\u2010\u03b2 in suppression of growth of human endothelial cells. Int J Cancer 108: 251\u2013257","journal-title":"Int J Cancer"},{"key":"BFEMBJ7600386_CR37","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","volume":"113","author":"Y Shi","year":"2003","unstructured":"Shi Y, Massagu\u00e9 J (2003) Mechanisms of TGF\u2010\u03b2 signaling from cell membrane to the nucleus. Cell 113: 685\u2013700","journal-title":"Cell"},{"key":"BFEMBJ7600386_CR38","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1210\/endo.134.6.8194490","volume":"134","author":"S St\u2010Jacques","year":"1994","unstructured":"St\u2010Jacques S, Cymerman U, Pece N, Letarte M (1994) Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor\u2010\u03b2 binding protein of endothelial and stromal cells. Endocrinology 134: 2645\u20132657","journal-title":"Endocrinology"},{"key":"BFEMBJ7600386_CR39","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1161\/01.CIR.0000058170.92267.00","volume":"107","author":"E Torsney","year":"2003","unstructured":"Torsney E, Charlton R, Diamond AG, Burn J, Soames JV, Arthur HM (2003) Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality. Circulation 107: 1653\u20131657","journal-title":"Circulation"},{"key":"BFEMBJ7600386_CR40","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/j.1460-2075.1995.tb07214.x","volume":"14","author":"R Wieser","year":"1995","unstructured":"Wieser R, Wrana JL, Massagu\u00e9 J (1995) GS domain mutations that constitutively activate T\u03b2R\u2010I, the downstream signaling component in the TGF\u2010\u03b2 receptor complex. EMBO J 14: 2199\u20132208","journal-title":"EMBO J"},{"key":"BFEMBJ7600386_CR41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0092-8674(88)90536-3","volume":"52","author":"RL Williams","year":"1988","unstructured":"Williams RL, Courtneidge SA, Wagner EF (1988) Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene. Cell 52: 121\u2013131","journal-title":"Cell"},{"key":"BFEMBJ7600386_CR42","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0092-8674(89)90343-7","volume":"57","author":"RL Williams","year":"1989","unstructured":"Williams RL, Risau W, Zerwes HG, Drexler H, Aguzii A, Wagner EF (1989) Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell 57: 1053\u20131063","journal-title":"Cell"},{"key":"BFEMBJ7600386_CR43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/01.WCB.0000107730.66603.51","volume":"24","author":"B Xu","year":"2004","unstructured":"Xu B, Wu YQ, Huey M, Arthur HM, Marchuk DA, Hashimoto T, Young WL, Yang GY (2004) Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain. J Cereb Blood Flow Metab 24: 237\u2013244","journal-title":"J Cereb Blood Flow Metab"},{"key":"BFEMBJ7600386_CR44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2144\/97231bm19","volume":"23","author":"YX Zeng","year":"1997","unstructured":"Zeng YX, Somasundaram K, Prabhu NS, Krishnadasan R, el\u2010Deiry WS (1997) Detection and analysis of living, growth\u2010inhibited mammalian cells following transfection. Biotechniques 23: 88, 90, 92, 94","journal-title":"Biotechniques"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.emboj.7600386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7600386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.emboj.7600386","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/sj.emboj.7600386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7600386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:16:36Z","timestamp":1779232596000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/sj.emboj.7600386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,23]]},"references-count":44,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2004,10,13]]}},"alternative-id":["BFEMBJ7600386"],"URL":"https:\/\/doi.org\/10.1038\/sj.emboj.7600386","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,23]]},"assertion":[{"value":"17 March 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}