{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:11:29Z","timestamp":1790975489725,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T00:00:00Z","timestamp":1108598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T00:00:00Z","timestamp":1108598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2005,3,9]]},"DOI":"10.1038\/sj.emboj.7600574","type":"journal-article","created":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T14:04:24Z","timestamp":1108649064000},"page":"929-941","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Calcium\u2010independent calmodulin binding and two\u2010metal\u2013ion catalytic mechanism of anthrax edema factor"],"prefix":"10.1038","volume":"24","author":[{"given":"Yuequan","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia L","family":"Zhukovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Flori\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Jen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,2,17]]},"reference":[{"key":"BFEMBJ7600574_CR1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/protein\/7.3.385","volume":"7","author":"J Aqvist","year":"1994","unstructured":"Aqvist J, Medina C, Samuelson JE (1994) A new model for predicting binding affinity in computer\u2010aided drug design. Protein Eng 7: 385\u2013391","journal-title":"Protein Eng"},{"key":"BFEMBJ7600574_CR2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/j.1365-2958.2004.04067.x","volume":"52","author":"DA Baker","year":"2004","unstructured":"Baker DA, Kelly JM (2004) Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Mol Microbiol 52: 1229\u20131242","journal-title":"Mol Microbiol"},{"key":"BFEMBJ7600574_CR3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev.biophys.27.1.133","volume":"27","author":"D Barford","year":"1998","unstructured":"Barford D, Das AK, Egloff MP (1998) The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct 27: 133\u2013164","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"BFEMBJ7600574_CR4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbamcr.2004.09.002","volume":"1742","author":"S Bhattacharya","year":"2004","unstructured":"Bhattacharya S, Bunick CG, Chazin WJ (2004) Target selectivity in EF\u2010hand calcium binding proteins. Biochim Biophys Acta 1742: 69\u201379","journal-title":"Biochim Biophys Acta"},{"key":"BFEMBJ7600574_CR5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/emboj\/20.3.433","volume":"20","author":"B Bieger","year":"2001","unstructured":"Bieger B, Essen LO (2001) Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state. EMBO J 20: 433\u2013445","journal-title":"EMBO J"},{"key":"BFEMBJ7600574_CR6","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1126\/science.280.5372.2129","volume":"280","author":"D Bowen","year":"1998","unstructured":"Bowen D, Rocheleau TA, Blackburn M, Andreev O, Golubeva E, Bhartia R, Ffrench\u2010Constant RH (1998) Insecticidal toxins from the bacterium Photorhabdus luminescens. Science 280: 2129\u20132132","journal-title":"Science"},{"key":"BFEMBJ7600574_CR7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1074-5521(00)80009-5","volume":"6","author":"CA Brautigam","year":"1999","unstructured":"Brautigam CA, Aschheim K, Steitz TA (1999) Structural elucidation of the binding and inhibitory properties of lanthanide (III) ions at the 3\u2032\u20135\u2032 exonucleolytic active site of the Klenow fragment. Chem Biol 6: 901\u2013908","journal-title":"Chem Biol"},{"key":"BFEMBJ7600574_CR8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0959-440X(98)80010-9","volume":"8","author":"CA Brautigam","year":"1998","unstructured":"Brautigam CA, Steitz TA (1998) Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Curr Opin Struct Biol 8: 54\u201363","journal-title":"Curr Opin Struct Biol"},{"key":"BFEMBJ7600574_CR9","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1128\/IAI.68.4.1781-1786.2000","volume":"68","author":"F Brossier","year":"2000","unstructured":"Brossier F, Weber\u2010Levy M, Mock M, Sirard JC (2000) Role of toxin functional domains in anthrax pathogenesis. Infect Immun 68: 1781\u20131786","journal-title":"Infect Immun"},{"key":"BFEMBJ7600574_CR10","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"AT Brunger","year":"1998","unstructured":"Brunger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse\u2010Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T, Warren GL (1998) Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr 54: 905\u2013921","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"BFEMBJ7600574_CR11","doi-asserted-by":"crossref","first-page":"12067","DOI":"10.1073\/pnas.182431199","volume":"99","author":"SJ Charnock","year":"2002","unstructured":"Charnock SJ, Brown IE, Turkenburg JP, Black GW, Davies GJ (2002) Convergent evolution sheds light on the anti\u2010beta\u2010elimination mechanism common to family 1 and 10 polysaccharide lyases. Proc Natl Acad Sci USA 99: 12067\u201312072","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600574_CR12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.19.111301.140655","volume":"19","author":"RJ Collier","year":"2003","unstructured":"Collier RJ, Young JA (2003) Anthrax Toxin. Annu Rev Cell Dev Biol 19: 45\u201370","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFEMBJ7600574_CR13","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1021\/ja00124a002","volume":"117","author":"WD Cornell","year":"1995","unstructured":"Cornell WD, Cieplak P, Bayly CI, Gould IR, Merz JKM, Ferguson DM, Spellmeyer DC, Fox T, Caldwell JW, Kollman PA (1995) A second generation force field for the simulation of proteins, nucleic acids and organic molecules. J Am Chem Soc 117: 5179\u20135197","journal-title":"J Am Chem Soc"},{"key":"BFEMBJ7600574_CR14","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1073\/pnas.062160399","volume":"99","author":"K Cunningham","year":"2002","unstructured":"Cunningham K, Lacy DB, Mogridge J, Collier RJ (2002) Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen. Proc Natl Acad Sci USA 99: 7049\u20137053","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600574_CR15","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1107\/S0907444901014937","volume":"57","author":"CL Drum","year":"2001","unstructured":"Drum CL, Shen Y, Rice PA, Bohm A, Tang WJ (2001) Crystallization and preliminary X\u2010ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin. Acta Crystallogr D 57: 1881\u20131884","journal-title":"Acta Crystallogr D"},{"key":"BFEMBJ7600574_CR16","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/415396a","volume":"415","author":"CL Drum","year":"2002","unstructured":"Drum CL, Yan SZ, Bard J, Shen Y, Lu D, Soelaiman S, Grabarek Z, Bohm A, Tang W\u2010J (2002) Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature 415: 396\u2013402","journal-title":"Nature"},{"key":"BFEMBJ7600574_CR17","doi-asserted-by":"crossref","first-page":"38514","DOI":"10.1074\/jbc.M304387200","volume":"278","author":"M El\u2010Azami\u2010El\u2010Idrissi","year":"2003","unstructured":"El\u2010Azami\u2010El\u2010Idrissi M, Bauche C, Loucka J, Osicka R, Sebo P, Ladant D, Leclerc C (2003) Interaction of Bordetella pertussis adenylate cyclase with CD11b\/CD18: role of toxin acylation and identification of the main integrin interaction domain. J Biol Chem 278: 38514\u201338521","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600574_CR18","unstructured":"Eldik LV, Watterson DM (1998) Calmodulin and Signal Transduction. New York: Academic Press"},{"key":"BFEMBJ7600574_CR19","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1021\/bi000310u","volume":"39","author":"JL Elliott","year":"2000","unstructured":"Elliott JL, Morgridge J, Collier RJ (2000) A quantitative study of the interactions of Bacillus anthracis edema factor and lethal factor with activated protective antigen. Biochemistry 39: 6706\u20136713","journal-title":"Biochemistry"},{"key":"BFEMBJ7600574_CR20","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.str.2003.09.004","volume":"11","author":"JL Fallon","year":"2003","unstructured":"Fallon JL, Quiocho FA (2003) A closed compact structure of native Ca2+\u2010calmodulin. Structure (Camb) 11: 1303\u20131307","journal-title":"Structure (Camb)"},{"key":"BFEMBJ7600574_CR21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0959-440X(02)00324-X","volume":"12","author":"MJ Fedor","year":"2002","unstructured":"Fedor MJ (2002) The role of metal ions in RNA catalysis. Curr Opin Struct Biol 12: 289\u2013295","journal-title":"Curr Opin Struct Biol"},{"key":"BFEMBJ7600574_CR22","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1021\/jp020790u","volume":"B106","author":"J Flori\u00e1n","year":"2002","unstructured":"Flori\u00e1n J, Goodman MF, Warshel A (2002a) Theoretical investigation of the binding free energies and key substrate\u2010recognition components of the replication fidelity of human DNA polymerase \u03b2. J Phys Chem B106: 5739\u20135753","journal-title":"J Phys Chem"},{"key":"BFEMBJ7600574_CR23","doi-asserted-by":"crossref","first-page":"8163","DOI":"10.1021\/ja028997o","volume":"125","author":"J Flori\u00e1n","year":"2003","unstructured":"Flori\u00e1n J, Goodman MF, Warshel A (2003) Computer simulation of the chemical catalysis of DNA polymerases: discriminating between alternative nucleotide insertion mechanism for T7 DNA polymerase. J Am Chem Soc 125: 8163\u20138177","journal-title":"J Am Chem Soc"},{"key":"BFEMBJ7600574_CR24","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1021\/jp020791m","volume":"B106","author":"J Flori\u00e1n","year":"2002","unstructured":"Flori\u00e1n J, Warshel A, Goodman MF (2002b) Molecular dynamics free\u2010energy simulations of the binding contribution to the fidelity of T7 DNA polymerase. J Phys Chem B106: 5754\u20135760","journal-title":"J Phys Chem"},{"key":"BFEMBJ7600574_CR25","doi-asserted-by":"crossref","first-page":"29427","DOI":"10.1074\/jbc.M402689200","volume":"279","author":"Q Guo","year":"2004","unstructured":"Guo Q, Shen Y, Zhukovskaya NL, Florian J, Tang W\u2010J (2004) Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products, cAMP and pyrophosphate. J Biol Chem 279: 29427\u201329435","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600574_CR26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0092-8674(02)00682-7","volume":"108","author":"KP Hoeflich","year":"2002","unstructured":"Hoeflich KP, Ikura M (2002) Calmodulin in action: diversity in target recognition and activation mechanisms. Cell 108: 739\u2013742","journal-title":"Cell"},{"key":"BFEMBJ7600574_CR27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/86149","volume":"8","author":"NC Horton","year":"2001","unstructured":"Horton NC, Perona JJ (2001) Making the most of metal ions. Nat Struct Biol 8: 290\u2013293","journal-title":"Nat Struct Biol"},{"key":"BFEMBJ7600574_CR28","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"W Humphrey","year":"1996","unstructured":"Humphrey W, Dalke A, Schulten K (1996) VMD \u2013 Visual Molecular Dynamics. J Mol Graphics 14: 33\u201338","journal-title":"J Mol Graphics"},{"key":"BFEMBJ7600574_CR29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"TA Jones","year":"1991","unstructured":"Jones TA, Zou JY, Cowan SW, Kjeldgaard M (1991) Improved methods for binding protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 47: 110\u2013119","journal-title":"Acta Crystallogr A"},{"key":"BFEMBJ7600574_CR30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1152\/physrev.1999.79.3.661","volume":"79","author":"LA Jurado","year":"1999","unstructured":"Jurado LA, Chockalingam PS, Jarrett HW (1999) Apocalmodulin. Physiol Rev 79: 661\u2013682","journal-title":"Physiol Rev"},{"key":"BFEMBJ7600574_CR31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0969-2126(97)00169-X","volume":"5","author":"JR Kiefer","year":"1997","unstructured":"Kiefer JR, Mao C, Hansen CJ, Basehore SL, Hogrefe HH, Braman JC, Beese LS (1997) Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 \u00c5 resolution. Structure (Camb) 5: 95\u2013108","journal-title":"Structure (Camb)"},{"key":"BFEMBJ7600574_CR32","doi-asserted-by":"crossref","first-page":"19111","DOI":"10.1074\/jbc.M300874200","volume":"278","author":"TP Ko","year":"2003","unstructured":"Ko TP, Lin JJ, Hu CY, Hsu YH, Wang AH, Liaw SH (2003) Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution. J Biol Chem 278: 19111\u201319117","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600574_CR33","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1021\/bi00472a024","volume":"29","author":"E Labruy\u00e8re","year":"1990","unstructured":"Labruy\u00e8re E, Mock M, Ladant D, Michelson S, Gilles AM, Laoide B, Barzu O (1990) Characterization of ATP and calmodulin\u2010binding properties of a truncated form of Bacillus anthracis adenylate cyclase. Biochemistry 29: 4922\u20134928","journal-title":"Biochemistry"},{"key":"BFEMBJ7600574_CR34","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1074\/jbc.M109997200","volume":"277","author":"DB Lacy","year":"2002","unstructured":"Lacy DB, Mourez M, Fouassier A, Collier RJ (2002) Mapping the anthrax protective antigen binding site on the lethal and edema factors. J Biol Chem 277: 3006\u20133010","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600574_CR35","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0966-842X(99)01468-7","volume":"7","author":"D Ladant","year":"1999","unstructured":"Ladant D, Ullmann A (1999) Bordatella pertussis adenylate cyclase: a toxin with multiple talents. Trends Microbiol 7: 172\u2013176","journal-title":"Trends Microbiol"},{"key":"BFEMBJ7600574_CR36","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1063\/1.462997","volume":"97","author":"FS Lee","year":"1992","unstructured":"Lee FS, Warshel A (1992) A local reaction field method for fast evaluation of long\u2010range electrostatic interactions in molecular simulations. J Chem Phys 97: 3100\u20133107","journal-title":"J Chem Phys"},{"key":"BFEMBJ7600574_CR37","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0898-6568(03)00130-X","volume":"15","author":"JU Linder","year":"2003","unstructured":"Linder JU, Schultz JE (2003) The class III adenylyl cyclase: multi\u2010purpose signalling modules. Cell Signal 15: 1081\u20131089","journal-title":"Cell Signal"},{"key":"BFEMBJ7600574_CR38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1093-3263(98)80006-5","volume":"16","author":"J Marelius","year":"1999","unstructured":"Marelius J, Kolmodin K, Feierberg I, Aqvist J (1999) Q: a molecular dynamics program for free energy calculations and empirical valence bond simulations in biomolecular systems. J Mol Graphics Model 16: 213\u2013225","journal-title":"J Mol Graphics Model"},{"key":"BFEMBJ7600574_CR39","doi-asserted-by":"crossref","first-page":"9816","DOI":"10.1016\/S0021-9258(19)50166-1","volume":"267","author":"H Munier","year":"1992","unstructured":"Munier H, Bouhss A, Krin E, Danchin A, Gilles AM, Glaser P, Barzu O (1992) The role of histidine 63 in the catalytic mechanism of Bordetella pertussis adenylate cyclase. J Biol Chem 267: 9816\u20139820","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600574_CR40","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1107\/S0907444901012422","volume":"57","author":"J Navaza","year":"2001","unstructured":"Navaza J (2001) Implementation of molecular replacement in AMoRe. Acta Crystallogr D Biol Crystallogr 57: 1367\u20131372","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"BFEMBJ7600574_CR41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Z Otwinowski","year":"1997","unstructured":"Otwinowski Z, Minor W (1997) Processing of X\u2010ray diffraction data collected in oscillation mode. Methods Enzymol 276: 307\u2013326","journal-title":"Methods Enzymol"},{"key":"BFEMBJ7600574_CR42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/n35101998","volume":"414","author":"A Pannifer","year":"2001","unstructured":"Pannifer A, Wong TY, Schwarzenbacher R, Renatus M, Petosa C, Bienkowska J, Lacy DB, Collier RJ, Park S, Leppla SH, Hanna PC, Liddington RC (2001) Crystal structure of the anthrax lethal factor. Nature 414: 229\u2013233","journal-title":"Nature"},{"key":"BFEMBJ7600574_CR43","doi-asserted-by":"crossref","first-page":"12742","DOI":"10.1021\/bi952955d","volume":"35","author":"H Pelletier","year":"1996","unstructured":"Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J (1996) Crystal structure of human DNA polymerase \u03b2 complexed with DNA: implications for catalytic mechanism, processivity and fidelity. Biochemistry 35: 12742\u201312761","journal-title":"Biochemistry"},{"key":"BFEMBJ7600574_CR44","doi-asserted-by":"crossref","unstructured":"Rossi Paccani S, Tonello F, Ghittoni R, Natale M, Muraro L, D'elios MM, Tang W\u2010J, Montecucco C, Baldari CT (2005) Anthrax toxins suppress T\u2010lymphocyte activation by disrupting antigen receptor signaling. J Exp Med 201, in press","DOI":"10.1084\/jem.20041557"},{"key":"BFEMBJ7600574_CR45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","volume":"23","author":"JP Ryckaert","year":"1977","unstructured":"Ryckaert JP, Ciccotti G, Berendsen HJC (1977) Numerical integration of the Cartesian equations of motion of a system with constraints: molecular dynamics of n\u2010alkanes. J Comput Phys 23: 327\u2013341","journal-title":"J Comput Phys"},{"key":"BFEMBJ7600574_CR46","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.str.2004.03.017","volume":"12","author":"MA Schumacher","year":"2004","unstructured":"Schumacher MA, Crum M, Miller CM (2004) Crystal structures of apocalmodulin and an apocalmodulin\/SK potassium channel gating domain complex. Structure (Camb) 12: 849\u2013860","journal-title":"Structure (Camb)"},{"key":"BFEMBJ7600574_CR47","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/35074145","volume":"410","author":"MA Schumacher","year":"2001","unstructured":"Schumacher MA, Rivard AF, Bachinger HP, Adelman JP (2001) Structure of the gating domain of a Ca2+\u2010activated K+ channel complexed with Ca2+\/calmodulin. Nature 410: 1120\u20131124","journal-title":"Nature"},{"key":"BFEMBJ7600574_CR48","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1093\/emboj\/cdf681","volume":"21","author":"YQ Shen","year":"2002","unstructured":"Shen YQ, Lee Y\u2010S, Soelaiman S, Bergson P, Lu D, Chen A, Beckingham K, Grabarek Z, Mrksich M, Tang W\u2010J (2002) Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins. EMBO J 21: 6721\u20136732","journal-title":"EMBO J"},{"key":"BFEMBJ7600574_CR49","doi-asserted-by":"crossref","first-page":"25990","DOI":"10.1074\/jbc.M301232200","volume":"278","author":"S Soelaiman","year":"2003","unstructured":"Soelaiman S, Wei BQ, Bergson P, Lee Y\u2010S, Shen Y\u2010Q, Mrksich M, Shoichet BK, Tang W\u2010J (2003) Structure\u2010based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough. J Biol Chem 278: 25990\u201325997","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600574_CR50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/34542","volume":"391","author":"TA Steitz","year":"1998","unstructured":"Steitz TA (1998) A mechanism for all polymerases. Nature 391: 231\u2013232","journal-title":"Nature"},{"key":"BFEMBJ7600574_CR51","doi-asserted-by":"crossref","first-page":"8595","DOI":"10.1016\/S0021-9258(18)93016-4","volume":"266","author":"WJ Tang","year":"1991","unstructured":"Tang WJ, Krupinski J, Gilman AG (1991) Expression and characterization of calmodulin\u2010activated (type I) adenylylcyclase. J Biol Chem 266: 8595\u20138603","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600574_CR52","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.285.5428.756","volume":"285","author":"JJ Tesmer","year":"1999","unstructured":"Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR (1999) Two\u2010metal\u2010Ion catalysis in adenylyl cyclase. Science 285: 756\u2013760","journal-title":"Science"},{"key":"BFEMBJ7600574_CR53","doi-asserted-by":"crossref","first-page":"29261","DOI":"10.1074\/jbc.M302837200","volume":"278","author":"TS Ulmer","year":"2003","unstructured":"Ulmer TS, Soelaiman S, Li S, Klee CB, Tang WJ, Bax A (2003) Calcium dependence of the interaction between calmodulin and anthrax edema factor. J Biol Chem 278: 29261\u201329266","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600574_CR54","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1107\/S0021889898010504","volume":"32","author":"CM Weeks","year":"1999","unstructured":"Weeks CM, Miller R (1999) The design and implementation of SnB version 2.0. J Appl Crystallogr 32: 120\u2013124","journal-title":"J Appl Crystallogr"},{"key":"BFEMBJ7600574_CR55","doi-asserted-by":"crossref","first-page":"13899","DOI":"10.1073\/pnas.95.23.13899","volume":"95","author":"TL Yahr","year":"1998","unstructured":"Yahr TL, Vallis AJ, Hancock MK, Barbieri JT, Frank DW (1998) ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system. Proc Natl Acad Sci USA 95: 13899\u201313904","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.emboj.7600574","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7600574.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.emboj.7600574","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/sj.emboj.7600574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7600574.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:20:10Z","timestamp":1779232810000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/sj.emboj.7600574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,17]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,3,9]]}},"alternative-id":["BFEMBJ7600574"],"URL":"https:\/\/doi.org\/10.1038\/sj.emboj.7600574","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,17]]},"assertion":[{"value":"23 November 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}