{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:05:49Z","timestamp":1792757149898,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T00:00:00Z","timestamp":1111622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T00:00:00Z","timestamp":1111622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2005,4,20]]},"DOI":"10.1038\/sj.emboj.7600640","type":"journal-article","created":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T08:24:28Z","timestamp":1111652668000},"page":"1634-1643","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":903,"title":["Receptor and viral determinants of SARS\u2010coronavirus adaptation to human ACE2"],"prefix":"10.1038","volume":"24","author":[{"given":"Wenhui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens H","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swee\u2010Kee","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Chueh","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya","family":"Vasilieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akikazu","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne A","family":"Marasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeryun","family":"Choe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Farzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,3,24]]},"reference":[{"key":"BFEMBJ7600640_CR1","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1128\/JVI.78.9.4552-4560.2004","volume":"78","author":"GJ Babcock","year":"2004","unstructured":"Babcock GJ, Esshaki DJ, Thomas Jr WD, Ambrosino DM (2004) Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor. J Virol 78: 4552\u20134560","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR2","doi-asserted-by":"crossref","first-page":"9084","DOI":"10.1128\/JVI.77.16.9084-9089.2003","volume":"77","author":"R Casais","year":"2003","unstructured":"Casais R, Dove B, Cavanagh D, Britton P (2003) Recombinant avian infectious bronchitis virus expressing a heterologous spike gene demonstrates that the spike protein is a determinant of cell tropism. J Virol 77: 9084\u20139089","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmv.20138","volume":"74","author":"PK Chan","year":"2004","unstructured":"Chan PK, To KF, Lo AW, Cheung JL, Chu I, Au FW, Tong JH, Tam JS, Sung JJ, Ng HK (2004) Persistent infection of SARS coronavirus in colonic cells in vitro. J Med Virol 74: 1\u20137","journal-title":"J Med Virol"},{"key":"BFEMBJ7600640_CR4","doi-asserted-by":"crossref","first-page":"11852","DOI":"10.1021\/ja0277226","volume":"124","author":"NA Dales","year":"2002","unstructured":"Dales NA, Gould AE, Brown JA, Calderwood EF, Guan B, Minor CA, Gavin JM, Hales P, Kaushik VK, Stewart M, Tummino PJ, Vickers CS, Ocain TD, Patane MA (2002) Substrate\u2010based design of the first class of angiotensin\u2010converting enzyme\u2010related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc 124: 11852\u201311853","journal-title":"J Am Chem Soc"},{"key":"BFEMBJ7600640_CR5","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/path.1560","volume":"203","author":"Y Ding","year":"2004","unstructured":"Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J, Wang H, Shen H, Qiu L, Li Z, Geng J, Cai J, Han H, Li X, Kang W, Weng D, Liang P, Jiang S (2004) Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS\u2010CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol 203: 622\u2013630","journal-title":"J Pathol"},{"key":"BFEMBJ7600640_CR6","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJMoa030747","volume":"348","author":"C Drosten","year":"2003","unstructured":"Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Muller S, Rickerts V, Sturmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW (2003) Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 348: 1967\u20131976","journal-title":"N Engl J Med"},{"key":"BFEMBJ7600640_CR7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/423240a","volume":"423","author":"RA Fouchier","year":"2003","unstructured":"Fouchier RA, Kuiken T, Schutten M, van Amerongen G, van Doornum GJ, van den Hoogen BG, Peiris M, Lim W, Stohr K, Osterhaus AD (2003) Aetiology: Koch's postulates fulfilled for SARS virus. Nature 423: 240","journal-title":"Nature"},{"key":"BFEMBJ7600640_CR8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/viro.2000.0757","volume":"279","author":"TM Gallagher","year":"2001","unstructured":"Gallagher TM, Buchmeier MJ (2001) Coronavirus spike proteins in viral entry and pathogenesis. Virology 279: 371\u2013374","journal-title":"Virology"},{"key":"BFEMBJ7600640_CR9","first-page":"4","volume":"4","author":"Y Guan","year":"2003","unstructured":"Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, Luo SW, Li PH, Zhang LJ, Guan YJ, Butt KM, Wong KL, Chan KW, Lim W, Shortridge KF, Yuen KY, Peiris JS, Poon LL (2003) Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China. Science 4: 4","journal-title":"Science"},{"key":"BFEMBJ7600640_CR10","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1128\/JVI.77.8.4528-4538.2003","volume":"77","author":"BJ Haijema","year":"2003","unstructured":"Haijema BJ, Volders H, Rottier PJ (2003) Switching species tropism: an effective way to manipulate the feline coronavirus genome. J Virol 77: 4528\u20134538","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/path.1570","volume":"203","author":"I Hamming","year":"2004","unstructured":"Hamming I, Timens W, Bulthuis ML, Lely AT, Navis GJ, van Goor H (2004) Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 203: 631\u2013637","journal-title":"J Pathol"},{"key":"BFEMBJ7600640_CR12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-5793(02)03640-2","volume":"532","author":"D Harmer","year":"2002","unstructured":"Harmer D, Gilbert M, Borman R, Clark KL (2002) Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Lett 532: 107\u2013110","journal-title":"FEBS Lett"},{"key":"BFEMBJ7600640_CR13","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1126\/science.1092002","volume":"303","author":"JF He","year":"2004","unstructured":"He JF, Peng GW, Min J, Yu DW, Liang WJ, Zhang SY, Xu RH, Zheng HY, Wu XW, Xu J, Wang ZH, Fang L, Zhang X, Li H, Yan XG, Lu JH, Hu ZH, Huang JC, Wan XW (2004) Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China. Science 303: 1666\u20131669, Epub 2004 Jan 29","journal-title":"Science"},{"key":"BFEMBJ7600640_CR14","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.bbrc.2004.05.114","volume":"319","author":"H Hofmann","year":"2004","unstructured":"Hofmann H, Geier M, Marzi A, Krumbiegel M, Peipp M, Fey GH, Gramberg T, Pohlmann S (2004) Susceptibility to SARS coronavirus S protein\u2010driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem Biophys Res Commun 319: 1216\u20131221","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ7600640_CR15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.tim.2004.08.008","volume":"12","author":"H Hofmann","year":"2004","unstructured":"Hofmann H, Pohlmann S (2004) Cellular entry of the SARS coronavirus. Trends Microbiol 12: 466\u2013472","journal-title":"Trends Microbiol"},{"key":"BFEMBJ7600640_CR16","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1056\/NEJMp030078","volume":"348","author":"KV Holmes","year":"2003","unstructured":"Holmes KV (2003) SARS\u2010associated coronavirus. N Engl J Med 348: 1948\u20131951","journal-title":"N Engl J Med"},{"key":"BFEMBJ7600640_CR17","doi-asserted-by":"crossref","first-page":"15748","DOI":"10.1073\/pnas.0403812101","volume":"101","author":"SA Jeffers","year":"2004","unstructured":"Jeffers SA, Tusell SM, Gillim\u2010Ross L, Hemmila EM, Achenbach JE, Babcock GJ, Thomas Jr WD, Thackray LB, Young MD, Mason RJ, Ambrosino DM, Wentworth DE, Demartini JC, Holmes KV (2004) CD209L (L\u2010SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci USA 101: 15748\u201315753, Epub 2004 Oct 20","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600640_CR18","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa030781","volume":"348","author":"TG Ksiazek","year":"2003","unstructured":"Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ (2003) A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 348: 1953\u20131966","journal-title":"N Engl J Med"},{"key":"BFEMBJ7600640_CR19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(03)13967-0","volume":"362","author":"T Kuiken","year":"2003","unstructured":"Kuiken T, Fouchier RA, Schutten M, Rimmelzwaan GF, van Amerongen G, van Riel D, Laman JD, de Jong T, van Doornum G, Lim W, Ling AE, Chan PK, Tam JS, Zambon MC, Gopal R, Drosten C, van der Werf S, Escriou N, Manuguerra JC, Stohr K, Peiris JS, Osterhaus AD (2003) Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 362: 263\u2013270","journal-title":"Lancet"},{"key":"BFEMBJ7600640_CR20","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1128\/JVI.74.3.1393-1406.2000","volume":"74","author":"L Kuo","year":"2000","unstructured":"Kuo L, Godeke GJ, Raamsman MJ, Masters PS, Rottier PJ (2000) Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier. J Virol 74: 1393\u20131406","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR21","doi-asserted-by":"crossref","first-page":"11429","DOI":"10.1128\/JVI.78.20.11429-11433.2004","volume":"78","author":"W Li","year":"2004","unstructured":"Li W, Greenough TC, Moore MJ, Vasilieva N, Somasundaran M, Sullivan JL, Farzan M, Choe H (2004) Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin\u2010converting enzyme 2. J Virol 78: 11429\u201311433","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR22","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","volume":"426","author":"W Li","year":"2003","unstructured":"Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzeriaga C, Greenough TC, Choe H, Farzan M (2003) Angiotensin\u2010converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426: 450\u2013454","journal-title":"Nature"},{"key":"BFEMBJ7600640_CR23","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.3201\/eid1010.040445","volume":"10","author":"G Liang","year":"2004","unstructured":"Liang G, Chen Q, Xu J, Liu Y, Lim W, Peiris JS, Anderson LJ, Ruan L, Li H, Kan B, Di B, Cheng P, Chan KH, Erdman D, Gu S, Xinge Y, Liang W, Zhou D, Haynes L (2004) Laboratory diagonosis of four recent sporadic cases of community\u2010acquired SARS, Guangdong Province, China. Emerg Infect Dis 10: 1774\u20131781","journal-title":"Emerg Infect Dis"},{"key":"BFEMBJ7600640_CR24","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.1085953","volume":"300","author":"MA Marra","year":"2003","unstructured":"Marra MA, Jones SJ, Astell CR, Holt RA, Brooks\u2010Wilson A, Butterfield YS, Khattra J, Asano JK, Barber SA, Chan SY, Cloutier A, Coughlin SM, Freeman D, Girn N, Griffith OL, Leach SR, Mayo M, McDonald H, Montgomery SB, Pandoh PK, Petrescu AS, Robertson AG, Schein JE, Siddiqui A, Smailus DE, Stott JM, Yang GS, Plummer F, Andonov A, Artsob H, Bastien N, Bernard K, Booth TF, Bowness D, Czub M, Drebot M, Fernando L, Flick R, Garbutt M, Gray M, Grolla A, Jones S, Feldmann H, Meyers A, Kabani A, Li Y, Normand S, Stroher U, Tipples GA, Tyler S, Vogrig R, Ward D, Watson B, Brunham RC, Krajden M, Petric M, Skowronski DM, Upton C, Roper RL (2003) The genome sequence of the SARS\u2010associated coronavirus. Science 300: 1399\u20131404","journal-title":"Science"},{"key":"BFEMBJ7600640_CR25","doi-asserted-by":"crossref","first-page":"12090","DOI":"10.1128\/JVI.78.21.12090-12095.2004","volume":"78","author":"A Marzi","year":"2004","unstructured":"Marzi A, Gramberg T, Simmons G, Moller P, Rennekamp AJ, Krumbiegel M, Geier M, Eisemann J, Turza N, Saunier B, Steinkasserer A, Becker S, Bates P, Hofmann H, Pohlmann S (2004) DC\u2010SIGN and DC\u2010SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus. J Virol 78: 12090\u201312095","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR26","doi-asserted-by":"crossref","first-page":"10628","DOI":"10.1128\/JVI.78.19.10628-10635.2004","volume":"78","author":"MJ Moore","year":"2004","unstructured":"Moore MJ, Dorfman T, Li W, Wong SK, Li Y, Kuhn JH, Coderre J, Vasilieva N, Han Z, Greenough TC, Farzan M, Choe H (2004) Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin\u2010converting enzyme 2. J Virol 78: 10628\u201310635","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR27","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.bbrc.2004.07.060","volume":"321","author":"Y Nie","year":"2004","unstructured":"Nie Y, Wang P, Shi X, Wang G, Chen J, Zheng A, Wang W, Wang Z, Qu X, Luo M, Tan L, Song X, Yin X, Ding M, Deng H (2004) Highly infectious SARS\u2010CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression. Biochem Biophys Res Commun 321: 994\u20131000","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ7600640_CR28","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1126\/science.304.5671.659","volume":"304","author":"D Normile","year":"2004","unstructured":"Normile D (2004) Infectious diseases. Mounting lab accidents raise SARS fears. Science 304: 659\u2013661","journal-title":"Science"},{"key":"BFEMBJ7600640_CR29","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1038\/nm1143","volume":"10","author":"JS Peiris","year":"2004","unstructured":"Peiris JS, Guan Y, Yuen KY (2004) Severe acute respiratory syndrome. Nat Med 10: S88\u201397","journal-title":"Nat Med"},{"key":"BFEMBJ7600640_CR30","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.1085952","volume":"300","author":"PA Rota","year":"2003","unstructured":"Rota PA, Oberste MS, Monroe SS, Nix WA, Campagnoli R, Icenogle JP, Penaranda S, Bankamp B, Maher K, Chen MH, Tong S, Tamin A, Lowe L, Frace M, DeRisi JL, Chen Q, Wang D, Erdman DD, Peret TC, Burns C, Ksiazek TG, Rollin PE, Sanchez A, Liffick S, Holloway B, Limor J, McCaustland K, Olsen\u2010Rasmussen M, Fouchier R, Gunther S, Osterhaus AD, Drosten C, Pallansch MA, Anderson LJ, Bellini WJ (2003) Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 300: 1394\u20131399","journal-title":"Science"},{"key":"BFEMBJ7600640_CR31","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.1128\/JVI.78.17.9073-9083.2004","volume":"78","author":"JH Schickli","year":"2004","unstructured":"Schickli JH, Thackray LB, Sawicki SG, Holmes KV (2004) The N\u2010terminal region of the murine coronavirus spike glycoprotein is associated with the extended host range of viruses from persistently infected murine cells. J Virol 78: 9073\u20139083","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR32","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1073\/pnas.0409608102","volume":"102","author":"HD Song","year":"2005","unstructured":"Song HD, Tu CC, Zhang GW, Wang SY, Zheng K, Lei LC, Chen QX, Gao YW, Zhou HQ, Xiang H, Zheng HJ, Chern SW, Cheng F, Pan CM, Xuan H, Chen SJ, Luo HM, Zhou DH, Liu YF, He JF, Qin PZ, Li LH, Ren YQ, Liang WJ, Yu YD, Anderson L, Wang M, Xu RH, Wu XW, Zheng HY, Chen JD, Liang G, Gao Y, Liao M, Fang L, Jiang LY, Li H, Chen F, Di B, He LJ, Lin JY, Tong S, Kong X, Du L, Hao P, Tang H, Bernini A, Yu XJ, Spiga O, Guo ZM, Pan HY, He WZ, Manuguerra JC, Fontanet A, Danchin A, Niccolai N, Li YX, Wu CI, Zhao GP (2005) Cross\u2010host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci USA 102: 2430\u20132435, Epub 2005 Feb 04","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600640_CR33","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1128\/JVI.78.7.3572-3577.2004","volume":"78","author":"K Subbarao","year":"2004","unstructured":"Subbarao K, McAuliffe J, Vogel L, Fahle G, Fischer S, Tatti K, Packard M, Shieh WJ, Zaki S, Murphy B (2004) Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice. J Virol 78: 3572\u20133577","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR34","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1073\/pnas.0307140101","volume":"101","author":"J Sui","year":"2004","unstructured":"Sui J, Li W, Murakami A, Tamin A, Matthews LJ, Wong SK, Moore MJ, St Clair Tallarico A, Olurinde M, Choe H, Anderson LJ, Bellini WJ, Farzan M, Marasco WA (2004) Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc Natl Acad Sci USA 101: 2536\u20132541","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600640_CR35","doi-asserted-by":"crossref","unstructured":"Sui J, Li W, Roberts A, Matthews LJ, Murakami A, Vogel L, Wong SK, Subbarao K, Farzan M, Marasco WA (2005) Evaluation of human mAb 80R in immunoprophylaxis of SARS by an animal study, epitope mapping and analysis of spike variants. J Virol in press","DOI":"10.1128\/JVI.79.10.5900-5906.2005"},{"key":"BFEMBJ7600640_CR36","doi-asserted-by":"crossref","first-page":"17996","DOI":"10.1074\/jbc.M311191200","volume":"279","author":"P Towler","year":"2004","unstructured":"Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW (2004) ACE2 X\u2010ray structures reveal a large hinge\u2010bending motion important for inhibitor binding and catalysis. J Biol Chem 279: 17996\u201318007, Epub 2004 Jan 30","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600640_CR37","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1038\/nm1151","volume":"10","author":"R Webby","year":"2004","unstructured":"Webby R, Hoffmann E, Webster R (2004) Molecular constraints to interspecies transmission of viral pathogens. Nat Med 10: S77\u2013S81","journal-title":"Nat Med"},{"key":"BFEMBJ7600640_CR38","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3201\/eid1007.031119","volume":"10","author":"DE Wentworth","year":"2004","unstructured":"Wentworth DE, Gillim\u2010Ross L, Espina N, Bernard KA (2004) Mice susceptible to SARS coronavirus. Emerg Infect Dis 10: 1293\u20131296","journal-title":"Emerg Infect Dis"},{"key":"BFEMBJ7600640_CR39","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1074\/jbc.C300520200","volume":"279","author":"SK Wong","year":"2004","unstructured":"Wong SK, Li W, Moore MJ, Choe H, Farzan M (2004) A 193\u2010amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin\u2010converting enzyme 2. J Biol Chem 279: 3197\u20133201, Epub 2003 Dec 11","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600640_CR40","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1128\/JVI.79.4.2620-2625.2005","volume":"79","author":"D Wu","year":"2005","unstructured":"Wu D, Tu C, Xin C, Xuan H, Meng Q, Liu Y, Yu Y, Guan Y, Jiang Y, Yin X, Crameri G, Wang M, Li C, Liu S, Liao M, Feng L, Xiang H, Sun J, Chen J, Sun Y, Gu S, Liu N, Fu D, Eaton BT, Wang LF, Kong X (2005) Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome coronavirus isolates. J Virol 79: 2620\u20132625","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR41","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.bbrc.2003.11.054","volume":"312","author":"X Xiao","year":"2003","unstructured":"Xiao X, Chakraborti S, Dimitrov AS, Gramatikoff K, Dimitrov DS (2003) The SARS\u2010CoV S glycoprotein: expression and functional characterization. Biochem Biophys Res Commun 312: 1159\u20131164","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ7600640_CR42","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1128\/JVI.78.11.5642-5650.2004","volume":"78","author":"ZY Yang","year":"2004","unstructured":"Yang ZY, Huang Y, Ganesh L, Leung K, Kong WP, Schwartz O, Subbarao K, Nabel GJ (2004) pH\u2010dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC\u2010SIGN. J Virol 78: 5642\u20135650","journal-title":"J Virol"},{"key":"BFEMBJ7600640_CR43","doi-asserted-by":"crossref","first-page":"17132","DOI":"10.1074\/jbc.M006723200","volume":"276","author":"H Zhang","year":"2001","unstructured":"Zhang H, Wada J, Hida K, Tsuchiyama Y, Hiragushi K, Shikata K, Wang H, Lin S, Kanwar YS, Makino H (2001) Collectrin, a collecting duct\u2010specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. J Biol Chem 276: 17132\u201317139","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600640_CR44","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1360\/04wc0153","volume":"49","author":"Y Zhang","year":"2004","unstructured":"Zhang Y, Zheng N, Hao P, Zhong Y (2004) Reconstruction of the most recent common ancestor sequences of SARS\u2010CoV S gene and detection of adaptive evolution in the spike protein. Chinese Sci Bull 49: 1311\u20131313","journal-title":"Chinese Sci Bull"},{"key":"BFEMBJ7600640_CR45","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1098\/rstb.2004.1491","volume":"359","author":"N Zhong","year":"2004","unstructured":"Zhong N (2004) Management and prevention of SARS in China. Philos Trans R Soc London B 359: 1115\u20131116","journal-title":"Philos Trans R Soc London B"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.emboj.7600640","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7600640.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.emboj.7600640","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/sj.emboj.7600640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7600640.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:22:03Z","timestamp":1779232923000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/sj.emboj.7600640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,24]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,4,20]]}},"alternative-id":["BFEMBJ7600640"],"URL":"https:\/\/doi.org\/10.1038\/sj.emboj.7600640","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,24]]},"assertion":[{"value":"9 December 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}