{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:31:35Z","timestamp":1787160695352,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2005,7,6]]},"DOI":"10.1038\/sj.emboj.7600715","type":"journal-article","created":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T09:14:56Z","timestamp":1118913296000},"page":"2318-2330","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2\u2013SUR1 interactions"],"prefix":"10.1038","volume":"24","author":[{"given":"Paolo","family":"Tammaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Molnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l R","family":"Nj\u00f8lstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M","family":"Ashcroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"BFEMBJ7600715_CR1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1126\/science.7716547","volume":"268","author":"L Aguilar\u2010Bryan","year":"1995","unstructured":"Aguilar\u2010Bryan L, Nichols CG, Wechsler SW, Clement IV JP, Boyd III AE, Gonzalez G, Herrera\u2010Sosa H, Nguy K, Bryan J, Nelson DA (1995) Cloning of the \u03b2\u2010cell high\u2010affinity sulfonylurea receptor: a regulator of insulin secretion. Science 268: 423\u2013426","journal-title":"Science"},{"key":"BFEMBJ7600715_CR2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/sj.emboj.7600487","volume":"24","author":"JF Antcliff","year":"2005","unstructured":"Antcliff JF, Haider S, Proks P, Sansom MSP, Ashcroft FM (2005) Functional analysis of a structural model of the ATP\u2010binding site of the KATP channel Kir6.2 subunit. EMBO J 24: 229\u2013239","journal-title":"EMBO J"},{"key":"BFEMBJ7600715_CR3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0166-2236(98)01225-9","volume":"21","author":"FM Ashcroft","year":"1998","unstructured":"Ashcroft FM, Gribble FM (1998) Correlating structure and function in ATP\u2010sensitive K+ channels. Trends Neurosci 21: 288\u2013294","journal-title":"Trends Neurosci"},{"key":"BFEMBJ7600715_CR4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0079-6107(89)90013-8","volume":"54","author":"FM Ashcroft","year":"1989","unstructured":"Ashcroft FM, Rorsman P (1989) Electrophysiology of the pancreatic \u03b2\u2010cell. Prog Biophys Mol Biol 54: 87\u2013143","journal-title":"Prog Biophys Mol Biol"},{"key":"BFEMBJ7600715_CR5","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1093\/hmg\/ddh066","volume":"13","author":"FM Ashcroft","year":"2004","unstructured":"Ashcroft FM, Rorsman P (2004) Type\u20102 diabetes mellitus: not quite exciting enough? Hum Mol Genet 13: R21\u2013R31","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ7600715_CR6","doi-asserted-by":"crossref","first-page":"43997","DOI":"10.1074\/jbc.M208085200","volume":"277","author":"AP Babenko","year":"2002","unstructured":"Babenko AP, Bryan J (2002) SUR\u2010dependent modulation of KATP channels by an N\u2010terminal KIR6.2 peptide. Defining intersubunit gating interactions. J Biol Chem 277: 43997\u201344004","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600715_CR7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/bbrc.1999.0172","volume":"255","author":"AP Babenko","year":"1999","unstructured":"Babenko AP, Gonzalez G, Bryan J (1999) The N\u2010terminus of KIR6.2 limits spontaneous bursting and modulates the ATP\u2010inhibition of KATP channels. Biochem Biophys Res Commun 255: 231\u2013238","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ7600715_CR8","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1126\/science.282.5391.1141","volume":"282","author":"T Baukrowitz","year":"1998","unstructured":"Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B (1998) PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science 282: 1141\u20131144","journal-title":"Science"},{"key":"BFEMBJ7600715_CR9","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0896-6273(00)80321-9","volume":"18","author":"JP Clement IV","year":"1997","unstructured":"Clement IV JP, Kunjilwar K, Gonzalez G, Schwanstecher M, Panten U, Aguilar\u2010Bryan L, Bryan J (1997) Association and stoichiometry of K(ATP) channel subunits. Neuron 18: 827\u2013838","journal-title":"Neuron"},{"key":"BFEMBJ7600715_CR10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1085\/jgp.20028621","volume":"120","author":"CA Cukras","year":"2002","unstructured":"Cukras CA, Jeliazkova I, Nichols CG (2002) The role of NH2\u2010terminal positive charges in the activity of inward rectifier KATP channels. J Gen Physiol 120: 437\u2013446","journal-title":"J Gen Physiol"},{"key":"BFEMBJ7600715_CR11","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1172\/JCI118219","volume":"96","author":"P Detimary","year":"1995","unstructured":"Detimary P, Jonas JC, Henquin JC (1995) Possible links between glucose\u2010induced changes in the energy state of pancreatic B cells and insulin release: unmasking by decreasing a stable pool of adenine nucleotides in mouse islets. J Clin Invest 96: 1738\u20131745","journal-title":"J Clin Invest"},{"key":"BFEMBJ7600715_CR12","doi-asserted-by":"crossref","first-page":"13953","DOI":"10.1073\/pnas.95.23.13953","volume":"95","author":"P Drain","year":"1998","unstructured":"Drain P, Li L, Wang J (1998) KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore\u2010forming subunit. Proc Natl Acad Sci USA 95: 13953\u201313958","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600715_CR13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0006-3495(01)76051-1","volume":"80","author":"D Enkvetchakul","year":"2001","unstructured":"Enkvetchakul D, Loussouarn G, Makhina E, Nichols CG (2001) ATP interaction with the open state of the KATP channel. Biophys J 80: 719\u2013728","journal-title":"Biophys J"},{"key":"BFEMBJ7600715_CR14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1085\/jgp.114.2.251","volume":"114","author":"Z Fan","year":"1999","unstructured":"Fan Z, Makielski JC (1999) Phosphoinositides decrease ATP sensitivity of the cardiac ATP\u2010sensitive K+ channel. A molecular probe for the mechanism of ATP\u2010sensitive inhibition. J Gen Physiol 114: 251\u2013269","journal-title":"J Gen Physiol"},{"key":"BFEMBJ7600715_CR15","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa032922","volume":"350","author":"AL Gloyn","year":"2004","unstructured":"Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JPH, Sumnik Z, van Rhijn A, Wales JKH, Clark P, Gorman S, Aisenberg J, Ellard S, Njolstad PR, Ashcroft FM, Hattersley AT (2004) Activating mutations in the gene encoding the ATP\u2010sensitive potassium channel subunit Kir6.2 gene and permanent neonatal diabetes. N Engl J Med 350: 1838\u20131849","journal-title":"N Engl J Med"},{"key":"BFEMBJ7600715_CR16","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/hmg\/ddi086","volume":"14","author":"AL Gloyn","year":"2005","unstructured":"Gloyn AL, Reimann F, Girard C, Edghill EL, Proks P, Pearson ER, Temple IK, Mackay DJG, Shield JPH, Freedenberg D, Noyes K, Ellard S, Ashcroft FM, Gribble FM, Hattersley AT (2005) Moderately activating mutations in KCNJ11 may result in relapsing diabetes. Hum Mol Genet 14: 925\u2013934","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ7600715_CR17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1113\/jphysiol.1997.sp021843","volume":"4981","author":"FM Gribble","year":"1997","unstructured":"Gribble FM, Ashfield R, \u00c4mm\u00e4l\u00e4 C, Ashcroft FM (1997a) Properties of cloned ATP\u2010sensitive K\u2010currents expressed in Xenopus oocytes. J Physiol 4981: 87\u201398","journal-title":"J Physiol"},{"key":"BFEMBJ7600715_CR18","doi-asserted-by":"crossref","first-page":"30046","DOI":"10.1074\/jbc.M001010200","volume":"275","author":"FM Gribble","year":"2000","unstructured":"Gribble FM, Loussouarn G, Tucker SJ, Zhao C, Nichols CG, Ashcroft FM (2000) A novel method for measurement of sub\u2010membrane ATP concentration. J Biol Chem 275: 30046\u201330049","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600715_CR19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00125-003-1143-3","volume":"46","author":"FM Gribble","year":"2003","unstructured":"Gribble FM, Reimann F (2003) Sulphonylurea action revisited: the post\u2010cloning era. Diabetologia 46: 875\u2013891","journal-title":"Diabetologia"},{"key":"BFEMBJ7600715_CR20","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/emboj\/16.6.1145","volume":"16","author":"FM Gribble","year":"1997","unstructured":"Gribble FM, Tucker SJ, Ashcroft FM (1997b) The essential role of the Walker A motifs of SUR1 in KATP channel activation by MgADP and diazoxide. EMBO J 16: 1145\u20131111","journal-title":"EMBO J"},{"key":"BFEMBJ7600715_CR21","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1073\/pnas.95.12.7185","volume":"95","author":"FM Gribble","year":"1998","unstructured":"Gribble FM, Tucker SJ, Haug T, Ashcroft FM (1998) MgATP activates the \u03b2\u2010cell KATP channel by interaction with its SUR1 subunit. Proc Natl Acad Sci USA 95: 7185\u20137190","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600715_CR22","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1126\/science.270.5239.1166","volume":"270","author":"N Inagaki","year":"1995","unstructured":"Inagaki N, Gonoi T, Clement IV JP, Namba N, Inazawa J, Gonzalez G, Aguilar\u2010Bryan L, Seino S, Bryan J (1995) Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 270: 1166\u20131169","journal-title":"Science"},{"key":"BFEMBJ7600715_CR23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/jphysiol.2003.048843","volume":"552","author":"SA John","year":"2003","unstructured":"John SA, Weiss JN, Xie LH, Ribalet B (2003) Molecular mechanism for ATP\u2010dependent closure of the K+ channel Kir6.2. J Physiol 552: 23\u201334","journal-title":"J Physiol"},{"key":"BFEMBJ7600715_CR24","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0006-3495(00)76340-5","volume":"79","author":"L Li","year":"2000","unstructured":"Li L, Wang J, Drain P (2000) The I182 region of K(ir)6.2 is closely associated with ligand binding in KATP channel inhibition by ATP. Biophys J 79: 841\u2013852","journal-title":"Biophys J"},{"key":"BFEMBJ7600715_CR25","doi-asserted-by":"crossref","first-page":"9058","DOI":"10.1073\/pnas.160068997","volume":"97","author":"PE Light","year":"2000","unstructured":"Light PE, Bladen C, Winkfein RJ, Walsh MP, French RJ (2000) Molecular basis of protein kinase C\u2010induced activation of ATP\u2010sensitive potassium channels. Proc Natl Acad Sci USA 97: 9058\u20139063","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600715_CR26","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.2337\/diabetes.49.9.1413","volume":"49","author":"E Markworth","year":"2000","unstructured":"Markworth E, Schwanstecher C, Schwanstecher M (2000) ATP4\u2212 mediates closure of pancreatic beta\u2010cell ATP\u2010sensitive potassium channels by interaction with 1 of 4 identical sites. Diabetes 49: 1413\u20131418","journal-title":"Diabetes"},{"key":"BFEMBJ7600715_CR27","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1126\/science.272.5269.1785","volume":"272","author":"CG Nichols","year":"1996","unstructured":"Nichols CG, Shyng SL, Nestorowicz A, Glaser B, Clement IV JP, Gonzalez G, Aguilar\u2010Bryan L, Permutt MA, Bryan J (1996) Adenosine diphosphate as an intracellular regulator of insulin secretion. Science 272: 1785\u20131787","journal-title":"Science"},{"key":"BFEMBJ7600715_CR28","doi-asserted-by":"crossref","first-page":"17539","DOI":"10.1073\/pnas.0404756101","volume":"101","author":"P Proks","year":"2004","unstructured":"Proks P, Antcliff JF, Lippiat J, Gloyn A, Hattersley AT, Ashcroft FM (2004) Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features. Proc Natl Acad Sci USA 101: 17539\u201317544","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7600715_CR29","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/sj.embor.7400393","volume":"6","author":"P Proks","year":"2005","unstructured":"Proks P, Girard C, Haider S, Gloyn AL, Hattersley AT, Sansom MSP, Ashcroft FM (2005) A novel gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome. EMBO Rep 6: 470\u2013475","journal-title":"EMBO Rep"},{"key":"BFEMBJ7600715_CR30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1469-7793.1999.0325p.x","volume":"518","author":"F Reimann","year":"1999","unstructured":"Reimann F, Tucker SJ, Proks P, Ashcroft FM (1999) Involvement of the N\u2010terminus of Kir6.2 in coupling to the sulphonylurea receptor. J Physiol 518: 325\u2013336","journal-title":"J Physiol"},{"key":"BFEMBJ7600715_CR31","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.1074\/jbc.275.13.9110","volume":"275","author":"JA Rosado","year":"2000","unstructured":"Rosado JA, Sage SO (2000) Phosphoinositides are required for store\u2010mediated calcium entry in human platelets. J Biol Chem 275: 9110\u20139113","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600715_CR32","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.2337\/diabetes.53.10.2713","volume":"53","author":"JV Sagen","year":"2004","unstructured":"Sagen JV, Raeder H, Hathout E, Shehadeh N, Gudmundsson K, Baevre H, Abuelo D, Phornphutkul C, Molnes J, Bell GI, Gloyn AL, Hattersley AT, Molven A, Sovik O, Njolstad PR (2004) Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. Diabetes 53: 2713\u20132718","journal-title":"Diabetes"},{"key":"BFEMBJ7600715_CR33","first-page":"338","volume":"77","author":"H Sakura","year":"1995","unstructured":"Sakura H, Ammala C, Smith PA, Gribble FM, Ashcroft FM (1995) Cloning and functional expression of the cDNA encoding a novel ATP\u2010sensitive potassium channel subunit expressed in pancreatic \u03b2\u2010cells, brain, heart and skeletal muscle. FEBS Lett 77: 338\u2013344","journal-title":"FEBS Lett"},{"key":"BFEMBJ7600715_CR34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0079-6107(02)00053-6","volume":"81","author":"S Seino","year":"2003","unstructured":"Seino S, Miki T (2003) Physiological and pathophysiological roles of ATP\u2010sensitive K+ channels. Prog Biophys Mol Biol 81: 133\u2013176","journal-title":"Prog Biophys Mol Biol"},{"key":"BFEMBJ7600715_CR35","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1085\/jgp.110.6.655","volume":"110","author":"S Shyng","year":"1997","unstructured":"Shyng S, Nichols CG (1997) Octameric stoichiometry of the KATP channel complex. J Gen Physiol 110: 655\u2013664","journal-title":"J Gen Physiol"},{"key":"BFEMBJ7600715_CR36","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.282.5391.1138","volume":"282","author":"S Shyng","year":"1998","unstructured":"Shyng S, Nichols CG (1998) Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science 282: 1138\u20131141","journal-title":"Science"},{"key":"BFEMBJ7600715_CR37","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1074\/jbc.M009959200","volume":"276","author":"D\u2010K Song","year":"2001","unstructured":"Song D\u2010K, Ashcroft FM (2001) ATP\u2010modulation of KATP channel ATP\u2010sensitivity varies with the type of SUR subunit. J Biol Chem 276: 7143\u20137149","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600715_CR38","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1074\/jbc.274.7.3931","volume":"274","author":"K Tanabe","year":"1999","unstructured":"Tanabe K, Tucker SJ, Matsuo M, Proks P, Ashcroft FM, Seino S, Amachi T, Ueda K (1999) Direct photoaffinity labeling of the Kir6.2 subunit of the ATP\u2010sensitive K+ channel by 8\u2010azido\u2010ATP. J Biol Chem 274: 3931\u20137149","journal-title":"J Biol Chem"},{"key":"BFEMBJ7600715_CR39","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.2337\/diabetes.53.suppl_3.S113","volume":"53","author":"A Tarasov","year":"2004","unstructured":"Tarasov A, Dusonchet J, Ashcroft FM (2004) Metabolic regulation of the pancreatic \u03b2\u2010cell KATP channel: a Pas de Deux. Diabetes 53: S123\u2013S127","journal-title":"Diabetes"},{"key":"BFEMBJ7600715_CR40","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1093\/emboj\/cdg282","volume":"22","author":"S Trapp","year":"2003","unstructured":"Trapp S, Haider S, Jones P, Sansom MSP, Ashcroft FMA (2003) Identification of residues contributing to the ATP binding site of Kir6.2. EMBO J 22: 2903\u20132912","journal-title":"EMBO J"},{"key":"BFEMBJ7600715_CR41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1085\/jgp.112.3.333","volume":"112","author":"S Trapp","year":"1998","unstructured":"Trapp S, Proks P, Tucker SJ, Ashcroft FM (1998) Molecular analysis of KATP channel gating and implications for channel inhibition by ATP. J Gen Physiol 112: 333\u2013349","journal-title":"J Gen Physiol"},{"key":"BFEMBJ7600715_CR42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/387179a0","volume":"387","author":"SJ Tucker","year":"1997","unstructured":"Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM (1997) Truncation of Kir6.2 produces ATP\u2010sensitive K\u2010channels in the absence of the sulphonylurea receptor. Nature 387: 179\u2013183","journal-title":"Nature"},{"key":"BFEMBJ7600715_CR43","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.2337\/diabetes.53.10.2719","volume":"53","author":"M Vaxillaire","year":"2004","unstructured":"Vaxillaire M, Populaire C, Busiah K, Cave H, Gloyn AL, Hattersley AT, Czernichow P, Froguel P, Polak M (2004) Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients. Diabetes 53: 2719\u20132722","journal-title":"Diabetes"},{"key":"BFEMBJ7600715_CR44","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0896-6273(00)80708-4","volume":"22","author":"N Zerangue","year":"1999","unstructured":"Zerangue N, Schwappach B, Jan YN, Jan LY (1999) A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron 22: 537\u2013548","journal-title":"Neuron"},{"key":"BFEMBJ7600715_CR45","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0896-6273(01)00356-7","volume":"31","author":"LV Zingman","year":"2001","unstructured":"Zingman LV, Alekseev AE, Bienengraeber M, Hodgson D, Karger AB, Dzeja PP, Terzic A (2001) Signaling in channel\/enzyme multimers: ATPase transitions in SUR module gate ATP\u2010sensitive K+ conductance. Neuron 31: 233\u2013245","journal-title":"Neuron"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.emboj.7600715","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7600715.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.emboj.7600715","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/sj.emboj.7600715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7600715.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:23:34Z","timestamp":1779233014000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/sj.emboj.7600715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,16]]},"references-count":45,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2005,7,6]]}},"alternative-id":["BFEMBJ7600715"],"URL":"https:\/\/doi.org\/10.1038\/sj.emboj.7600715","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,16]]},"assertion":[{"value":"19 January 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}