{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:13:10Z","timestamp":1790161990643,"version":"4.1.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"21","license":[{"start":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T00:00:00Z","timestamp":1161216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T00:00:00Z","timestamp":1161216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2006,11,1]]},"DOI":"10.1038\/sj.emboj.7601379","type":"journal-article","created":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T11:55:20Z","timestamp":1161258920000},"page":"5201-5213","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["The Kruppel\u2010like transcription factor KLF13 is a novel regulator of heart development"],"prefix":"10.1038","volume":"25","author":[{"given":"Genevi\u00e8ve","family":"Lavall\u00e9e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Andelfinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Nemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko E","family":"Horb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Nemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,10,19]]},"reference":[{"key":"BFEMBJ7601379_CR1","first-page":"777","volume":"14","author":"S Argentin","year":"1994","unstructured":"Argentin S, Ardati A, Tremblay S, Lihrmann I, Robitaille L, Drouin J, Nemer M (1994) Developmental stage\u2010specific regulation of atrial natriuretic factor gene transcription in cardiac cells. Mol Cell Biol 14: 777\u2013790","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601379_CR2","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1073\/pnas.0401833101","volume":"101","author":"A Aries","year":"2004","unstructured":"Aries A, Paradis P, Lefebvre C, Schwartz RJ, Nemer M (2004) Essential role of GATA\u20104 in cell survival and drug\u2010induced cardiotoxicity. Proc Natl Acad Sci USA 101: 6975\u20136980","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601379_CR3","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1128\/MCB.19.5.3571","volume":"19","author":"H Asano","year":"1999","unstructured":"Asano H, Li XS, Stamatoyannopoulos G (1999) FKLF, a novel Kruppel\u2010like factor that activates human embryonic and fetal \u03b2\u2010like globin genes. Mol Cell Biol 19: 3571\u20133579","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601379_CR4","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1182\/blood.V95.11.3578","volume":"95","author":"H Asano","year":"2000","unstructured":"Asano H, Li XS, Stamatoyannopoulos G (2000) FKLF\u20102: a novel Kruppel\u2010like transcriptional factor that activates globin and other erythroid lineage genes. Blood 95: 3578\u20133584","journal-title":"Blood"},{"key":"BFEMBJ7601379_CR5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/ng0197-30","volume":"15","author":"CT Basson","year":"1997","unstructured":"Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc\u2010Straceski J, Renault B, Kucherlapati R, Seidman JG, Seidman CE (1997) Mutations in human TBX5 (corrected) cause limb and cardiac malformation in Holt\u2013Oram syndrome. Nat Genet 15: 30\u201335","journal-title":"Nat Genet"},{"key":"BFEMBJ7601379_CR6","doi-asserted-by":"crossref","first-page":"11439","DOI":"10.1074\/jbc.M100208200","volume":"276","author":"SS Bhalla","year":"2001","unstructured":"Bhalla SS, Robitaille L, Nemer M (2001) Cooperative activation by GATA\u20104 and YY1 of the cardiac B\u2010type natriuretic peptide promoter. J Biol Chem 276: 11439\u201311445","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601379_CR7","doi-asserted-by":"crossref","first-page":"34355","DOI":"10.1074\/jbc.R100043200","volume":"276","author":"JJ Bieker","year":"2001","unstructured":"Bieker JJ (2001) Kruppel\u2010like factors: three fingers in many pies. J Biol Chem 276: 34355\u201334358","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601379_CR8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1242\/dev.118.3.719","volume":"118","author":"R Bodmer","year":"1993","unstructured":"Bodmer R (1993) The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118: 719\u2013729","journal-title":"Development"},{"key":"BFEMBJ7601379_CR9","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/S0925-4773(03)00104-7","volume":"119","author":"A Brewer","year":"2002","unstructured":"Brewer A, Nemer G, Gove C, Rawlins F, Nemer M, Patient R, Pizzey J (2002) Widespread expression of an extended peptide sequence of GATA\u20106 during murine embryogenesis and non\u2010equivalence of RNA and protein expression domains. Mech Dev 119 (Suppl 1): S121\u2013S129","journal-title":"Mech Dev"},{"key":"BFEMBJ7601379_CR10","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/01.RES.0000013072.51957.B7","volume":"90","author":"BG Bruneau","year":"2002","unstructured":"Bruneau BG (2002) Transcriptional regulation of vertebrate cardiac morphogenesis. Circ Res 90: 509\u2013519","journal-title":"Circ Res"},{"key":"BFEMBJ7601379_CR11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0092-8674(01)00493-7","volume":"106","author":"BG Bruneau","year":"2001","unstructured":"Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG (2001) A murine model of Holt\u2013Oram syndrome defines roles of the T\u2010box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 721","journal-title":"Cell"},{"key":"BFEMBJ7601379_CR12","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1038\/sj.onc.1205326","volume":"21","author":"AB Cantor","year":"2002","unstructured":"Cantor AB, Orkin SH (2002) Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 21: 3368\u20133376","journal-title":"Oncogene"},{"key":"BFEMBJ7601379_CR13","unstructured":"Centers for Disease Control and Prevention (2001) Infant deaths, and infant mortality rates by race of mother and 130 selected causes of infant death http:\/\/www.cdc.gov\/nchs\/data\/dvs\/LINK01WK45.pdf"},{"key":"BFEMBJ7601379_CR14","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1128\/MCB.19.6.4355","volume":"19","author":"F Charron","year":"1999","unstructured":"Charron F, Paradis P, Bronchain O, Nemer G, Nemer M (1999) Cooperative interaction between GATA\u20104 and GATA\u20106 regulates myocardial gene expression. Mol Cell Biol 19: 4355\u20134365","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601379_CR15","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1101\/gad.915701","volume":"15","author":"F Charron","year":"2001","unstructured":"Charron F, Tsimiklis G, Arcand M, Robitaille L, Liang Q, Molkentin JD, Meloche S, Nemer M (2001) Tissue\u2010specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev 15: 2702\u20132719","journal-title":"Genes Dev"},{"key":"BFEMBJ7601379_CR16","doi-asserted-by":"crossref","first-page":"13490","DOI":"10.1073\/pnas.0504295102","volume":"102","author":"X Chi","year":"2005","unstructured":"Chi X, Chatterjee PK, Wilson III W, Zhang SX, DeMayo FJ, Schwartz RJ (2005) Complex cardiac Nkx2\u20105 gene expression activated by noggin\u2010sensitive enhancers followed by chamber\u2010specific modules. Proc Natl Acad Sci USA 102: 13490\u201313495","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601379_CR17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.physiol.68.040104.113828","volume":"68","author":"KL Clark","year":"2006","unstructured":"Clark KL, Yutzey KE, Benson DW (2006) Transcription factors and congenital heart defects. Annu Rev Physiol 68: 97\u2013121","journal-title":"Annu Rev Physiol"},{"key":"BFEMBJ7601379_CR18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1097-2765(00)80312-3","volume":"3","author":"JD Crispino","year":"1999","unstructured":"Crispino JD, Lodish MB, Mackay JP, Orkin SH (1999) Use of altered specificity mutants to probe a specific protein\u2013protein interaction in differentiation: the GATA\u20101:FOG complex. Mol Cell 3: 219\u2013228","journal-title":"Mol Cell"},{"key":"BFEMBJ7601379_CR19","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1101\/gad.875201","volume":"15","author":"JD Crispino","year":"2001","unstructured":"Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH (2001) Proper coronary vascular development and heart morphogenesis depend on interaction of GATA\u20104 with FOG cofactors. Genes Dev 15: 839\u2013844","journal-title":"Genes Dev"},{"key":"BFEMBJ7601379_CR20","doi-asserted-by":"crossref","first-page":"24390","DOI":"10.1074\/jbc.M202490200","volume":"277","author":"YS Dai","year":"2002","unstructured":"Dai YS, Cserjesi P, Markham BE, Molkentin JD (2002) The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300\u2010dependent mechanism. J Biol Chem 277: 24390\u201324398","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601379_CR21","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1093\/emboj\/16.18.5687","volume":"16","author":"D Durocher","year":"1997","unstructured":"Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M (1997) The cardiac transcription factors Nkx2\u20105 and GATA\u20104 are mutual cofactors. EMBO J 16: 5687\u20135696","journal-title":"EMBO J"},{"key":"BFEMBJ7601379_CR22","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1073\/pnas.131215798","volume":"98","author":"N Fossett","year":"2001","unstructured":"Fossett N, Tevosian SG, Gajewski K, Zhang Q, Orkin SH, Schulz RA (2001) The Friend of GATA proteins U\u2010shaped, FOG\u20101, and FOG\u20102 function as negative regulators of blood, heart, and eye development in Drosophila. Proc Natl Acad Sci USA 98: 7342\u20137347","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601379_CR23","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1242\/dev.126.24.5679","volume":"126","author":"K Gajewski","year":"1999","unstructured":"Gajewski K, Fossett N, Molkentin JD, Schulz RA (1999) The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. Development 126: 5679\u20135688","journal-title":"Development"},{"key":"BFEMBJ7601379_CR24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature01827","volume":"424","author":"V Garg","year":"2003","unstructured":"Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama\u2010Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D (2003) GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 424: 443\u2013447","journal-title":"Nature"},{"key":"BFEMBJ7601379_CR25","first-page":"3115","volume":"14","author":"C Gr\u00e9pin","year":"1994","unstructured":"Gr\u00e9pin C, Dagnino L, Robitaille L, Haberstroh L, Antakly T, Nemer M (1994) A hormone\u2010encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol Cell Biol 14: 3115\u20133129","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601379_CR26","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1242\/dev.124.12.2387","volume":"124","author":"C Gr\u00e9pin","year":"1997","unstructured":"Gr\u00e9pin C, Nemer G, Nemer M (1997) Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA\u20104 transcription factor. Development 124: 2387\u20132395","journal-title":"Development"},{"key":"BFEMBJ7601379_CR27","first-page":"1295","volume":"9","author":"B Herber","year":"1994","unstructured":"Herber B, Truss M, Beato M, Muller R (1994) Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9: 1295\u20131304","journal-title":"Oncogene"},{"key":"BFEMBJ7601379_CR28","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1242\/dev.126.8.1739","volume":"126","author":"ME Horb","year":"1999","unstructured":"Horb ME, Thomsen GH (1999) Tbx5 is essential for heart development. Development 126: 1739\u20131751","journal-title":"Development"},{"key":"BFEMBJ7601379_CR29","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/dbio.1996.0071","volume":"174","author":"Y Jiang","year":"1996","unstructured":"Jiang Y, Evans T (1996) The Xenopus GATA\u20104\/5\/6 genes are associated with cardiac specification and can regulate cardiac\u2010specific transcription during embryogenesis. Dev Biol 174: 258\u2013270","journal-title":"Dev Biol"},{"key":"BFEMBJ7601379_CR30","doi-asserted-by":"crossref","first-page":"26658","DOI":"10.1016\/S0021-9258(19)74362-2","volume":"268","author":"K Kariya","year":"1993","unstructured":"Kariya K, Farrance IK, Simpson PC (1993) Transcriptional enhancer factor\u20101 in cardiac myocytes interacts with an alpha 1\u2010adrenergic\u2010 and beta\u2010protein kinase C\u2010inducible element in the rat beta\u2010myosin heavy chain promoter. J Biol Chem 268: 26658\u201326662","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601379_CR31","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1242\/dev.00517","volume":"130","author":"SL Klinedinst","year":"2003","unstructured":"Klinedinst SL, Bodmer R (2003) Gata factor Pannier is required to establish competence for heart progenitor formation. Development 130: 3027\u20133038","journal-title":"Development"},{"key":"BFEMBJ7601379_CR32","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1073\/pnas.90.17.8145","volume":"90","author":"I Komuro","year":"1993","unstructured":"Komuro I, Izumo S (1993) Csx: a murine homeobox\u2010containing gene specifically expressed in the developing heart. Proc Natl Acad Sci USA 90: 8145\u20138149","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601379_CR33","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","volume":"11","author":"CT Kuo","year":"1997","unstructured":"Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM (1997) GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 11: 1048\u20131060","journal-title":"Genes Dev"},{"key":"BFEMBJ7601379_CR34","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1242\/dev.00599","volume":"130","author":"BV Latinkic","year":"2003","unstructured":"Latinkic BV, Kotecha S, Mohun TJ (2003) Induction of cardiomyocytes by GATA4 in Xenopus ectodermal explants. Development 130: 3865\u20133876","journal-title":"Development"},{"key":"BFEMBJ7601379_CR35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.ATV.0000152725.76020.3c","volume":"25","author":"JJ Lepore","year":"2005","unstructured":"Lepore JJ, Cappola TP, Mericko PA, Morrisey EE, Parmacek MS (2005) GATA\u20106 regulates genes promoting synthetic functions in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 25: 309\u2013314","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFEMBJ7601379_CR36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/dev.126.1.75","volume":"126","author":"CL Lien","year":"1999","unstructured":"Lien CL, Wu C, Mercer B, Webb R, Richardson JA, Olson EN (1999) Control of early cardiac\u2010specific transcription of Nkx2\u20105 by a GATA\u2010dependent enhancer. Development 126: 75\u201384","journal-title":"Development"},{"key":"BFEMBJ7601379_CR37","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1242\/dev.119.2.419","volume":"119","author":"TJ Lints","year":"1993","unstructured":"Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP (1993) Nkx\u20102.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119: 419\u2013431","journal-title":"Development"},{"key":"BFEMBJ7601379_CR38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/bj20030870","volume":"375","author":"KM Martin","year":"2003","unstructured":"Martin KM, Ellis PD, Metcalfe JC, Kemp PR (2003) Selective modulation of the SM22alpha promoter by the binding of BTEB3 (basal transcription element\u2010binding protein 3) to TGGG repeats. Biochem J 375: 457\u2013463","journal-title":"Biochem J"},{"key":"BFEMBJ7601379_CR39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0925-4773(01)00343-4","volume":"103","author":"KM Martin","year":"2001","unstructured":"Martin KM, Metcalfe JC, Kemp PR (2001) Expression of Klf9 and Klf13 in mouse development. Mech Dev 103: 149\u2013151","journal-title":"Mech Dev"},{"key":"BFEMBJ7601379_CR40","doi-asserted-by":"crossref","first-page":"8403","DOI":"10.1038\/sj.onc.1206877","volume":"22","author":"K McBride","year":"2003","unstructured":"McBride K, Charron F, Lefebvre C, Nemer M (2003) Interaction with GATA transcription factors provides a mechanism for cell\u2010specific effects of c\u2010Fos. Oncogene 22: 8403\u20138412","journal-title":"Oncogene"},{"key":"BFEMBJ7601379_CR41","first-page":"600","volume":"13","author":"K McBride","year":"1993","unstructured":"McBride K, Robitaille L, Tremblay S, Argentin S, Nemer M (1993) Fos\/jun repression of cardiac\u2010specific transcription in quiescent and growth stimulated myocytes is targeted at a tissue\u2010specific cis\u2010element. Mol Cell Biol 13: 600\u2013612","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601379_CR42","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1242\/dev.127.24.5331","volume":"127","author":"DG McFadden","year":"2000","unstructured":"McFadden DG, Charit\u00e9 J, Richardson JA, Srivastava D, Firulli AB, Olson EN (2000) A GATA\u2010dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127: 5331\u20135341","journal-title":"Development"},{"key":"BFEMBJ7601379_CR43","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1101\/gad.11.8.1061","volume":"11","author":"JD Molkentin","year":"1997","unstructured":"Molkentin JD, Lin Q, Duncan SA, Olson EN (1997) Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 11: 1061\u20131072","journal-title":"Genes Dev"},{"key":"BFEMBJ7601379_CR44","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.1128\/MCB.19.10.7096","volume":"19","author":"K Monzen","year":"1999","unstructured":"Monzen K, Shiojima I, Hiroi Y, Kudoh S, Oka T, Takimoto E, Hayashi D, Hosoda T, Habara\u2010Ohkubo A, Nakaoka T, Fujita T, Yazaki Y, Komuro I (1999) Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen\u2010activated protein kinase TAK1 and cardiac transcription factors Csx\/Nkx\u20102.5 and GATA\u20104. Mol Cell Biol 19: 7096\u20137105","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601379_CR45","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1093\/emboj\/19.9.2046","volume":"19","author":"S Morin","year":"2000","unstructured":"Morin S, Charron F, Robitaille L, Nemer M (2000) GATA\u2010dependent recruitment of MEF2 proteins to target promoters. EMBO J 19: 2046\u20132055","journal-title":"EMBO J"},{"key":"BFEMBJ7601379_CR46","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1128\/MCB.21.4.1036-1044.2001","volume":"21","author":"S Morin","year":"2001","unstructured":"Morin S, Paradis P, Aries A, Nemer M (2001) Serum response factor\u2010GATA ternary complex required for nuclear signaling by a G\u2010protein\u2010coupled receptor. Mol Cell Biol 21: 1036\u20131044","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601379_CR47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/humu.9410","volume":"27","author":"G Nemer","year":"2006","unstructured":"Nemer G, Fadlalah F, Usta J, Nemer M, Dbaibo G, Obeid M, Bitar F (2006) A novel mutation in the GATA4 gene in patients with tetralogy of Fallot. Hum Mutat 27: 293\u2013294","journal-title":"Hum Mutat"},{"key":"BFEMBJ7601379_CR48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0012-1606(02)00026-X","volume":"254","author":"G Nemer","year":"2003","unstructured":"Nemer G, Nemer M (2003) Transcriptional activation of BMP\u20104 and regulation of mammalian organogenesis by GATA\u20104 and \u20106. Dev Biol 254: 131\u2013148","journal-title":"Dev Biol"},{"key":"BFEMBJ7601379_CR49","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/375316a0","volume":"375","author":"B Nuez","year":"1995","unstructured":"Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F (1995) Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375: 316\u2013318","journal-title":"Nature"},{"key":"BFEMBJ7601379_CR50","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1101\/gad.1110103","volume":"17","author":"EN Olson","year":"2003","unstructured":"Olson EN, Schneider MD (2003) Sizing up the heart: development redux in disease. Genes Dev 17: 1937\u20131956","journal-title":"Genes Dev"},{"key":"BFEMBJ7601379_CR51","first-page":"1967","volume":"12","author":"MS Parmacek","year":"1992","unstructured":"Parmacek MS, Vora AJ, Shen T, Barr E, Jung F, Leiden JM (1992) Identification and characterization of a cardiac\u2010specific transcriptional regulatory element in the slow\/cardiac troponin C gene. Mol Cell Biol 12: 1967\u20131976","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601379_CR52","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/375318a0","volume":"375","author":"AC Perkins","year":"1995","unstructured":"Perkins AC, Sharpe AH, Orkin SH (1995) Lethal beta\u2010thalassaemia in mice lacking the erythroid CACCC\u2010transcription factor EKLF. Nature 375: 318\u2013322","journal-title":"Nature"},{"key":"BFEMBJ7601379_CR53","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ydbio.2004.08.008","volume":"275","author":"WT Pu","year":"2004","unstructured":"Pu WT, Ishiwata T, Juraszek AL, Ma Q, Izumo S (2004) GATA4 is a dosage\u2010sensitive regulator of cardiac morphogenesis. Dev Biol 275: 235\u2013244","journal-title":"Dev Biol"},{"key":"BFEMBJ7601379_CR54","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1242\/dev.122.6.1799","volume":"122","author":"RS Ross","year":"1996","unstructured":"Ross RS, Navankasattusas S, Harvey RP, Chien KR (1996) An HF\u20101a\/HF1b\/MEF\u20102 combinatorial element confers cardiac ventricular specificity and established an anterior\u2013posterior gradient of expression. Development 122: 1799\u20131809","journal-title":"Development"},{"key":"BFEMBJ7601379_CR55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/geno.2000.6362","volume":"70","author":"S Scohy","year":"2000","unstructured":"Scohy S, Gabant P, Van Reeth T, Hertveldt V, Dreze PL, Van Vooren P, Riviere M, Szpirer J, Szpirer C (2000) Identification of KLF13 and KLF14 (SP6), novel members of the SP\/XKLF transcription factor family. Genomics 70: 93\u2013101","journal-title":"Genomics"},{"key":"BFEMBJ7601379_CR56","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/11926","volume":"22","author":"JA Segre","year":"1999","unstructured":"Segre JA, Bauer C, Fuchs E (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet 22: 356\u2013360","journal-title":"Nat Genet"},{"key":"BFEMBJ7601379_CR57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1097-2765(03)00500-8","volume":"13","author":"K Senger","year":"2004","unstructured":"Senger K, Armstrong GW, Rowell WJ, Kwan JM, Markstein M, Levine M (2004) Immunity regulatory DNAs share common organizational features in Drosophila. Mol Cell 13: 19\u201332","journal-title":"Mol Cell"},{"key":"BFEMBJ7601379_CR58","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1242\/dev.125.6.1095","volume":"125","author":"GN Serbedzija","year":"1998","unstructured":"Serbedzija GN, Chen JN, Fishman MC (1998) Regulation in the heart field of zebrafish. Development 125: 1095\u20131101","journal-title":"Development"},{"key":"BFEMBJ7601379_CR59","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/nm738","volume":"8","author":"T Shindo","year":"2002","unstructured":"Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai\u2010Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R (2002) Kruppel\u2010like zinc\u2010finger transcription factor KLF5\/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med 8: 856\u2013863","journal-title":"Nat Med"},{"key":"BFEMBJ7601379_CR60","doi-asserted-by":"crossref","first-page":"30055","DOI":"10.1074\/jbc.M204278200","volume":"277","author":"A Song","year":"2002","unstructured":"Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (2002) Functional domains and DNA\u2010binding sequences of RFLAT\u20101\/KLF13, a Kruppel\u2010like transcription factor of activated T lymphocytes. J Biol Chem 277: 30055\u201330065","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601379_CR61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0022-2836(03)00429-7","volume":"329","author":"CZ Song","year":"2003","unstructured":"Song CZ, Keller K, Chen Y, Stamatoyannopoulos G (2003) Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity. J Mol Biol 329: 207\u2013215","journal-title":"J Mol Biol"},{"key":"BFEMBJ7601379_CR62","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ygeno.2005.01.005","volume":"85","author":"G Suske","year":"2005","unstructured":"Suske G, Bruford E, Philipsen S (2005) Mammalian SP\/KLF transcription factors: bring in the family. Genomics 85: 551\u2013556","journal-title":"Genomics"},{"key":"BFEMBJ7601379_CR63","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.regpep.2004.12.026","volume":"128","author":"R Temsah","year":"2005","unstructured":"Temsah R, Nemer M (2005) GATA factors and transcriptional regulation of cardiac natriuretic peptide genes. Regul Pept 128: 177\u2013185","journal-title":"Regul Pept"},{"key":"BFEMBJ7601379_CR64","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0092-8674(00)80885-5","volume":"101","author":"SG Tevosian","year":"2000","unstructured":"Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH (2000) FOG\u20102, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell 101: 729\u2013739","journal-title":"Cell"},{"key":"BFEMBJ7601379_CR65","doi-asserted-by":"crossref","first-page":"10444","DOI":"10.1073\/pnas.89.21.10444","volume":"89","author":"M Walters","year":"1992","unstructured":"Walters M, Martin DI (1992) Functional erythroid promoters created by interaction of the transcription factor GATA\u20101 with CACCC and AP\u20101\/NFE\u20102 elements. Proc Natl Acad Sci USA 89: 10444\u201310448","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601379_CR66","doi-asserted-by":"crossref","first-page":"12573","DOI":"10.1073\/pnas.0400752101","volume":"101","author":"AJ Watt","year":"2004","unstructured":"Watt AJ, Battle MA, Li J, Duncan SA (2004) GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc Natl Acad Sci USA 101: 12573\u201312578","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601379_CR67","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1242\/dev.129.9.2233","volume":"129","author":"H Yang","year":"2002","unstructured":"Yang H, Lu MM, Zhang L, Whitsett JA, Morrisey EE (2002) GATA6 regulates differentiation of distal lung epithelium. Development 129: 2233\u20132246","journal-title":"Development"},{"key":"BFEMBJ7601379_CR68","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1172\/JCI23769","volume":"115","author":"EM Zeisberg","year":"2005","unstructured":"Zeisberg EM, Ma Q, Juraszek AL, Moses K, Schwartz RJ, Izumo S, Pu WT (2005) Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest 115: 1522\u20131531","journal-title":"J Clin Invest"},{"key":"BFEMBJ7601379_CR69","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S1097-2765(03)00179-5","volume":"11","author":"J Zhao","year":"2003","unstructured":"Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL (2003) Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell 11: 1503\u20131515","journal-title":"Mol Cell"},{"key":"BFEMBJ7601379_CR70","first-page":"4432","volume":"13","author":"H Zhu","year":"1993","unstructured":"Zhu H, Nguyen VT, Brown AB, Pourhosseini A, Garcia AV, van Bilsen M, Chien KR (1993) A novel, tissue\u2010restricted zinc finger protein (HF\u20101b) binds to the cardiac regulatory element (HF\u20101b\/MEF\u20102) in the rat myosin light\u2010chain 2 gene. Mol Cell Biol 13: 4432\u20134444","journal-title":"Mol Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.emboj.7601379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7601379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.emboj.7601379","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/sj.emboj.7601379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7601379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:36:28Z","timestamp":1779233788000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/sj.emboj.7601379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,19]]},"references-count":70,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2006,11,1]]}},"alternative-id":["BFEMBJ7601379"],"URL":"https:\/\/doi.org\/10.1038\/sj.emboj.7601379","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,19]]},"assertion":[{"value":"7 April 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}