{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:46:14Z","timestamp":1793418374505,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"22","license":[{"start":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T00:00:00Z","timestamp":1162425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T00:00:00Z","timestamp":1162425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2006,11,15]]},"DOI":"10.1038\/sj.emboj.7601417","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T11:02:30Z","timestamp":1162465350000},"page":"5305-5316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":381,"title":["TRPC3 and TRPC6 are essential for angiotensin II\u2010induced cardiac hypertrophy"],"prefix":"10.1038","volume":"25","author":[{"given":"Naoya","family":"Onohara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sumimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kurose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,11,2]]},"reference":[{"key":"BFEMBJ7601417_CR1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1124\/mol.63.3.478","volume":"63","author":"K Arai","year":"2003","unstructured":"Arai K, Maruyama Y, Nishida M, Tanabe S, Takagahara S, Kozasa T, Mori Y, Nagao T, Kurose H (2003) Endothelin\u20101\u2010induced MAPK activation and cardiomyocyte hypertrophy are mediated by G\u03b112 and G\u03b113 as well as G\u03b1q and G\u03b2\u03b3 subunits. Mol Pharmacol 63: 478\u2013488","journal-title":"Mol Pharmacol"},{"key":"BFEMBJ7601417_CR2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.bjp.0705702","volume":"141","author":"I BACzk\u00f3","year":"2004","unstructured":"BACzk\u00f3 I, Giles WR, Light PE (2004) Pharmacological activation of plasma\u2010membrane KATP channels reduces reoxygenation\u2010induced Ca2+ overload in cardiac myocytes via modulation of the diastolic membrane potential. Br J Pharmacol 141: 1059\u20131067","journal-title":"Br J Pharmacol"},{"key":"BFEMBJ7601417_CR3","doi-asserted-by":"crossref","unstructured":"Bush EW, Hood DB, Papst PJ, Chapo JA, Minobe W, Bristow MR, Olson EN, McKinsey TA (2006) TRPC channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling. J Biol Chem, (in press) (doi: 10.1074\/jbc.M605536200)","DOI":"10.1074\/jbc.M605536200"},{"key":"BFEMBJ7601417_CR4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","volume":"426","author":"DE Clapham","year":"2003","unstructured":"Clapham DE (2003) TRP channels as cellular sensors. Nature 426: 517\u2013524","journal-title":"Nature"},{"key":"BFEMBJ7601417_CR5","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0092-8674(02)00699-2","volume":"109","author":"GR Crabtree","year":"2002","unstructured":"Crabtree GR, Olson EN (2002) NFAT signaling: choreographing the social lives of cells. Cell 109: S67\u2013S79","journal-title":"Cell"},{"key":"BFEMBJ7601417_CR6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0896-6273(02)00641-4","volume":"34","author":"P Delmas","year":"2002","unstructured":"Delmas P, Wanaverbecq N, Abogadie FC, Mistry M, Brown DA (2002) Signaling microdomains define the specificity of receptor\u2010mediated InsP3 pathways in neurons. Neuron 34: 209\u2013220","journal-title":"Neuron"},{"key":"BFEMBJ7601417_CR7","doi-asserted-by":"crossref","unstructured":"Dolmetsch R (2003) Excitation\u2010transcription coupling: signaling by ion channels to the nucleus. Science's stke, www.stke.org\/cgi\/content\/full\/sigtrans;2003\/166\/pe4","DOI":"10.1126\/stke.2003.166.pe4"},{"key":"BFEMBJ7601417_CR8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/386855a0","volume":"386","author":"RE Dolmetsch","year":"1997","unstructured":"Dolmetsch RE, Lewis RS, Goodnow CC, Healy JI (1997) Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 386: 855\u2013858","journal-title":"Nature"},{"key":"BFEMBJ7601417_CR9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1126\/science.1063395","volume":"294","author":"RE Dolmetsch","year":"2001","unstructured":"Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME (2001) Signaling to the nucleus by an L\u2010type calcium channel\u2010calmodulin complex through the MAP kinase pathway. Science 294: 333\u2013339","journal-title":"Science"},{"key":"BFEMBJ7601417_CR10","doi-asserted-by":"crossref","first-page":"C838","DOI":"10.1152\/ajpcell.1992.263.4.C838","volume":"263","author":"DE Dostal","year":"1992","unstructured":"Dostal DE, Rothblum KN, Chernin MI, Cooper GR, Baker KM (1992) Intracardiac detection of angiotensinogen and renin: a localized rennin\u2013angiotensin system in neonatal rat heart. Am J Physiol 263: C838\u2013C850","journal-title":"Am J Physiol"},{"key":"BFEMBJ7601417_CR11","doi-asserted-by":"crossref","first-page":"23041","DOI":"10.1074\/jbc.M409397200","volume":"280","author":"T Fujii","year":"2005","unstructured":"Fujii T, Onohara N, Maruyama Y, Tanabe S, Kobayashi H, Fukutomi M, Nagamatsu Y, Nishihara N, Inoue R, Sumimoto H, Shibasaki F, Nagao T, Nishida M, Kurose H (2005) G\u03b112\/13\u2010mediated production of reactive oxygen species is critical for angiotensin receptor\u2010induced NFAT activation in cardiac fibroblasts. J Biol Chem 280: 23041\u201323047","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601417_CR12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1046\/j.1540-8167.2004.03477.x","volume":"15","author":"R Guinamard","year":"2004","unstructured":"Guinamard R, Chatelier A, Lenfant J, Bois P (2004) Activation of the Ca2+\u2010activated nonselective cation channel by diacylglycerol analogues in rat cardiomyocytes. J Cardiovas Electrophysiol 15: 342\u2013348","journal-title":"J Cardiovas Electrophysiol"},{"key":"BFEMBJ7601417_CR13","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","volume":"95","author":"TC He","year":"1998","unstructured":"He TC, Zhou S, da Costa LT, Yu J, KInzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95: 2509\u20132514","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601417_CR14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/01.RES.0000152967.88472.3e","volume":"96","author":"Y He","year":"2005","unstructured":"He Y, Yao G, Savoia C, Touyz RM (2005) Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells. Role of angiotensin II. Circ Res 96: 207\u2013215","journal-title":"Circ Res"},{"key":"BFEMBJ7601417_CR15","doi-asserted-by":"crossref","first-page":"18887","DOI":"10.1074\/jbc.M311274200","volume":"279","author":"C Hisatsune","year":"2004","unstructured":"Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K (2004) Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem 279: 18887\u201318894","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601417_CR16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/16711","volume":"397","author":"T Hofmann","year":"1999","unstructured":"Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397: 259\u2013263","journal-title":"Nature"},{"key":"BFEMBJ7601417_CR17","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1073\/pnas.102596199","volume":"99","author":"T Hofmann","year":"2002","unstructured":"Hofmann T, Schaefer M, Schultz G, Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99: 7461\u20137466","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7601417_CR18","doi-asserted-by":"crossref","first-page":"14266","DOI":"10.1074\/jbc.M107167200","volume":"277","author":"DL Hunton","year":"2002","unstructured":"Hunton DL, Lucchesi PA, Pang Y, Cheng X, Dell'Italia LJ, Marchase RB (2002) Capacitative calcium entry contributes to nuclear factor of activated T cells nuclear translocation and hypertrophy in cardiomyocytes. J Biol Chem 277: 14266\u201314273","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601417_CR19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.RES.88.3.325","volume":"88","author":"R Inoue","year":"2001","unstructured":"Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular \u03b11\u2010adrenoceptor\u2010activated Ca2+\u2010permeable cation channel. Circ Res 88: 325\u2013332","journal-title":"Circ Res"},{"key":"BFEMBJ7601417_CR20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1046\/j.1540-8167.2002.00493.x","volume":"13","author":"WA Large","year":"2002","unstructured":"Large WA (2002) Receptor\u2010operated Ca2+\u2010permeable nonselective cation channels in vascular smooth muscle: a physiologic perspective. J Cardiovas Electrophysiol 13: 493\u2013501","journal-title":"J Cardiovas Electrophysiol"},{"key":"BFEMBJ7601417_CR21","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbrc.2004.12.112","volume":"327","author":"Y Liao","year":"2005","unstructured":"Liao Y, Asakura M, Takashima S, Kato H, Asano Y, Shintani Y, Minamino T, Tomoike H, Hori M, Kitakaze M (2005) Amlodipine ameliorates myocardial hypertrophy by inhibiting EGFR phosphorylation. Biochem Biophys Res Commun 327: 1083\u20131087","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ7601417_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0005-2736(98)00035-2","volume":"1372","author":"L Linares\u2010Hernandez","year":"1998","unstructured":"Linares\u2010Hernandez L, Guzman\u2010Grenfell AM, Hicks\u2010Gomez JJ, Gonzalez\u2010Martinez MT (1998) Voltage dependent calcium influx in human sperm assessed by spontaneous detection of intracellular calcium and membrane potential. Biochem Biophys Acta 1372: 1\u201312","journal-title":"Biochem Biophys Acta"},{"key":"BFEMBJ7601417_CR23","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0022-3565(25)22427-2","volume":"270","author":"SP Lubic","year":"1994","unstructured":"Lubic SP, Giacomini KM, Giacomini JC (1994) Increased 1,4\u2010dihydropyridine binding sites in serum\u2010stimulated cardiomyocytes hypertrophy. J Pharmacol Exp Ther 270: 697\u2013701","journal-title":"J Pharmacol Exp Ther"},{"key":"BFEMBJ7601417_CR24","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0022-2828(95)90042-X","volume":"27","author":"SP Lubic","year":"1995","unstructured":"Lubic SP, Giacomini KM, Giacomini JC (1995) The effects of modulation of calcium influx through the voltage\u2010sensitive calcium channel on cardiomyocyte hypertrophy. J Mol Cell Cardiol 27: 917\u2013925","journal-title":"J Mol Cell Cardiol"},{"key":"BFEMBJ7601417_CR26","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/01.RES.0000226495.34949.28","volume":"98","author":"Y Maruyama","year":"2006","unstructured":"Maruyama Y, Nakanishi Y, Walsh EJ, Wilson DP, Welsh DG, Cole WC (2006) Heteromultimeric TRPC6\u2010TRPC7 channels contribute to arginine vasopressin\u2010induced cation current of A7r5 vascular smooth muscle cells. Circ Res 98: 1520\u20131527","journal-title":"Circ Res"},{"key":"BFEMBJ7601417_CR25","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/01.RES.0000043282.39776.7C","volume":"91","author":"Y Maruyama","year":"2002","unstructured":"Maruyama Y, Nishida M, Sugimoto Y, Tanabe S, Turner JH, Kozasa T, Wada T, Nagao T, Kurose H (2002) G\u03b112\/13 mediate \u03b11\u2010adrenergic receptor\u2010induced cardiac hypertrophy. Circ Res 91: 961\u2013969","journal-title":"Circ Res"},{"key":"BFEMBJ7601417_CR28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.physiol.63.1.391","volume":"63","author":"JD Molkentin","year":"2001","unstructured":"Molkentin JD, Dorn II GW (2001) Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol 63: 391\u2013426","journal-title":"Annu Rev Physiol"},{"key":"BFEMBJ7601417_CR27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0092-8674(00)81573-1","volume":"93","author":"JD Molkentin","year":"1998","unstructured":"Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN (1998) A calcineurin\u2010dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215\u2013228","journal-title":"Cell"},{"key":"BFEMBJ7601417_CR29","first-page":"1137","volume":"120","author":"MC Moschella","year":"1993","unstructured":"Moschella MC, Marks AR (1993) Inositol 1,4,5\u2010trisphosphate receptor expression in cardiac myocytes. J Clin Invest 120: 1137\u20131146","journal-title":"J Clin Invest"},{"key":"BFEMBJ7601417_CR30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/35044120","volume":"408","author":"M Nishida","year":"2000","unstructured":"Nishida M, Maruyama Y, Tanaka R, Kontani K, Nagao T, Kurose H (2000) G\u03b1i and G\u03b1o are target proteins of reactive oxygen species. Nature 408: 492\u2013495","journal-title":"Nature"},{"key":"BFEMBJ7601417_CR31","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1093\/emboj\/cdg457","volume":"22","author":"M Nishida","year":"2003","unstructured":"Nishida M, Sugimoto K, Hara Y, Mori E, Morii T, Kurosaki T, Mori Y (2003) Amplification of receptor signalling by Ca2+ entry\u2010mediated translocation and activation of PLC\u03b32 in B lymphocytes. EMBO J 22: 4677\u20134688","journal-title":"EMBO J"},{"key":"BFEMBJ7601417_CR32","doi-asserted-by":"crossref","first-page":"18434","DOI":"10.1074\/jbc.M409710200","volume":"280","author":"M Nishida","year":"2005","unstructured":"Nishida M, Tanabe S, Maruyama Y, Mangmool S, Urayama K, Nagamatsu Y, Takagahara S, Turner JH, Kozasa T, Kobayashi H, Sato Y, Kawanishi T, Inoue R, Nagao T, Kurose H (2005) G\u03b112\/13\u2010 and reactive oxygen species\u2010dependent activation of c\u2010Jun NH2\u2010terminal kinase and p38 MAPK by angiotensin receptor stimulation in rat neonatal cardiomyocytes. J Biol Chem 280: 18434\u201318441","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601417_CR33","first-page":"H2055","volume":"288","author":"SA Reading","year":"2005","unstructured":"Reading SA, Early S, Waldron BJ, Welsh DG, Brayden JE (2005) TRPC3 mediates pyrimidine receptor\u2010induced depolarization of cerebral arteries. Am J Physiol 288: H2055\u2013H2061","journal-title":"Am J Physiol"},{"key":"BFEMBJ7601417_CR34","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0092-8674(93)90541-W","volume":"75","author":"J Sadoshima","year":"1993","unstructured":"Sadoshima J, Xu Y, Slayter HS, Izumo S (1993) Autocrine release of angiotensin II mediates stretch\u2010induced hypertrophy of cardiac myocytes in vitro. Cell 75: 977\u2013984","journal-title":"Cell"},{"key":"BFEMBJ7601417_CR35","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1073\/pnas.0407537101","volume":"101","author":"M Seth","year":"2004","unstructured":"Seth M, Sumbilla C, Mullen SP, Lewis D, Klein G, Hussain A, Soboloff J, Gill DL, Inesi G (2004) Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes. Proc Natl Acd Sci USA 101: 16683\u201316688","journal-title":"Proc Natl Acd Sci USA"},{"key":"BFEMBJ7601417_CR36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1113\/jphysiol.2004.075051","volume":"561","author":"J Shi","year":"2004","unstructured":"Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, Inoue R (2004) Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol 561: 415\u2013432","journal-title":"J Physiol"},{"key":"BFEMBJ7601417_CR37","doi-asserted-by":"crossref","first-page":"39786","DOI":"10.1074\/jbc.M506064200","volume":"280","author":"J Soboloff","year":"2005","unstructured":"Soboloff J, Spassova M, Xu W, He LP, Cuesta N, Gill DL (2005) Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. J Biol Chem 280: 39786\u201339794","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601417_CR38","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1073\/pnas.97.3.1196","volume":"97","author":"T Taigen","year":"2000","unstructured":"Taigen T, De Windt LJ, Lim HW, Molkentin JD (2000) Targeted inhibition of calcineurin prevents agonist\u2010induced cardiomyocyte hypertrophy. Proc Natl Acd Sci USA 97: 1196\u20131201","journal-title":"Proc Natl Acd Sci USA"},{"key":"BFEMBJ7601417_CR39","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/383837a0","volume":"383","author":"LA Timmerman","year":"1996","unstructured":"Timmerman LA, Clipstone NA, Ho SN, Northrop JP, Crabtree GR (1996) Rapid shuttling of NF\u2010AT in discrimination of Ca2+ signals and immunosuppression. Nature 383: 837\u2013840","journal-title":"Nature"},{"key":"BFEMBJ7601417_CR40","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1093\/emboj\/cdg381","volume":"22","author":"T Tomida","year":"2003","unstructured":"Tomida T, Hirose K, Takizawa A, Shibasaki F, Iino M (2003) NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J 22: 3825\u20133832","journal-title":"EMBO J"},{"key":"BFEMBJ7601417_CR41","first-page":"R73","volume":"290","author":"RM Touyz","year":"2006","unstructured":"Touyz RM, He Y, Montezano ACI, Yao G, Chubanov V, Gudermann T, Callera GE (2006) Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneous hypertensive rats. Am J Physiol 290: R73\u2013R78","journal-title":"Am J Physiol"},{"key":"BFEMBJ7601417_CR42","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1074\/jbc.M108337200","volume":"277","author":"T Uchiyama","year":"2002","unstructured":"Uchiyama T, Yoshikawa F, Hishida A, Furuichi T, Mikoshiba K (2002) A novel recombinant hyperaffinity inositol 1,4,5\u2010trisphosphate (IP3) absorbent traps IP3, resulting in specific inhibition of IP3\u2010mediated calcium signaling. J Biol Chem 277: 8106\u20138113","journal-title":"J Biol Chem"},{"key":"BFEMBJ7601417_CR43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1161\/hh0302.105662","volume":"90","author":"DG Welsh","year":"2002","unstructured":"Welsh DG, Morielli AD, Nelson MT, Brayden JE (2002) Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res 90: 248\u2013250","journal-title":"Circ Res"},{"key":"BFEMBJ7601417_CR44","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1006\/jmcc.1999.0990","volume":"31","author":"Jr RM Whitehurst","year":"1999","unstructured":"Whitehurst Jr RM, Zhang M, Bhattacharjee A, Li M (1999) Dexamethasone\u2010induced hypertrophy in rat neonatal cardiac myocytes involves an elevated L\u2010type Ca2+ current. J Mol Cell Cardiol 31: 1551\u20131558","journal-title":"J Mol Cell Cardiol"},{"key":"BFEMBJ7601417_CR45","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1128\/MCB.22.21.7603-7613.2002","volume":"22","author":"BJ Wilkins","year":"2002","unstructured":"Wilkins BJ, De Windt LJ, Bueno OF, Braz JC, Glascock BJ, Kimball TF, Molkentin JD (2002) Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin\u2010mediated cardiac hypertrophic growth. Mol Cell Biol 22: 7603\u20137613","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7601417_CR46","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbrc.2004.07.121","volume":"322","author":"BJ Wilkins","year":"2004","unstructured":"Wilkins BJ, Molkentin JD (2004) Calcium\u2010calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 322: 1178\u20131191","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMBJ7601417_CR47","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1106215","volume":"308","author":"MP Winn","year":"2005","unstructured":"Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak\u2010Vance MA, Howell DN, Vance JM, Rosenberg PB (2005) A mutation of TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308: 1801\u20131804","journal-title":"Science"},{"key":"BFEMBJ7601417_CR48","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.pharmthera.2005.04.002","volume":"107","author":"EA Woodcock","year":"2005","unstructured":"Woodcock EA, Matkovich SJ (2005) Ins(1,4,5)P3 receptors and inositol phosphates in the heart\u2010evolutionary artifacts or active signal transducers? Pharmacol Therap 107: 240\u2013251","journal-title":"Pharmacol Therap"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.emboj.7601417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7601417.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.emboj.7601417","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1038\/sj.emboj.7601417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.emboj.7601417.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:37:22Z","timestamp":1779233842000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/sj.emboj.7601417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,2]]},"references-count":48,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2006,11,15]]}},"alternative-id":["BFEMBJ7601417"],"URL":"https:\/\/doi.org\/10.1038\/sj.emboj.7601417","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,2]]},"assertion":[{"value":"10 February 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}