{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:13:17Z","timestamp":1792131197768,"version":"4.4.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2003,6,2]],"date-time":"2003-06-02T00:00:00Z","timestamp":1054512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,6,2]],"date-time":"2003-06-02T00:00:00Z","timestamp":1054512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Rep"],"published-print":{"date-parts":[[2003,7,1]]},"DOI":"10.1038\/sj.embor.embor866","type":"journal-article","created":{"date-parts":[[2003,6,2]],"date-time":"2003-06-02T11:06:45Z","timestamp":1054552005000},"page":"723-728","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":431,"title":["Dendritic\u2010cell\u2010specific ICAM3\u2010grabbing non\u2010integrin is essential for the productive infection of human dendritic cells by mosquito\u2010cell\u2010derived dengue viruses"],"prefix":"10.1038","volume":"4","author":[{"given":"Erika","family":"Navarro\u2010Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Altmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Amara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Fieschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Virelizier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Arenzana\u2010Seisdedos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Despr\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,6,2]]},"reference":[{"key":"BFEMBR866_CR1","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1128\/JVI.76.13.6841-6844.2002","volume":"76","author":"C.P. Alvarez","year":"2002","unstructured":"Alvarez, C.P., Lasala, F., Carillo, J., Muniz, O., Corbi, A.L. & Delgado, R. (2002) C\u2010type lectins DC\u2010SIGN and L\u2010SIGN mediate cellular entry by Ebola virus in cis and in trans. J.Virol., 76, 6841\u20136844.","journal-title":"J.Virol."},{"key":"BFEMBR866_CR2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0168-1702(00)00233-1","volume":"73","author":"H. Bielefeldt\u2010Ohmann","year":"2001","unstructured":"Bielefeldt\u2010Ohmann, H., Meyer, M., Fitzpatrick, D.R. & Mackenzie, J.S. (2001) Dengue virus binding to human leukocyte cell lines: receptor usage differs between cell types and virus strains. Virus Res., 73, 81\u201389.","journal-title":"Virus Res."},{"key":"BFEMBR866_CR3","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nm0897-866","volume":"3","author":"Y. Chen","year":"1997","unstructured":"Chen, Y., Maguire, T., Hileman, R.E., Fromm, J.R., Esko, J.D., Linhardt, R.J. & Marks, R.M. (1997) Dengue virus infectivity depends on envelope protein binding to target cell heparane sulfate. Nature Med., 3, 866\u2013871.","journal-title":"Nature Med."},{"key":"BFEMBR866_CR4","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/JVI.74.1.564-572.2000","volume":"74","author":"M.\u2010P. Courageot","year":"2000","unstructured":"Courageot, M.\u2010P., Frenkiel, M.\u2010P., Duarte Dos Santos, C., Deubel, V. & Despr\u00e8s, P. (2000) \u03b1\u2010Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum. J. Virol., 74, 564\u2013572.","journal-title":"J. Virol."},{"key":"BFEMBR866_CR5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1099\/0022-1317-72-6-1331","volume":"72","author":"P. Despr\u00e8s","year":"1991","unstructured":"Despr\u00e8s, P., Girard, M. & Bouloy, M. (1991) Characterization of yellow fever virus E and NS1 proteins expressed in Vero and Spodoptera frugiperda cells. J. Gen. Virol., 72, 1331\u20131342.","journal-title":"J. Gen. Virol."},{"key":"BFEMBR866_CR6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/viro.1993.1469","volume":"196","author":"P. Despr\u00e8s","year":"1993","unstructured":"Despr\u00e8s, P., Frenkiel, M.\u2010P. & Deubel, V. (1993). Difference between cell membrane fusion activities of two dengue type\u20101 isolates reflect modifications of viral structure. Virology, 196, 209\u2013219.","journal-title":"Virology"},{"key":"BFEMBR866_CR7","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1128\/JVI.72.1.823-829.1998","volume":"72","author":"P. Despr\u00e8s","year":"1998","unstructured":"Despr\u00e8s, P., Frenkiel, M.\u2010P., Ceccaldi, P.\u2010E., Duarte dos Santos, C.N. & Deubel, V. (1998) Apoptosis in the mouse central nervous system in response to infection with mouse\u2010neurovirulent dengue virus. J. Virol., 72, 823\u2013829.","journal-title":"J. Virol."},{"key":"BFEMBR866_CR8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/viro.2000.0457","volume":"274","author":"C.N. Duarte dos Santos","year":"2000","unstructured":"Duarte dos Santos, C.N., Frenkiel, M.\u2010P., Courageot, M.\u2010P., Rocha, C.F.S., Vazeille\u2010Falcoz, M.C., Wien, M.W., Rey, F.A., Deubel, V. & Despr\u00e8s, P. (2000) Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type\u20101 virus. Virology, 274, 292\u2013308.","journal-title":"Virology"},{"key":"BFEMBR866_CR9","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1126\/science.1066371","volume":"294","author":"H. Feinberg","year":"2001","unstructured":"Feinberg, H., Mitchell, D.A., Drickamer, K. & Wesi, W.I. (2001) Structural analysis for selective recognition of oligosaccharides by DC\u2010SIGN and DC\u2010SIGNR. Science, 294, 2163\u20132166.","journal-title":"Science"},{"key":"BFEMBR866_CR10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nri723","volume":"2","author":"C.G. Figdor","year":"2002","unstructured":"Figdor, C.G., van Kooyk, Y. & Adema, G.J. (2002) C\u2010type lectin receptors on dendritic cells and Langerhans cells. Nature Rev. Immunol., 2, 77\u201384.","journal-title":"Nature Rev. Immunol."},{"key":"BFEMBR866_CR11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/79815","volume":"1","author":"T.B.H. Geijtenbeek","year":"2000","unstructured":"Geijtenbeek, T.B.H., Krooshoop, D.J.E.B., Bleijs, D.A., van Vliet, S.J, van Duijnoven, G.C.F., Grabovski, V., Alon, R., Figdor, C.J. & van Kooyk, Y. (2000a) DC\u2010SIGN\u2010ICAM\u20102 interaction mediates dendritic cell trafficking. Nature Immunol., 1, 353\u2013357.","journal-title":"Nature Immunol."},{"key":"BFEMBR866_CR12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80694-7","volume":"100","author":"T.B.H. Geijtenbeek","year":"2000","unstructured":"Geijtenbeek, T.B.H. et al. (2000b) DC\u2010SIGN, a dendritic cell\u2010specific HIV\u20101\u2010binding protein that enhances trans\u2010infection of T cells. Cell, 100, 587\u2013597.","journal-title":"Cell"},{"key":"BFEMBR866_CR13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/viro.2001.1232","volume":"292","author":"R. Germi","year":"2002","unstructured":"Germi, R., Crance, J.\u2010M., Garin, D., Guimet, J., Lortat\u2010Jacob, H., Ruigrok, R.W.H., Zarski, J.P. & Drouet, E. (2002) Heparan sulfate\u2010mediated binding of infectious dengue virus type\u20102 and yellow fever virus. Virology, 292, 162\u2013168.","journal-title":"Virology"},{"key":"BFEMBR866_CR14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1473-3099(01)00171-2","volume":"2","author":"M.G. Guzman","year":"2002","unstructured":"Guzman, M.G. & Kouri, G. (2002) Dengue: an update. Lancet Infect. Dis., 2, 33\u201342.","journal-title":"Lancet Infect. Dis."},{"key":"BFEMBR866_CR15","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1074-7613(02)00447-8","volume":"17","author":"F. Halary","year":"2002","unstructured":"Halary, F., Amara, A., Lortat\u2010Jacob, H., Messerle, M., Delaunay, T., Houles, C., Fieschi, F., Arenzana\u2010Seisdedos, F., Moreau, J.F. & Dechanet\u2010Merville, J. (2002) Human cytomegalovirus binding to DC\u2010SIGN is required for dendritic infection and target cell trans\u2010infection. Immunity, 17, 653\u2013664.","journal-title":"Immunity"},{"key":"BFEMBR866_CR16","doi-asserted-by":"crossref","first-page":"S830","DOI":"10.1093\/clinids\/11.Supplement_4.S830","volume":"11","author":"S.B. Halstead","year":"1989","unstructured":"Halstead, S.B. (1989) Antibody, macrophages, dengue virus infection, shock, and hemorrhage: a pathogenic cascade. Rev. Infect. Dis., 11, S830\u2013S839.","journal-title":"Rev. Infect. Dis."},{"key":"BFEMBR866_CR17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0065-3527(00)55005-2","volume":"55","author":"F.X. Heinz","year":"2000","unstructured":"Heinz, F.X. & Allison, S.L. (2000) Structures and mechanisms in flavivirus fusion. Adv.Virus Res., 55, 231\u2013269.","journal-title":"Adv.Virus Res."},{"key":"BFEMBR866_CR18","first-page":"1499","volume":"166","author":"L.\u2010J. Ho","year":"2001","unstructured":"Ho, L.\u2010J., Wang, J.\u2010J., Shiao, M.\u2010F., Kao, C.\u2010L., Chang, D.\u2010M., Han, S.\u2010W. & Lai, J.H. (2001) Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production. Immunology, 166, 1499\u20131506.","journal-title":"Immunology"},{"key":"BFEMBR866_CR19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/viro.1999.9633","volume":"257","author":"S.\u2010L. Hung","year":"1999","unstructured":"Hung, S.\u2010L., Lee, P.\u2010L., Chen, H.\u2010W., Chen, L.\u2010K., Kao, C.\u2010L. & King, C.\u2010C. (1999) Analysis of the steps in dengue virus entry into host cells. Virology, 257, 156\u2013167.","journal-title":"Virology"},{"key":"BFEMBR866_CR20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/viro.1994.1481","volume":"203","author":"A.J. Johnson","year":"1994","unstructured":"Johnson, A.J., Guirakhoo, F. & Roehrig, J.T. (1994) The envelope glycoproteins of dengue 1 and dengue 2 grown in mosquito cells differ in their utilization of potential glycosylation sites. Virology, 203, 241\u2013249.","journal-title":"Virology"},{"key":"BFEMBR866_CR21","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ni0802-699","volume":"3","author":"B.L. Kelsall","year":"2002","unstructured":"Kelsall, B.L., Biron, C.A., Sharma, O. & Kaye, P.M. (2002) Dendritic cells at the host\u2013pathogen interface. Nature Immunol., 3, 699\u2013702.","journal-title":"Nature Immunol."},{"key":"BFEMBR866_CR22","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(02)00660-8","volume":"108","author":"R.J. Kuhn","year":"2002","unstructured":"Kuhn, R.J. et al. (2002) Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell, 108, 717\u2013725.","journal-title":"Cell"},{"key":"BFEMBR866_CR23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1074-7613(02)00259-5","volume":"16","author":"D.S. Kwon","year":"2002","unstructured":"Kwon, D.S., Gregorio, G., Bitton, N., Hendrickson, W.A. & Littman, D.R. (2002) DC\u2010SIGN\u2010mediated internalization of HIV is required for trans\u2010enhancement of T cell infection. Immunity, 16, 135\u2013144.","journal-title":"Immunity"},{"key":"BFEMBR866_CR24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF02255946","volume":"8","author":"H.Y. Lei","year":"2001","unstructured":"Lei, H.Y., Yeh, T.M., Liu, H.S., Lin, Y.S., Chen, S.H. & Liu, C.C. (2001) Immunopathogenesis of dengue virus infection. J. Biomed. Sci., 8, 377\u2013388.","journal-title":"J. Biomed. Sci."},{"key":"BFEMBR866_CR25","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1128\/JVI.77.2.1337-1346.2003","volume":"77","author":"G. Lin","year":"2003","unstructured":"Lin, G. et al. (2003) Differential N\u2010linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC\u2010SIGN and DC\u2010SIGNR. J. Virol., 77, 1337\u20131346.","journal-title":"J. Virol."},{"key":"BFEMBR866_CR26","doi-asserted-by":"crossref","first-page":"20358","DOI":"10.1074\/jbc.M301284200","volume":"278","author":"P.Y. Lozach","year":"2003","unstructured":"Lozach, P.Y. et al. (2003) DC\u2010SIGN and L\u2010SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2. J. Biol. Chem., 278, 20358\u201320366.","journal-title":"J. Biol. Chem."},{"key":"BFEMBR866_CR27","first-page":"219","volume":"6","author":"M. Marovich","year":"2001","unstructured":"Marovich, M. et al. (2001) Human dendritic cells as targets of dengue virus infection. JID Symp. Proc., 6, 219\u2013224.","journal-title":"JID Symp. Proc."},{"key":"BFEMBR866_CR28","doi-asserted-by":"crossref","first-page":"11311","DOI":"10.1073\/pnas.172195399","volume":"99","author":"T. Mashimo","year":"2002","unstructured":"Mashimo, T., Lucas, M., Simon\u2010Chazottes, D., Frenkiel, M.\u2010P., Montagutelli, X., Ceccaldi, P.\u2010E., Deubel, V., Guenet, J.L. & Despr\u00e8s, P. (2002) A nonsense mutation in the gene encoding 2\u2018\u20105\u2019\u2010oligoadenylate synthetase\/L\u20101 isoform is associated with West Nile virus susceptibility in laboratory mice. Proc. Natl Acad. Sci. USA, 99, 11311\u201311316.","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFEMBR866_CR29","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4269\/ajtmh.1991.45.644","volume":"45","author":"D.M. Morens","year":"1991","unstructured":"Morens, D.M., Marchette, N.J., Chu, M.C. & Halstead, S.B. (1991) Growth of dengue type 2 virus isolates in human peripheral leukocytes correlates with severe and mild dengue diesease. Am. J. Trop. Med. Hyg., 45, 644\u2013651.","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"BFEMBR866_CR30","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/77470","volume":"6","author":"A.K. Palucka","year":"2000","unstructured":"Palucka, A.K. (2000) Dengue virus and dendritic cells. Nature Med., 6, 748\u2013749.","journal-title":"Nature Med."},{"key":"BFEMBR866_CR31","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1128\/JVI.77.7.4070-4080.2003","volume":"77","author":"S. P\u00f6hlmann","year":"2003","unstructured":"P\u00f6hlmann, S., Zhang, J., Baribaud, F., Chen, Z., Leslie, G.J., Lin, G., Granelli\u2010Piperno, A., Doms, R.W., Rice, C.M. & McKeating, J.A. (2003) Hepatitis C virus glycoproteins interact with DC\u2010SIGN and DC\u2010SIGNR. J. Virol., 77, 4070\u20134080.","journal-title":"J. Virol."},{"key":"BFEMBR866_CR32","first-page":"931","volume-title":"Fields Virology","author":"C.M. Rice","year":"1996","unstructured":"Rice, C.M. (1996) in Fields Virology 3rd edn. (eds Fields, B.N., Knipe, D.M. & Howley, P.M.), 931\u2013959. Lippincott\u2013Raven, Philadelphia, Pennsylvania, USA.","edition":"3rd"},{"key":"BFEMBR866_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/viro.1999.9656","volume":"257","author":"A. Rothman","year":"1999","unstructured":"Rothman, A. & Ennis, F. (1999) Immunopathogenesis of dengue hemorrhagic fever. Virology, 257, 1\u20136.","journal-title":"Virology"},{"key":"BFEMBR866_CR34","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.4049\/jimmunol.165.6.2937","volume":"165","author":"E.J. Soilleux","year":"2000","unstructured":"Soilleux, E.J., Barten, R. & Trowsdale, J. (2000) DC\u2010SIGN; a related gene, DC\u2010SIGNR; and CD23 form a cluster on 19p13. J. Immunol., 165, 2937\u20132942.","journal-title":"J. Immunol."},{"key":"BFEMBR866_CR35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0092-8674(00)80684-4","volume":"100","author":"R.M. Steiman","year":"2000","unstructured":"Steiman, R.M. (2000) DC\u2010SIGN: a guide to some mysteries of dendritic cells. Cell, 100, 491\u2013494.","journal-title":"Cell"},{"key":"BFEMBR866_CR36","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/77553","volume":"6","author":"S.J. Wu","year":"2000","unstructured":"Wu, S.J. et al. (2000) Human skin Langerhans are targets of dengue virus infection. Nature Med., 6, 816\u2013820.","journal-title":"Nature Med."}],"container-title":["The EMBO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.embor.embor866","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.embor.embor866.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1038\/sj.embor.embor866","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1038\/sj.embor.embor866\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.1038\/sj.embor.embor866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1038\/sj.embor.embor866.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:26:16Z","timestamp":1779135976000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1038\/sj.embor.embor866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,2]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,7,1]]}},"alternative-id":["BFEMBR866"],"URL":"https:\/\/doi.org\/10.1038\/sj.embor.embor866","relation":{},"ISSN":["1469-221X","1469-3178"],"issn-type":[{"value":"1469-221X","type":"print"},{"value":"1469-3178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,2]]},"assertion":[{"value":"6 February 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2003","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}