{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:23:25Z","timestamp":1792650205593,"version":"4.5.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1038\/sj.eye.6700616","type":"journal-article","created":{"date-parts":[[2003,11,21]],"date-time":"2003-11-21T09:56:35Z","timestamp":1069408595000},"page":"989-995","source":"Crossref","is-referenced-by-count":360,"title":["Neurotrophic keratitis"],"prefix":"10.1038","volume":"17","author":[{"given":"S","family":"Bonini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Olzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lambiase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,11,20]]},"reference":[{"key":"BF6700616_CR1","first-page":"1340","volume-title":"Cornea: Clinical Diagnosis and Management","author":"EB Groos Jr","year":"1997","unstructured":"Groos Jr EB . Neurotrophic keratitis. In: Krachmer JH, Mannis MJ, Holland EJ (eds.) Cornea: Clinical Diagnosis and Management. Mosby: St Louis, 1997, pp 1340."},{"key":"BF6700616_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000117086","volume":"35","author":"A Puca","year":"1995","unstructured":"Puca A, Meglio M, Vari R, Tamburrini G, Tancredi A . Evaluation of fifth nerve dysfunction in 136 patients with middle and posterior cranial fossae. Eur Neurol 1995; 35: 33\u201337.","journal-title":"Eur Neurol"},{"key":"BF6700616_CR3","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1001\/archopht.1977.04450120099012","volume":"95","author":"RA Hyndiuk","year":"1977","unstructured":"Hyndiuk RA, Kazarian EL, Schultz RO, Seideman S . Neurotrophic corneal ulcers in diabetes mellitus. Arch Ophthalmol 1977; 95: 2193\u20132196.","journal-title":"Arch Ophthalmol"},{"key":"BF6700616_CR4","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1001\/archopht.1977.04450120099012","volume":"95","author":"MA Kara-corlu","year":"1977","unstructured":"Kara-corlu MA, Cakiner T, Saylan T . Neurotrophic corneal ulcers in diabetes mellitus. Arch Ophthalmol 1977; 95: 2193\u20132196.","journal-title":"Arch Ophthalmol"},{"key":"BF6700616_CR5","first-page":"452","volume-title":"Current Ocular Therapy","author":"IA Mackie","year":"1995","unstructured":"Mackie IA . Neuroparalytic keratitis. In: Fraunfelder F, Roy FH, Meyer SM (eds). Current Ocular Therapy. WB Saunders: Philadelphia, PA, 1995, pp 452\u2013454."},{"key":"BF6700616_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1001\/archopht.1954.00920050048005","volume":"52","author":"S Sigelman","year":"1954","unstructured":"Sigelman S, Friedenwald JS . Mitotic and wound healing activities of the corneal epithelium: effect of sensory denervation. Arch Ophthalmol 1954; 52: 46\u201357.","journal-title":"Arch Ophthalmol"},{"key":"BF6700616_CR7","first-page":"151","volume":"62","author":"S Simone","year":"1958","unstructured":"Simone S . De ricerche sul contenuto in acqua totale ed in azoto totale della cornea di coniglio in condizione di cheratite neuroparalitica sperimentale. Arch Ottalmol 1958; 62: 151.","journal-title":"Arch Ottalmol"},{"key":"BF6700616_CR8","first-page":"323","volume":"73","author":"MG Alper","year":"1975","unstructured":"Alper MG . The anhestetic eye: an investigation of changes in the anterior ocular segment of the monkey caused by interrupting the trigeminal nerve at various levels along its course. Trans Am Ophthalmol Soc 1975; 73: 323\u2013365.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"BF6700616_CR9","first-page":"343","volume":"93","author":"IA Mackie","year":"1978","unstructured":"Mackie IA . Role of the corneal nerves in destructive disease of the cornea. Trans Ophthalmol Soc UK 1978; 93: 343.","journal-title":"Trans Ophthalmol Soc UK"},{"key":"BF6700616_CR10","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/S0161-6420(90)32587-3","volume":"97","author":"JP Gilbard","year":"1990","unstructured":"Gilbard JP, Rossi SR . Tear film and ocular surface changes in a rabbit model of neurotrophic keratitis. Ophthalmology 1990; 97: 308\u2013312.","journal-title":"Ophthalmology"},{"key":"BF6700616_CR11","first-page":"65","volume":"1","author":"S Mishima","year":"1957","unstructured":"Mishima S . The effects of the denervation and the stimulation of the sympathetic and trigeminal nerve on the mitotic rate of the corneal epithelium in the rabbit. Jpn J Ophthalmol 1957; 1: 65\u201373.","journal-title":"Jpn J Ophthalmol"},{"key":"BF6700616_CR12","first-page":"690","volume":"243","author":"T Shimizu","year":"1987","unstructured":"Shimizu T, Izumi K, Fuijta S, Koja T, Sorimachi M, Ohba N et al. capsaicin-induced corneal lesions in mice and the effects of chemical sympathectomy. J Pharmacol Exp Ther 1987; 243: 690\u2013695.","journal-title":"J Pharmacol Exp Ther"},{"key":"BF6700616_CR13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1755-3768.1989.tb07103.x","volume":"192","author":"HD Cavanagh","year":"1989","unstructured":"Cavanagh HD, Colley AM . The molecular basis of neurotrophic keratitis. Acta Ophthalmol Suppl 1989; 192: 115\u2013134.","journal-title":"Acta Ophthalmol Suppl"},{"key":"BF6700616_CR14","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1089\/jop.1996.12.417","volume":"12","author":"AA Mikulec","year":"1996","unstructured":"Mikulec AA, Tanelian DL . CGRP increases the rate of corneal re-epithelization in an in vitro whole mount preparation. J Ocul Pharmacol Ter 1996; 12: 417\u2013423.","journal-title":"J Ocul Pharmacol Ter"},{"key":"BF6700616_CR15","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1002\/jcb.240520411","volume":"52","author":"TW Reid","year":"1993","unstructured":"Reid TW, Murphy CJ, Iwahashi CK, Foster BA, Mannis MJ . Stimulation of epithelial cell growth by the neuropeptide substance P. J Cell Biochem 1993; 52: 476\u2013485.","journal-title":"J Cell Biochem"},{"key":"BF6700616_CR16","first-page":"388","volume":"38","author":"RE Kingsley","year":"1997","unstructured":"Kingsley RE, Marffurt CF . Topical substance P and corneal epithelia wound closure in the rabbit. Invest Ophthalmol Vis Sci 1997; 38: 388\u2013395.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6700616_CR17","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/S0140-6736(98)24024-4","volume":"351","author":"T Chikama","year":"1998","unstructured":"Chikama T, Fukuda K, Morishige N, Nishida T . Treatment of neurotrophic keratopathy with substance-P-derived peptide (FGLM) and insulin growth factor 1. Lancet 1998; 351: 1783\u20131784.","journal-title":"Lancet"},{"key":"BF6700616_CR18","first-page":"412","volume":"31","author":"S Fujita","year":"1987","unstructured":"Fujita S, Miyazono Y, Ohba N . Capsaicin-induced corneal changes associated with sensory denervation in neonatal rat. Jpn J Ophthalmol 1987; 31: 412\u2013424.","journal-title":"Jpn J Ophthalmol"},{"key":"BF6700616_CR19","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/S0161-6420(00)00163-9","volume":"107","author":"S Bonini","year":"2000","unstructured":"Bonini S, Lambiase A, Rama P, Caprioglio G, Aloe L . Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology 2000; 107, 1347\u20131351, discussion 1351\u20131352.","journal-title":"Ophthalmology"},{"key":"BF6700616_CR20","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1056\/NEJM199804233381702","volume":"338","author":"A Lambiase","year":"1998","unstructured":"Lambiase A, Rama P, Bonini S, Caprioglio G, Aloe L . Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med 1998; 338: 1174\u20131180.","journal-title":"N Engl J Med"},{"key":"BF6700616_CR21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0006-8993(96)00905-5","volume":"741","author":"J Donnerer","year":"1996","unstructured":"Donnerer J, Amann R, Schuligoi R, Skofitsch G . Complete recovery by nerve growth factor of neuropeptide content and function in capsaicin-impaired sensory neurons. Brain Res 1996; 741: 103\u2013108.","journal-title":"Brain Res"},{"key":"BF6700616_CR22","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1126\/science.3306916","volume":"237","author":"R Levi-Montalcini","year":"1987","unstructured":"Levi-Montalcini R . The nerve growth factor 35 years later. Science 1987; 237: 1154\u20131162.","journal-title":"Science"},{"key":"BF6700616_CR23","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0006-8993(98)01094-4","volume":"815","author":"R Schicho","year":"1999","unstructured":"Schicho R, Skofitsch G, Donnerer J . Regenerative effect of human recombinant NGF on capsaicin-lesioned sensory neurons in the adult rat. Brain Res 1999; 815: 60\u201369.","journal-title":"Brain Res"},{"key":"BF6700616_CR24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1046\/j.1460-9568.1998.00037.x","volume":"10","author":"F de Castro","year":"1998","unstructured":"de Castro F, Silos-Santiago I, Lopez de Armentia M, Barbacid M, Belmonte C . Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice. Eur J Neurosci 1998; 10: 146\u2013152.","journal-title":"Eur J Neurosci"},{"key":"BF6700616_CR25","first-page":"1963","volume":"34","author":"FE Kruse","year":"1993","unstructured":"Kruse FE, Tseng SCG . Growth factors modulate clonal growth and differentiation of cultured rabbit limbal and corneal epithelium. Invest Ophthalmol Vis Sci 1993; 34: 1963\u20131976.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6700616_CR26","first-page":"275","volume-title":"Cornea: Foundamentals of Cornea and External Disease","author":"WJ Faulkner","year":"1997","unstructured":"Faulkner WJ, Varley GA . Corneal diagnostic tecnique. In: Krachmer JH, Mannis MJ, Holland EJ (eds). Cornea: Foundamentals of Cornea and External Disease. Mosby: St Louis, MO, 1997, pp 275\u2013281."},{"key":"BF6700616_CR27","volume-title":"External Eye Diseases. Methods of Examination","author":"MS Norn","year":"1974","unstructured":"Norn MS . Measurement of sensitivity .In: Norn MS (ed). External Eye Diseases. Methods of Examination. Munksgaard International Publisher Ltd: Copenhagen, 1974."},{"key":"BF6700616_CR28","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/00003226-199603000-00005","volume":"15","author":"TJ Heigle","year":"1996","unstructured":"Heigle TJ, Pflugfelder SC . Aqueous tear production in patients with neurotrophic keratitis. Cornea 1996; 15: 135\u2013138.","journal-title":"Cornea"},{"key":"BF6700616_CR29","first-page":"1","volume":"97","author":"P Wright","year":"1977","unstructured":"Wright P, Mackie IA . Mucus in the healthy and diseased eye. Trans Ophthalmol Soc UK 1977; 97: 1\u20137.","journal-title":"Trans Ophthalmol Soc UK"},{"key":"BF6700616_CR30","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/S0046-8177(97)90222-7","volume":"28","author":"MJ Elder","year":"1997","unstructured":"Elder MJ, Hiscott P, Dart JK . Intermediate filament expression by normal and diseased human corneal epithelium. Hum Pathol 1997; 28: 1348\u20131354.","journal-title":"Hum Pathol"},{"key":"BF6700616_CR31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/00055735-199908000-00009","volume":"10","author":"A Lambiase","year":"1999","unstructured":"Lambiase A, Rama P, Aloe L, Bonini S . Management of neurotrophic keratopathy. Curr Opin Ophthalmol 1999; 10: 270\u2013276.","journal-title":"Curr Opin Ophthalmol"},{"key":"BF6700616_CR32","first-page":"1406","volume":"46","author":"HL Gould","year":"1967","unstructured":"Gould HL . Treatment of neurotrophic keratitis with scleral contact lenses. Eye Ear Nose Throat Mon 1967; 46: 1406\u20131414.","journal-title":"Eye Ear Nose Throat Mon"},{"key":"BF6700616_CR33","first-page":"49","volume":"16","author":"HD Kent","year":"1990","unstructured":"Kent HD, Cohen EJ, Laibson PR, Arentsen JJ . Microbial keratitis and corneal ulceration associated with therapeutic soft contact lenses. CLAO J 1990; 16: 49\u201352.","journal-title":"CLAO J"},{"key":"BF6700616_CR34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1755-3768.1992.tb02172.x","volume":"202","author":"RR Pfister","year":"1992","unstructured":"Pfister RR . Clinical measures to promote corneal epithelial healing. Acta Ophthalmol Suppl 1992; 202: 73\u201383.","journal-title":"Acta Ophthalmol Suppl"},{"key":"BF6700616_CR35","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0002-9394(14)70125-4","volume":"123","author":"SH Lee","year":"1997","unstructured":"Lee SH, Tseng SC . Amniotic membrane transplantation for persistent epithelial defects with ulceration. Am J Ophthalmol 1997; 123: 303\u2013312.","journal-title":"Am J Ophthalmol"},{"key":"BF6700616_CR36","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0161-6420(88)33163-5","volume":"95","author":"CM Kirkness","year":"1988","unstructured":"Kirkness CM, Adams GGW, Dilly PN, Lee JP . Botulinum toxin A-induced protective ptosis in corneal disease. Ophthalmology 1988; 95: 473\u2013480.","journal-title":"Ophthalmology"},{"key":"BF6700616_CR37","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S0161-6420(91)32229-2","volume":"98","author":"JI Mc Neill","year":"1991","unstructured":"Mc Neill JI, Oh YH . An improved palpebral spring for the management of paralytic lagophthalmos. Ophthalmology 1991; 98: 715\u2013719.","journal-title":"Ophthalmology"},{"key":"BF6700616_CR38","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/00004397-197919020-00012","volume":"19","author":"HD Cavanagh","year":"1979","unstructured":"Cavanagh HD, Colley AM, Pihlaja DJ . Persistent corneal epithelial defects. Int Ophthalmol Clin 1979; 19: 197\u2013206.","journal-title":"Int Ophthalmol Clin"},{"key":"BF6700616_CR39","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1001\/archopht.1990.01070060125062","volume":"108","author":"PS Hersh","year":"1990","unstructured":"Hersh PS, Rice BA, Baer JC, Wells PA, Lynch SE, McGuigan LJB et al. Topical nonsteroidal agents and corneal wound healing. Arch Ophthalmol 1990; 108: 577\u2013583.","journal-title":"Arch Ophthalmol"},{"key":"BF6700616_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00004397-200101000-00003","volume":"41","author":"EA Davis","year":"2001","unstructured":"Davis EA, Dohlman CH . Neurotrophic keratitis. Int Ophthalmol Clin 2001; 41: 1\u201311.","journal-title":"Int Ophthalmol Clin"},{"key":"BF6700616_CR41","first-page":"78","volume":"67","author":"T Gundersen","year":"1969","unstructured":"Gundersen T, Pearlson HR . Conjunctival flaps for corneal diseases: their usefulness and complications. Trans Am Ophthalmol Soc 1969; 67: 78\u201395.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"BF6700616_CR42","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/S0002-9394(14)74337-5","volume":"103","author":"M Lugo","year":"1987","unstructured":"Lugo M, Arentsen JJ . Treatment of neurotrophic ulcers with conjunctival flaps. Am J Ophthalmol 1987; 103: 711\u2013712.","journal-title":"Am J Ophthalmol"},{"key":"BF6700616_CR43","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/0002-9394(80)90168-3","volume":"89","author":"JA Fogle","year":"1980","unstructured":"Fogle JA, Kenyon KR, Foster CS . Tissue adhesive arrests stromal melting in the human cornea. Am J Ophthalmol 1980; 89: 795\u2013802.","journal-title":"Am J Ophthalmol"},{"key":"BF6700616_CR44","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/S0161-6420(82)34742-9","volume":"89","author":"LW Hirst","year":"1982","unstructured":"Hirst LW, Smiddy WE, Stark WJ . Corneal perforations: changing methods of treatment, 1960\u20131980. Ophthalmology 1982; 89: 630\u2013634.","journal-title":"Ophthalmology"},{"key":"BF6700616_CR45","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1001\/archopht.1968.00980050707004","volume":"80","author":"RG Webster","year":"1968","unstructured":"Webster RG, Slansky HH, Refojo MF, Boruchoff SA, Dohlman CH . The use of adhesive for the closure of corneal perforation. Arch Ophthalmol 1968; 80: 705\u2013709.","journal-title":"Arch Ophthalmol"},{"key":"BF6700616_CR46","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0002-9394(89)90309-7","volume":"107","author":"JW Reed","year":"1989","unstructured":"Reed JW, Joyner SJ, Knauer III WJ . Penetrating keratoplasty for herpes zoster keratopathy. Am J Ophthalmol 1989; 107: 257\u2013261.","journal-title":"Am J Ophthalmol"},{"key":"BF6700616_CR47","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/00003226-198801000-00007","volume":"7","author":"LM Cobo","year":"1988","unstructured":"Cobo LM . Corneal complications of herpes zoster ophthalmicus. Prevention and treatment. Cornea 1988; 7: 50\u201356.","journal-title":"Cornea"},{"key":"BF6700616_CR48","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1177\/003693308703200313","volume":"32","author":"GG Adams","year":"1987","unstructured":"Adams GG, Cullen JF . Neuroparalytic keratitis and the effect of cervical sympathectomy following operative procedurs for trigeminal neuralgia. Scott Med J 1987; 32: 86\u201388.","journal-title":"Scott Med J"},{"key":"BF6700616_CR49","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/0741-5214(84)90199-X","volume":"1","author":"E Welch","year":"1984","unstructured":"Welch E, Geary J . Current status of thoracic dorsal sympathectomy. J Vasc Surg 1984; 1: 202\u2013214.","journal-title":"J Vasc Surg"},{"key":"BF6700616_CR50","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S0002-9394(14)71169-9","volume":"119","author":"H Hosotani","year":"1995","unstructured":"Hosotani H, Ohashi Y, Yamada M, Tsubota K . Reversal of abnormal corneal epithelial cell morphologic characteristics and reduced corneal sensitivity in diabetic patients by aldose reductase inhibitor, CT-112. Am J Ophthalmol 1995; 119: 288\u2013294.","journal-title":"Am J Ophthalmol"},{"key":"BF6700616_CR51","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1001\/archopht.1997.01100160096021","volume":"115","author":"SM Brown","year":"1997","unstructured":"Brown SM, Lamberts DW, Reid TW, Nishida T, Murphy CJ . Neurotrophic and anhydrotic keratopathy treated with substance P and insulin like growth factor 1. Arch Ophthalmol 1997; 115: 926\u2013927.","journal-title":"Arch Ophthalmol"},{"key":"BF6700616_CR52","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/BF00165937","volume":"230","author":"S Daniele","year":"1992","unstructured":"Daniele S, Gilbard JP, Schepens CL . Treatment of persistent epithelial defects in neurotrophic keratitis with epidermal growth factor: a preliminary open study. Graefes Arch Clin Exp Ophthalmol 1992; 230: 314\u2013317.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"BF6700616_CR53","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/0002-9394(84)90121-1","volume":"98","author":"AS Kandarakis","year":"1984","unstructured":"Kandarakis AS, Page C, Kaufman HE . The effect of epidermal growth factor on epithelial healing after penetrating keratoplasty in human eyes. Am J Ophthalmol 1984; 98: 411\u2013415.","journal-title":"Am J Ophthalmol"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6700616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6700616","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6700616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T13:24:37Z","timestamp":1704979477000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6700616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["BF6700616"],"URL":"https:\/\/doi.org\/10.1038\/sj.eye.6700616","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}