{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:03:55Z","timestamp":1790834635455,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T00:00:00Z","timestamp":1136505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1038\/sj.eye.6702204","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T10:14:28Z","timestamp":1136542468000},"page":"229-237","source":"Crossref","is-referenced-by-count":61,"title":["Diagnostic performance of tear function tests in Sjogren's syndrome patients"],"prefix":"10.1038","volume":"21","author":[{"given":"P","family":"Versura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Frigato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Mul\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Malavolta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,1,6]]},"reference":[{"key":"BF6702204_CR1","volume-title":"Textbook of Rheumatology","author":"DM O'Day","year":"2001","unstructured":"O'Day DM, Horn JD . The eye and rheumatic disease. In: Kelley WN (ed). Textbook of Rheumatology, 6th ed. Saunders: Philadelphia, 2001 Chapter 29."},{"key":"BF6702204_CR2","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1093\/rheumatology\/37.10.1069","volume":"37","author":"E Thomas","year":"1998","unstructured":"Thomas E, Hay EM, Hajeer A, Silman AJ . Sjogren's syndrome: a community-based study of prevalence and impact. Br J Rheum 1998; 37: 1069\u20131076.","journal-title":"Br J Rheum"},{"key":"BF6702204_CR3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10067-002-0696-8","volume":"22","author":"LS Martin-Martin","year":"2003","unstructured":"Martin-Martin LS, Latini A, Pagano A, Ragno A, Stasi R . A new mathematical model based on clinical and laboratory variables for the diagnosis of Sjogren's syndrome. Clin Rheumatol 2003; 22: 123\u2013126.","journal-title":"Clin Rheumatol"},{"key":"BF6702204_CR4","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1136\/ard.61.6.554","volume":"61","author":"C Vitali","year":"2002","unstructured":"Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM . Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554\u2013558.","journal-title":"Ann Rheum Dis"},{"key":"BF6702204_CR5","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0002-9394(14)71700-3","volume":"124","author":"SC Tseng","year":"1997","unstructured":"Tseng SC, Tsubota K . Important concepts for treating ocular surface and tear disorders. Am J Ophthalmol 1997; 124: 825\u2013835.","journal-title":"Am J Ophthalmol"},{"key":"BF6702204_CR6","first-page":"141","volume":"7","author":"JU Prause","year":"1989","unstructured":"Prause JU . Clinical ophthalmological tests for the diagnosis of keratoconjunctivitis sicca. Clin Exp Rheumatol 1989; 7: 141\u2013144.","journal-title":"Clin Exp Rheumatol"},{"key":"BF6702204_CR7","first-page":"221","volume":"21","author":"MA Lemp","year":"1995","unstructured":"Lemp MA . Report of the national eye institute\/industry workshop on clinical trials in dry eyes. CLAO J 1995; 21: 221\u2013232.","journal-title":"CLAO J"},{"key":"BF6702204_CR8","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1001\/archopht.118.5.615","volume":"118","author":"RM Schiffman","year":"2000","unstructured":"Schiffman RM, Christanson MD, Jacobsen G . Reliability and validity of the ocular surface disease index. Arch Ophthalmol 2000; 118: 615\u2013621.","journal-title":"Arch Ophthalmol"},{"key":"BF6702204_CR9","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/00003226-200305000-00001","volume":"22","author":"AM Bawazeer","year":"2003","unstructured":"Bawazeer AM, Hodge WG . One-minute Schirmer test with anaesthesia. Cornea 2003; 22: 285\u2013287.","journal-title":"Cornea"},{"key":"BF6702204_CR10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s004170050090","volume":"236","author":"L Ravazzoni","year":"1998","unstructured":"Ravazzoni L, Ghini C, Macri A, Rolando M . Forecasting of hydrophilic contact lens tolerance by means of tear ferning test. Graefe's Arch Clin Exp Ophthalmol 1998; 236: 354\u2013358.","journal-title":"Graefe's Arch Clin Exp Ophthalmol"},{"key":"BF6702204_CR11","first-page":"1046","volume":"35","author":"J Chodosh","year":"1994","unstructured":"Chodosh J, Dix R, Howell RC, Dtroop WG, Tseng SC . Staining characteristics and antiviral activity of sulphorodamine B and lissamine green B. Invest Ophthalmol Vis Sci 1994; 35: 1046\u20131058.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702204_CR12","first-page":"2915","volume":"41","author":"ME Rosenberg","year":"2000","unstructured":"Rosenberg ME, Tervo TM, Immonen IJ, Muller IJ, Vesaluoma MH . Corneal structure and sensitivity in type 1 diabetes mellitus. Invest Ophthalmol Vis Sci 2000; 41: 2915\u20132921.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702204_CR13","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1001\/archopht.1995.01100010086025","volume":"113","author":"KE Xu","year":"1995","unstructured":"Xu KE, Yagi Y, Toda I, Tsubota K . Tear function index. A new measure of dry eye. Arch Ophthalmol 1995; 113: 84\u201388.","journal-title":"Arch Ophthalmol"},{"key":"BF6702204_CR14","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/S0161-6420(85)33967-2","volume":"92","author":"SCG Tseng","year":"1985","unstructured":"Tseng SCG . Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology 1985; 92: 728\u2013733.","journal-title":"Ophthalmology"},{"key":"BF6702204_CR15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/clinchem\/39.4.561","volume":"39","author":"MH Zweig","year":"1993","unstructured":"Zweig MH, Campbell R . Receiver-Operating Characteristic (ROC) Plot. A fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39: 561\u2013577.","journal-title":"Clin Chem"},{"key":"BF6702204_CR16","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/ard.53.10.637","volume":"53","author":"C Vitali","year":"1994","unstructured":"Vitali C, Moutsopoulos HM, Bombardieri S . The European Community Study Group on diagnostic criteria for Sjogren's syndrome. Sensitivity and specificity of tests for ocular and oral involvement in Sjogren's syndrome. Ann Rheum Dis 1994; 53: 637\u2013647.","journal-title":"Ann Rheum Dis"},{"key":"BF6702204_CR17","first-page":"604","volume":"26","author":"HJ Haga","year":"1999","unstructured":"Haga HJ, Hulten B, Bolstad AI, Ulvestad E, Jonsson R . Reliability and sensitivity of diagnostic tests for primary Sjogren's syndrome. J Rheumatol 1999; 26: 604\u2013608.","journal-title":"J Rheumatol"},{"key":"BF6702204_CR18","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/00003226-200404000-00010","volume":"23","author":"KK Nichols","year":"2004","unstructured":"Nichols KK, Mitchell GL, Zadnik K . The repeatability of clinical measurements of dry eye. Cornea 2004; 23: 272\u2013285.","journal-title":"Cornea"},{"key":"BF6702204_CR19","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1136\/ard.57.1.20","volume":"57","author":"EM Hay","year":"1998","unstructured":"Hay EM, Thomas E, Pal B . Weak association between subjective symptoms or and objective testing for dry eyes and dry mouth: results from a population based study. Ann Rheum Dis 1998; 57: 20\u201324.","journal-title":"Ann Rheum Dis"},{"key":"BF6702204_CR20","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1097\/00003226-199405000-00002","volume":"13","author":"K Tsubota","year":"1994","unstructured":"Tsubota K, Toda I, Yagi Y, Ogawa Y, Ono M, Yoshino K . Three different types of dry eye syndrome. Cornea 1994; 13: 202\u2013209.","journal-title":"Cornea"},{"key":"BF6702204_CR21","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1001\/archotol.129.9.966","volume":"129","author":"A Vissing","year":"2003","unstructured":"Vissing A, Kalk WW, Mansour K, Spijkervet FK, Bootsma H . Comparison of lachrymal and salivary gland involvement in Sjogren's syndrome. Arch Otolaryngol Head Neck Surg 2003; 129: 966\u2013971.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"BF6702204_CR22","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.exer.2003.09.009","volume":"78","author":"M Calonge","year":"2004","unstructured":"Calonge M, Diebold Y, Saez V . Impression cytology of the ocular surface: a review. Exp Eye Res 2004; 78: 457\u2013472.","journal-title":"Exp Eye Res"},{"key":"BF6702204_CR23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4321\/S0365-66912002001100007","volume":"77","author":"L Rivas","year":"2002","unstructured":"Rivas L, Murube J, Shalaby O, Oroza MA, Sanz AI . Impression cytology contribution to differential diagnosis of Sjogren's syndrome in the ophthalmological clinic. Arch Soc Esp Oftalmol 2002; 77: 63\u201372.","journal-title":"Arch Soc Esp Oftalmol"},{"key":"BF6702204_CR24","first-page":"649","volume":"12","author":"JG Brun","year":"1994","unstructured":"Brun JG, Jacobsen H, Kloster R, Cuida M, Johannesen AC, Hoyeraal HM et al. Use of a sicca symptoms questionnaire for the identification of patients with Sjogren's syndrome in a heterogeneous hospital population with various rheumatic diseases. Clin Exp Rheumatol 1994; 12: 649\u2013652.","journal-title":"Clin Exp Rheumatol"},{"key":"BF6702204_CR25","first-page":"1259","volume":"30","author":"SJ Bowman","year":"2003","unstructured":"Bowman SJ, Booth DA, Platts RG . Validation of the Sicca Symptoms Inventory for clinical studies of Sjogren's syndrome. J Rheumatol 2003; 30: 1259\u20131266.","journal-title":"J Rheumatol"},{"key":"BF6702204_CR26","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1136\/bjo.83.1.89","volume":"83","author":"K Tsubota","year":"1999","unstructured":"Tsubota K, Kaido M, Yagi Y, Fujihara T, Shimmura S . Diseases associated with ocular surface abnormalities: the importance of reflex tearing. Br J Ophthalmol 1999; 83: 89\u201391.","journal-title":"Br J Ophthalmol"},{"key":"BF6702204_CR27","first-page":"313","volume":"23","author":"K Tsubota","year":"1996","unstructured":"Tsubota K, Xu KP, Fujihara T, Katagiri S, Takeuchi T . Decreased reflex tearing is associated with lymphocytic infiltration in lachrymal glands. J Rheumatol 1996; 23: 313\u2013320.","journal-title":"J Rheumatol"},{"key":"BF6702204_CR28","first-page":"153","volume":"49","author":"VS Sangwan","year":"2001","unstructured":"Sangwan VS, Tseng SCG . New perspectives in ocular surface disorders. An integrated approach for diagnosis and management. Indian J Ophthalmol 2001; 49: 153\u2013168.","journal-title":"Indian J Ophthalmol"},{"key":"BF6702204_CR29","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0074-7696(03)31004-6","volume":"231","author":"RR Hodges","year":"2003","unstructured":"Hodges RR, Dartt DA . Regulatory pathways in lachrymal gland epithelium. Int Rev Cytol 2003; 231: 129\u2013196.","journal-title":"Int Rev Cytol"},{"key":"BF6702204_CR30","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.exer.2003.08.003","volume":"78","author":"C Sade de Paiva","year":"2004","unstructured":"Sade de Paiva C, Plugfelder SC . Tear clearance implications for ocular surface health. Exp Eye Res 2004; 78: 395\u2013397.","journal-title":"Exp Eye Res"},{"key":"BF6702204_CR31","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/00003226-199605000-00002","volume":"15","author":"KP Xu","year":"1996","unstructured":"Xu KP, Yagi Y, Tsubota K . Decrease in corneal sensitivity and change in tear function in dry eye. Cornea 1996; 15: 235\u2013239.","journal-title":"Cornea"},{"key":"BF6702204_CR32","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0008-4182(04)80071-1","volume":"39","author":"FA Adatia","year":"2004","unstructured":"Adatia FA, Michaeli-Cohen A, Naor J, Caffery B, Bookman A, Slomovic A . Correlation between corneal sensitivity, subjective dry eye symptoms and corneal staining in Sjogren's syndrome. Can J Ophthalmol 2004; 39: 767\u2013771.","journal-title":"Can J Ophthalmol"},{"key":"BF6702204_CR33","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1167\/iovs.02-1260","volume":"44","author":"ISJ Tuominen","year":"2003","unstructured":"Tuominen ISJ, Konttinen YT, Vesaluoma MH, Moilanen JAO, Helinto M, Tervo TMT . Corneal innervation and morphology in primary Sjogren's Syndrome. Invest Ophthalmol Vis Sci 2003; 44: 2545\u20132549.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702204_CR34","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1136\/ard.59.1.48","volume":"59","author":"L Kovacs","year":"2000","unstructured":"Kovacs L, Torok T, Bari F . Impaired microvascular response to cholinergic stimuli in primary Sjogren's syndrome. Ann Rheum Dis 2000; 59: 48\u201353.","journal-title":"Ann Rheum Dis"},{"key":"BF6702204_CR35","first-page":"697","volume":"21","author":"L Kovacs","year":"2003","unstructured":"Kovacs L, Papos M, Takacs F . Autonomic nervous system dysfunction involving the gastrointestinal and the urinary tracts in primary Sjogren's syndrome. Clin Exp Rheumatol 2003; 21: 697\u2013703.","journal-title":"Clin Exp Rheumatol"},{"key":"BF6702204_CR36","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1080\/030097400447525","volume":"29","author":"R Jonsson","year":"2000","unstructured":"Jonsson R, Haga HJ, Gordon TP . Current concepts on diagnosis, autoantibodies and therapy in Sjogren's syndrome. Scand J Rheumatol 2000; 29: 341\u2013348.","journal-title":"Scand J Rheumatol"},{"key":"BF6702204_CR37","first-page":"321","volume":"42","author":"S Bacman","year":"2001","unstructured":"Bacman S, Berra A, Sterin-Borda L, Borda E . Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjogren's syndrome. Invest Ophthalmol Vis Sci 2001; 42: 321\u2013327.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702204_CR38","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1046\/j.1365-2249.1996.42748.x","volume":"104","author":"S Bacman","year":"1996","unstructured":"Bacman S, Sterin-borda L, Camusso JJ . Circulating antibodies against rat parotid gland M-3 muscarinic receptors in primary Sjogren's syndrome. Clin Exp Immunol 1996; 104: 454\u2013459.","journal-title":"Clin Exp Immunol"},{"key":"BF6702204_CR39","first-page":"27","volume-title":"Scand J Rheumatol","author":"M Rolando","year":"2001","unstructured":"Rolando M . Sjogren's syndrome as seen by an ophthalmologist. Scand J Rheumatol 2001; 115(suppl): 27\u201333."},{"key":"BF6702204_CR40","first-page":"2283","volume":"42","author":"A Solomon","year":"2001","unstructured":"Solomon A, Dursun D, Liu Z . Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry eye disease. Invest Ophthalmol Vis Sci 2001; 42: 2283\u20132292.","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6702204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6702204","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6702204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:23:48Z","timestamp":1684412628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6702204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,6]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["BF6702204"],"URL":"https:\/\/doi.org\/10.1038\/sj.eye.6702204","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,6]]}}}