{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:56:56Z","timestamp":1787003816629,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eye"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1038\/sj.eye.6702212","type":"journal-article","created":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T02:31:04Z","timestamp":1134095464000},"page":"367-376","source":"Crossref","is-referenced-by-count":54,"title":["Functional observations in vitamin A deficiency: diagnosis and time course of recovery"],"prefix":"10.1038","volume":"21","author":[{"given":"V A","family":"McBain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Pieris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Supramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A R","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G E","family":"Holder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"BF6702212_CR1","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1006\/exer.1993.1084","volume":"56","author":"ML Katz","year":"1993","unstructured":"Katz ML, Chen DM, Stientjes HJ, Stark WS . Photoreceptor recovery in retinoid deprived rats after vitamin A replenishment. Exp Eye Res 1993; 56: 671\u2013682.","journal-title":"Exp Eye Res"},{"key":"BF6702212_CR2","first-page":"437","volume":"18","author":"L Carter-Dawson","year":"1979","unstructured":"Carter-Dawson L, Kuwabara T, O\u2019Brien PJ, Bieri JG . Structural and biochemical changes in vitamin A-deficient rat retinas. Invest Ophthalmol Vis Sci 1979; 18: 437\u2013446.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF6702212_CR3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1126\/science.172.3978.72","volume":"172","author":"WK Noell","year":"1971","unstructured":"Noell WK, Delmelle MC, Albrecht R . Vitamin A deficiency effect on retina: dependence on light. Science 1971; 172: 72\u201375.","journal-title":"Science"},{"key":"BF6702212_CR4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0014-4835(88)80076-9","volume":"46","author":"CM Kemp","year":"1988","unstructured":"Kemp CM, Jacobson SG, Faulkner DJ, Walt RW . Visual function and rhodopsin levels in humans with vitamin A deficiency. Exp Eye Res 1988; 46: 185\u2013197.","journal-title":"Exp Eye Res"},{"key":"BF6702212_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1136\/bjo.67.1.37","volume":"67","author":"I Perlman","year":"1983","unstructured":"Perlman I, Barzilai D, Haim T, Schramk A . Night vision in a case of vitamin A deficiency due to malabsorption. Br J Ophthalmol 1983; 67: 37\u201342.","journal-title":"Br J Ophthalmol"},{"key":"BF6702212_CR6","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/0002-9394(80)90164-6","volume":"89","author":"GC Brown","year":"1980","unstructured":"Brown GC, Felton SM, Benson WE . Reversible night blindness associated with intestinal bypass surgery. Am J Ophthalmol 1980; 89: 776\u2013779.","journal-title":"Am J Ophthalmol"},{"key":"BF6702212_CR7","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1136\/bmj.288.6423.1030","volume":"288","author":"RP Walt","year":"1984","unstructured":"Walt RP, Kemp CM, Lyness L, Bird AC, Sherlock S . Vitamin A treatment for night blindness in primary biliary cirrhosis. BMJ 1984; 288: 1030\u20131031.","journal-title":"BMJ"},{"key":"BF6702212_CR8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1755-3768.1988.tb04607.x","volume":"66","author":"L Wachtmeister","year":"1988","unstructured":"Wachtmeister L, Bjorkhem I, Diczfalusy U, Emami A . Attempts to define the minimal serum level of vitamin A required for normal visual function in a patient with severe fat malabsorption. Acta Ophthalmol (Copenhagen) 1988; 66: 341\u2013348.","journal-title":"Acta Ophthalmol (Copenhagen)"},{"key":"BF6702212_CR9","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/0002-9394(77)90381-6","volume":"84","author":"MA Sandberg","year":"1977","unstructured":"Sandberg MA, Rosen JB, Berson EL . Cone and rod function in vitamin A deficiency with chronic alcoholism and in retinitis pigmentosa. Am J Ophthalmol 1977; 84: 658\u2013665.","journal-title":"Am J Ophthalmol"},{"key":"BF6702212_CR10","first-page":"737","volume-title":"Principles and Practice of Clinical Electrophysiology of Vision","author":"RE Carr","year":"1991","unstructured":"Carr RE . Vitamin A deficiency. In: Heckinlively JR, Arden GB (eds). Principles and Practice of Clinical Electrophysiology of Vision. Mosby Year Book: St Louis, MO, 1991 pp 737\u2013740."},{"key":"BF6702212_CR11","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/S0161-6420(94)38029-8","volume":"101","author":"NJ Newman","year":"1994","unstructured":"Newman NJ, Capone A, Leeper HF, O\u2019Day DG, Mandell B, Lambert SR et al. Clinical and subclinical ophthalmic findings with retinol deficiency. Opthalmology 1994; 101: 1077\u20131083.","journal-title":"Opthalmology"},{"key":"BF6702212_CR12","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1136\/bjo.2003.022459","volume":"88","author":"Y Spits","year":"2004","unstructured":"Spits Y, De Laey J-J, Leroy BP . Rapid recovery of night blindness due to obesity surgery after vitamin A repletion therapy. Br J Ophthamol 2004; 88: 583\u2013585.","journal-title":"Br J Ophthamol"},{"key":"BF6702212_CR13","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1023\/A:1002016531591","volume":"97","author":"MF Marmor","year":"1999","unstructured":"Marmor MF, Zrenner E . Standard for clinical electroretinography (1999 update). Doc Ophthalmol 1999; 97: 143\u2013156.","journal-title":"Doc Ophthalmol"},{"key":"BF6702212_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1023\/A:1002732114721","volume":"101","author":"M Bach","year":"2000","unstructured":"Bach M, Hawlina M, Holder GE, Marmour M, Meigan T, Vaegan et al. Standard for pattern electroretinography. Doc Ophthalmol 2000; 101: 11\u201318.","journal-title":"Doc Ophthalmol"},{"key":"BF6702212_CR15","first-page":"701","volume":"91","author":"PA Seiving","year":"1993","unstructured":"Seiving PA . Photopic ON- and OFF-pathway abnormalities in retinal dystrophies. Trans Am Ophthalmol Soc 1993; 91: 701\u2013773.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"BF6702212_CR16","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0042-6989(98)00182-5","volume":"39","author":"GE Arden","year":"1998","unstructured":"Arden GE, Wolf J, Beringer T, Hog CR, Tzekov R, Holder GE . S-cone ERGs elicited by a simple technique in normals and in tritanopes. Vis Res 1998; 39: 641\u2013650.","journal-title":"Vis Res"},{"key":"BF6702212_CR17","first-page":"303","volume":"2","author":"GB Arden","year":"1988","unstructured":"Arden GB, G\u00fbnd\u00fbz K, Perry S . Colour vision testing with a computer graphics system. Clin Vis Sci 1988; 2: 303\u2013320.","journal-title":"Clin Vis Sci"},{"key":"BF6702212_CR18","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/BF00154382","volume":"80","author":"N Wali","year":"1992","unstructured":"Wali N, Leguire LE . The photopic hill: a new phenomenon of the light adapted electroretinogram. Doc Ophthalmol 1992; 80: 335\u2013342.","journal-title":"Doc Ophthalmol"},{"key":"BF6702212_CR19","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1167\/iovs.03-0657","volume":"45","author":"S Ueno","year":"2004","unstructured":"Ueno S, Konodo M, Niwa Y, Terasaki H, Miyake Y . Luminance dependence of neural components that underlies the primate photopic electroretinogram. Invest Ophtnalmol Vis Sci 2004; 45: 1033\u20131040.","journal-title":"Invest Ophtnalmol Vis Sci"},{"key":"BF6702212_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1023\/A:1024498826904","volume":"107","author":"M Nakamura","year":"2003","unstructured":"Nakamura M, Skalet J, Miyake Y . RDH5 mutations and electroretinograms in fundus albipunctatus with or without macular dystrophy. Doc Ophthalmol 2003; 107: 3\u201311.","journal-title":"Doc Ophthalmol"},{"key":"BF6702212_CR21","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0896-6273(02)00912-1","volume":"36","author":"N Mata","year":"2002","unstructured":"Mata N, Radu R, Clemmons R, Travis GH . Isomerization and oxidation of vitamin A in cone-dominant retinas. A novel pathway for visual-pigment regeneration in daylight. Neuron 2002; 36: 69\u201380.","journal-title":"Neuron"}],"container-title":["Eye"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/6702212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6702212","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/6702212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:23:54Z","timestamp":1684398234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6702212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["BF6702212"],"URL":"https:\/\/doi.org\/10.1038\/sj.eye.6702212","relation":{},"ISSN":["0950-222X","1476-5454"],"issn-type":[{"value":"0950-222X","type":"print"},{"value":"1476-5454","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,9]]}}}